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OPRK1 opioid receptor kappa 1 [ Homo sapiens (human) ]

Gene ID: 4986, updated on 15-May-2016
Official Symbol
OPRK1provided by HGNC
Official Full Name
opioid receptor kappa 1provided by HGNC
Primary source
HGNC:HGNC:8154
See related
Ensembl:ENSG00000082556 HPRD:01309; MIM:165196; Vega:OTTHUMG00000164276
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KOR; OPRK; KOR-1; K-OR-1
Summary
This gene encodes an opioid receptor, which is a member of the 7 transmembrane-spanning G protein-coupled receptor family. It functions as a receptor for endogenous ligands, as well as a receptor for various synthetic opioids. Ligand binding results in inhibition of adenylate cyclase activity and neurotransmitter release. This opioid receptor plays a role in the perception of pain and mediating the hypolocomotor, analgesic and aversive actions of synthetic opioids. Variations in this gene have also been associated with alcohol dependence and opiate addiction. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Jan 2016]
Orthologs
Location:
8q11.2
Exon count:
5
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 8 NC_000008.11 (53225716..53251697, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (54138276..54164257, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene E3 ubiquitin-protein ligase RING2-like Neighboring gene uncharacterized LOC105375836 Neighboring gene EI24, autophagy associated transmembrane protein pseudogene 5 Neighboring gene uncharacterized LOC105375837 Neighboring gene uncharacterized LOC102724359 Neighboring gene polymerase (DNA) epsilon 2, accessory subunit pseudogene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
A genome-wide association study of total serum and mite-specific IgEs in asthma patients.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Kappa-opioid receptor (KOR) agonist treatment of CD4(+) lymphocytes inhibits HIV-1 envelope gp120/41-mediated membrane fusion via downregulation of CXCR4 PubMed
Tat tat Morphine treatment in the presence of Tat significantly increases intracellular expression of opioid receptors (mu, delta, and kappa) and prevents morphine-induced cell surface opioid receptor down-regulation in microglia PubMed

Go to the HIV-1, Human Interaction Database

  • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
    Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
  • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
    GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.cmbi.kun.nl/7tm/. The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used ...
  • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, organism-specific biosystem
    Neuroactive ligand-receptor interaction
  • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, conserved biosystem
    Neuroactive ligand-receptor interaction
  • Peptide GPCRs, organism-specific biosystem (from WikiPathways)
    Peptide GPCRs, organism-specific biosystem
    Peptide GPCRs
  • Peptide ligand-binding receptors, organism-specific biosystem (from REACTOME)
    Peptide ligand-binding receptors, organism-specific biosystemThese receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins.
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
dynorphin receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
dynorphin receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuropeptide binding IBA
Inferred from Biological aspect of Ancestor
more info
 
opioid receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
adenylate cyclase-inhibiting opioid receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
behavior TAS
Traceable Author Statement
more info
PubMed 
behavioral response to cocaine IEA
Inferred from Electronic Annotation
more info
 
cellular response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 
conditioned place preference IEA
Inferred from Electronic Annotation
more info
 
defense response to virus IDA
Inferred from Direct Assay
more info
PubMed 
eating behavior IEA
Inferred from Electronic Annotation
more info
 
estrous cycle IEA
Inferred from Electronic Annotation
more info
 
immune response IDA
Inferred from Direct Assay
more info
PubMed 
locomotory behavior ISS
Inferred from Sequence or Structural Similarity
more info
 
maternal behavior IEA
Inferred from Electronic Annotation
more info
 
negative regulation of luteinizing hormone secretion IEA
Inferred from Electronic Annotation
more info
 
neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
opioid receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
phospholipase C-activating G-protein coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of dopamine secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of locomotion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of p38MAPK cascade IEA
Inferred from Electronic Annotation
more info
 
positive regulation of potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
regulation of aerobic respiration IEA
Inferred from Electronic Annotation
more info
 
regulation of energy homeostasis IEA
Inferred from Electronic Annotation
more info
 
regulation of saliva secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
response to acrylamide IEA
Inferred from Electronic Annotation
more info
 
response to estrogen IEA
Inferred from Electronic Annotation
more info
 
response to ethanol IEA
Inferred from Electronic Annotation
more info
 
response to insulin IEA
Inferred from Electronic Annotation
more info
 
response to morphine IEA
Inferred from Electronic Annotation
more info
 
response to radiation IEA
Inferred from Electronic Annotation
more info
 
sensory perception TAS
Traceable Author Statement
more info
PubMed 
sensory perception of pain IBA
Inferred from Biological aspect of Ancestor
more info
 
sensory perception of pain ISS
Inferred from Sequence or Structural Similarity
more info
 
sensory perception of temperature stimulus IEA
Inferred from Electronic Annotation
more info
 
synaptic transmission TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
axon terminus IEA
Inferred from Electronic Annotation
more info
 
dendrite IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
 
perikaryon IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
synapse IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
kappa-type opioid receptor
Names
Opiate receptor, kappa-1
kappa opioid receptor
opioid receptor, kappa 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000912.4NP_000903.2  kappa-type opioid receptor isoform 1

    See identical proteins and their annotated locations for NP_000903.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon (nt 1439-1441), while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UGA termination codon (nt 1526-1528). This RefSeq represents the shorter isoform.
    Source sequence(s)
    AK023198, AY466378, BC099912, DA264471, U17298
    Consensus CDS
    CCDS6152.1
    UniProtKB/Swiss-Prot
    P41145
    Related
    ENSP00000265572, OTTHUMP00000226313, ENST00000265572, OTTHUMT00000378048
    Conserved Domains (2) summary
    pfam00001
    Location:82330
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:71271
    7tm_4; Olfactory receptor
  2. NM_001282904.1NP_001269833.1  kappa-type opioid receptor isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an additional exon in the mid-region, which results in translation initiation at an in-frame downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC009646, AK310407, BF061371
    Consensus CDS
    CCDS64895.1
    UniProtKB/Swiss-Prot
    P41145
    Related
    ENSP00000483000, ENST00000612786
    Conserved Domains (1) summary
    pfam00001
    Location:1241
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  3. NM_001318497.1NP_001305426.1  kappa-type opioid receptor isoform 1x

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1) results from translation termination at the upstream UGA stop codon (nt 1439-1441), while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UGA termination codon (nt 1526-1528). This RefSeq represents the longer, C-terminally extended isoform. As the UGA stop codon has been reported to specify several alternative amino acids (tryptophan, cysteine, arginine and serine), the location of the upstream UGA stop codon in the longer isoform is denoted by an 'X'.
    Source sequence(s)
    AK023198, AY466378, BC099912, DA264471, U17298
    UniProtKB/Swiss-Prot
    P41145
    Conserved Domains (2) summary
    pfam00001
    Location:82330
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:71271
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p2 Primary Assembly

    Range
    53225716..53251697 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018919.2 Alternate CHM1_1.1

    Range
    54189898..54215870 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)