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Postn periostin, osteoblast specific factor [ Mus musculus (house mouse) ]

Gene ID: 50706, updated on 28-May-2016
Official Symbol
Postnprovided by MGI
Official Full Name
periostin, osteoblast specific factorprovided by MGI
Primary source
MGI:MGI:1926321
See related
Ensembl:ENSMUSG00000027750 Vega:OTTMUSG00000029043
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PN; PLF; Osf2; OSF-2; AI747096; A630052E07Rik
Summary
This gene encodes a secreted extracellular matrix protein that functions in tissue development and regeneration, including wound healing and ventricular remodeling following myocardial infarction. The encoded protein binds to integrins to support adhesion and migration of epithelial cells. This protein plays a role in cancer stem cell maintenance and metastasis. Mice lacking this gene exhibit cardiac valve disease, and skeletal and dental defects. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]
Orthologs
Location:
3; 3 C
Exon count:
23
Annotation release Status Assembly Chr Location
105 current GRCm38.p3 (GCF_000001635.23) 3 NC_000069.6 (54361096..54391041)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (54165047..54194954)

Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene transient receptor potential cation channel, subfamily C, member 4 Neighboring gene predicted gene, 31095 Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene Neighboring gene predicted gene, 31154

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
cell adhesion molecule binding IBA
Inferred from Biological aspect of Ancestor
more info
 
heparin binding IDA
Inferred from Direct Assay
more info
PubMed 
metal ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
cell adhesion ISO
Inferred from Sequence Orthology
more info
 
cellular response to vitamin K IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to vitamin K ISO
Inferred from Sequence Orthology
more info
 
extracellular matrix organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
 
neuron projection extension ISO
Inferred from Sequence Orthology
more info
 
positive regulation of chemokine (C-C motif) ligand 2 secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of smooth muscle cell migration ISO
Inferred from Sequence Orthology
more info
 
regulation of Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of systemic arterial blood pressure ISO
Inferred from Sequence Orthology
more info
 
tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
extracellular matrix ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with extracellular matrix ISO
Inferred from Sequence Orthology
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
extracellular space ISO
Inferred from Sequence Orthology
more info
 
neuromuscular junction ISO
Inferred from Sequence Orthology
more info
 
proteinaceous extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
trans-Golgi network ISO
Inferred from Sequence Orthology
more info
 
Preferred Names
periostin
Names
osteoblast specific factor 2 (fasciclin I-like)
osteoblast-specific factor 2
periostin-like factor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001198765.1NP_001185694.1  periostin isoform 2 precursor

    See identical proteins and their annotated locations for NP_001185694.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate in-frame exon, and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AC139043, AK030756, BE850247, BF020820
    Consensus CDS
    CCDS57211.1
    UniProtKB/Swiss-Prot
    Q62009
    Related
    ENSMUSP00000103619, OTTMUSP00000037007, ENSMUST00000107985, OTTMUST00000072061
    Conserved Domains (2) summary
    pfam02469
    Location:247369
    Fasciclin; Fasciclin domain
    pfam07546
    Location:4289
    EMI; EMI domain
  2. NM_001198766.1NP_001185695.1  periostin isoform 3 precursor

    See identical proteins and their annotated locations for NP_001185695.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. It encodes isoform 3, which is shorter than isoform 1.
    Source sequence(s)
    AC139043
    Consensus CDS
    CCDS57212.1
    UniProtKB/Swiss-Prot
    Q62009
    Related
    ENSMUSP00000112735, OTTMUSP00000037008, ENSMUST00000117373, OTTMUST00000072062
    Conserved Domains (2) summary
    pfam02469
    Location:247369
    Fasciclin; Fasciclin domain
    pfam07546
    Location:4289
    EMI; EMI domain
  3. NM_001313898.1NP_001300827.1  periostin isoform 4 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an alternate in-frame exon, and lacks two alternate in-frame exons in the 3' coding region, compared to variant 1. It encodes isoform 4, which is shorter than isoform 1.
    Source sequence(s)
    AC139043
    UniProtKB/TrEMBL
    A0A097BW21
    Conserved Domains (2) summary
    pfam02469
    Location:247369
    Fasciclin; Fasciclin domain
    pfam07546
    Location:4289
    EMI; EMI domain
  4. NM_001313899.1NP_001300828.1  periostin isoform 5 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks two alternate in-frame exons in the 3' coding region, compared to variant 1. It encodes isoform 5, which is shorter than isoform 1.
    Source sequence(s)
    AC139043
    UniProtKB/TrEMBL
    A0A097BW18
    Conserved Domains (2) summary
    pfam02469
    Location:247369
    Fasciclin; Fasciclin domain
    pfam07546
    Location:4289
    EMI; EMI domain
  5. NM_015784.3NP_056599.1  periostin isoform 1 precursor

    See identical proteins and their annotated locations for NP_056599.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC139043, BE850247, BF020820, D13664
    Consensus CDS
    CCDS17351.1
    UniProtKB/Swiss-Prot
    Q62009
    Related
    ENSMUSP00000072773, OTTMUSP00000037009, ENSMUST00000073012, OTTMUST00000072063
    Conserved Domains (2) summary
    pfam02469
    Location:247369
    Fasciclin; Fasciclin domain
    pfam07546
    Location:4289
    EMI; EMI domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p3 C57BL/6J

Genomic

  1. NC_000069.6 Reference GRCm38.p3 C57BL/6J

    Range
    54361096..54391041
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006501653.1XP_006501716.1  

    See identical proteins and their annotated locations for XP_006501716.1

    UniProtKB/Swiss-Prot
    Q62009
    Related
    ENSMUSP00000080276, OTTMUSP00000037010, ENSMUST00000081564, OTTMUST00000072064
    Conserved Domains (2) summary
    pfam02469
    Location:247369
    Fasciclin; Fasciclin domain
    pfam07546
    Location:4289
    EMI; EMI domain
  2. XM_006501654.1XP_006501717.1  

    Conserved Domains (2) summary
    pfam02469
    Location:247369
    Fasciclin; Fasciclin domain
    pfam07546
    Location:4289
    EMI; EMI domain
  3. XM_006501655.1XP_006501718.1  

    Conserved Domains (2) summary
    pfam02469
    Location:247369
    Fasciclin; Fasciclin domain
    pfam07546
    Location:4289
    EMI; EMI domain

Alternate Mm_Celera

Genomic

  1. AC_000025.1 Alternate Mm_Celera

    Range
    54083048..54112955
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)