OPRM1 opioid receptor, mu 1 [Homo sapiens (human)] - Gene

Summary

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Official Symbol: OPRM1provided by HGNC
Official Full Name: opioid receptor, mu 1provided by HGNC
Primary source: HGNC:8156
See related: Ensembl:ENSG00000112038; HPRD:02484; MIM:600018; Vega:OTTHUMG00000015870
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MOP; MOR; LMOR; MOR1; OPRM; M-OR-1
Summary: This gene encodes one of three opioid receptors. The mu opioid receptor is the principal target of endogenous opioid peptides and opioid analgesic agents such a s beta-endorphn and enkephalins. The NM_001008503.1:c.118A>G allele had been associated with opioid and alcohol addiction and variations in pain sensitivity but evidence is conflicting. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2012]

Genomic context

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Location :: 6q24-q25

Sequence :: Chromosome: 6; NC_000006.11 (154331631..154568001)

See OPRM1 in Epigenomics, MapViewer

Chromosome 6 - NC_000006.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Among infants with neonatal abstinence syndrome (NAS), variants in the OPRM1 and COMT genes were associated with shorter length of hospital stay and less need for treatment. These preliminary findings may provide insight into the mechanisms underlying NAS
Title: Association of OPRM1 and COMT single-nucleotide polymorphisms with hospital length of stay and treatment of neonatal abstinence syndrome.
This is the first report of an association between the occurrence of fentanyl-induced emesis in Chinese women undergoing gynaecological surgery and an OPRM1 splice variant single nucleotide polymorphism, rs540825.
Title: A non-synonymous single nucleotide polymorphism in an OPRM1 splice variant is associated with fentanyl-induced emesis in women undergoing minor gynaecological surgery.
There was a significantly higher DNA methylation of the OPRM1 promoter region in alcohol dependence cases.
Title: Hypermethylation of OPRM1 promoter region in European Americans with alcohol dependence.
these data suggest that mu opioid receptor availability is decreased in the brains of people with schizophrenia who died as a result of suicide
Title: Mu opioid receptor availability in people with psychiatric disorders who died by suicide: a case control study.
Thus, the OPRM1 118A>G SNP variant not only reduces mu-opioid receptor signalling efficiency, but, reduces opioid receptor expression and therefore, depletes the opioid system of a compensatory reaction to chronic exposure.
Title: Genetic-epigenetic interaction modulates μ-opioid receptor regulation.
delta and mu-opioid receptors, but not kappa-opioid receptors, are functional in the neuronally stimulated longitudinal human vas deferens
Title: Opioid receptor characterisation of neuronally stimulated isolated human vas deferens.
This study was underpowered to draw firm conclusions on the influence of OPRM1 and COMT genotypes on labor analgesia with IV fentanyl
Title: The effect of OPRM1 and COMT genotypes on the analgesic response to intravenous fentanyl labor analgesia.
This study identified haplotypes of the OPRM1 receptor that predicted increases in self-reported pain on the third postoperative day after thoracotomy.
Title: Natural variation in the μ-opioid gene OPRM1 predicts increased pain on third day after thoracotomy.
Attentional bias is positively associated with adolescent alcohol use only for OPRM1 G-allele carriers.
Title: The effect of the OPRM1 and DRD4 polymorphisms on the relation between attentional bias and alcohol use in adolescence and young adulthood.
Carriers of the G allele of OPRM1 are less prone to develop severe respiratory syncytial virus infection than those carrying the A allele. The protective effect of a more sensitive opioid system was more prominent in ventilated children.
Title: Opioid receptors control viral replication in the airways.

Submit: New GeneRIF Correction See all (214)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

NHGRI GWAS Catalog

Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.

HIV-1 protein interactions

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Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 induces desensitization of a mu-opioid-receptor-mediated response in brain periaqueductal gray neurons	PubMed
	env	HIV-1 gp120 upregulates mu opioid receptor (MOR) expression in TPA-differentiated HL-60 cells; treatment with TNF-alpha neutralizing antibody as well as anti-TNF-alpha receptor type II (TNFR-II) antibody, inhibits gp120-induced upregulation of MOR	PubMed
	env	HIV-1 gp120 upregulates mu opiate receptor expression in human vascular endothelium; in contrast, morphine decreases mu opioid receptor expression	PubMed
Tat, p14	tat	Morphine treatment in the presence of Tat significantly increases intracellular expression of opioid receptors (mu, delta, and kappa) and prevents morphine-induced cell surface opioid receptor down-regulation in microglia	PubMed

Go to the HIV-1, Human Protein Interaction Database

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
AAB60354.1			BIND	PubMed	Mu-2 interacts with Ketamine.
NP_000905.1	NP_055525.1	GPRASP1	BIND	PubMed	GASP-1 interacts with MOR.
P35372	P35626	ADRBK2	HPRD	PubMed
P35372	Calmodulin 1	CALM1	HPRD	PubMed
P35372	Q9UDY4	DNAJB4	HPRD	PubMed
P35372	P21333	FLNA	HPRD	PubMed
P35372	P30679	GNA15	HPRD	PubMed
P35372	P63096	GNAI1	HPRD	PubMed
P35372	P04899	GNAI2	HPRD	PubMed
P35372	P09471	GNAO1	HPRD	PubMed
P35372	Q5JY77	GPRASP1	HPRD	PubMed
P35372	P41143	OPRD1	HPRD	PubMed
P35372	O14939	PLD2	HPRD	PubMed
P35372	O60437	PPL	HPRD	PubMed
BioGRID:111033	BioGRID:106870	ARF1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111033	BioGRID:107252	CALM1	BioGRID	PubMed	Reconstituted Complex
BioGRID:111033	BioGRID:109037	GNAO1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111033	BioGRID:111030	OPRD1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111033	BioGRID:111354	PLD2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:111033	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex

Pathways from BioSystems

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Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
Estrogen signaling pathway, organism-specific biosystem (from KEGG)
Estrogen signaling pathway, organism-specific biosystemEstrogens are steroid hormones that regulate a plethora of physiological processes in mammals, including reproduction, cardiovascular protection, bone integrity, cellular homeostasis, and behavior. E...
Estrogen signaling pathway, conserved biosystem (from KEGG)
Estrogen signaling pathway, conserved biosystemEstrogens are steroid hormones that regulate a plethora of physiological processes in mammals, including reproduction, cardiovascular protection, bone integrity, cellular homeostasis, and behavior. E...
G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
G-protein activation, organism-specific biosystem (from REACTOME)
G-protein activation, organism-specific biosystemReceptor activated heterotrimeric G proteins consist of the Galpha and the tightly associated Gbeta-gamma subunits. When a ligand binds to a G protein-coupled receptor, it stabilises a conformation ...
GPCR downstream signaling, organism-specific biosystem (from REACTOME)
GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
GPCR ligand binding, organism-specific biosystem (from REACTOME)
GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.cmbi.kun.nl/7tm/. The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used ...
IL4-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
IL4-mediated signaling events, organism-specific biosystem
IL4-mediated signaling events
Morphine addiction, organism-specific biosystem (from KEGG)
Morphine addiction, organism-specific biosystemMorphine is an alkaloid from the plant extracts of opium poppy. Although morphine is highly effective for the treatment of pain, it is also known to be intensely addictive. We now know that the most ...
Morphine addiction, conserved biosystem (from KEGG)
Morphine addiction, conserved biosystemMorphine is an alkaloid from the plant extracts of opium poppy. Although morphine is highly effective for the treatment of pain, it is also known to be intensely addictive. We now know that the most ...
Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
Neuroactive ligand-receptor interaction, organism-specific biosystem
Neuroactive ligand-receptor interaction
Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
Neuroactive ligand-receptor interaction, conserved biosystem
Neuroactive ligand-receptor interaction
Opioid Signalling, organism-specific biosystem (from REACTOME)
Opioid Signalling, organism-specific biosystemOpioids are chemical substances similar to opiates, the active substances found in opium (morphine, codeine etc.). Opioid action is mediated by the receptors for endogenous opioids; peptides such as...
Peptide GPCRs, organism-specific biosystem (from WikiPathways)
Peptide GPCRs, organism-specific biosystem
Peptide GPCRs
Peptide ligand-binding receptors, organism-specific biosystem (from REACTOME)
Peptide ligand-binding receptors, organism-specific biosystemThese receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins.
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
Signaling by GPCR, organism-specific biosystem (from REACTOME)
Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
TCR Signaling Pathway, organism-specific biosystem (from WikiPathways)
TCR Signaling Pathway, organism-specific biosystemThe T-cell antigen receptor (TCR) complex is composed of a ligand-binding subunit, the ? and ? chains, and a signaling subunit, namely the CD3?, ? and ? chains and the TCR? chain. This complex partic...

General gene information

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Markers

G62475 (e-PCR)
- UniSTS:139533

D6S1836 (e-PCR)
- UniSTS:28223

NoName (e-PCR)
- UniSTS:486727

D6S2185 (e-PCR)
- UniSTS:8525

NoName (e-PCR)
- UniSTS:495199

NoName (e-PCR)
- UniSTS:482168

WI-17899 (e-PCR)
- UniSTS:7310

OPRM1 (e-PCR)
- UniSTS:479916

WI-20576 (e-PCR)
- UniSTS:75214

RH46629 (e-PCR)
- UniSTS:72151

SHGC-84785 (e-PCR)
- UniSTS:104160

Genotypes

See OPRM1 SNP Geneview Report
See OPRM1 SNP Genotype Report
See OPRM1 SNP Variation Viewer Report

Homology

Homologs of the OPRM1 gene: The OPRM1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and zebrafish.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
G-protein alpha-subunit binding	IDA Inferred from Direct Assay more info
G-protein coupled receptor activity	ISS Inferred from Sequence or Structural Similarity more info
beta-endorphin receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
morphine receptor activity	ISS Inferred from Sequence or Structural Similarity more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
voltage-gated calcium channel activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	TAS Traceable Author Statement more info	PubMed
adenylate cyclase-activating dopamine receptor signaling pathway	IEA Inferred from Electronic Annotation more info
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
behavior	NAS Non-traceable Author Statement more info	PubMed
behavioral response to ethanol	IMP Inferred from Mutant Phenotype more info
cellular response to stress	IMP Inferred from Mutant Phenotype more info
elevation of cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info
locomotory behavior	IEA Inferred from Electronic Annotation more info
negative regulation of Wnt protein secretion	IMP Inferred from Mutant Phenotype more info
negative regulation of adenylate cyclase activity	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of cAMP-mediated signaling	IDA Inferred from Direct Assay more info
negative regulation of cell proliferation	TAS Traceable Author Statement more info	PubMed
negative regulation of nitric oxide biosynthetic process	IDA Inferred from Direct Assay more info
phospholipase C-activating G-protein coupled receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of ERK1 and ERK2 cascade	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of cAMP-mediated signaling	IDA Inferred from Direct Assay more info
positive regulation of neurogenesis	ISS Inferred from Sequence or Structural Similarity more info
positive regulation of nitric oxide biosynthetic process	IDA Inferred from Direct Assay more info
reduction of cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info
regulation of N-methyl-D-aspartate selective glutamate receptor activity	ISS Inferred from Sequence or Structural Similarity more info
regulation of behavior	IMP Inferred from Mutant Phenotype more info
sensory perception	NAS Non-traceable Author Statement more info	PubMed
sensory perception of pain	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
Golgi apparatus	TAS Traceable Author Statement more info	PubMed
endoplasmic reticulum	TAS Traceable Author Statement more info	PubMed
integral to plasma membrane	TAS Traceable Author Statement more info	PubMed
plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: mu-type opioid receptor

Names: mu-type opioid receptor; mu opiate receptor; mu opioid receptor hMOR-1a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_021208.1 RefSeqGene

Range

4996..241366

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_000914.3 → NP_000905.3 mu-type opioid receptor isoform MOR-1

Status: REVIEWED

Description

Transcript Variant: This variant (MOR-1) represents use of an alternate promoter and 5' UTR and uses a downstream start codon, compared to variant MOR-1H. The resulting isoform (MOR-1) has a shorter N-terminus, compared to isoform MOR-1H. An in-frame, upstream AUG is present that would extend the N-terminus by 62-aa, but the longer N-terminus is not annotated to conform to the annotation commonly used in the literature.

Source sequence(s)

AL132774, BC074927, L29301

Consensus CDS

CCDS55070.1

UniProtKB/Swiss-Prot

P35372

Related

ENSP00000328264, OTTHUMP00000017463, ENST00000330432, OTTHUMT00000042786

Conserved Domains (2) summary

pfam00001
Location:93 – 338
Blast Score: 513

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl10458
Location:79 – 285
Blast Score: 108

7tm_4; Olfactory receptor
NM_001008503.1 → NP_001008503.2 mu-type opioid receptor isoform MOR-1O

Status: REVIEWED

Description

Transcript Variant: This variant (MOR-1O) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and uses an alternate 3' exon, compared to variant MOR-1H. The resulting isoform (MOR-1O) has a shorter N-terminus and a longer and distinct C-terminus, compared to isoform MOR-1H. An in-frame, upstream AUG is present that would extend the N-terminus by 62-aa, but the longer N-terminus is not annotated to conform to the annotation commonly used in the literature.

Source sequence(s)

AY036623, L25119, L29301

Consensus CDS

CCDS43517.1

UniProtKB/Swiss-Prot

P35372

Related

ENSP00000338381, OTTHUMP00000225133, ENST00000337049, OTTHUMT00000375913

Conserved Domains (2) summary

pfam00001
Location:93 – 338
Blast Score: 515

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl10458
Location:79 – 285
Blast Score: 109

7tm_4; Olfactory receptor
NM_001008504.2 → NP_001008504.2 mu-type opioid receptor isoform MOR-1A

Status: REVIEWED

Description

Transcript Variant: This variant (MOR-1A) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and uses an alternate 3' exon, compared to variant MOR-1H. The resulting isoform (MOR-1A) has a shorter N-terminus and a shorter and distinct C-terminus, compared to isoform MOR-1H. An in-frame, upstream AUG is present that would extend the N-terminus by 62-aa, but the longer N-terminus is not annotated to conform to the annotation commonly used in the literature.

Source sequence(s)

AY309001, AY364890, L29301

Consensus CDS

CCDS47508.1

UniProtKB/Swiss-Prot

P35372

Conserved Domains (2) summary

pfam00001
Location:93 – 338
Blast Score: 507

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl10458
Location:79 – 285
Blast Score: 105

7tm_4; Olfactory receptor
NM_001008505.1 → NP_001008505.2 mu-type opioid receptor isoform MOR-1X

Status: REVIEWED

Description

Transcript Variant: This variant (MOR-1X), also known as MOR-1R, represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and uses an alternate 3' exon, compared to variant MOR-1H. The resulting isoform (MOR-1X) has a shorter N-terminus and a longer and distinct C-terminus, compared to isoform MOR-1H. An in-frame, upstream AUG is present that would extend the N-terminus by 62-aa, but the longer N-terminus is not annotated to conform to the annotation commonly used in the literature.

Source sequence(s)

AL136444, AY036622, L25119, L29301

Consensus CDS

CCDS43518.1

UniProtKB/Swiss-Prot

P35372

Related

ENSP00000229768, OTTHUMP00000225139, ENST00000229768, OTTHUMT00000375933

Conserved Domains (2) summary

pfam00001
Location:93 – 338
Blast Score: 513

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl10458
Location:79 – 285
Blast Score: 111

7tm_4; Olfactory receptor
NM_001145279.2 → NP_001138751.1 mu-type opioid receptor isoform MOR-1H

Status: REVIEWED

Description

Transcript Variant: This variant (MOR-1H) represents the longest transcript and encodes the longest isoform (MOR-1H).

Source sequence(s)

AL132774, DQ680044, EU340241, EU360599

Consensus CDS

CCDS47503.1

UniProtKB/TrEMBL

B8K2Q5

UniProtKB/Swiss-Prot

P35372

Conserved Domains (2) summary

pfam00001
Location:186 – 431
Blast Score: 535

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl10458
Location:172 – 378
Blast Score: 120

7tm_4; Olfactory receptor
NM_001145280.2 → NP_001138752.1 mu-type opioid receptor isoform MOR-1G1

Status: REVIEWED

Description

Transcript Variant: This variant (MOR-1G1) lacks two alternate exons and uses a downstream start codon, compared to variant MOR-1H. The resulting isoform (MOR-1G1) has a shorter N-terminus, compared to isoform MOR-1H.

Source sequence(s)

AL132774, DQ680044, EU340242, EU360599

Consensus CDS

CCDS55071.1

UniProtKB/TrEMBL

B8K2Q5

UniProtKB/Swiss-Prot

P35372

Conserved Domains (2) summary

pfam00001
Location:1 – 238
Blast Score: 481

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl10458
Location:47 – 206
Blast Score: 90

7tm_4; Olfactory receptor
NM_001145281.1 → NP_001138753.1 mu-type opioid receptor isoform MOR-1G2

Status: REVIEWED

Description

Transcript Variant: This variant (MOR-1G2) lacks two alternate exons and uses an alternate splice site in the 5' region, compared to variant MOR-1H. The resulting isoform (MOR-1G2) has a shorter and distinct N-terminus, compared to isoform MOR-1H.

Source sequence(s)

AL132774, EU340243

Consensus CDS

CCDS55068.1

UniProtKB/Swiss-Prot

P35372

Conserved Domains (2) summary

pfam00001
Location:15 – 257
Blast Score: 498

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl10458
Location:66 – 225
Blast Score: 92

7tm_4; Olfactory receptor
NM_001145282.1 → NP_001138754.1 mu-type opioid receptor isoform MOR-1B1

Status: REVIEWED

Description

Transcript Variant: This variant (MOR-1B1) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and uses an alternate 3' exon, compared to variant MOR-1H. The resulting isoform (MOR-1B1) has a shorter N-terminus and a longer and distinct C-terminus, compared to isoform MOR-1H. An in-frame, upstream AUG is present that would extend the N-terminus by 62-aa, but the longer N-terminus is not annotated to conform to the annotation commonly used in the literature.

Source sequence(s)

AY225404, L29301

Consensus CDS

CCDS47504.1

UniProtKB/Swiss-Prot

P35372

Related

ENSP00000410497, OTTHUMP00000225135, ENST00000452687, OTTHUMT00000375915

Conserved Domains (2) summary

pfam00001
Location:93 – 338
Blast Score: 513

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl10458
Location:79 – 285
Blast Score: 106

7tm_4; Olfactory receptor
NM_001145283.1 → NP_001138755.1 mu-type opioid receptor isoform MOR-1B2

Status: REVIEWED

Description

Transcript Variant: This variant (MOR-1B2) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and uses an alternate 3' exon, compared to variant MOR-1H. The resulting isoform (MOR-1B2) has a shorter N-terminus and a shorter and distinct C-terminus, compared to isoform MOR-1H. An in-frame, upstream AUG is present that would extend the N-terminus by 62-aa, but the longer N-terminus is not annotated to conform to the annotation commonly used in the literature.

Source sequence(s)

AL132774, AY309005, L29301

Consensus CDS

CCDS47505.1

UniProtKB/Swiss-Prot

P35372

Related

ENSP00000413752, OTTHUMP00000225168, ENST00000435918, OTTHUMT00000375972

Conserved Domains (2) summary

pfam00001
Location:93 – 338
Blast Score: 515

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl10458
Location:79 – 285
Blast Score: 108

7tm_4; Olfactory receptor
NM_001145284.2 → NP_001138756.1 mu-type opioid receptor isoform MOR-1B3

Status: REVIEWED

Description

Transcript Variant: This variant (MOR-1B3) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and uses an alternate 3' exon, compared to variant MOR-1H. The resulting isoform (MOR-1B3) has a shorter N-terminus and a longer and distinct C-terminus, compared to isoform MOR-1H. An in-frame, upstream AUG is present that would extend the N-terminus by 62-aa, but the longer N-terminus is not annotated to conform to the annotation commonly used in the literature.

Source sequence(s)

AL132774, AY309006, L29301

Consensus CDS

CCDS47506.1

UniProtKB/Swiss-Prot

P35372

Related

ENSP00000399359, OTTHUMP00000225167, ENST00000414028, OTTHUMT00000375971

Conserved Domains (2) summary

pfam00001
Location:93 – 338
Blast Score: 514

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl10458
Location:79 – 285
Blast Score: 108

7tm_4; Olfactory receptor
NM_001145285.1 → NP_001138757.1 mu-type opioid receptor isoform MOR-1B4

Status: REVIEWED

Description

Transcript Variant: This variant (MOR-1B4) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and uses an alternate 3' exon, compared to variant MOR-1H. The resulting isoform (MOR-1B4) has a shorter N-terminus and a shorter and distinct C-terminus, compared to isoform MOR-1H. An in-frame, upstream AUG is present that would extend the N-terminus by 62-aa, but the longer N-terminus is not annotated to conform to the annotation commonly used in the literature.

Source sequence(s)

AY309007, L25119, L29301

Consensus CDS

CCDS55069.1

UniProtKB/Swiss-Prot

P35372

Related

ENSP00000430097, OTTHUMP00000225165, ENST00000524163, OTTHUMT00000375969

Conserved Domains (2) summary

pfam00001
Location:93 – 338
Blast Score: 507

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl10458
Location:79 – 285
Blast Score: 105

7tm_4; Olfactory receptor
NM_001145286.1 → NP_001138758.1 mu-type opioid receptor isoform MOR-1B5

Status: REVIEWED

Description

Transcript Variant: This variant (MOR-1B5) represents use of an alternate promoter and 5' UTR, uses a downstream start codon, and uses an alternate 3' exon, compared to variant MOR-1H. The resulting isoform (MOR-1B5) has a shorter N-terminus and a longer and distinct C-terminus, compared to isoform MOR-1H. An in-frame, upstream AUG is present that would extend the N-terminus by 62-aa, but the longer N-terminus is not annotated to conform to the annotation commonly used in the literature.

Source sequence(s)

AL132774, AY309008, L29301

Consensus CDS

CCDS47507.1

UniProtKB/Swiss-Prot

P35372

Related

ENSP00000403549, OTTHUMP00000225164, ENST00000419506, OTTHUMT00000375968

Conserved Domains (2) summary

pfam00001
Location:93 – 338
Blast Score: 517

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl10458
Location:79 – 285
Blast Score: 109

7tm_4; Olfactory receptor
NM_001145287.1 → NP_001138759.1 mu-type opioid receptor isoform MOR1-K1

Status: REVIEWED

Description

Transcript Variant: This variant (MOR1-K1) represents use of an alternate promoter and 5' UTR and uses a downstream start codon, compared to variant MOR-1H. The resulting isoform (MOR1-K1) has a shorter N-terminus, compared to isoform MOR-1H.

Source sequence(s)

AL132774, AL136444, EU362990, L25119

Consensus CDS

CCDS55071.1

UniProtKB/Swiss-Prot

P35372

Related

ENSP00000429373, OTTHUMP00000225170, ENST00000522236, OTTHUMT00000375975

Conserved Domains (2) summary

pfam00001
Location:1 – 238
Blast Score: 481

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl10458
Location:47 – 206
Blast Score: 90

7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000006.11 Reference GRCh37.p10 Primary Assembly

Range

154331631..154568001

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000138.1 Alternate HuRef

Range

151895214..152131143

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018917.1 Alternate CHM1_1.0

Range

154331311..154567230

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01025599.1 (12017..74665)	None
genomic	ABBA01025600.1	None
genomic	ABBA01025601.1	None
genomic	ABBA01025602.1	None
genomic	AF024515.1	AAC51877.1
genomic	AF024516.1	AAC51878.1
genomic	AF024517.1	None
genomic	AF153500.1	AAD44318.1
genomic	AF547997.1	AAQ12260.1
genomic	AL132774.20 (2000..98104)	None
genomic	AL136444.16	None
genomic	AL359850.7	None
genomic	AL445220.5 (101..46000)	None
genomic	AMYH01016755.1 (220908..456827)	None
genomic	AY292290.1	AAP44409.1
genomic	AY292291.1	AAP44410.1
genomic	AY299483.1	AAP58255.1
genomic	AY587764.1	AAS83107.1
genomic	CH471051.2	EAW47704.1
		EAW47705.1
mRNA	AK313901.1	BAG36624.1
mRNA	AY036622.1	AAK74189.1
mRNA	AY036623.1	AAK74190.1
mRNA	AY195733.2	AAO21305.1
mRNA	AY225404.1	AAP44727.1
mRNA	AY309001.1	AAQ77385.1
mRNA	AY309005.1	AAQ77389.1
mRNA	AY309006.1	AAQ77390.1
mRNA	AY309007.1	AAQ77391.1
mRNA	AY309008.1	AAQ77392.1
mRNA	AY309009.1	AAQ77393.1
mRNA	AY364230.1	AAR12887.1
mRNA	AY364890.1	AAR11568.1
mRNA	AY521028.1	AAS00462.1
mRNA	BC074927.2	AAH74927.1
mRNA	DQ680044.1	ABH03503.1
mRNA	EF666090.1	None
mRNA	EU340241.1	ACA49726.1
mRNA	EU340242.1	ACA49727.1
mRNA	EU340243.1	ACA49728.1
mRNA	EU360599.2	ABY61366.1
mRNA	EU362990.2	ABY66530.1
mRNA	FJ041290.1	ACM90348.1
mRNA	FJ041291.1	ACM90349.1
mRNA	FJ041292.1	ACM90350.1
mRNA	FJ041293.1	ACM90351.1
mRNA	FJ041294.1	ACM90352.1
mRNA	GQ258059.1	ACT35692.1
mRNA	HQ699462.1	AET97615.1
mRNA	L25119.1	AAA20580.1
mRNA	L29301.1	AAA73958.1
mRNA	U12569.1	AAB60354.1