ODF1 outer dense fiber of sperm tails 1 [Homo sapiens] - Gene

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Summary

Official Symbol: ODF1provided by HGNC
Official Full Name: outer dense fiber of sperm tails 1provided by HGNC
Primary source: HGNC:8113
See related: Ensembl:ENSG00000155087; HPRD:01687; MIM:182878; Vega:OTTHUMG00000164719
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ODF; RT7; ODF2; ODFP; SODF; CT133; ODF27; ODFPG; HSPB10; ODFPGA; ODFPGB; MGC129928; MGC129929
Summary: The outer dense fibers are cytoskeletal structures that surround the axoneme in the middle piece and principal piece of the sperm tail. The fibers function in maintaining the elastic structure and recoil of the sperm tail as well as in protecting the tail from shear forces during epididymal transport and ejaculation. Defects in the outer dense fibers lead to abnormal sperm morphology and infertility. The human outer dense fibers contains at least 10 major proteins and this gene encodes the main protein. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 8q22.3

Sequence :: Chromosome: 8; NC_000008.10 (103563848..103573245)

See ODF1 in Epigenomics, MapViewer

Chromosome 8 - NC_000008.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
The expression of ODF1 was significantly decreased in the ejaculated spermatozoa of asthenozoospermic men.
Title: [Differential expression of ODF1 in human ejaculated spermatozoa and its clinical significance].

Submit: New GeneRIF Correction

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

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Products	Interactant	Other Gene	Source	Pubs	Description
Q14990	Q07866	KLC1	HPRD	PubMed
Q14990	Q14990	ODF1	HPRD	PubMed
Q14990	Outer dense fiber of sperm tails 2	ODF2	HPRD	PubMed
Q14990	Q9NPE6	SPAG4	HPRD	PubMed
Q14990	Q96R06	SPAG5	HPRD	PubMed
Q14990	Q15654	TRIP6	HPRD	PubMed
BioGRID:111009	BioGRID:112558	SPAG4	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:111009	BioGRID:113056	TRIP6	BioGRID	PubMed	Reconstituted Complex

Function	Evidence Code	Pubs
protein domain specific binding	IEA Inferred from Electronic Annotation more info
structural molecule activity	NAS Non-traceable Author Statement more info

Process	Evidence Code	Pubs
cell differentiation	IEA Inferred from Electronic Annotation more info
multicellular organismal development	IEA Inferred from Electronic Annotation more info
spermatogenesis	NAS Non-traceable Author Statement more info

Component	Evidence Code	Pubs
outer dense fiber	NAS Non-traceable Author Statement more info

General protein information

Preferred Names: outer dense fiber protein 1

Names: outer dense fiber protein 1; cancer/testis antigen 133; outer dense fiber of sperm tails, 27-kD

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_028006.1 RefSeqGene

Range

5001..14398

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_024410.3 → NP_077721.2 outer dense fiber protein 1

Status: REVIEWED

Source sequence(s)

AP002851, BG214987, DB457574

Consensus CDS

CCDS6293.1

UniProtKB/Swiss-Prot

Q14990

Related

ENSP00000285402, OTTHUMP00000227289, ENST00000285402, OTTHUMT00000379884

Conserved Domains (1) summary

cd06482
Location:116 – 199
Blast Score: 395

ACD_HspB10; Alpha crystallin domain (ACD) found in mammalian small heat shock protein (sHsp) HspB10, also known as sperm outer dense fiber protein (ODFP), and similar proteins. sHsps are molecular chaperones that suppress protein aggregation and protect against cell ...

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000008.10 Reference GRCh37.p5 Primary Assembly

Range

103563848..103573245

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000140.1 Alternate HuRef

Range

98764996..98774369

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AP002851.2 (28749..38126)	None
genomic	AP002852.3 (150338..155901)	None
genomic	CH471060.1	EAW91847.1
		EAW91848.1
		EAW91849.1
genomic	M93131.1	None
genomic	M93132.1	None
genomic	X74614.1	CAA52685.1
mRNA	AK315276.1	None
mRNA	BC104456.1	AAI04457.1
mRNA	BC104457.1	AAI04458.1
mRNA	BG214987.1	None
mRNA	DB457574.1	None