OPCML opioid binding protein/cell adhesion molecule-like [Homo sapiens] - Gene

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Summary

Official Symbol: OPCMLprovided by HGNC
Official Full Name: opioid binding protein/cell adhesion molecule-likeprovided by HGNC
Primary source: HGNC:8143
See related: Ensembl:ENSG00000183715; HPRD:07198; MIM:600632; Vega:OTTHUMG00000163658
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: OPCM; OBCAM; IGLON1
Summary: This gene encodes a member of the IgLON subfamily in the immunoglobulin protein superfamily. The encoded protein is localized in the plasma membrane and may have an accessory role in opioid receptor function. This gene has an ortholog in rat and bovine. The opioid binding-cell adhesion molecule encoded by the rat gene binds opioid alkaloids in the presence of acidic lipids, exhibits selectivity for mu ligands and acts as a GPI-anchored protein. Since the encoded protein is highly conserved in species during evolution, it may have a fundamental role in mammalian systems. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 11q25

Sequence :: Chromosome: 11; NC_000011.9 (132284875..133402403, complement); Chromosome: 11; NC_000011.9 (132526971..133402733)

See OPCML in Epigenomics, MapViewer

Chromosome 11 - NC_000011.9 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

opioid binding protein/cell adhesion molecule-like promoter methylation has a role in bladder carcinoma
Title: Prognostic value of opioid binding protein/cell adhesion molecule-like promoter methylation in bladder carcinoma.
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Observational study of gene-disease association. (HuGE Navigator)
Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
OPCML is a broad tumor suppressor, which is frequently inactivated by methylation in multiple malignancies.
Title: OPCML is a broad tumor suppressor for multiple carcinomas and lymphomas with frequently epigenetic inactivation.
OPCML gene promoter methylation may play an important role in the carcinogenesis of cervical carcinoma. OPCML may be a cervical carcinoma-associated candidate tumor suppressor gene.
Title: OPCML gene promoter methylation and gene expression in tumor and stroma cells of invasive cervical carcinoma.
loss of OPCML expression occurs frequently in ovarian serous carcinoma. CpG island methylation and LOH are probably two mechanisms of OPCML inactivation
Title: Loss of OPCML expression and the correlation with CpG island methylation and LOH in ovarian serous carcinoma.
Results identified OPCML loci showing significant differential DNA methylation levels between tumor and non-tumor lung and highly significant hypermethylation in adenocarcinoma.
Title: Identification of a panel of sensitive and specific DNA methylation markers for lung adenocarcinoma.
OPCML at 11q25 is epigenetically inactivated and has tumor-suppressor function in epithelial ovarian cancer
Title: OPCML at 11q25 is epigenetically inactivated and has tumor-suppressor function in epithelial ovarian cancer.
The results were confirmed at the level of mRNA and protein, and suggested that four genes (OPCML, RNASE1, YES1 and ACK1) could play a key role in the tumorigenesis and metastasis of gastric cancer.
Title: Comparison of gene expression profiles between primary tumor and metastatic lesions in gastric cancer patients using laser microdissection and cDNA microarray.

Submit: New GeneRIF Correction See all (13)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Epithelial ovarian cancer, somatic

MIM: 604370

Products	Interactant	Other Gene	Complex	Source	Pubs	Description
Q14982	P04156	PRNP		HPRD	PubMed

Function	Evidence Code	Pubs
opioid receptor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
cell adhesion	IEA Inferred from Electronic Annotation more info
neuron recognition	TAS Traceable Author Statement more info	PubMed
opioid receptor signaling pathway	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
anchored to membrane	IEA Inferred from Electronic Annotation more info
integral to plasma membrane	TAS Traceable Author Statement more info	PubMed
plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: opioid-binding protein/cell adhesion molecule

Names: opioid-binding protein/cell adhesion molecule; IgLON family member 1; opioid binding protein/cell adhesion molecule-like preprotein

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012107.1 RefSeqGene

Range

5001..1122529

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001012393.1 → NP_001012393.1 opioid-binding protein/cell adhesion molecule isoform b preproprotein

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding region compared to variant 1. The resulting isoform (b) is shorter and has a distinct N-terminus compared to isoform a.

Source sequence(s)

AP000843, BX537377, W39242

Consensus CDS

CCDS31722.1

Related

ENSP00000434750, OTTHUMP00000235237, ENST00000524381, OTTHUMT00000393269

Conserved Domains (2) summary

pfam07679
Location:216 – 304
Blast Score: 168

I-set; Immunoglobulin I-set domain

cl11960
Location:37 – 125
Blast Score: 142

Ig; Immunoglobulin domain
NM_002545.3 → NP_002536.1 opioid-binding protein/cell adhesion molecule isoform a preproprotein

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (a).

Source sequence(s)

AP000843, BX537377, L34774

Consensus CDS

CCDS8492.1

UniProtKB/TrEMBL

A8K0Y0

UniProtKB/Swiss-Prot

Q14982

Related

ENSP00000330862, OTTHUMP00000224510, ENST00000331898, OTTHUMT00000374689

Conserved Domains (3) summary

cd00096
Location:241 – 310
Blast Score: 138

Ig; Immunoglobulin domain

pfam07679
Location:223 – 311
Blast Score: 168

I-set; Immunoglobulin I-set domain

cl11960
Location:44 – 132
Blast Score: 142

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000011.9

Range

132284875..133402403, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

RNA

XR_110538.2 RNA Sequence

Alternate HuRef

Genomic

AC_000143.1 Alternate HuRef

Range

128240684..128768428, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AP000843.5 (74711..191203)	None
genomic	AP000863.4	None
genomic	AP000903.6	None
genomic	AP003029.2 (61912..134583)	None
genomic	AP003784.2 (25928..144783)	None
genomic	AP003972.2	None
genomic	AP004606.4 (36308..58100)	None
genomic	AP004782.3	None
genomic	AP005122.2	None
genomic	AP005133.2 (40736..62567)	None
genomic	AP005638.2	None
genomic	CH471065.1	EAW67804.1
		EAW67805.1
mRNA	AF070577.1	None
mRNA	AK125185.1	None
mRNA	AK289695.1	BAF82384.1
mRNA	AK299528.1	BAG61477.1
mRNA	AK299908.1	BAG61748.1
mRNA	AK314077.1	None
mRNA	AK315859.1	BAF98750.1
mRNA	AK316273.1	BAH14644.1
mRNA	AK316491.1	BAH14862.1
mRNA	BC074742.2	AAH74742.1
mRNA	BC074773.2	AAH74773.1
mRNA	BC117254.1	AAI17255.1
mRNA	BC126251.1	AAI26252.1
mRNA	BC143945.1	AAI43946.1
mRNA	BC143946.1	AAI43947.1
mRNA	BX537377.1	CAD97619.1
mRNA	EU562295.1	ACB56655.1
mRNA	EU562296.1	ACB56656.1
mRNA	EU562297.1	ACB56657.1
mRNA	EU562298.1	ACB56658.1
mRNA	EU562299.1	ACB56659.1
mRNA	EU562300.1	ACB56660.1
mRNA	L34774.1	AAA36387.1
mRNA	U79251.1	None
mRNA	W39242.1	None