- Base Excision Repair, organism-specific biosystem (from REACTOME)
Base Excision Repair, organism-specific biosystemOf the three major pathways involved in the repair of nucleotide damage in DNA, base excision repair (BER) involves the greatest number of individual enzymatic activities. This is the consequence of...
- Base excision repair, organism-specific biosystem (from KEGG)
Base excision repair, organism-specific biosystemBase excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair ...
- Base excision repair, conserved biosystem (from KEGG)
Base excision repair, conserved biosystemBase excision repair (BER) is the predominant DNA damage repair pathway for the processing of small base lesions, derived from oxidation and alkylation damages. BER is normally defined as DNA repair ...
- Base-Excision Repair, AP Site Formation, organism-specific biosystem (from REACTOME)
Base-Excision Repair, AP Site Formation, organism-specific biosystemBase excision repair is initiated by DNA glycosylases that hydrolytically cleave of the base-deoxyribose glycosyl bond of a damaged nucleotide residue releasing the damaged base (Lindahl and Wood, ...
- Base-free sugar-phosphate removal via the single-nucleotide replacement pathway, organism-specific biosystem (from REACTOME)
Base-free sugar-phosphate removal via the single-nucleotide replacement pathway, organism-specific biosystemBase-free sugar-phosphate removal via the single-nucleotide replacement pathway requires displacement of DNA glycosylase by APE1, APE1 mediated endonucleolytic cleavage at the 5' side of the base-fre...
- Cleavage of the damaged purine, organism-specific biosystem (from REACTOME)
Cleavage of the damaged purine, organism-specific biosystemDamaged purines are first cleaved by purine-specific glycosylases (see Lindahl and Wood 1999).
- DNA Repair, organism-specific biosystem (from REACTOME)
DNA Repair, organism-specific biosystemDNA repair is a phenomenal multi-enzyme, multi-pathway system required to ensure the integrity of the cellular genome. These cellular mechanisms that must cope with the plethora of DNA base pair ad...
- Depurination, organism-specific biosystem (from REACTOME)
Depurination, organism-specific biosystemDepurination of a damaged nucleotide is mediated by a purine-specific DNA glycosylase. The glycosylase cleaves the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar generat...
- Displacement of DNA glycosylase by APE1, organism-specific biosystem (from REACTOME)
Displacement of DNA glycosylase by APE1, organism-specific biosystemFollowing cleavage of the damaged base, DNA glycosylase is displaced by APE1.
- Recognition and association of DNA glycosylase with site containing an affected purine, organism-specific biosystem (from REACTOME)
Recognition and association of DNA glycosylase with site containing an affected purine, organism-specific biosystemThe recognition and cleavage of an altered base by a DNA glycosylase is thought to involve the diffusion of the enzyme along the minor grove of the DNA molecule. The enzyme presumably compresses the...
- Removal of DNA patch containing abasic residue, organism-specific biosystem (from REACTOME)
Removal of DNA patch containing abasic residue, organism-specific biosystemDuring removal of DNA patch containing abasic residue, DNA glycosylase is displaced by APE1 which endonucleolytically cleaves the 5' side of the base-free deoxyribose residue. POL Beta is recruite...
- Resolution of AP sites via the multiple-nucleotide patch replacement pathway, organism-specific biosystem (from REACTOME)
Resolution of AP sites via the multiple-nucleotide patch replacement pathway, organism-specific biosystemWhile the single-nucleotide replacement pathway appears to facilitate the repair of most damaged bases, an alternative BER pathway is evoked when the structure of the terminal sugar phosphate is such...
- Resolution of AP sites via the single-nucleotide replacement pathway, organism-specific biosystem (from REACTOME)
Resolution of AP sites via the single-nucleotide replacement pathway, organism-specific biosystemThe single-nucleotide replacement pathway of base excision repair appears to facilitate the repair of most damaged bases. Following DNA glycosylase mediated cleavage of the damaged base, the endonucl...
- Resolution of Abasic Sites (AP sites), organism-specific biosystem (from REACTOME)
Resolution of Abasic Sites (AP sites), organism-specific biosystemResolution of AP sites can occur through the single-nucleotide replacement pathway or through the multiple-nucleotide patch replacement pathway.