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Itgax integrin subunit alpha X [ Rattus norvegicus (Norway rat) ]

Gene ID: 499271, updated on 13-Apr-2024

Summary

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Official Symbol
Itgaxprovided by RGD
Official Full Name
integrin subunit alpha Xprovided by RGD
Primary source
RGD:1561123
See related
Ensembl:ENSRNOG00000036703 AllianceGenome:RGD:1561123
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1561123
Summary
Predicted to enable receptor tyrosine kinase binding activity. Predicted to be involved in several processes, including positive regulation of angiogenesis; positive regulation of endothelial tube morphogenesis; and positive regulation of myelination. Predicted to act upstream of or within defense response to virus. Predicted to be located in external side of plasma membrane. Predicted to be part of integrin complex. Orthologous to human ITGAX (integrin subunit alpha X). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 157.0), Lung (RPKM 72.7) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
1q37
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (192140089..192171151)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (182709653..182740709)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (199555560..199576948)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene RNA, U1 small nuclear 140 Neighboring gene integrin subunit alpha M Neighboring gene integrin subunit alpha D Neighboring gene cytochrome c oxidase subunit 6A2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Integrin alpha x stimulates cancer angiogenesis through PI3K/Akt signaling-mediated VEGFR2/VEGF-A overexpression in blood vessel endothelial cells. Wang J, et al. J Cell Biochem, 2019 Feb. PMID 30873824
  2. A novel microglial subset plays a key role in myelinogenesis in developing brain. Wlodarczyk A, et al. EMBO J, 2017 Nov 15. PMID 28963396, Free PMC Article
  3. Co-stimulation of murine CD4 T cell growth: cooperation between B7 and heat-stable antigen. Liu Y, et al. Eur J Immunol, 1992 Nov. PMID 1385153
  4. Slc11a1 enhances the autoimmune diabetogenic T-cell response by altering processing and presentation of pancreatic islet antigens. Dai YD, et al. Diabetes, 2009 Jan. PMID 18984740, Free PMC Article
  5. Cell-mediated fas-based lysis of dendritic cells which are apparently resistant to anti-Fas antibody. Yokota A, et al. Microbiol Immunol, 2003. PMID 12801066

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables receptor tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
NOT acts_upstream_of_or_within activated T cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in cell adhesion mediated by integrin IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within defense response to virus ISO
Inferred from Sequence Orthology
more info
  
involved_in heterotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of endothelial tube morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of myelination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of integrin complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
integrin alpha-X
Names
integrin, alpha X

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001419757.1 → NP_001406686.1  integrin alpha-X precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    D3ZWZ1
    Related
    ENSRNOP00000051866.4, ENSRNOT00000054983.5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    192140089..192171151
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039101230.2 → XP_038957158.1  integrin alpha-X isoform X1

    UniProtKB/TrEMBL
    A6I9Y3
    Conserved Domains (3) summary
    smart00191
    Location:460 → 515
    Int_alpha; Integrin alpha (beta-propellor repeats)
    cd01469
    Location:93 → 268
    vWA_integrins_alpha_subunit; Integrins are a class of adhesion receptors that link the extracellular matrix to the cytoskeleton and cooperate with growth factor receptors to promote celll survival, cell cycle progression and cell migration. Integrins consist of an alpha and a beta ...
    pfam08441
    Location:558 → 983
    Integrin_alpha2; Integrin alpha

  2. XM_039101233.2 → XP_038957161.1  integrin alpha-X isoform X4

    Conserved Domains (1) summary
    cl00057
    Location:150 → 242
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  3. XM_039101231.1 → XP_038957159.1  integrin alpha-X isoform X2

    Conserved Domains (3) summary
    smart00191
    Location:243 → 298
    Int_alpha; Integrin alpha (beta-propellor repeats)
    pfam08441
    Location:341 → 766
    Integrin_alpha2; Integrin alpha
    cl00057
    Location:1 → 51
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

  4. XM_063271412.1 → XP_063127482.1  integrin alpha-X isoform X3

RNA

  1. XR_005499481.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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