Ttf1 transcription termination factor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ttf1provided by RGD
Official Full Name: transcription termination factor 1provided by RGD
Primary source: RGD:1565673
See related: Ensembl:ENSRNOG00000039777 AllianceGenome:RGD:1565673
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1565673
Summary: Predicted to enable DNA binding activity and chromatin binding activity. Predicted to be involved in termination of RNA polymerase I transcription. Predicted to act upstream of or within chromatin remodeling and transcription initiation from RNA polymerase I promoter. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be active in nucleolus. Orthologous to human TTF1 (transcription termination factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 76.8), Thymus (RPKM 75.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3p12

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (32782544..32807202)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (12384626..12409257)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (7635630..7660153)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Together with results showing involvement of TTF-1 in the TNF-alpha-induced increase in interleukin 1 beta and monocyte chemotactic protein 1 production, this study suggests that TTF-1 plays an important role in the mouse hypothalamus TNF-alpha-induced inflammatory response for regulating HO-1 gene expression.
Title: Role of thyroid transcription factor-1 in transcriptional regulation of heme oxygenase-1.
data extend the known roles of TTF-1 in thyroid development and in the expression of differentiated function in the adult organ to the control of epithelial morphology and of cell division in mature thyrocytes
Title: Functional inactivation of thyroid transcription factor-1 in PCCl3 thyroid cells.
These results suggest that TTF-1 is physiologically involved in the control of thermogenesis by regulating COX-2 transcription in the brain.
Title: TTF-1 action on the transcriptional regulation of cyclooxygenase-2 gene in the rat brain.
These results suggest that TTF-1 plays a role in the circadian rhythm regulation of the AoGen gene expression via interacting with Per proteins in the rat suprachiasmatic nucleus.
Title: Expression and role of TTF-1 in the rat suprachiasmatic nucleus.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within chromatin remodeling	ISO Inferred from Sequence Orthology more info
involved_in termination of RNA polymerase I transcription	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within termination of RNA polymerase I transcription	ISO Inferred from Sequence Orthology more info
involved_in termination of RNA polymerase I transcription	ISO Inferred from Sequence Orthology more info
involved_in transcription by RNA polymerase I	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within transcription initiation at RNA polymerase I promoter	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transcription termination factor 1

Names: transcription termination factor, RNA polymerase I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427196.1 → NP_001414125.1 transcription termination factor 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/TrEMBL

A6JTQ6, D4A1Z7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

32782544..32807202

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006233882.5 → XP_006233944.1 transcription termination factor 1 isoform X1

See identical proteins and their annotated locations for XP_006233944.1

UniProtKB/TrEMBL

A0A8I6AA77

Conserved Domains (1) summary

pfam13921
Location:621 → 676

Myb_DNA-bind_6; Myb-like DNA-binding domain
XM_039106155.2 → XP_038962083.1 transcription termination factor 1 isoform X3
XM_039106156.2 → XP_038962084.1 transcription termination factor 1 isoform X4
XM_063284344.1 → XP_063140414.1 transcription termination factor 1 isoform X2