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TBC1D25 TBC1 domain family member 25 [ Homo sapiens (human) ]

Gene ID: 4943, updated on 8-May-2016
Official Symbol
TBC1D25provided by HGNC
Official Full Name
TBC1 domain family member 25provided by HGNC
Primary source
HGNC:HGNC:8092
See related
Ensembl:ENSG00000068354 HPRD:08948; MIM:311240; Vega:OTTHUMG00000024123
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MG81; OATL1
Summary
This gene encodes a protein with a TBC domain and may function as a Rab GTPase activating protein. This gene was previously known as ornithine aminotransferase-like 1, but has no similarity to ornithine aminotransferase. [provided by RefSeq, Jul 2008]
Orthologs
Location:
Xp11.23
Exon count:
6
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) X NC_000023.11 (48539687..48562609)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (48398075..48420997)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene porcupine homolog (Drosophila) Neighboring gene emopamil binding protein (sterol isomerase) Neighboring gene RNA binding motif (RNP1, RRM) protein 3 Neighboring gene mitochondrial ribosomal protein L32 pseudogene 1

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC126866, MGC126868, MGC149731, MGC149732

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
Rab GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
activation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
autophagy IEA
Inferred from Electronic Annotation
more info
 
intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
 
regulation of autophagosome maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
autophagosome IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
 
Preferred Names
TBC1 domain family member 25
Names
5SN3 snoRNA
TBC1 domain family, member 25
ornithine aminotransferase-like 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002536.2NP_002527.1  TBC1 domain family member 25

    See identical proteins and their annotated locations for NP_002527.1

    Status: VALIDATED

    Source sequence(s)
    AC115618, AF196969, BC052609, BC125088, CA447032, DA087200
    Consensus CDS
    CCDS35242.1
    UniProtKB/Swiss-Prot
    Q3MII6
    Related
    ENSP00000365962, OTTHUMP00000025803, ENST00000376771, OTTHUMT00000060764
    Conserved Domains (1) summary
    smart00164
    Location:225454
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p2 Primary Assembly

    Range
    48539687..48562609
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018934.2 Alternate CHM1_1.1

    Range
    48429335..48452245
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001006113.1: Suppressed sequence

    Description
    NM_001006113.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.