WRAP73 WD repeat containing, antisense to TP73 [Homo sapiens (human)] - Gene

Summary

Official Symbol: WRAP73provided by HGNC
Official Full Name: WD repeat containing, antisense to TP73provided by HGNC
Primary source: HGNC:HGNC:12759
See related: Ensembl:ENSG00000116213 MIM:606040; AllianceGenome:HGNC:12759
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: WDR8
Summary: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Studies of the related mouse protein suggest that the encoded protein may play a role in the process of ossification. [provided by RefSeq, Mar 2009]
Expression: Ubiquitous expression in bone marrow (RPKM 7.8), testis (RPKM 7.1) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 1p36.32

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (3630770..3650103, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (3140840..3159976, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (3547334..3566667, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mitotic Maturation Compensates for Premature Centrosome Splitting and PCM Loss in Human cep135 Knockout Cells.
Title: Mitotic Maturation Compensates for Premature Centrosome Splitting and PCM Loss in Human cep135 Knockout Cells.
Exome sequencing and functional studies in zebrafish identify WDR8 as the causative gene for isolated Microspherophakia in Indian families.
Title: Exome sequencing and functional studies in zebrafish identify WDR8 as the causative gene for isolated Microspherophakia in Indian families.
Cep135 is required for the recruitment of WDR8 to centrioles.
Title: WDR8 is a centriolar satellite and centriole-associated protein that promotes ciliary vesicle docking during ciliogenesis.
Knockdown of Wdr8 or hMsd1/SSX2IP displayed very similar mitotic defects, in which spindle microtubules became shortened and misoriented.
Title: The conserved Wdr8-hMsd1/SSX2IP complex localises to the centrosome and ensures proper spindle length and orientation.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SHGC-32565 (e-PCR)
- UniSTS:63527

RH93413 (e-PCR)
- UniSTS:90735

SHGC-80737 (e-PCR)
- UniSTS:102270

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell projection organization	IEA Inferred from Electronic Annotation more info
involved_in mitotic spindle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of non-motile cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of MWP complex	IBA Inferred from Biological aspect of Ancestor more info
located_in centriolar satellite	IEA Inferred from Electronic Annotation more info
located_in centriole	IEA Inferred from Electronic Annotation more info
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in ciliary basal body	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in microtubule organizing center	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: WD repeat-containing protein WRAP73

Names: WD repeat domain 8; epididymis secretory sperm binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_033937.1 RefSeqGene

Range

5005..24338

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_017818.4 → NP_060288.3 WD repeat-containing protein WRAP73

See identical proteins and their annotated locations for NP_060288.3

Status: REVIEWED

Source sequence(s)

AI376011, BC086311, DC380547

Consensus CDS

CCDS48.1

UniProtKB/Swiss-Prot

Q5T0D6, Q9BUH7, Q9NTK7, Q9NX56, Q9P2S5

UniProtKB/TrEMBL

A0A0A0MRV3, A0A384MQZ3

Related

ENSP00000270708.7, ENST00000270708.12

Conserved Domains (2) summary

COG2319
Location:49 → 438

WD40; WD40 repeat [General function prediction only]

sd00039
Location:14 → 47

7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

3630770..3650103 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047421661.1 → XP_047277617.1 WD repeat-containing protein WRAP73 isoform X3
XM_005244754.3 → XP_005244811.1 WD repeat-containing protein WRAP73 isoform X2

See identical proteins and their annotated locations for XP_005244811.1

UniProtKB/TrEMBL

A0A0A0MRV3

Conserved Domains (3) summary

COG2319
Location:13 → 360

WD40; WD40 repeat [General function prediction only]

sd00039
Location:14 → 47

7WD40; WD40 repeat [structural motif]

cl02567
Location:14 → 356

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_047421663.1 → XP_047277619.1 WD repeat-containing protein WRAP73 isoform X4
XM_017001387.3 → XP_016856876.1 WD repeat-containing protein WRAP73 isoform X1

UniProtKB/TrEMBL

A0A0A0MRV3