OLR1 oxidized low density lipoprotein (lectin-like) receptor 1 [Homo sapiens] - Gene

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Summary

Official Symbol: OLR1provided by HGNC
Official Full Name: oxidized low density lipoprotein (lectin-like) receptor 1provided by HGNC
Primary source: HGNC:8133
See related: Ensembl:ENSG00000173391; HPRD:04003; MIM:602601; Vega:OTTHUMG00000168527
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: LOX1; LOXIN; SLOX1; CLEC8A; SCARE1
Summary: This gene encodes a low density lipoprotein receptor that belongs to the C-type lectin superfamily. This gene is regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk of Alzheimer's disease. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010]

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Genomic context

Location :: 12p13.2-p12.3

Sequence :: Chromosome: 12; NC_000012.11 (10310899..10324790, complement)

See OLR1 in Epigenomics, MapViewer

Chromosome 12 - NC_000012.11 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

genetic association studies in a population in Italy: An SNP in LOX-1 (IVS4-14 A/G) is associated with insulin resistance, decreased beta cell function, and severity of liver disease/dysfunction/pathology in nonalcoholic steatohepatitis subjects.
Title: Effect of lectin-like oxidized LDL receptor-1 polymorphism on liver disease, glucose homeostasis, and postprandial lipoprotein metabolism in nonalcoholic steatohepatitis.
changes in aged endothelial cells are suggestive of aberrant responses to stimuli resulting in a less permissive environment for tissue remodeling and progression of diseases requiring angiogenesis and cell adhesion in elderly, possibly, mediated by LOX-1
Title: Potential involvement of LOX-1 in functional consequences of endothelial senescence.
Hypertriglyceridemia and smoking are determinants of LOX-1 ligand activity in healthy men and are thus thought to be crucial risk factors for initiation of atherosclerotic progression through generation of OxLDL
Title: Associations of atherosclerotic risk factors with oxidized low-density lipoprotein evaluated by LOX-1 ligand activity in healthy men.
p66(Shc) silencing blunted oxidized LDL-induced O(2)(-.) production, underscoring the critical role of p66(Shc) in oxidized LDL-induced oxidative stress in endothelial cells
Title: Oxidized low-density lipoprotein activates p66Shc via lectin-like oxidized low-density lipoprotein receptor-1, protein kinase C-beta, and c-Jun N-terminal kinase kinase in human endothelial cells.
OLR1 may act as an oncogene by activation of NF-kB target genes responsible for proliferation, migration and inhibition of apoptosis and de novo lipogenesis genes.
Title: Oxidized LDL receptor 1 (OLR1) as a possible link between obesity, dyslipidemia and cancer.
Plasma sLOX-1 diagnosed the early stages of ST elevation myocardial infarction more accurately than H-FABP, myoglobin, troponin T and CK-MB.
Title: Soluble lectin-like oxidized low-density lipoprotein receptor-1 as an early biomarker for ST elevation myocardial infarction: time-dependent comparison with other biomarkers: time-dependent comparison with other biomarkers.
The expressions of LOX-1, caspase-3, and Bax are upregulated in placentas of preeclampsia.
Title: [Relationship between the expressions of lectin-like oxidized low-density lipoprotein receptor-1 and apoptosis associated genes in placenta tissues and the pathogenesis of preeclampsia].
In pre-eclamptic patients the levels of LOX-1 mRNA in placenta were positively correlated with the the expression of caspase-3 and the plasma concentrations of oxLDL.
Title: [Correlation of oxidized low-density lipoprotein and lectin-like oxidized low-density lipoprotein receptor-1 with pre-eclampsia].
Chlamydia pneumoniae GroEL1 protein increases LOX-1 and Toll-like receptor (TLR)4 expression in coronary artery endothelial cells in vitro, which may contribute by specific mechanisms to vascular inflammation and cardiovascular disorders.
Title: GroEL1, a heat shock protein 60 of Chlamydia pneumoniae, induces lectin-like oxidized low-density lipoprotein receptor 1 expression in endothelial cells and enhances atherogenesis in hypercholesterolemic rabbits.
Results indicate minimally modified LDL as a new inducer for LOX-1 expression and as a new ligand for LOX-1.
Title: Upregulation of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) by 15-lipoxygenase-modified LDL in endothelial cells.

Submit: New GeneRIF Correction See all (115)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Myocardial infarction, susceptibility to

MIM: 608446

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description
P78380	P34932	HSPA4		HPRD	PubMed

Function	Evidence Code	Pubs
binding	IEA Inferred from Electronic Annotation more info
low-density lipoprotein receptor activity	IEA Inferred from Electronic Annotation more info
receptor activity	IEA Inferred from Electronic Annotation more info
sugar binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
blood circulation	TAS Traceable Author Statement more info	PubMed
blood coagulation	TAS Traceable Author Statement more info
cell adhesion	IEA Inferred from Electronic Annotation more info
cell death	IEA Inferred from Electronic Annotation more info
inflammatory response	IEA Inferred from Electronic Annotation more info
leukocyte cell-cell adhesion	IEA Inferred from Electronic Annotation more info
leukocyte migration	TAS Traceable Author Statement more info
lipoprotein metabolic process	IEA Inferred from Electronic Annotation more info
proteolysis	TAS Traceable Author Statement more info	PubMed
response to hydrogen peroxide	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
extracellular region	IEA Inferred from Electronic Annotation more info
integral to plasma membrane	TAS Traceable Author Statement more info	PubMed
membrane fraction	TAS Traceable Author Statement more info	PubMed
plasma membrane	TAS Traceable Author Statement more info

General protein information

Preferred Names: oxidized low-density lipoprotein receptor 1

Names: oxidized low-density lipoprotein receptor 1; hLOX-1; ox LDL receptor 1; lectin-type oxidized LDL receptor 1; scavenger receptor class E, member 1; C-type lectin domain family 8 member A; oxidized low-density lipoprotein receptor 1, soluble form

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_016743.1 RefSeqGene

Range

5001..18892

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001172632.1 → NP_001166103.1 oxidized low-density lipoprotein receptor 1 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an exon in the coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC024224, AK295409, BP219342, CA309323

Consensus CDS

CCDS53745.1

UniProtKB/TrEMBL

B4DI48

Related

ENSP00000405116, OTTHUMP00000238955, ENST00000432556, OTTHUMT00000400096
NM_001172633.1 → NP_001166104.1 oxidized low-density lipoprotein receptor 1 isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an exon in the coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AC024224, AK295409, AL551100, BP219342, CA309323

Consensus CDS

CCDS53746.1

UniProtKB/TrEMBL

B4DI48

UniProtKB/TrEMBL

G3V1I4

Related

ENSP00000439251, OTTHUMP00000238954, ENST00000545927, OTTHUMT00000400095

Conserved Domains (1) summary

cl02432
Location:144 – 188
Blast Score: 167

CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
NM_002543.3 → NP_002534.1 oxidized low-density lipoprotein receptor 1 isoform 1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AB010710, AC024224, BP219342, CA309323

Consensus CDS

CCDS8618.1

UniProtKB/Swiss-Prot

P78380

Related

ENSP00000309124, OTTHUMP00000238950, ENST00000309539, OTTHUMT00000400091

Conserved Domains (1) summary

cd03593
Location:144 – 266
Blast Score: 338

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000012.11 Reference GRCh37.p5 Primary Assembly

Range

10310899..10324790, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000144.1 Alternate HuRef

Range

10054056..10067944, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC024224.33 (148886..157391)	None
genomic	AF079164.1	AAC97927.1
genomic	AF079167.1	AAC97927.1
genomic	AJ131757.1	CAB38175.1
genomic	CH471094.1	EAW96156.1
		EAW96157.1
		EAW96158.1
		EAW96159.1
genomic	CS443020.1	CAL68889.1
genomic	DQ314885.1	ABC40744.1
mRNA	AB010710.1	BAA24580.1
mRNA	AB102861.1	BAC81565.1
mRNA	AF035776.1	AAC82329.1
mRNA	AK292124.1	BAF84813.1
mRNA	AK295409.1	BAG58360.1
mRNA	AK298040.1	BAG60339.1
mRNA	AK308009.1	None
mRNA	AK316353.1	BAH14724.1
mRNA	AL551100.3	None
mRNA	BC022295.1	AAH22295.1
mRNA	BC055085.1	None
mRNA	BP219342.1	None
mRNA	BQ028409.1	None
mRNA	CA309323.1	None
mRNA	CB955704.1	None
other-genetic	DQ891409.2	ABM82335.1
other-genetic	DQ894585.2	ABM85511.1