ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide [Homo sapiens] - Gene

Help top of page

Summary

Official Symbol: ATP5Bprovided by HGNC
Official Full Name: ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptideprovided by HGNC
Primary source: HGNC:830
See related: Ensembl:ENSG00000110955; HPRD:00044; MIM:102910; Vega:OTTHUMG00000170291
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ATPMB; ATPSB; MGC5231
Summary: This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the beta subunit of the catalytic core. [provided by RefSeq, Jul 2008]

Help top of page

Genomic context

Location :: 12q13.13

Sequence :: Chromosome: 12; NC_000012.11 (57031959..57039852, complement)

See ATP5B in Epigenomics, MapViewer

Chromosome 12 - NC_000012.11 Genomic Context describing neighboring genes

Help top of page

Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Help top of page

Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Immunohistochemical analysis on a malignant mesothelioma tissue microarray showed cytoplasmic staining in 28 of 33 samples for vimentin and strong cytoplasmic staining in14 and weak in 16 samples for ss-F1-ATPase.
Title: Auto-antibodies to β-F1-ATPase and vimentin in malignant mesothelioma.
Data suggest that F1-ATPase catalytic site show the correlation between the phosphate binding and the tightening of the alphabeta-interface.
Title: Structural comparison of F1-ATPase: interplay among enzyme structures, catalysis, and rotations.
Disturbed flow and hypercholesterolemia synergistically promote gamma/delta T-lymphocyte activation by the membrane translocation of ATPSbeta in endothelial cells.
Title: A novel mechanism of γ/δ T-lymphocyte and endothelial activation by shear stress: the role of ecto-ATP synthase β chain.
Results suggested that the ectopic expression of ATP synthase is a consequence of translocation from the mitochondria.
Title: Mitochondrial F1Fo-ATP synthase translocates to cell surface in hepatocytes and has high activity in tumor-like acidic and hypoxic environment.
Molecular and functional studies indicate that the interaction of G3BP1 with beta-F1 mRNA inhibits its translation at the initiation level, supporting a role for G3BP1 in the glycolytic switch that occurs in cancer.
Title: Human G3BP1 interacts with beta-F1-ATPase mRNA and inhibits its translation.
ATP synthase beta is phosphorylated at multiple sites and shows abnormal phosphorylation at specific sites in insulin-resistant muscle
Title: Human ATP synthase beta is phosphorylated at multiple sites and shows abnormal phosphorylation at specific sites in insulin-resistant muscle.
Findings of the present study support the hypothesis that down-regulation of the bioenergetic activity of mitochondria in human tumours is exerted by translation silencing of beta-F1-ATPase mRNA.
Title: Selective inhibition of beta-F1-ATPase mRNA translation in human tumours.
Co-immunoprecipitation experiments in the presence of alpha-methyl mannose verified the binding of Escherichia coli FimH to ATP synthase beta-subunit of human brain microvascular endothelial cells.
Title: Human brain endothelial ATP synthase beta-subunit is mannose-insensitive binding target of FimH.
Observational study of gene-disease association. (HuGE Navigator)
Title: Candidate genetic analysis of plasma high-density lipoprotein-cholesterol and severity of coronary atherosclerosis.
Low levels of beta-F1-ATPase are sensitive to combined platinum and 2-deoxy-D-glucose treatment in ovarian carcinoma.
Title: Ovarian carcinoma cells with low levels of beta-F1-ATPase are sensitive to combined platinum and 2-deoxy-D-glucose treatment.

Submit: New GeneRIF Correction See all (16)

Help top of page

Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Help top of page

Products	Interactant	Other Gene	Source	Pubs	Description
P06576	P02647	APOA1	HPRD	PubMed
P06576	P36542	ATP5C1	HPRD	PubMed
P06576	ATP synthase mitochondrial F1 complex assembly factor 1	ATPAF1	HPRD	PubMed
P06576	Q8N5M1	ATPAF2	HPRD	PubMed
P06576	P00747	PLG	HPRD	PubMed
P06576	P61289	PSME3	HPRD	PubMed
P06576	Q6EEV6	SUMO4	HPRD	PubMed
P06576	P61981	YWHAG	HPRD	PubMed
BioGRID:106994	BioGRID:106807	ANXA7	BioGRID	PubMed	Two-hybrid
BioGRID:106994	BioGRID:122270	ATPAF1	BioGRID	PubMed	Two-hybrid
BioGRID:106994	BioGRID:107454	CDK4	BioGRID	PubMed	Two-hybrid
BioGRID:106994	BioGRID:107460	CDKN1A	BioGRID	PubMed	Two-hybrid
BioGRID:106994	BioGRID:108472	FANCA	BioGRID	PubMed	Two-hybrid
BioGRID:106994	BioGRID:109143	GRB7	BioGRID	PubMed	Two-hybrid
BioGRID:106994	BioGRID:115719	HAX1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:106994	BioGRID:115331	HDAC5	BioGRID	PubMed	Affinity Capture-MS
BioGRID:106994	BioGRID:109406	HMOX2	BioGRID	PubMed	Two-hybrid
BioGRID:106994	BioGRID:109622	ICT1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:106994	BioGRID:111581	MAPK3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:106994	BioGRID:111317	PIN1	BioGRID	PubMed	Two-hybrid
BioGRID:106994	BioGRID:111657	PSMA3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:106994	BioGRID:111683	PSMD4	BioGRID	PubMed	Affinity Capture-MS
BioGRID:106994	BioGRID:115492	PSME3	BioGRID	PubMed	Two-hybrid
BioGRID:106994	BioGRID:116283	RPP14	BioGRID	PubMed	Two-hybrid
BioGRID:106994	BioGRID:116982	SIRT3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:106994	BioGRID:112490	SMN1	BioGRID	PubMed	Two-hybrid
BioGRID:106994	BioGRID:113188	SUMO1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:106994	BioGRID:112938	TK1	BioGRID	PubMed	Two-hybrid
BioGRID:106994	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:106994	BioGRID:116168	YWHAQ	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
contributes_to ATPase activity	IDA Inferred from Direct Assay more info	PubMed
MHC class I protein binding	IDA Inferred from Direct Assay more info	PubMed
calcium ion binding	IEA Inferred from Electronic Annotation more info
eukaryotic cell surface binding	IDA Inferred from Direct Assay more info	PubMed
hydrogen ion transporting ATP synthase activity, rotational mechanism	IEA Inferred from Electronic Annotation more info
hydrogen-exporting ATPase activity, phosphorylative mechanism	IEA Inferred from Electronic Annotation more info
hydrolase activity	IEA Inferred from Electronic Annotation more info
hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances	IEA Inferred from Electronic Annotation more info
lipoprotein particle receptor activity	IEA Inferred from Electronic Annotation more info
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
proton-transporting ATPase activity, rotational mechanism	IMP Inferred from Mutant Phenotype more info	PubMed
transmembrane transporter activity	IC Inferred by Curator more info	PubMed
transporter activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
ADP biosynthetic process	IEA Inferred from Electronic Annotation more info
ATP biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
ATP catabolic process	IDA Inferred from Direct Assay more info	PubMed
ATP hydrolysis coupled proton transport	IEA Inferred from Electronic Annotation more info
angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
generation of precursor metabolites and energy	NAS Non-traceable Author Statement more info	PubMed
ion transport	IEA Inferred from Electronic Annotation more info
lipid metabolic process	IEA Inferred from Electronic Annotation more info
mitochondrial ATP synthesis coupled proton transport	IC Inferred by Curator more info	PubMed
mitochondrial ATP synthesis coupled proton transport	TAS Traceable Author Statement more info
negative regulation of cell adhesion involved in substrate-bound cell migration	IEA Inferred from Electronic Annotation more info
proton transport	IMP Inferred from Mutant Phenotype more info	PubMed
receptor-mediated endocytosis	IEA Inferred from Electronic Annotation more info
regulation of intracellular pH	IMP Inferred from Mutant Phenotype more info	PubMed
respiratory electron transport chain	TAS Traceable Author Statement more info
small molecule metabolic process	TAS Traceable Author Statement more info
transport	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
cell surface	IDA Inferred from Direct Assay more info	PubMed
mitochondrial matrix	NAS Non-traceable Author Statement more info	PubMed
mitochondrial matrix	TAS Traceable Author Statement more info
mitochondrial membrane	IDA Inferred from Direct Assay more info	PubMed
mitochondrial nucleoid	IDA Inferred from Direct Assay more info	PubMed
mitochondrial proton-transporting ATP synthase complex	IDA Inferred from Direct Assay more info	PubMed
mitochondrial proton-transporting ATP synthase, catalytic core	NAS Non-traceable Author Statement more info	PubMed
mitochondrion	IC Inferred by Curator more info	PubMed
mitochondrion	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

Preferred Names: ATP synthase subunit beta, mitochondrial

Names: ATP synthase subunit beta, mitochondrial; mitochondrial ATP synthase beta subunit; mitochondrial ATP synthetase, beta subunit

NP_001677.2

EC 3.6.3.14

Help top of page

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001686.3 → NP_001677.2 ATP synthase subunit beta, mitochondrial precursor

Status: REVIEWED

Source sequence(s)

BC016512, BI561028

Consensus CDS

CCDS8924.1

UniProtKB/Swiss-Prot

P06576

Related

ENSP00000262030, OTTHUMP00000243448, ENST00000262030, OTTHUMT00000408380

Conserved Domains (4) summary

cd01133
Location:131 – 410
Blast Score: 1267

F1-ATPase_beta; F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a ...

pfam00306
Location:418 – 525
Blast Score: 312

ATP-synt_ab_C; ATP synthase alpha/beta chain, C terminal domain

PRK09280
Location:58 – 524
Blast Score: 2443

PRK09280; F0F1 ATP synthase subunit beta; Validated

cl15275
Location:63 – 129
Blast Score: 195

ATP-synt_ab_N; ATP synthase alpha/beta family, beta-barrel domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000012.11 Reference GRCh37.p5 Primary Assembly

Range

57031959..57039852, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000144.1 Alternate HuRef

Range

54071237..54079130, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Help top of page

Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC090681.13 (68589..76482)	None
genomic	CH471054.1	EAW96952.1
genomic	HC091114.1	CBI68016.1
genomic	M19483.1	AAA51808.1
genomic	M27132.1	AAA51809.1
mRNA	AK291085.1	BAF83774.1
mRNA	BC016512.1	AAH16512.1
mRNA	BI561028.1	None
mRNA	DQ403107.1	ABD77240.1
mRNA	X05606.1	CAA29095.1
other-genetic	DQ891585.2	ABM82511.1
other-genetic	DQ894779.2	ABM85705.1