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SERPINB2 serpin family B member 2 [ Homo sapiens (human) ]

Gene ID: 5055, updated on 12-May-2016
Official Symbol
SERPINB2provided by HGNC
Official Full Name
serpin family B member 2provided by HGNC
Primary source
HGNC:HGNC:8584
See related
Ensembl:ENSG00000197632 HPRD:01420; MIM:173390; Vega:OTTHUMG00000060592
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAI; PAI2; PAI-2; PLANH2; HsT1201
Orthologs
Location:
18q21.3
Exon count:
9
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 18 NC_000018.10 (63887705..63903890)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (61554939..61571124)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372164 Neighboring gene serpin family B member 7 Neighboring gene serpin family B member 10 Neighboring gene histocompatibility minor serpin domain containing

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of serpin peptidase inhibitor, clade B, member 2 (SERPINB2) in human B cells PubMed
env HIV-1 infection and HIV-1 gp120 treatment of human peripheral blood mononuclear cells result in induction of SerpinB2 and this induction enhances transcription from the HIV-1 LTR PubMed
Tat tat HIV-1 Tat upregulates the expression of serpin peptidase inhibitor, clade B, member 2 (SERPINB2) in human primary T cells PubMed
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies downregulation of serpin peptidase inhibitor, clade B2 (SERPINB2) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

Go to the HIV-1, Human Interaction Database

  • Blood Clotting Cascade, organism-specific biosystem (from WikiPathways)
    Blood Clotting Cascade, organism-specific biosystemCoagulation is a complex process by which blood forms clots. It is an important part of hemostasis (the cessation of blood loss from a damaged vessel), wherein a damaged blood vessel wall is covered ...
  • Complement and coagulation cascades, organism-specific biosystem (from KEGG)
    Complement and coagulation cascades, organism-specific biosystemThe complement system is a proteolytic cascade in blood plasma and a mediator of innate immunity, a nonspecific defense mechanism against pathogens. There are three pathways of complement activation:...
  • Complement and coagulation cascades, conserved biosystem (from KEGG)
    Complement and coagulation cascades, conserved biosystemThe complement system is a proteolytic cascade in blood plasma and a mediator of innate immunity, a nonspecific defense mechanism against pathogens. There are three pathways of complement activation:...
  • Dissolution of Fibrin Clot, organism-specific biosystem (from REACTOME)
    Dissolution of Fibrin Clot, organism-specific biosystemThe crosslinked fibrin multimers in a clot are broken down to soluble polypeptides by plasmin, a serine protease. Plasmin can be generated from its inactive precursor plasminogen and recruited to the...
  • Hemostasis, organism-specific biosystem (from REACTOME)
    Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
  • Senescence and Autophagy, organism-specific biosystem (from WikiPathways)
    Senescence and Autophagy, organism-specific biosystemSenescense and Autophagy Pathways in Cancer
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
serine-type endopeptidase inhibitor activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
fibrinolysis TAS
Traceable Author Statement
more info
 
negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
wound healing IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
plasminogen activator inhibitor 2
Names
monocyte Arg-serpin
placental plasminogen activator inhibitor
plasminogen activator inhibitor, type II (arginine-serpin)
serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 2
serpin B2
serpin peptidase inhibitor, clade B (ovalbumin), member 2
urokinase inhibitor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001143818.1NP_001137290.1  plasminogen activator inhibitor 2

    See identical proteins and their annotated locations for NP_001137290.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC072051, CD366374, DA543366, DQ656059
    Consensus CDS
    CCDS11989.1
    UniProtKB/Swiss-Prot
    P05120
    Related
    ENSP00000401645, ENST00000457692
    Conserved Domains (1) summary
    cd02058
    Location:4415
    PAI-2; Plasminogen Activator Inhibitor-2 (PAI-2). PAI-2 is a serine protease inhibitor that belongs to the ov-serpin branch of the serpin superfamily. It is is an effective inhibitor of urinary plasminogen activator (urokinase or uPA) and is involved in cell ...
  2. NM_002575.2NP_002566.1  plasminogen activator inhibitor 2

    See identical proteins and their annotated locations for NP_002566.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC072051, BC012609, CD366374
    Consensus CDS
    CCDS11989.1
    UniProtKB/Swiss-Prot
    P05120
    Related
    ENSP00000299502, OTTHUMP00000066997, ENST00000299502, OTTHUMT00000134009
    Conserved Domains (1) summary
    cd02058
    Location:4415
    PAI-2; Plasminogen Activator Inhibitor-2 (PAI-2). PAI-2 is a serine protease inhibitor that belongs to the ov-serpin branch of the serpin superfamily. It is is an effective inhibitor of urinary plasminogen activator (urokinase or uPA) and is involved in cell ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p2 Primary Assembly

    Range
    63887705..63903890
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018929.2 Alternate CHM1_1.1

    Range
    61551138..61567323
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)