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OXT oxytocin/neurophysin I prepropeptide [ Homo sapiens (human) ]

Gene ID: 5020, updated on 14-Apr-2014
Official Symbol
OXTprovided by HGNC
Official Full Name
oxytocin/neurophysin I prepropeptideprovided by HGNC
Primary source
HGNC:8528
See related
Ensembl:ENSG00000101405; HPRD:08880; MIM:167050; Vega:OTTHUMG00000031724
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OT; OT-NPI; OXT-NPI
Summary
This gene encodes a precursor protein that is processed to produce oxytocin and neurophysin I. Oxytocin is a posterior pituitary hormone which is synthesized as an inactive precursor in the hypothalamus along with its carrier protein neurophysin I. Together with neurophysin, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis, where it is either stored or secreted into the bloodstream. The precursor seems to be activated while it is being transported along the axon to the posterior pituitary. This hormone contracts smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions. [provided by RefSeq, Dec 2013]
Location :
20p13
Sequence :
Chromosome: 20; NC_000020.11 (3071620..3072517)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene gonadotropin-releasing hormone 2 Neighboring gene mitochondrial ribosomal protein S26 Neighboring gene uncharacterized LOC101929098 Neighboring gene arginine vasopressin Neighboring gene UBOX5 antisense RNA 1 Neighboring gene U-box domain containing 5 Neighboring gene FAST kinase domains 5

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
    Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
  • G alpha (q) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (q) signalling events, organism-specific biosystemThe classic signalling route for G alpha (q) is activation of phospholipase C beta thereby triggering phosphoinositide hydrolysis, calcium mobilization and protein kinase C activation. This provides ...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystem (from REACTOME)
    Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystemGastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic fac...
  • Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
    Myometrial Relaxation and Contraction Pathways, organism-specific biosystemThis pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile ac...
  • Peptide ligand-binding receptors, organism-specific biosystem (from REACTOME)
    Peptide ligand-binding receptors, organism-specific biosystemThese receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins.
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
  • Vasopressin-like receptors, organism-specific biosystem (from REACTOME)
    Vasopressin-like receptors, organism-specific biosystemThe vasopressins are peptide hormones consisting of nine amino acids (nonapeptides). They include arginine vasopressin (AVP; anti-diuretic hormone, ADH) and oxytocin. They are synthesized in the hypo...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
neurohypophyseal hormone activity IEA
Inferred from Electronic Annotation
more info
 
oxytocin receptor binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
drinking behavior IEA
Inferred from Electronic Annotation
more info
 
eating behavior IEA
Inferred from Electronic Annotation
more info
 
female pregnancy IEA
Inferred from Electronic Annotation
more info
 
grooming behavior IEA
Inferred from Electronic Annotation
more info
 
heart development IEA
Inferred from Electronic Annotation
more info
 
hyperosmotic salinity response IEA
Inferred from Electronic Annotation
more info
 
male mating behavior IEA
Inferred from Electronic Annotation
more info
 
maternal aggressive behavior IEA
Inferred from Electronic Annotation
more info
 
maternal behavior IEA
Inferred from Electronic Annotation
more info
 
memory IEA
Inferred from Electronic Annotation
more info
 
negative regulation of blood pressure IEA
Inferred from Electronic Annotation
more info
 
negative regulation of gastric acid secretion IEA
Inferred from Electronic Annotation
more info
 
negative regulation of urine volume IEA
Inferred from Electronic Annotation
more info
 
positive regulation of blood pressure IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of female receptivity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of hindgut contraction IEA
Inferred from Electronic Annotation
more info
 
positive regulation of norepinephrine secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of ossification IEA
Inferred from Electronic Annotation
more info
 
positive regulation of penile erection IEA
Inferred from Electronic Annotation
more info
 
positive regulation of prostaglandin secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of renal sodium excretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of synapse assembly IEA
Inferred from Electronic Annotation
more info
 
positive regulation of synaptic transmission IEA
Inferred from Electronic Annotation
more info
 
positive regulation of uterine smooth muscle contraction IEA
Inferred from Electronic Annotation
more info
 
regulation of heart rate IEA
Inferred from Electronic Annotation
more info
 
regulation of sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
response to activity IEA
Inferred from Electronic Annotation
more info
 
response to amphetamine IEA
Inferred from Electronic Annotation
more info
 
response to cAMP IEA
Inferred from Electronic Annotation
more info
 
response to cocaine IEA
Inferred from Electronic Annotation
more info
 
response to electrical stimulus IEA
Inferred from Electronic Annotation
more info
 
response to estradiol IEA
Inferred from Electronic Annotation
more info
 
response to ether IEA
Inferred from Electronic Annotation
more info
 
response to food IEA
Inferred from Electronic Annotation
more info
 
response to glucocorticoid IEA
Inferred from Electronic Annotation
more info
 
response to peptide hormone IEA
Inferred from Electronic Annotation
more info
 
response to progesterone IEA
Inferred from Electronic Annotation
more info
 
response to prostaglandin E IEA
Inferred from Electronic Annotation
more info
 
response to retinoic acid IEA
Inferred from Electronic Annotation
more info
 
response to sucrose IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
sleep IEA
Inferred from Electronic Annotation
more info
 
social behavior IEA
Inferred from Electronic Annotation
more info
 
sperm ejaculation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
secretory granule IEA
Inferred from Electronic Annotation
more info
 
terminal bouton IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
oxytocin-neurophysin 1
Names
oxytocin-neurophysin 1
neurophysin I
oxytocin, prepropeptide
oxytocin, prepro- (neurophysin I)
oxytocin-neurophysin I, preproprotein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000915.3NP_000906.1  oxytocin-neurophysin 1 preproprotein

    See proteins identical to NP_000906.1

    Status: REVIEWED

    Source sequence(s)
    AI185553, BC069144
    Consensus CDS
    CCDS13044.1
    UniProtKB/Swiss-Prot
    P01178
    Related
    ENSP00000217386, OTTHUMP00000030079, ENST00000217386, OTTHUMT00000077698
    Conserved Domains (1) summary
    smart00003
    Location:39116
    Blast Score: 262
    NH; Neurohypophysial hormones

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38 Primary Assembly

    Range
    3071620..3072517
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

  1. AC_000152.1 Alternate HuRef

    Range
    2998607..2999505
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018931.2 Alternate CHM1_1.1

    Range
    3046806..3047704
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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