PA2G4 proliferation-associated 2G4, 38kDa [Homo sapiens] - Gene

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Summary

Official Symbol: PA2G4provided by HGNC
Official Full Name: proliferation-associated 2G4, 38kDaprovided by HGNC
Primary source: HGNC:8550
See related: Ensembl:ENSG00000170515; HPRD:03685; MIM:602145; Vega:OTTHUMG00000170173
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: EBP1; HG4-1; p38-2G4
Summary: This gene encodes an RNA-binding protein that is involved in growth regulation. This protein is present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA processing. This protein can interact with the cytoplasmic domain of the ErbB3 receptor and may contribute to transducing growth regulatory signals. This protein is also a transcriptional co-repressor of androgen receptor-regulated genes and other cell cycle regulatory genes through its interactions with histone deacetylases. This protein has been implicated in growth inhibition and the induction of differentiation of human cancer cells. Six pseudogenes, located on chromosomes 3, 6, 9, 18, 20 and X, have been identified. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 12q13.2

Sequence :: Chromosome: 12; NC_000012.11 (56498103..56507694)

See PA2G4 in Epigenomics, MapViewer

Chromosome 12 - NC_000012.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

It was shown that high level of Ebp1 expression led to enhancee HDM2 phosphorylation by Akt and inhibited the self-ubiquitination of HDM2 by up-regulation of Akt activity.
Title: Long isoform of ErbB3 binding protein, p48, mediates protein kinase B/Akt-dependent HDM2 stabilization and nuclear localization.
the Ebp1 promoter localizes between -664 nt and the initiation site of the Ebp1 gene, +317-nt long sequence in the noncoding region is required for regulation of Ebp1 gene expression.
Title: Influenza virus infection induces cellular Ebp1 gene expression.
These studies suggest that one pathway of EBP1 down-regulation of AR levels may be lost in castration-resistant prostate cancer.
Title: EBP1 inhibits translation of androgen receptor mRNA in castration resistant prostate cancer cells.
Ebp1 contributes to neuronal cell differentiation and growth factor specificity through the activation of protein kinase Cdelta acting as a crucial downstream effector of neurotrophin signaling.
Title: p48 Ebp1 acts as a downstream mediator of Trk signaling in neurons, contributing neuronal differentiation.
Ablation of EBP1 expression led to tamoxifen resistance in breast cancer.
Title: The ErbB3 binding protein EBP1 regulates ErbB2 protein levels and tamoxifen sensitivity in breast cancer cells.
Data show that E2F is likely a central coordinator of multiple responses that culminate in regulation of EBP1 gene expression, and which may vary depending on cell type and context.
Title: EBP1 is a novel E2F target gene regulated by transforming growth factor-β.
Findings suggest that eBP1 p48 functions as an oncogene by promoting glioma tumorigenicity via interactions with HDM2 that contribute to p53 downregulation.
Title: Negative regulation of p53 by the long isoform of ErbB3 binding protein Ebp1 in brain tumors.
our results reveal an EBP1-Foxa-AGR2 signaling circuit with functional significance in metastatic prostate cancer
Title: ErbB3 binding protein 1 represses metastasis-promoting gene anterior gradient protein 2 in prostate cancer.
hBre1 inhibits Ebp1's tumor suppressive activity through mediating its polyubiquitination and degradation.
Title: Human BRE1 is an E3 ubiquitin ligase for Ebp1 tumor suppressor.
These data support a role for EBP1 in the development of hormone-refractory prostate cancer.
Title: EBP1, an ErbB3-binding protein, is decreased in prostate cancer and implicated in hormone resistance.

Submit: New GeneRIF Correction See all (23)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_006182.1	NP_001973.1	ERBB3	BIND	PubMed	ErbB-3 interacts with EBP1.
NP_006182.1	NP_001518.1	HDAC2	BIND	PubMed	HDAC2 interacts with Ebp1
Q9UQ80	P10275	AR	HPRD	PubMed
Q9UQ80	P21860	ERBB3	HPRD	PubMed
Q9UQ80	Q9NQT4	EXOSC5	HPRD	PubMed
Q9UQ80	Q92769	HDAC2	HPRD	PubMed
Q9UQ80	P17252	PRKCA	HPRD	PubMed
Q9UQ80	P05771	PRKCB	HPRD	PubMed
Q9UQ80	P05129	PRKCG	HPRD	PubMed
Q9UQ80	P06400	RB1	HPRD	PubMed
Q9UQ80	Q96ST3	SIN3A	HPRD	PubMed
Q9UQ80	Q6EEV6	SUMO4	HPRD	PubMed
BioGRID:111075	BioGRID:223223	AI837181	BioGRID	PubMed	Affinity Capture-MS
BioGRID:111075	BioGRID:106710	AKT1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111075	BioGRID:106862	AR	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:111075	BioGRID:107027	ATR	BioGRID	PubMed	Protein-peptide
BioGRID:111075	BioGRID:121948	C12orf44	BioGRID	PubMed	Affinity Capture-MS
BioGRID:111075	BioGRID:122485	DDA1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:111075	BioGRID:108377	ERBB3	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:111075	BioGRID:108901	GBAS	BioGRID	PubMed	Affinity Capture-MS
BioGRID:111075	BioGRID:109316	HDAC2	BioGRID	PubMed	Reconstituted Complex
BioGRID:111075	BioGRID:115331	HDAC5	BioGRID	PubMed	Affinity Capture-MS
BioGRID:111075	BioGRID:114089	IKBKG	BioGRID	PubMed	Two-hybrid
BioGRID:111075	BioGRID:110358	MDM2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111075	BioGRID:108757	MTOR	BioGRID	PubMed	Reconstituted Complex
BioGRID:111075	BioGRID:119009	NRBF2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:111075	BioGRID:111196	PDPK1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:111075	BioGRID:111304	PIK3C2A	BioGRID	PubMed	Affinity Capture-MS
BioGRID:111075	BioGRID:111549	PRKAA1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:111075	BioGRID:111558	PRKAG1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:111075	BioGRID:111860	RB1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:111075	BioGRID:121119	RNF20	BioGRID	PubMed	Reconstituted Complex
BioGRID:111075	BioGRID:112344	SGK1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:111075	BioGRID:121234	SH3GLB2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:111075	BioGRID:117439	SIN3A	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:111075	BioGRID:132223	SUMO4	BioGRID	PubMed	Affinity Capture-MS
BioGRID:111075	BioGRID:122964	UBA5	BioGRID	PubMed	Affinity Capture-MS
BioGRID:111075	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:111075	BioGRID:115939	USP39	BioGRID	PubMed	Affinity Capture-MS

Function	Evidence Code	Pubs
DNA binding	IDA Inferred from Direct Assay more info	PubMed
RNA binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
sequence-specific DNA binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
cell cycle arrest	TAS Traceable Author Statement more info	PubMed
cell proliferation	TAS Traceable Author Statement more info	PubMed
cellular process	IEA Inferred from Electronic Annotation more info
negative regulation of transcription, DNA-dependent	IDA Inferred from Direct Assay more info	PubMed
rRNA processing	IEA Inferred from Electronic Annotation more info
regulation of translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
nucleolus	IDA Inferred from Direct Assay more info	PubMed
NOT nucleolus	IDA Inferred from Direct Assay more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed
ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: proliferation-associated protein 2G4

Names: proliferation-associated protein 2G4; erbB3-binding protein 1; ErbB-3 binding protein 1; ErbB3-binding protein Ebp1; cell cycle protein p38-2G4 homolog

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_006191.2 → NP_006182.2 proliferation-associated protein 2G4

Status: REVIEWED

Source sequence(s)

AC034102, BC001951, BU683753

Consensus CDS

CCDS8902.1

UniProtKB/Swiss-Prot

Q9UQ80

Related

ENSP00000302886, OTTHUMP00000243116, ENST00000303305, OTTHUMT00000407767

Conserved Domains (3) summary

cd01089
Location:18 – 198
Blast Score: 640

PA2G4-like; Related to aminopepdidase M, this family contains proliferation-associated protein 2G4. Family members have been implicated in cell cycle control.

PRK08671
Location:20 – 334
Blast Score: 411

PRK08671; methionine aminopeptidase; Provisional

cl00279
Location:293 – 335
Blast Score: 175

APP_MetAP; A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity ...

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000012.11 Reference GRCh37.p5 Primary Assembly

Range

56498103..56507694

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000144.1 Alternate HuRef

Range

53537242..53546835

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC034102.32 (47935..56979)	None
genomic	AF104670.1	AAD05561.1
genomic	CH471054.1	EAW96884.1
		EAW96885.1
mRNA	AK291796.1	BAF84485.1
mRNA	BC001951.1	AAH01951.1
mRNA	BC007561.1	AAH07561.1
mRNA	BC019222.1	AAH19222.1
mRNA	BC032111.2	AAH32111.1
mRNA	BC069786.1	AAH69786.1
mRNA	BC072007.1	AAH72007.1
mRNA	BU683753.1	None
mRNA	U50137.1	AAA91484.1
mRNA	U59435.1	AAB91536.1
mRNA	U87954.1	AAD00646.1
other-genetic	DQ893446.2	ABM84372.1
other-genetic	DQ896751.2	ABM87750.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
Q05D08	GenPept	UniProtKB/TrEMBL:Q05D08
Q13548	GenPept	UniProtKB/TrEMBL:Q13548
Q6PIN5	GenPept	UniProtKB/TrEMBL:Q6PIN5
Q9UQ80.3	GenPept	UniProtKB/Swiss-Prot:Q9UQ80