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IL20 interleukin 20 [ Homo sapiens (human) ]

Gene ID: 50604, updated on 26-Jul-2015
Official Symbol
IL20provided by HGNC
Official Full Name
interleukin 20provided by HGNC
Primary source
HGNC:HGNC:6002
See related
Ensembl:ENSG00000162891; HPRD:05728; MIM:605619
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IL-20; IL10D; ZCYTO10
Summary
The protein encoded by this gene is a cytokine structurally related to interleukin 10 (IL10). This cytokine has been shown to transduce its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis. [provided by RefSeq, Jul 2008]
Orthologs
See IL20 in Epigenomics, MapViewer
Location:
1q32
Exon count:
6
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 1 NC_000001.11 (206865354..206869223)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (207038699..207042568)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene interleukin 10 Neighboring gene interleukin 19 Neighboring gene uncharacterized LOC105372878 Neighboring gene uncharacterized LOC105372879 Neighboring gene interleukin 24 Neighboring gene Fc fragment of IgM receptor

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Tat tat IL-20 is upregulated by HIV-1 Tat treatment in human epithelial cells PubMed

Go to the HIV-1, Human Interaction Database

  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
    Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
    Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC96907

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
 
interleukin-20 receptor binding TAS
Traceable Author Statement
more info
PubMed 
interleukin-22 receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
immune response IBA
Inferred from Biological aspect of Ancestor
more info
 
inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
 
positive regulation of epidermal cell differentiation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of keratinocyte differentiation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of osteoclast differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of tyrosine phosphorylation of Stat3 protein TAS
Traceable Author Statement
more info
PubMed 
regulation of inflammatory response TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
interleukin-20
Names
cytokine Zcyto10
four alpha helix cytokine

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018724.3NP_061194.2  interleukin-20 precursor

    See identical proteins and their annotated locations for NP_061194.2

    Status: REVIEWED

    Source sequence(s)
    AF224266, AY358320, BC069311
    Consensus CDS
    CCDS1470.1
    UniProtKB/Swiss-Prot
    Q9NYY1
    Related
    ENSP00000375796, ENST00000391930
    Conserved Domains (1) summary
    cl02501
    Location:21173
    IL10; Interleukin 10

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p2 Primary Assembly

    Range
    206865354..206869223
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005273152.2XP_005273209.1  

    See identical proteins and their annotated locations for XP_005273209.1

    Conserved Domains (1) summary
    cl02501
    Location:106258
    IL10; Interleukin 10

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 Alternate CHM1_1.1

    Range
    208311726..208315140
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)