U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

vIRF-2 vIRF-2 [ Human gammaherpesvirus 8 ]

Gene ID: 4961491, updated on 20-Nov-2023

Summary

Go to the top of the page Help
Gene symbol
vIRF-2
Gene description
vIRF-2
Locus tag
HHV8GK18_gp65
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Human gammaherpesvirus 8 (strain: GK18, type: P, common: Kaposi's sarcoma-associated herpesvirus, acronym: HHV-8, acronym: KSHV, nat-host: Homo sapiens)
Lineage
Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Gammaherpesvirinae; Rhadinovirus
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_009333.1 (91853..94353, complement)

NC_009333.1Genomic Context describing neighboring genes Neighboring gene vIRF-4 Neighboring gene vIRF-3 Neighboring gene ORF58 Neighboring gene ORF60 Neighboring gene ORF61 Neighboring gene ORF59 Neighboring gene ORF62 Neighboring gene ORF63 Neighboring gene ORF64 Neighboring gene ORF67A Neighboring gene ORF65 Neighboring gene ORF66 Neighboring gene ORF67

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_009333.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Genome-Wide Mapping of the Binding Sites and Structural Analysis of Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 2 Reveal that It Is a DNA-Binding Transcription Factor. Hu H, et al. J Virol, 2016 Feb 1. PMID 26537687, Free PMC Article
  2. Latently expressed human herpesvirus 8-encoded interferon regulatory factor 2 inhibits double-stranded RNA-activated protein kinase. Burýsek L, et al. J Virol, 2001 Mar. PMID 11160738, Free PMC Article
  3. The viral interferon regulatory factors of kaposi's sarcoma-associated herpesvirus differ in their inhibition of interferon activation mediated by toll-like receptor 3. Jacobs SR, et al. J Virol, 2013 Jan. PMID 23115281, Free PMC Article
  4. Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor-2 inhibits type 1 interferon signalling by targeting interferon-stimulated gene factor-3. Mutocheluh M, et al. J Gen Virol, 2011 Oct. PMID 21697347
  5. Functional analysis of human herpesvirus 8-encoded viral interferon regulatory factor 1 and its association with cellular interferon regulatory factors and p300. Burýsek L, et al. J Virol, 1999 Sep. PMID 10438822, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. data identify a new molecular determinant of USP7 recognition, TRAF3/6-specific targeting by the deubiquitinase, associated activation of these TRAFs by vIRF-2, and activities of vIRF-2 and vIRF-2-USP7 interaction in HHV-8 latent and lytic biology.
    Title: USP7-Dependent Regulation of TRAF Activation and Signaling by a Viral Interferon Regulatory Factor Homologue.
  2. The study provided unique insights into the DNA-binding potency of vIRF2 and suggested that vIRF2 could act as a transcription factor of its target genes in the host antiviral immune response.
    Title: Genome-Wide Mapping of the Binding Sites and Structural Analysis of Kaposi's Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor 2 Reveal that It Is a DNA-Binding Transcription Factor.
  3. Kaposi's sarcoma-associated herpesvirus vIRF1 and vIRF2 inhibited increases in both IFN-beta message and protein levels following TLR3 activation.
    Title: The viral interferon regulatory factors of kaposi's sarcoma-associated herpesvirus differ in their inhibition of interferon activation mediated by toll-like receptor 3.
  4. Western blot and electrophoretic mobility-shift assays identified the interferon-stimulated gene factor-3 (ISGF-3) components STAT1 and IRF-9 as the proximal targets of human herpesvirus 8 vIRF-2 activity.
    Title: Kaposi's sarcoma-associated herpesvirus viral interferon regulatory factor-2 inhibits type 1 interferon signalling by targeting interferon-stimulated gene factor-3.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

polyA_site

  • Loc: c91853

regulatory

  • Loc: c91886-91881 regulatory_class = polyA_signal_sequence
  • Loc: c94353-94348 regulatory_class = TATA_box

General protein information

Go to the top of the page Help
Preferred Names
vIRF-2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_009333.1 Reference assembly

    Range
    91853..94353 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_001129414.1 vIRF-2 [Human gammaherpesvirus 8]

    See identical proteins and their annotated locations for YP_001129414.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    D0UZS4, Q2HR71
    UniProtKB/TrEMBL
    F5H9G3, J9QJB3
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.