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PA2G4 proliferation-associated 2G4, 38kDa [ Homo sapiens (human) ]

Gene ID: 5036, updated on 12-May-2015
Official Symbol
PA2G4provided by HGNC
Official Full Name
proliferation-associated 2G4, 38kDaprovided by HGNC
Primary source
HGNC:HGNC:8550
See related
Ensembl:ENSG00000170515; HPRD:03685; MIM:602145; Vega:OTTHUMG00000170173
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EBP1; HG4-1; p38-2G4
Summary
This gene encodes an RNA-binding protein that is involved in growth regulation. This protein is present in pre-ribosomal ribonucleoprotein complexes and may be involved in ribosome assembly and the regulation of intermediate and late steps of rRNA processing. This protein can interact with the cytoplasmic domain of the ErbB3 receptor and may contribute to transducing growth regulatory signals. This protein is also a transcriptional co-repressor of androgen receptor-regulated genes and other cell cycle regulatory genes through its interactions with histone deacetylases. This protein has been implicated in growth inhibition and the induction of differentiation of human cancer cells. Six pseudogenes, located on chromosomes 3, 6, 9, 18, 20 and X, have been identified. [provided by RefSeq, Jul 2008]
Orthologs
See PA2G4 in MapViewer
Location:
12q13.2
Exon count:
13
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 12 NC_000012.12 (56104319..56113910)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (56498103..56507694)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein S26 Neighboring gene erb-b2 receptor tyrosine kinase 3 Neighboring gene uncharacterized LOC105369782 Neighboring gene ribosomal protein L41 Neighboring gene zinc finger CCCH-type containing 10

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Association analyses identify three susceptibility Loci for vitiligo in the Chinese Han population.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr downregulates proliferation-associated protein 2G4 (PA2G4) and upregulates p53 in glioblastoma U87MG cells PubMed
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human proliferation-associated 2G4, 38kDa (PA2G4) at amino acid residues 346-347 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
poly(A) RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell cycle arrest TAS
Traceable Author Statement
more info
PubMed 
cell proliferation TAS
Traceable Author Statement
more info
PubMed 
negative regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
rRNA processing IEA
Inferred from Electronic Annotation
more info
 
regulation of translation IEA
Inferred from Electronic Annotation
more info
 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
proliferation-associated protein 2G4
Names
proliferation-associated protein 2G4
ErbB-3 binding protein 1
ErbB3-binding protein Ebp1
cell cycle protein p38-2G4 homolog
erbB3-binding protein 1
proliferation-associated 2G4, 38kD

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006191.2NP_006182.2  proliferation-associated protein 2G4

    See identical proteins and their annotated locations for NP_006182.2

    Status: REVIEWED

    Source sequence(s)
    AC034102, BC001951, BU683753
    Consensus CDS
    CCDS8902.1
    UniProtKB/TrEMBL
    A0A024RB85
    UniProtKB/Swiss-Prot
    Q9UQ80
    Related
    ENSP00000302886, OTTHUMP00000243116, ENST00000303305, OTTHUMT00000407767
    Conserved Domains (1) summary
    cd01089
    Location:18334
    PA2G4-like; Related to aminopepdidase M, this family contains proliferation-associated protein 2G4. Family members have been implicated in cell cycle control.

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p2 Primary Assembly

    Range
    56104319..56113910
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018923.2 Alternate CHM1_1.1

    Range
    56465468..56475059
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)