IL20 interleukin 20 [Homo sapiens] - Gene

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Summary

Official Symbol: IL20provided by HGNC
Official Full Name: interleukin 20provided by HGNC
Primary source: HGNC:6002
Locus tag: UNQ852/PRO1801
See related: Ensembl:ENSG00000162891; HPRD:05728; MIM:605619; Vega:OTTHUMG00000036456
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: IL-20; IL10D; ZCYTO10; MGC96907
Summary: The protein encoded by this gene is a cytokine structurally related to interleukin 10 (IL10). This cytokine has been shown to transduce its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 1q32

Sequence :: Chromosome: 1; NC_000001.10 (207039154..207042568)

See IL20 in Epigenomics, MapViewer

Chromosome 1 - NC_000001.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

crystallographic asymmetric unit contains one IL-20-IL-20R1-IL-20R2 complex, corresponding to a solvent content of approximately 54%
Title: Purification, crystallization and preliminary X-ray diffraction analysis of the IL-20-IL-20R1-IL-20R2 complex.
IL-20 & its receptors were epigenetically regulated through histone post-translational modifications and DNA CpG residue methylation. Also, treatment with recombinant IL-20 resulted in decreased expression of the VEGF family members at the mRNA level.
Title: IL-20 is epigenetically regulated in NSCLC and down regulates the expression of VEGF.
The G allele of the IL-20 -1723C to G polymorphism may contribute to a genetic susceptibility to psoriasis in the Chinese Han population, particularly in patients with psoriasis triggered or exacerbated by an upper respiratory tract infection.
Title: The association between the IL-20-1723C→G allele on the 1q chromosome and psoriasis triggered or exacerbated by an upper respiratory tract infection in the Chinese Han population.
in premenopausal obese women, interleukin-20 levels are higher than matched normal weight control women, are associated with body weight and waist-hip ratio, and are reduced by weight loss
Title: Interleukin-20 circulating levels in obese women: effect of weight loss.
Essentially identical phenotypes in transgenic mouse models for IL-20, IL-22, and IL-24 suggest that the three related cytokines play a redundant role in keratinocyte differentiation and proliferation.
Title: IL-24 transgenic mice: in vivo evidence of overlapping functions for IL-20, IL-22, and IL-24 in the epidermis.
Data show that JAK1/STAT-activating ligands, interleukin 10, IL20, IL24, and IL6 were expressed by senescent cells, supporting autocrine/paracrine activation of JAK1/STAT.
Title: Cytokine expression and signaling in drug-induced cellular senescence.
Data show that in lesional skin of psoriasis patients, highly elevated IL-20 levels strongly correlated with IL-22, and to a lesser extent, with IL-17A and TNF-alpha.
Title: The Th17 cytokine IL-22 induces IL-20 production in keratinocytes: a novel immunological cascade with potential relevance in psoriasis.
Observational study, meta-analysis, and genome-wide association study of gene-disease association. (HuGE Navigator)
Title: Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.
IL-20 was responsive to hypoxia in vitro and in the ischemic stroke model and that up-regulation of IL-20 in the ischemic brain may contribute to brain injury
Title: IL-20 is regulated by hypoxia-inducible factor and up-regulated after experimental ischemic stroke.
Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes.

Submit: New GeneRIF Correction See all (31)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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HIV-1 protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	IL-20 is upregulated by HIV-1 Tat treatment in human epithelial cells	PubMed

Go to the HIV-1, Human Protein Interaction Database

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description
Q9NYY1	Q9UHF4	IL20RA		HPRD	PubMed
Q9NYY1	Q6UXL0	IL20RB		HPRD	PubMed

Function	Evidence Code	Pubs
cytokine activity	IEA Inferred from Electronic Annotation more info
interleukin-20 receptor binding	TAS Traceable Author Statement more info	PubMed
receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
positive regulation of epidermal cell differentiation	TAS Traceable Author Statement more info	PubMed
positive regulation of keratinocyte differentiation	TAS Traceable Author Statement more info	PubMed
positive regulation of tyrosine phosphorylation of Stat3 protein	TAS Traceable Author Statement more info	PubMed
regulation of inflammatory response	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
extracellular region	TAS Traceable Author Statement more info	PubMed
extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: interleukin-20

Names: interleukin-20; cytokine Zcyto10; four alpha helix cytokine

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_018724.3 → NP_061194.2 interleukin-20 precursor

Status: REVIEWED

Source sequence(s)

AF224266, AY358320, BC069311

Consensus CDS

CCDS1470.1

UniProtKB/Swiss-Prot

Q9NYY1

Related

ENSP00000356063, OTTHUMP00000034617, ENST00000367096, OTTHUMT00000088675

Conserved Domains (1) summary

cl02501
Location:39 – 173
Blast Score: 104

IL10; Interleukin 10

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000001.10 Reference GRCh37.p5 Primary Assembly

Range

207039154..207042568

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000133.1 Alternate HuRef

Range

177737423..177740838

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC098935.2 (17836..21250)	None
genomic	AF402002.1	AAK84423.1
genomic	CH471100.2	EAW93520.1
		EAW93521.1
mRNA	AF224266.1	AAF36679.1
mRNA	AY358320.1	AAQ88686.1
mRNA	AY876922.1	AAW78348.1
mRNA	BC069311.1	AAH69311.1
mRNA	BC069364.1	AAH69364.1
mRNA	BC069398.1	AAH69398.1
mRNA	BC069425.1	AAH69425.1
mRNA	BC069449.1	AAH69449.1
mRNA	BC069487.1	AAH69487.1
mRNA	BC069523.1	AAH69523.1
mRNA	BC069559.1	AAH69559.1
mRNA	BC074948.2	AAH74948.1
mRNA	BC074949.2	AAH74949.1
mRNA	BC117386.1	AAI17387.1
mRNA	BC117390.1	AAI17391.1
other-genetic	HQ258739.1	ADR83490.1