CXCL12 C-X-C motif chemokine ligand 12 [Felis catus (domestic cat)] - Gene

Summary

Gene symbol: CXCL12
Gene description: C-X-C motif chemokine ligand 12
See related: EnsemblRapid:ENSFCTG00005005045
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Felis catus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis
Also known as: SDF1; SDF-1
Orthologs: human mouse all
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Genomic context

Location:: chromosome: D2

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
105	current	F.catus_Fca126_mat1.0 (GCF_018350175.1)	D2	NC_058378.1 (48733367..48745201)
104	previous assembly	Felis_catus_9.0 (GCF_000181335.3)	D2	NC_018733.3 (50847763..50859579)

Chromosome D2 - NC_058378.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SDF1 directly promotes key periovulatory genes in cumulus-oocyte complexes.
Title: Stromal-derived factor 1 directly promotes genes expressed within the ovulatory cascade in feline cumulus oocyte complexes.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables CXCR chemokine receptor binding	IEA Inferred from Electronic Annotation more info	PubMed
enables chemokine activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in axon guidance	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cell chemotaxis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in chemokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in defense response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in immune response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in induction of positive chemotaxis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of cell migration	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: stromal cell-derived factor 1

Names: C-X-C motif chemokine 12; chemokine (C-X-C motif) ligand 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001009847.1 → NP_001009847.1 stromal cell-derived factor 1 precursor

See identical proteins and their annotated locations for NP_001009847.1

Status: PROVISIONAL

Source sequence(s)

AB011966

UniProtKB/Swiss-Prot

O62657, Q54AJ3

Related

ENSFCTP00005008950.1, ENSFCTT00005013771.1

Conserved Domains (1) summary

cd00273
Location:27 → 88

Chemokine_CXC; 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members contain an RCxC motif ...

RefSeqs of Annotated Genomes: Felis catus Annotation Release 105 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference F.catus_Fca126_mat1.0 Primary Assembly

Genomic

NC_058378.1 Reference F.catus_Fca126_mat1.0 Primary Assembly

Range

48733367..48745201

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006937984.5 → XP_006938046.1 stromal cell-derived factor 1 isoform X1

UniProtKB/TrEMBL

A0A2I2U9C3

Conserved Domains (1) summary

cd00273
Location:27 → 88

Chemokine_CXC; 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteine residues; includes a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; many members contain an RCxC motif ...