Display Settings:

Format

Send to:

Choose Destination

DEFB107B defensin, beta 107B [ Homo sapiens (human) ]

Gene ID: 503614, updated on 7-Dec-2014
Official Symbol
DEFB107Bprovided by HGNC
Official Full Name
defensin, beta 107Bprovided by HGNC
Primary source
HGNC:HGNC:31918
See related
Ensembl:ENSG00000198129; Vega:OTTHUMG00000149987
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HsT21816
Summary
Defensins form a family of antimicrobial and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 107, DEFB107A and DEFB107B, in tail-to-tail orientation. This gene, DEFB107B, represents the more telomeric copy. [provided by RefSeq, Oct 2014]
See DEFB107B in Epigenomics, MapViewer
Location:
8p23.1
Exon count:
2
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 8 NC_000008.11 (7495846..7509311)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (7353368..7366833)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene defensin, beta 106B Neighboring gene defensin, beta 105B Neighboring gene proline-rich protein 23C-like Neighboring gene proline rich 23 domain containing 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Beta defensins, organism-specific biosystem (from REACTOME)
    Beta defensins, organism-specific biosystemHumans have 38 beta-defensin genes plus 9-10 pseudogenes (details available on the HGNC website at http://www.genenames.org/genefamilies/DEFB). Many beta-defensins are encoded by recently duplicated ...
  • Defensins, organism-specific biosystem (from REACTOME)
    Defensins, organism-specific biosystemThe defensins are a family of antimicrobial cationic peptide molecules which in mammals have a characteristic beta-sheet-rich fold and framework of six disulphide-linked cysteines (Selsted & Ouellet...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
Preferred Names
beta-defensin 107
Names
beta-defensin 107
beta-defensin 7
defensin, beta 107

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040705.1NP_001035795.1  beta-defensin 107 precursor

    See proteins identical to NP_001035795.1

    Status: REVIEWED

    Source sequence(s)
    AC134684
    Consensus CDS
    CCDS43696.1
    UniProtKB/Swiss-Prot
    Q8IZN7
    Related
    ENSP00000347810, OTTHUMP00000195800, ENST00000355602, OTTHUMT00000315231

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000008.11 

    Range
    7495846..7509311
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38 ALT_REF_LOCI_1

Genomic

  1. NT_187570.1 

    Range
    178949..192414
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018919.2 

    Range
    7260964..7274426
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000140.1 

    Range
    6940286..6940525
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
  2. AC_000140.1 

    Range
    6956308..6956491
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)