CG14476 [Drosophila melanogaster] - Gene

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Summary

Official Symbol: CG14476provided by Flybase
Primary source: FLYBASE:FBgn0027588
Locus tag: Dmel_CG14476
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:GH04962; clot#312; Dmel\CG14476

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Genomic context

Location :: 20A4-20A4

Sequence :: Chromosome: X; NC_004354.3 (21471627..21476294, complement)

See CG14476 in Epigenomics, MapViewer

Chromosome X - NC_004354.3 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Analysis of the structure and expression of the cluster of Drosophila melanogaster genes DIP1, CG32500, CG32819, and CG14476 in the flamenco gene region
Title: [Analysis of the structure and expression of the cluster of Drosophila melanogaster genes DIP1, CG32500, CG32819, and CG14476 in the flamenco gene region].

Submit: New GeneRIF Correction

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Interactions

Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:72489	BioGRID:63300	CG9875	BioGRID	PubMed	Two-hybrid
BioGRID:72489	BioGRID:78249	RpL5	BioGRID	PubMed	Two-hybrid
BioGRID:72489	BioGRID:68605	ci	BioGRID	PubMed	Two-hybrid
BioGRID:72489	BioGRID:70682	term	BioGRID	PubMed	Two-hybrid

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General gene information

Homology

Homologs of the CG14476 gene: The CG14476 gene is conserved in human, chimpanzee, , dog, cow, mouse, rat, zebrafish, mosquito, C.elegans, S.cerevisiae, K.lactis, , S.pombe, , N.crassa, A.thaliana, and rice.

Pathways from BioSystems

Metabolic pathways, organism-specific biosystem (from KEGG)
Metabolic pathways, organism-specific biosystem
Metabolic pathways
N-Glycan biosynthesis, organism-specific biosystem (from KEGG)
N-Glycan biosynthesis, organism-specific biosystemN-glycans or asparagine-linked glycans are major constituents of glycoproteins in eukaryotes. N-glycans are covalently attached to asparagine with the consensus sequence of Asn-X-Ser/Thr by an N-glyc...
N-Glycan biosynthesis, conserved biosystem (from KEGG)
N-Glycan biosynthesis, conserved biosystemN-glycans or asparagine-linked glycans are major constituents of glycoproteins in eukaryotes. N-glycans are covalently attached to asparagine with the consensus sequence of Asn-X-Ser/Thr by an N-glyc...
N-glycan precursor trimming, organism-specific biosystem (from KEGG)
N-glycan precursor trimming, organism-specific biosystemPathway module; Carbohydrate and lipid metabolism; Glycan metabolism
N-glycan precursor trimming, conserved biosystem (from KEGG)
N-glycan precursor trimming, conserved biosystemPathway module; Carbohydrate and lipid metabolism; Glycan metabolism
Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...

mobile_element

Loc: c21475407-21475059 mobile_element_type = transposon:INE-1{}2000

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
alpha-glucosidase activity	ISS Inferred from Sequence or Structural Similarity more info
carbohydrate binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
glucosidase II complex	ISS Inferred from Sequence or Structural Similarity more info
microtubule associated complex	IDA Inferred from Direct Assay more info	PubMed

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General protein information

Preferred Names: CG14476 gene product from transcript CG14476-RB

Names: CG14476; CG14476-PA; CG14476-PB; CG14476-PC; CG14476-PD; CG14476-PE; alpha-glucosidase; glucosidase II

NP_652145.1

EC 3.2.1.20

NP_728434.1

EC 3.2.1.20

NP_728435.1

EC 3.2.1.20

NP_728436.1

EC 3.2.1.20

NP_728437.1

EC 3.2.1.20

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NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004354.3

Range

21471627..21476294, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_143888.4 → NP_652145.1 CG14476, isoform B [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

Q7KMM4

Related

FBpp0070057, FBtr0070058

Conserved Domains (3) summary

COG1501
Location:108 – 891
Blast Score: 1168

COG1501; Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]

cd06603
Location:362 – 699
Blast Score: 1619

GH31_GANC_GANAB_alpha; This family includes the closely related glycosyl hydrolase family 31 (GH31) isozymes, neutral alpha-glucosidase C (GANC) and the alpha subunit of heterodimeric neutral alpha-glucosidase AB (GANAB). Initially distinguished on the basis of differences in ...

pfam13802
Location:236 – 304
Blast Score: 194

Gal_mutarotas_2; Galactose mutarotase-like
NM_167758.1 → NP_728435.1 CG14476, isoform C [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

Q7KMM4

Related

FBpp0070058, FBtr0070059

Conserved Domains (3) summary

COG1501
Location:108 – 891
Blast Score: 1168

COG1501; Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]

cd06603
Location:362 – 699
Blast Score: 1619

GH31_GANC_GANAB_alpha; This family includes the closely related glycosyl hydrolase family 31 (GH31) isozymes, neutral alpha-glucosidase C (GANC) and the alpha subunit of heterodimeric neutral alpha-glucosidase AB (GANAB). Initially distinguished on the basis of differences in ...

pfam13802
Location:236 – 304
Blast Score: 194

Gal_mutarotas_2; Galactose mutarotase-like
NM_167757.2 → NP_728434.1 CG14476, isoform A [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

Q7KMM4

Related

FBpp0070059, FBtr0070060

Conserved Domains (3) summary

COG1501
Location:108 – 891
Blast Score: 1168

COG1501; Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]

cd06603
Location:362 – 699
Blast Score: 1619

GH31_GANC_GANAB_alpha; This family includes the closely related glycosyl hydrolase family 31 (GH31) isozymes, neutral alpha-glucosidase C (GANC) and the alpha subunit of heterodimeric neutral alpha-glucosidase AB (GANAB). Initially distinguished on the basis of differences in ...

pfam13802
Location:236 – 304
Blast Score: 194

Gal_mutarotas_2; Galactose mutarotase-like
NM_167760.1 → NP_728437.1 CG14476, isoform E [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

Q7KMM4

Related

FBpp0070060, FBtr0070061

Conserved Domains (3) summary

COG1501
Location:108 – 891
Blast Score: 1168

COG1501; Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]

cd06603
Location:362 – 699
Blast Score: 1619

GH31_GANC_GANAB_alpha; This family includes the closely related glycosyl hydrolase family 31 (GH31) isozymes, neutral alpha-glucosidase C (GANC) and the alpha subunit of heterodimeric neutral alpha-glucosidase AB (GANAB). Initially distinguished on the basis of differences in ...

pfam13802
Location:236 – 304
Blast Score: 194

Gal_mutarotas_2; Galactose mutarotase-like
NM_167759.1 → NP_728436.1 CG14476, isoform D [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

Q7KMM4

Related

FBpp0070061, FBtr0070062

Conserved Domains (3) summary

COG1501
Location:108 – 891
Blast Score: 1168

COG1501; Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]

cd06603
Location:362 – 699
Blast Score: 1619

GH31_GANC_GANAB_alpha; This family includes the closely related glycosyl hydrolase family 31 (GH31) isozymes, neutral alpha-glucosidase C (GANC) and the alpha subunit of heterodimeric neutral alpha-glucosidase AB (GANAB). Initially distinguished on the basis of differences in ...

pfam13802
Location:236 – 304
Blast Score: 194

Gal_mutarotas_2; Galactose mutarotase-like

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AE014298.4	AAN08995.1
genomic	AE014298.4	AAN08996.1
mRNA	AF145625.1	AAD38600.1
genomic	AE014298.4	AAG22460.1
genomic	AE014298.4	AAF45432.1
genomic	AE014298.4	AAN08997.1