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Dnajc19 DnaJ heat shock protein family (Hsp40) member C19 [ Rattus norvegicus (Norway rat) ]

Gene ID: 502525, updated on 5-Mar-2024

Summary

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Official Symbol
Dnajc19provided by RGD
Official Full Name
DnaJ heat shock protein family (Hsp40) member C19provided by RGD
Primary source
RGD:1560220
See related
Ensembl:ENSRNOG00000049819 AllianceGenome:RGD:1560220
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1560220
Summary
Predicted to enable ATPase activator activity. Predicted to be involved in several processes, including protein import into mitochondrial matrix; regulation of cardiolipin metabolic process; and visual perception. Predicted to be located in matrix side of mitochondrial inner membrane. Predicted to be part of PAM complex, Tim23 associated import motor. Human ortholog(s) of this gene implicated in 3-methylglutaconic aciduria type 5. Orthologous to human DNAJC19 (DnaJ heat shock protein family (Hsp40) member C19). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 257.9), Heart (RPKM 184.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dnajc19 in Genome Data Viewer
Location:
2q24
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (118851497..118875813, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (116923272..116945312, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (120503093..120531782)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC120100800 Neighboring gene uncharacterized LOC103691527 Neighboring gene FMR1 autosomal homolog 1 Neighboring gene peptidylprolyl isomerase D, pseudogene 11 Neighboring gene uncharacterized LOC108349992

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mutation of DNAJC19, a human homologue of yeast inner mitochondrial membrane co-chaperones, causes DCMA syndrome, a novel autosomal recessive Barth syndrome-like condition. Davey KM, et al. J Med Genet, 2006 May. PMID 16055927, Free PMC Article
  2. Characterization of the human heart mitochondrial proteome. Taylor SW, et al. Nat Biotechnol, 2003 Mar. PMID 12592411
  3. The mitochondrial protein translocation motor: structural conservation between the human and yeast Tim14/Pam18-Tim16/Pam16 co-chaperones. Elsner S, et al. Int J Mol Sci, 2009 May 6. PMID 19564938, Free PMC Article
  4. Unlocking the presequence import pathway. Schulz C, et al. Trends Cell Biol, 2015 May. PMID 25542066
  5. Role of Magmas in protein transport and human mitochondria biogenesis. Sinha D, et al. Hum Mol Genet, 2010 Apr 1. PMID 20053669, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in genitalia development ISO
Inferred from Sequence Orthology
more info
  
involved_in protein import into mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cardiolipin metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in visual perception ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of PAM complex, Tim23 associated import motor IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of inner mitochondrial membrane protein complex ISO
Inferred from Sequence Orthology
more info
  
located_in matrix side of mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mitochondrial import inner membrane translocase subunit TIM14
Names
DnaJ (Hsp40) homolog, subfamily C, member 19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134640.1 → NP_001128112.1  mitochondrial import inner membrane translocase subunit TIM14

    See identical proteins and their annotated locations for NP_001128112.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473961
    UniProtKB/TrEMBL
    A0A8I5ZMN9, A6IHT6, M0R6L8
    Related
    ENSRNOP00000065070.1, ENSRNOT00000071944.2
    Conserved Domains (1) summary
    cl02542
    Location:53 → 94
    DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    118851497..118875813 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063282411.1 → XP_063138481.1  mitochondrial import inner membrane translocase subunit TIM14 isoform X1

  2. XM_006232259.5 → XP_006232321.1  mitochondrial import inner membrane translocase subunit TIM14 isoform X2

    See identical proteins and their annotated locations for XP_006232321.1

    UniProtKB/TrEMBL
    A0A8I6A7G6, A6IHT7
    Related
    ENSRNOP00000086942.1
    Conserved Domains (1) summary
    cl02542
    Location:53 → 110
    DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
Nucleotide Protein Strain
Heading Accession and Version

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