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OGN osteoglycin [ Homo sapiens (human) ]

Gene ID: 4969, updated on 26-May-2016
Official Symbol
OGNprovided by HGNC
Official Full Name
osteoglycinprovided by HGNC
Primary source
HGNC:HGNC:8126
See related
Ensembl:ENSG00000106809 HPRD:03856; MIM:602383; Vega:OTTHUMG00000020224
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OG; OIF; SLRR3A
Summary
This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded protein induces ectopic bone formation in conjunction with transforming growth factor beta and may regulate osteoblast differentiation. High expression of the encoded protein may be associated with elevated heart left ventricular mass. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Orthologs
Location:
9q22
Exon count:
7
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 9 NC_000009.12 (92383967..92404655, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (95146249..95166976, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene nucleolar protein 8 Neighboring gene chromosome 16 open reading frame 70 pseudogene Neighboring gene centromere protein P Neighboring gene osteomodulin Neighboring gene asporin

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Defective B4GALT1 causes B4GALT1-CDG (CDG-2d), organism-specific biosystem (from REACTOME)
    Defective B4GALT1 causes B4GALT1-CDG (CDG-2d), organism-specific biosystemCongenital disorders of glycosylation (CDG, previously called carbohydrate-deficient glycoprotein syndromes, CDGSs), are a group of hereditary multisystem disorders. They are characterized biochemica...
  • Defective CHST6 causes MCDC1, organism-specific biosystem (from REACTOME)
    Defective CHST6 causes MCDC1, organism-specific biosystemCarbohydrate sulfotransferase 6 (CHST6) catalyzes the transfer of sulfate to position 6 of non-reducing ends of N-acetylglucosamine (GlcNAc) residues on keratan sulfate (KS). KS plays a central role ...
  • Defective ST3GAL3 causes MCT12 and EIEE15, organism-specific biosystem (from REACTOME)
    Defective ST3GAL3 causes MCT12 and EIEE15, organism-specific biosystemCMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase (ST3GAL3) mediates the transfer of sialic acid from CMP-sialic acid to galactose-containing glycoproteins and forms the sialyl...
  • Disease, organism-specific biosystem (from REACTOME)
    Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
  • Diseases associated with glycosaminoglycan metabolism, organism-specific biosystem (from REACTOME)
    Diseases associated with glycosaminoglycan metabolism, organism-specific biosystemA number of genetic disorders are caused by mutations in the genes encoding glycosyltransferases and sulfotransferases, enzymes responsible for the synthesis of glycosaminoglycans (GAGs) as well as ...
  • Diseases of glycosylation, organism-specific biosystem (from REACTOME)
    Diseases of glycosylation, organism-specific biosystemDiseases of glycosylation, usually referred to as congenital disorders of glycosylation (CDG), are rare inherited disorders ascribing defects of nucleotide-sugar biosynthesis and transport, glycosylt...
  • Glycosaminoglycan metabolism, organism-specific biosystem (from REACTOME)
    Glycosaminoglycan metabolism, organism-specific biosystemGlycosaminoglycans (GAGs) are long, unbranched polysaccharides containing a repeating disaccharide unit composed of a hexosamine (either N-acetylgalactosamine (GalNAc) or N-acetylglucosamine (GlcNAc)...
  • Keratan sulfate biosynthesis, organism-specific biosystem (from REACTOME)
    Keratan sulfate biosynthesis, organism-specific biosystemKeratan sulfate (KSI) is the best characterised keratan sulfate. It is 10 times more abundant in cornea than cartilage. KSI is attached to an asparagine (Asn) residue on the core protein via an N-lin...
  • Keratan sulfate degradation, organism-specific biosystem (from REACTOME)
    Keratan sulfate degradation, organism-specific biosystemKeratan sulfate proteoglycans (KSPGs) are degraded in lysosomes as part of normal homeostasis of glycoproteins. Glycoproteins must be completely degraded to avoid undigested fragments building up and...
  • Keratan sulfate/keratin metabolism, organism-specific biosystem (from REACTOME)
    Keratan sulfate/keratin metabolism, organism-specific biosystemKeratan sulfate (KS) (a glycosaminoglycan, GAG) is a linear polysaccharide that consists of the repeating disaccharide unit GlcNAc-Gal (N-acetylglucosamine-galactose). KS can perform a structural fun...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of carbohydrates, organism-specific biosystem (from REACTOME)
    Metabolism of carbohydrates, organism-specific biosystemThese pathways together are responsible for: 1) the extraction of energy and carbon skeletons for biosyntheses from dietary sugars and related molecules; 2) the short-term storage of glucose in the b...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • DKFZp586P2421

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NOT Roundabout binding IBA
Inferred from Biological aspect of Ancestor
more info
 
growth factor activity IEA
Inferred from Electronic Annotation
more info
 
heparin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
NOT Roundabout signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
NOT axon extension involved in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
 
axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
keratan sulfate biosynthetic process TAS
Traceable Author Statement
more info
 
keratan sulfate catabolic process TAS
Traceable Author Statement
more info
 
negative regulation of smooth muscle cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT regulation of axonogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
Golgi lumen TAS
Traceable Author Statement
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
extracellular vesicle IDA
Inferred from Direct Assay
more info
PubMed 
lysosomal lumen TAS
Traceable Author Statement
more info
 
proteinaceous extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
mimecan
Names
corneal keratan sulfate proteoglycan
mimecan proteoglycan
osteoinductive factor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014057.4NP_054776.1  mimecan isoform 2 precursor

    See identical proteins and their annotated locations for NP_054776.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Both variants 1 and 3 encode the same isoform (2).
    Source sequence(s)
    AF086912, AF100758, AK295433, AL137848, BM679549
    Consensus CDS
    CCDS6695.1
    UniProtKB/Swiss-Prot
    P20774
    UniProtKB/TrEMBL
    A8K0R3, B4DI63, Q7Z532
    Related
    ENSP00000364711, OTTHUMP00000021650, ENST00000375561, OTTHUMT00000053086
    Conserved Domains (2) summary
    pfam13855
    Location:143225
    LRR_8; Leucine rich repeat
    sd00033
    Location:123144
    LRR_RI; leucine-rich repeat [structural motif]
  2. NM_024416.4NP_077727.3  mimecan isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate translation start site compared to variant 1. The encoded isoform (1) has a longer N-terminus and lacks a predicted signal peptide compared to isoform 2.
    Source sequence(s)
    AF086912, AK295433, AL137848, BC095443, BG772245, BM679549
    UniProtKB/Swiss-Prot
    P20774
    UniProtKB/TrEMBL
    B4DI63, Q7Z532
    Conserved Domains (2) summary
    pfam13855
    Location:201283
    LRR_8; Leucine rich repeat
    sd00033
    Location:181202
    LRR_RI; leucine-rich repeat [structural motif]
  3. NM_033014.3NP_148935.1  mimecan isoform 2 precursor

    See identical proteins and their annotated locations for NP_148935.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the shorter isoform (2). Both variants 1 and 3 encode the same isoform (2).
    Source sequence(s)
    AK295433, AL137848, BC095443, BG772245, BM679549, CB268982
    Consensus CDS
    CCDS6695.1
    UniProtKB/Swiss-Prot
    P20774
    UniProtKB/TrEMBL
    A8K0R3, B4DI63
    Related
    ENSP00000262551, OTTHUMP00000021651, ENST00000262551, OTTHUMT00000053087
    Conserved Domains (2) summary
    pfam13855
    Location:143225
    LRR_8; Leucine rich repeat
    sd00033
    Location:123144
    LRR_RI; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p2 Primary Assembly

    Range
    92383967..92404655 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018920.2 Alternate CHM1_1.1

    Range
    95292689..95313376 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)