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    Npcd neuronal pentraxin chromo domain [ Mus musculus ]

    Gene ID: 504193, updated on 11-May-2012

    Summary

    Official Symbol
    Npcdprovided by MGI
    Official Full Name
    neuronal pentraxin chromo domainprovided by MGI
    Primary source
    MGI:3845555
    See related
    Ensembl:ENSMUSG00000089837; Vega:OTTMUSG00000017448
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cbx6-Nptxr
    Summary
    This gene encodes multiple cytoplasmic proteins composed of a neuronal pentraxin domain linked to a chromo domain. These isoforms are expressed in numerous regions of the central nervous system, where they are present in distinct subcellular arrangements in different brain regions. This gene may play a role in neuronal differentiation. [provided by RefSeq, Jul 2008]

    Genomic context

    Location :
    15E2; 15
    Sequence :
    Chromosome: 15; NC_000081.6 (79786351..79834333, complement)
    See Npcd in Epigenomics, MapViewer

    Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene predicted gene 16576 Neighboring gene dynein, axonemal, light chain 4 Neighboring gene neuronal pentraxin receptor Neighboring gene chromobox homolog 6 Neighboring gene predicted gene 10856 Neighboring gene RIKEN cDNA D730005E14 gene Neighboring gene apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3

    Genomic regions, transcripts, and products

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:243519 BioGRID:218522 Klhl2    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:243519 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-Western 

    General gene information

    Markers

    Readthrough Npcd

    Included genes: Nptxr, Cbx6

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    biological_process ND
    No biological Data available
    more info
     
    Component Evidence Code Pubs
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    filopodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    internal side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nuclear part IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    neuronal pentraxin with chromo domain
    Names
    neuronal pentraxin with chromo domain
    Cbx6-Nptxr readthrough transcripts

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013360.2NP_001013378.2  neuronal pentraxin with chromo domain isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC113595, AC118227, AY394488, BC060093, CD578976
      Consensus CDS
      CCDS27651.1
      UniProtKB/TrEMBL
      E9PZM8
      UniProtKB/TrEMBL
      Q6TLW1
      Related
      ENSMUSP00000023060, OTTMUSP00000041656, ENSMUST00000023060, OTTMUST00000078351
      Conserved Domains (2) summary
      cd00024
      Location:2760
      Blast Score: 114
      CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
      cd00152
      Location:164360
      Blast Score: 624
      PTX; Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated ...
    2. NM_001013362.2NP_001013380.2  neuronal pentraxin with chromo domain isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC113595, AC118227, AY394489, BC060093, CD578976
      Consensus CDS
      CCDS27652.1
      UniProtKB/TrEMBL
      F8VQB8
      UniProtKB/TrEMBL
      Q6TLW0
      Related
      ENSMUSP00000086714, OTTMUSP00000041657, ENSMUST00000089299, OTTMUST00000078352
      Conserved Domains (2) summary
      cd00024
      Location:2760
      Blast Score: 115
      CHROMO; Chromatin organization modifier (chromo) domain is a conserved region of around 50 amino acids found in a variety of chromosomal proteins, which appear to play a role in the functional organization of the eukaryotic nucleus. Experimental evidence ...
      cd00152
      Location:261457
      Blast Score: 635
      PTX; Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated ...

    RefSeqs of Annotated Genomes: Build 38.1

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38 C57BL/6J

    Genomic

    1. NC_000081.6 Reference GRCm38 C57BL/6J

      Range
      79786351..79834333, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate Mm_Celera

    Genomic

    1. AC_000037.1 Alternate Mm_Celera

      Range
      81905537..81953546, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_029079.2: Suppressed sequence

      Description
      NM_029079.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

    Related Sequences

    Nucleotide Protein Strain
    Heading Accession and Version
    genomic AC113595.11 (27345..49233) None
    genomic AC118227.12 (176955..200662) None
    mRNA AY394488.1 AAQ98932.1 C57BL/6
    mRNA AY394489.1 AAQ98933.1 C57BL/6
    mRNA AY395907.1 AAQ95736.1 C57BL/6
    mRNA BC060093.1 None C57BL/6
    mRNA CD578976.1 None C57BL/6
    other-genetic BC152773.1 AAI52774.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6TKP2 GenPept UniProtKB/TrEMBL:Q6TKP2

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