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ORM1 orosomucoid 1 [ Homo sapiens (human) ]

Gene ID: 5004, updated on 19-Mar-2015
Official Symbol
ORM1provided by HGNC
Official Full Name
orosomucoid 1provided by HGNC
Primary source
HGNC:HGNC:8498
See related
Ensembl:ENSG00000229314; HPRD:00724; MIM:138600; Vega:OTTHUMG00000021012
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ORM; AGP1; AGP-A; HEL-S-153w
Summary
This gene encodes a key acute phase plasma protein. Because of its increase due to acute inflammation, this protein is classified as an acute-phase reactant. The specific function of this protein has not yet been determined; however, it may be involved in aspects of immunosuppression. [provided by RefSeq, Jul 2008]
Orthologs
See ORM1 in MapViewer
Location:
9q32
Exon count:
6
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 9 NC_000009.12 (114323023..114326479)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (117085303..117088759)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene collagen, type XXVII, alpha 1 Neighboring gene microRNA 455 Neighboring gene uncharacterized LOC105376224 Neighboring gene orosomucoid 2 Neighboring gene AT-hook transcription factor Neighboring gene uncharacterized LOC105376227

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A meta-analysis of genome-wide association studies identifies ORM1 as a novel gene controlling thrombin generation potential.
NHGRI GWA Catalog
Genome-wide association study of Tourette's syndrome.
NHGRI GWA Catalog
Ischemic stroke is associated with the ABO locus: the EuroCLOT study.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env AGP inhibits the binding of the HIV-1 gp120 consensus V3 domain (V3Cs) and macrophage inflammatory protein-1beta (MIP-1beta) to CCR5 on human monocyte-derived macrophages (MDM) PubMed
env Recombinant precursor gp160 (rgp160) or surface unit gp120 (rgp120) of HIV-1 and alpha 1-acid glycoprotein (AGP) show a specific low-affinity binding via N-linked glycans PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acute-phase response IEA
Inferred from Electronic Annotation
more info
 
inflammatory response TAS
Traceable Author Statement
more info
PubMed 
negative regulation of interleukin-6 production IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of tumor necrosis factor production IDA
Inferred from Direct Assay
more info
PubMed 
regulation of immune system process IEA
Inferred from Electronic Annotation
more info
 
transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
blood microparticle IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
alpha-1-acid glycoprotein 1
Names
alpha-1-acid glycoprotein 1
AGP 1
OMD 1
epididymis secretory sperm binding protein Li 153w
orosomucoid-1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012108.1 RefSeqGene

    Range
    5001..8457
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000607.2NP_000598.2  alpha-1-acid glycoprotein 1 precursor

    See proteins identical to NP_000598.2

    Status: REVIEWED

    Source sequence(s)
    BI908589, M13692, N68733
    Consensus CDS
    CCDS6803.1
    UniProtKB/Swiss-Prot
    P02763
    Related
    ENSP00000259396, OTTHUMP00000022741, ENST00000259396, OTTHUMT00000055426
    Conserved Domains (1) summary
    pfam00061
    Location:40180
    Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p2 Primary Assembly

    Range
    114323023..114326479
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018920.2 Alternate CHM1_1.1

    Range
    117232023..117235479
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)