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Gsk3a glycogen synthase kinase 3 alpha [ Rattus norvegicus (Norway rat) ]

Gene ID: 50686, updated on 17-May-2016
Official Symbol
Gsk3aprovided by RGD
Official Full Name
glycogen synthase kinase 3 alphaprovided by RGD
Primary source
RGD:620351
See related
Ensembl:ENSRNOG00000020417
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Rattus
Summary
protein-serine kinase; may mediate hormonal control of several regulatory proteins including glycogen synthase and the transcription factor c-jun [RGD, Feb 2006]
Annotation information
Annotation category: suggests misassembly
Orthologs
Location:
1q21
Exon count:
11
Annotation release Status Assembly Chr Location
105 current Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (82097244..82108203, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 1 NC_005100.3 (83365717..83374707, complement)

Chromosome 1 - NC_005100.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103691054 Neighboring gene death effector domain containing 2 Neighboring gene zinc finger protein 526 Neighboring gene Ets2 repressor factor Neighboring gene capicua transcriptional repressor

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase A catalytic subunit binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase A catalytic subunit binding ISO
Inferred from Sequence Orthology
more info
 
protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
tau-protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
aging IDA
Inferred from Direct Assay
more info
PubMed 
cardiac left ventricle morphogenesis IEA
Inferred from Electronic Annotation
more info
 
cardiac left ventricle morphogenesis ISO
Inferred from Sequence Orthology
more info
 
cell migration IEA
Inferred from Electronic Annotation
more info
 
cell migration ISO
Inferred from Sequence Orthology
more info
 
cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to interleukin-3 IEA
Inferred from Electronic Annotation
more info
 
cellular response to interleukin-3 ISO
Inferred from Sequence Orthology
more info
 
cellular response to interleukin-3 ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to lithium ion IEA
Inferred from Electronic Annotation
more info
 
cellular response to lithium ion ISO
Inferred from Sequence Orthology
more info
 
cellular response to organic cyclic compound IEA
Inferred from Electronic Annotation
more info
 
cellular response to organic cyclic compound ISO
Inferred from Sequence Orthology
more info
 
extrinsic apoptotic signaling pathway in absence of ligand IEA
Inferred from Electronic Annotation
more info
 
extrinsic apoptotic signaling pathway in absence of ligand ISO
Inferred from Sequence Orthology
more info
 
extrinsic apoptotic signaling pathway in absence of ligand ISS
Inferred from Sequence or Structural Similarity
more info
 
glycogen metabolic process IEA
Inferred from Electronic Annotation
more info
 
hypermethylation of CpG island IEA
Inferred from Electronic Annotation
more info
 
hypermethylation of CpG island ISO
Inferred from Sequence Orthology
more info
 
insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of TOR signaling IEA
Inferred from Electronic Annotation
more info
 
negative regulation of TOR signaling ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell growth involved in cardiac muscle cell development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell growth involved in cardiac muscle cell development ISO
Inferred from Sequence Orthology
more info
 
negative regulation of dendrite development IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of glucose import ISO
Inferred from Sequence Orthology
more info
 
negative regulation of glycogen synthase activity, transferring glucose-1-phosphate ISO
Inferred from Sequence Orthology
more info
 
negative regulation of insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of adrenergic receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of adrenergic receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cAMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cAMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of glycogen (starch) synthase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of glycogen (starch) synthase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of heart contraction IEA
Inferred from Electronic Annotation
more info
 
positive regulation of heart contraction ISO
Inferred from Sequence Orthology
more info
 
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of peptidyl-threonine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein targeting to mitochondrion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription from RNA polymerase II promoter IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription from RNA polymerase II promoter ISO
Inferred from Sequence Orthology
more info
 
proteasome-mediated ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
proteasome-mediated ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
regulation of gene expression by genetic imprinting IEA
Inferred from Electronic Annotation
more info
 
regulation of gene expression by genetic imprinting ISO
Inferred from Sequence Orthology
more info
 
regulation of mitophagy ISO
Inferred from Sequence Orthology
more info
 
regulation of systemic arterial blood pressure IEA
Inferred from Electronic Annotation
more info
 
regulation of systemic arterial blood pressure ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
microtubule IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
glycogen synthase kinase-3 alpha
Names
FA
GSK-3 alpha
factor A
serine/threonine-protein kinase GSK3A
NP_059040.1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017344.1NP_059040.1  glycogen synthase kinase-3 alpha

    See identical proteins and their annotated locations for NP_059040.1

    Status: PROVISIONAL

    Source sequence(s)
    X53427
    UniProtKB/Swiss-Prot
    P18265
    UniProtKB/TrEMBL
    F1LP91
    Related
    ENSRNOP00000027677, ENSRNOT00000027677
    Conserved Domains (2) summary
    pfam00069
    Location:119403
    Pkinase; Protein kinase domain
    cd14137
    Location:114406
    STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005100.4 Reference Rnor_6.0 Primary Assembly

    Range
    82097244..82108203 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008758972.1XP_008757194.1  

    Conserved Domains (2) summary
    pfam00069
    Location:119410
    Pkinase; Protein kinase domain
    cd14137
    Location:114413
    STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3

Alternate Rn_Celera

Genomic

  1. AC_000069.1 Alternate Rn_Celera

    Range
    75259483..75269362 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)