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    DCAF8 DDB1 and CUL4 associated factor 8 [ Homo sapiens ]

    Gene ID: 50717, updated on 11-May-2012

    Summary

    Official Symbol
    DCAF8provided by HGNC
    Official Full Name
    DDB1 and CUL4 associated factor 8provided by HGNC
    Primary source
    HGNC:24891
    Locus tag
    RP11-574F21.1
    See related
    Ensembl:ENSG00000132716; Ensembl:ENSG00000258465; HPRD:18300; Vega:OTTHUMG00000031604; Vega:OTTHUMG00000171815
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    H326; WDR42A; FLJ35857; MGC99640; MGC117276; MGC118891; DKFZp781G1096
    Summary
    This gene encodes a WD repeat-containing protein that interacts with the Cul4-Ddb1 E3 ligase macromolecular complex. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2009]

    Genomic context

    Location :
    1q22-q23
    Sequence :
    Chromosome: 1; NC_000001.10 (160185505..160232350, complement)
    See DCAF8 in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene calsequestrin 1 (fast-twitch, skeletal muscle) Neighboring gene phosphoprotein enriched in astrocytes 15 Neighboring gene uncharacterized LOC100505686 Neighboring gene uncharacterized LOC100287049 Neighboring gene ribosomal protein SA pseudogene 18 Neighboring gene peroxisomal biogenesis factor 19

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    WD repeat domain 42A Q16531 DDB1    HPRD  PubMed  
    WD repeat domain 42A Q969Y2 GTPBP3    HPRD  PubMed  
    WD repeat domain 42A Q99750 MDFI    HPRD  PubMed  
    BioGRID:119121 BioGRID:198236 Atm    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119121 BioGRID:114029 CUL4A    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119121 BioGRID:114028 CUL4B    BioGRID  PubMed Reconstituted Complex 
    BioGRID:119121 BioGRID:108009 DDB1    BioGRID  PubMed Affinity Capture-MS; Reconstituted Complex 
    BioGRID:119121 BioGRID:199074 Ddb1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:119121 BioGRID:124216 GTPBP3    BioGRID  PubMed Two-hybrid 
    BioGRID:119121 BioGRID:110353 MDFI    BioGRID  PubMed Two-hybrid 
    BioGRID:119121 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 

    General gene information

    Markers

    Potential readthrough

    Included gene: PEX19

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    protein ubiquitination IC
    Inferred by Curator
    more info
    PubMed 
    Component Evidence Code Pubs
    CUL4 RING ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    DDB1- and CUL4-associated factor 8
    Names
    DDB1- and CUL4-associated factor 8
    WD repeat domain 42A
    WD repeat-containing protein 42A

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015726.3NP_056541.2  DDB1- and CUL4-associated factor 8

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the functional protein.
      Source sequence(s)
      AK303188, AL139011, BC099709, BU629460, DA622120
      Consensus CDS
      CCDS1200.1
      UniProtKB/TrEMBL
      B7Z8C9
      UniProtKB/Swiss-Prot
      Q5TAQ9
      Related
      ENSP00000357053, OTTHUMP00000029884, ENST00000368074, OTTHUMT00000077403
      Conserved Domains (1) summary
      cl02567
      Location:189506
      Blast Score: 268
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RNA

    1. NR_028103.1 RNA Sequence

      Description
      Transcript Variant: This variant (2) contains an alternate 5' exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is expected to inhibit the translation of the longest ORF; translation of the upstream ORF would result in nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL139011, BC099709, BU629460, DC296401
    2. NR_028104.1 RNA Sequence

      Description
      Transcript Variant: This variant (3) contains an alternate 5' exon and lacks an internal exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is expected to inhibit the translation of the longest ORF; translation of the upstream ORF would result in nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK312690, AL139011, BC099709, BU629460, DC296401
    3. NR_028105.1 RNA Sequence

      Description
      Transcript Variant: This variant (4) contains an alternate exon in the 5' region and differs in the presence and absence of exons in the 3' region, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is expected to inhibit the translation of the longest ORF; translation of the upstream ORF would result in nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      BC111063, DC296401
    4. NR_028106.1 RNA Sequence

      Description
      Transcript Variant: This variant (5) contains an alternate exon and uses an alternate splice site in the 5' region, and differs in the presence and absence of exons in the 3' region, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is expected to inhibit the translation of the longest ORF; translation of the upstream ORF would result in nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      BC013107, BC111063, BP359560

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p5 Primary Assembly

      Range
      160185505..160232350, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      131542143..131588999, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

      Supplemental Content

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