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    ORC4 origin recognition complex, subunit 4 [ Homo sapiens ]

    Gene ID: 5000, updated on 23-May-2012
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    Summary

    Official Symbol
    ORC4provided by HGNC
    Official Full Name
    origin recognition complex, subunit 4provided by HGNC
    Primary source
    HGNC:8490
    See related
    Ensembl:ENSG00000115947; HPRD:09118; MIM:603056; Vega:OTTHUMG00000131849
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ORC4L; ORC4P; FLJ46668
    Summary
    The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. This gene encodes a subunit of the ORC complex. Several alternatively spliced transcript variants, some of which encode the same protein, have been reported for this gene. [provided by RefSeq, Oct 2010]
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    Genomic context

    Location :
    2q22-q23
    Sequence :
    Chromosome: 2; NC_000002.11 (148687966..148779173, complement)
    See ORC4 in Epigenomics, MapViewer

    Chromosome 2 - NC_000002.11Genomic Context describing neighboring genes Neighboring gene glioblastoma amplified sequence pseudogene Neighboring gene ribosomal protein L26 pseudogene 14 Neighboring gene activin A receptor, type IIA Neighboring gene methyl-CpG binding domain protein 5 Neighboring gene ubiquitin specific peptidase 12 pseudogene Neighboring gene ADP-ribosylation factor-like 5A pseudogene

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    2. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    3. Interactions of MCP1 with components of the replication machinery in mammalian cells. Bronze-da-Rocha E, et al. Int J Biol Sci, 2011 Feb 17. PMID 21383955.
    4. Mutations in the pre-replication complex cause Meier-Gorlin syndrome. Bicknell LS, et al. Nat Genet, 2011 Feb 27. PMID 21358632.
    5. Mutations in origin recognition complex gene ORC4 cause Meier-Gorlin syndrome. Guernsey DL, et al. Nat Genet, 2011 Feb 27. PMID 21358631.

    See all (42) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. identified three different mutations in the gene encoding ORC4, a component of the eukaryotic origin recognition complex, in five individuals with Meier-Gorlin syndrome
      Title: Mutations in origin recognition complex gene ORC4 cause Meier-Gorlin syndrome.
    2. DNA binding activity of HsOrc4 depends on length and structure of DNA with triplex being the protein's preferred binding target.
      Title: Human initiation protein Orc4 prefers triple stranded DNA.
    3. describe 3 patients with B-cell lymphoproliferative disorders (2 with non-Hodgkin lymphoma and 1 with nonsecretory multiple myeloma) carrying a novel A286V mutation within ORC4L gene
      Title: Novel ORC4L gene mutation in B-cell lymphoproliferative disorders.
    4. Observational study of gene-disease association. (HuGE Navigator)
      Title: Genetic variants in apoptosis and immunoregulation-related genes are associated with risk of chronic lymphocytic leukemia.
    5. Study using HCT116 haplo-insufficient cells and Orc2 hypomorphic cells demonstrates that the binding of human Ku to replication origins precedes that of Orc-3, -4, and -6 subunit binding.
      Title: Ku80 binds to human replication origins prior to the assembly of the ORC complex.
    6. Biochemical characterization of the mouse homolog
      Title: Identification and characterization of MmORC4 and MmORC5, two subunits of the mouse origin of replication recognition complex.
    Submit: New GeneRIF Correction
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    Phenotypes

    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Genome-wide association of lipid-lowering response to statins in combined study populations.

    Meier-Gorlin syndrome 2

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    O43929 P24385 CCND1    HPRD  PubMed  
    O43929 Q8N726 CDKN2A    HPRD  PubMed  
    O43929 Q7L590 MCM10    HPRD  PubMed  
    O43929 P49736 MCM2    HPRD  PubMed  
    O43929 P25205 MCM3    HPRD  PubMed  
    O43929 P33993 MCM7    HPRD  PubMed  
    O43929 Q13416 ORC2    HPRD  PubMed  
    O43929 Q9UBD5 ORC3    HPRD  PubMed  
    O43929 O43913 ORC5    HPRD  PubMed  
    O43929 Q9Y5N6 ORC6    HPRD  PubMed  
    BioGRID:111042 BioGRID:112251 CCL2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111042 BioGRID:116129 DBF4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111042 BioGRID:110339 MCM2    BioGRID  PubMed Two-hybrid 
    BioGRID:111042 BioGRID:110340 MCM3    BioGRID  PubMed Two-hybrid 
    BioGRID:111042 BioGRID:110341 MCM4    BioGRID  PubMed Two-hybrid 
    BioGRID:111042 BioGRID:110343 MCM6    BioGRID  PubMed Two-hybrid 
    BioGRID:111042 BioGRID:111040 ORC1    BioGRID  PubMed Two-hybrid 
    BioGRID:111042 BioGRID:111041 ORC2    BioGRID  PubMed Affinity Capture-Western; Co-purification; Reconstituted Complex; Two-hybrid 
    BioGRID:111042 BioGRID:117130 ORC3    BioGRID  PubMed Affinity Capture-Western; Co-purification; Reconstituted Complex 
    BioGRID:111042 BioGRID:111043 ORC5    BioGRID  PubMed Affinity Capture-Western; Co-purification; Two-hybrid 
    BioGRID:111042 BioGRID:117129 ORC6    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:111042 BioGRID:112038 RPA2    BioGRID  PubMed Two-hybrid 
    BioGRID:111042 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:111042 BioGRID:113353 XRCC5    BioGRID  PubMed Affinity Capture-Western; Co-localization 
    BioGRID:111042 BioGRID:108822 XRCC6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:111042 BioGRID:1205541 tat    BioGRID  PubMed Reconstituted Complex 
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    General gene information

    Markers

    Genotypes

    Homology

    • Homologs of the ORC4 gene: The ORC4 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, S.cerevisiae, K.lactis, , N.crassa, A.thaliana, and rice.
    • Map Viewer (Mouse, Rat)

    Pathways from BioSystems

    • Activation of ATR in response to replication stress, organism-specific biosystem (from REACTOME)
      Activation of ATR in response to replication stress, organism-specific biosystemGenotoxic stress caused by DNA damage or stalled replication forks can lead to genomic instability. To guard against such instability, genotoxically-stressed cells activate checkpoint factors that ha...
    • Activation of the pre-replicative complex, organism-specific biosystem (from REACTOME)
      Activation of the pre-replicative complex, organism-specific biosystemIn S. cerevisiae, two ORC subunits, Orc1 and Orc5, both bind ATP, and Orc1 in addition has ATPase activity. Both ATP binding and ATP hydrolysis appear to be essential functions in vivo. ATP binding b...
    • Assembly of the ORC complex at the origin of replication, organism-specific biosystem (from REACTOME)
      Assembly of the ORC complex at the origin of replication, organism-specific biosystemIn Saccharomyces cerevisiae, the entire ORC complex is constitutively bound to the origin of replication. However, in mammalian cells, Orc1, and possibly other Orc subunits, dissociate from origins o...
    • Assembly of the pre-replicative complex, organism-specific biosystem (from REACTOME)
      Assembly of the pre-replicative complex, organism-specific biosystemDNA replication pre-initiation in eukaryotic cells begins with the formation of the pre-replicative complex (pre-RC) during the late M phase and continues in the G1 phase of the mitotic cell cycle, a...
    • Association of licensing factors with the pre-replicative complex, organism-specific biosystem (from REACTOME)
      Association of licensing factors with the pre-replicative complex, organism-specific biosystemThe eukaryotic six-subunit origin recognition complex (ORC) governs the initiation site of DNA replication and formation of the prereplication complex.
    • CDC6 association with the ORC:origin complex, organism-specific biosystem (from REACTOME)
      CDC6 association with the ORC:origin complex, organism-specific biosystemCdc6 is a regulator of DNA replication initiation in both yeasts and human cells, but its mechanism of action differs between the two systems. Genetic studies in budding yeast (S. cerevisiae) and fis...
    • CDT1 association with the CDC6:ORC:origin complex, organism-specific biosystem (from REACTOME)
      CDT1 association with the CDC6:ORC:origin complex, organism-specific biosystemInitiation protein Cdt1 was first identified in X. laevis, where it has been shown to be the second component of licensing factor (RLF-B) and in S. pombe. Cdt1 homologs have been identified in D. mel...
    • Cell Cycle, organism-specific biosystem (from REACTOME)
      Cell Cycle, organism-specific biosystem
      Cell Cycle
    • Cell Cycle Checkpoints, organism-specific biosystem (from REACTOME)
      Cell Cycle Checkpoints, organism-specific biosystemA hallmark of the human cell cycle in normal somatic cells is its precision. This remarkable fidelity is achieved by a number of signal transduction pathways, known as checkpoints, which monitor cell...
    • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
      Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
    • Cell cycle, organism-specific biosystem (from WikiPathways)
      Cell cycle, organism-specific biosystem(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle in...
    • Cell cycle, organism-specific biosystem (from KEGG)
      Cell cycle, organism-specific biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • Cell cycle, conserved biosystem (from KEGG)
      Cell cycle, conserved biosystemMitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cycli...
    • DNA Replication, organism-specific biosystem (from WikiPathways)
      DNA Replication, organism-specific biosystemStudies in the past decade have suggested that the basic mechanism of DNA replication initiation is conserved in all kingdoms of life. Initiation in unicellular eukaryotes, in particular Saccharomyce...
    • DNA Replication, organism-specific biosystem (from REACTOME)
      DNA Replication, organism-specific biosystemStudies in the past decade have suggested that the basic mechanism of DNA replication initiation is conserved in all kingdoms of life. Initiation in unicellular eukaryotes, in particular Saccharomyce...
    • DNA Replication Pre-Initiation, organism-specific biosystem (from REACTOME)
      DNA Replication Pre-Initiation, organism-specific biosystemAlthough, DNA replication occurs in the S phase of the cell cycle, the formation of the DNA replication pre-initiation complex begins during G1 phase.
    • E2F mediated regulation of DNA replication, organism-specific biosystem (from REACTOME)
      E2F mediated regulation of DNA replication, organism-specific biosystemProgression through G1 and G1 to S-phase transition that initiates DNA synthesis involve many complexes that are regulated by RB1:E2F pathway. RB1:E2F pathway plays a key role in gene expression regu...
    • E2F-enabled inhibition of pre-replication complex formation, organism-specific biosystem (from REACTOME)
      E2F-enabled inhibition of pre-replication complex formation, organism-specific biosystemUnder specific conditions, Cyclin B, a mitotic cyclin, can inhibit the functions of pre-replicative complex. E2F1 activates Cdc25A protein which regulates Cyclin B in a positive manner. Cyclin B/Cdk...
    • G1 to S cell cycle control, organism-specific biosystem (from WikiPathways)
      G1 to S cell cycle control, organism-specific biosystemIn the G1 phase there are two types of DNA damage responses, the p53-dependent and the p53-independent pathways. The p53-dependent responses inhibit CDKs through the up-regulation of genes encoding C...
    • G1/S Transition, organism-specific biosystem (from REACTOME)
      G1/S Transition, organism-specific biosystemCyclin E - Cdk2 complexes control the transition from G1 into S-phase. In this case, the binding of p21Cip1/Waf1 or p27kip1 is inhibitory. Important substrates for Cyclin E - Cdk2 complexes include p...
    • G2/M Checkpoints, organism-specific biosystem (from REACTOME)
      G2/M Checkpoints, organism-specific biosystemG2/M checkpoints include the checks for damaged DNA, unreplicated DNA, and checks that ensure that the genome is replicated once and only once per cell cycle. If cells pass these checkpoints, they f...
    • M/G1 Transition, organism-specific biosystem (from REACTOME)
      M/G1 Transition, organism-specific biosystemFinally, progression out of mitosis and division of the cell into two daughters (cytokinesis) requires the inactivation of Cyclin B - Cdc2 by ubiquitin-dependent proteolysis of Cyclin A and B, which ...
    • Mitotic G1-G1/S phases, organism-specific biosystem (from REACTOME)
      Mitotic G1-G1/S phases, organism-specific biosystem
      Mitotic G1-G1/S phases
    • Mitotic M-M/G1 phases, organism-specific biosystem (from REACTOME)
      Mitotic M-M/G1 phases, organism-specific biosystem
      Mitotic M-M/G1 phases
    • Orc1 removal from chromatin, organism-specific biosystem (from REACTOME)
      Orc1 removal from chromatin, organism-specific biosystem
      Orc1 removal from chromatin
    • Origin recognition complex, organism-specific biosystem (from KEGG)
      Origin recognition complex, organism-specific biosystemStructural complex; Genetic information processing; Replication system
    • Regulation of DNA replication, organism-specific biosystem (from REACTOME)
      Regulation of DNA replication, organism-specific biosystemDNA replication is regulated at various levels via ORC proteins. This pathway includes annotation of individual events that lead to the regulation of replication.
    • Removal of licensing factors from origins, organism-specific biosystem (from REACTOME)
      Removal of licensing factors from origins, organism-specific biosystemLicensing factors are removed from the origin by various means like biochemical modification (phosphorylation) or by physical association with other proteins. This pathway includes the annotations of...
    • S Phase, organism-specific biosystem (from REACTOME)
      S Phase, organism-specific biosystemDNA synthesis occurs in the S phase, or the synthesis phase, of the cell cycle. The cell duplicates its hereditary material, and two copies of the chromosome are formed. As DNA replication continu...
    • Switching of origins to a post-replicative state, organism-specific biosystem (from REACTOME)
      Switching of origins to a post-replicative state, organism-specific biosystem
      Switching of origins to a post-replicative state
    • Synthesis of DNA, organism-specific biosystem (from REACTOME)
      Synthesis of DNA, organism-specific biosystemThe actual synthesis of DNA occurs in the S phase of the cell cycle. This includes the initiation of DNA replication, when the first nucleotide of the new strand is laid down during the synthesis of ...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    DNA replication origin binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    nucleoside-triphosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    nucleotide binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    DNA replication TAS
    Traceable Author Statement
    more info
    		  
    DNA-dependent DNA replication initiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    G1/S transition of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    M/G1 transition of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    S phase of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    cell cycle checkpoint TAS
    Traceable Author Statement
    more info
    		  
    mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    nuclear origin of replication recognition complex IDA
    Inferred from Direct Assay
    more info
    		  
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    origin recognition complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    origin recognition complex subunit 4
    Names
    origin recognition complex subunit 4
    origin recognition complex, subunit 4-like
    origin recognition complex, subunit 4 homolog
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_028252.1 RefSeqGene

      Range
      5001..96208
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001190879.2 → NP_001177808.1  origin recognition complex subunit 4 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) represents the longest transcript. Variants 1 through 4 encode the same protein (isoform 1).
      Source sequence(s)
      AC009480, BC014847, BX423253, DC302315, DC399282
      Consensus CDS
      CCDS2187.1
      UniProtKB/Swiss-Prot
      O43929
      Related
      ENSP00000441953, ENST00000535373
      Conserved Domains (2) summary
      cd00009
      Location:46 – 213
      Blast Score: 132
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      smart00382
      Location:61 – 217
      Blast Score: 117
      AAA; ATPases associated with a variety of cellular activities

    2. NM_001190881.2 → NP_001177810.1  origin recognition complex subunit 4 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks several exons in the 5' region, which results in the use of a downstream start codon, compared to variant 4. The resulting protein (isoform 2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC009480, AK295721, BP277082
      Consensus CDS
      CCDS54404.1
      UniProtKB/TrEMBL
      B7Z3D0
      Related
      ENSP00000441502, ENST00000536575
      Conserved Domains (1) summary
      COG1474
      Location:2 – 134
      Blast Score: 148
      CDC6; Cdc6-related protein, AAA superfamily ATPase [DNA replication, recombination, and repair / Posttranslational modification, protein turnover, chaperones]

    3. NM_001190882.2 → NP_001177811.1  origin recognition complex subunit 4 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks two consecutive exons in the 5' region, which results in the use of a downstream start codon, compared to variant 4. The resulting protein (isoform 3) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC009480, AK298862, BC005388
      Consensus CDS
      CCDS54405.1
      UniProtKB/TrEMBL
      B7Z5F1
      UniProtKB/TrEMBL
      F5H069
      Related
      ENSP00000438326, ENST00000540442
      Conserved Domains (1) summary
      COG1474
      Location:4 – 144
      Blast Score: 150
      CDC6; Cdc6-related protein, AAA superfamily ATPase [DNA replication, recombination, and repair / Posttranslational modification, protein turnover, chaperones]

    4. NM_002552.4 → NP_002543.2  origin recognition complex subunit 4 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an alternate segment in the 5' UTR, compared to variant 4. Variants 1 through 4 encode the same protein (isoform 1).
      Source sequence(s)
      AC009480, AK291989, AK298862, DC317404
      Consensus CDS
      CCDS2187.1
      UniProtKB/TrEMBL
      A8K7H4
      UniProtKB/TrEMBL
      B7Z5F1
      UniProtKB/Swiss-Prot
      O43929
      Related
      ENSP00000376598, ENST00000392858
      Conserved Domains (2) summary
      cd00009
      Location:46 – 213
      Blast Score: 132
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      smart00382
      Location:61 – 217
      Blast Score: 117
      AAA; ATPases associated with a variety of cellular activities

    5. NM_181741.3 → NP_859525.1  origin recognition complex subunit 4 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) lacks an exon in the 5' UTR, compared to variant 4. Variants 1 through 4 encode the same protein (isoform 1).
      Source sequence(s)
      AC009480, BC014847, DA227202
      Consensus CDS
      CCDS2187.1
      UniProtKB/Swiss-Prot
      O43929
      Related
      ENSP00000376597, OTTHUMP00000162673, ENST00000392857, OTTHUMT00000254797
      Conserved Domains (2) summary
      cd00009
      Location:46 – 213
      Blast Score: 132
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      smart00382
      Location:61 – 217
      Blast Score: 117
      AAA; ATPases associated with a variety of cellular activities

    6. NM_181742.3 → NP_859526.1  origin recognition complex subunit 4 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, as compared to variant 4. Variants 1 through 4 encode the same protein (isoform 1).
      Source sequence(s)
      AC009480, BC016177, DC365653
      Consensus CDS
      CCDS2187.1
      UniProtKB/Swiss-Prot
      O43929
      UniProtKB/TrEMBL
      Q96B14
      Related
      ENSP00000264169, ENST00000264169
      Conserved Domains (2) summary
      cd00009
      Location:46 – 213
      Blast Score: 132
      AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
      smart00382
      Location:61 – 217
      Blast Score: 117
      AAA; ATPases associated with a variety of cellular activities

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000002.11 Reference GRCh37.p5 Primary Assembly

      Range
      148687966..148779173, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000134.1 Alternate HuRef

      Range
      140685335..140777468, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AC009480.4 AAX93051.1
    genomic AC019226.5 AAY24232.1
    genomic AY600302.1 AAS94326.1
    genomic CH471058.2 EAX11555.1
      EAX11556.1
      EAX11557.1
      EAX11558.1
      EAX11559.1
      EAX11560.1
    mRNA AF022108.1 AAC01957.1
    mRNA AF047598.1 AAC80282.1
    mRNA AF132596.1 AAD22110.1
    mRNA AK055257.1 None
    mRNA AK128860.1 None
    mRNA AK225092.1 None
    mRNA AK291989.1 BAF84678.1
    mRNA AK294878.1 BAH11910.1
    mRNA AK295721.1 BAH12166.1
    mRNA AK298862.1 BAH12887.1
    mRNA AK299749.1 BAH13118.1
    mRNA AV708885.2 None
    mRNA BC005388.1 None
    mRNA BC014847.1 AAH14847.1
    mRNA BC016177.1 AAH16177.1
    mRNA BI603609.1 None
    mRNA BM468640.1 None
    mRNA BM926755.1 None
    mRNA BP277082.1 None
    mRNA BP345092.1 None
    mRNA BQ716497.1 None
    mRNA BX423253.2 None
    mRNA CD242597.1 None
    mRNA DA120022.1 None
    mRNA DA227202.1 None
    mRNA DB558580.1 None
    mRNA DC302315.1 None
    mRNA DC317404.1 None
    mRNA DC329505.1 None
    mRNA DC365436.1 None
    mRNA DC365653.1 None
    mRNA DC399282.1 None
    mRNA DC399552.1 None
    other-genetic EU446991.1 ABZ92520.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    O43929.2 GenPept UniProtKB/Swiss-Prot:O43929
    Q53SE3 GenPept UniProtKB/TrEMBL:Q53SE3
    Q53TH5 GenPept UniProtKB/TrEMBL:Q53TH5
    Q96B14 GenPept UniProtKB/TrEMBL:Q96B14
    Help top of page

    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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    Research Materials
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