My NCBISign In

Display Settings:

Format

Send to:

Choose Destination

    NUP98 nucleoporin 98kDa [ Homo sapiens ]

    Gene ID: 4928, updated on 11-May-2012
    Help top of page

    Summary

    Official Symbol
    NUP98provided by HGNC
    Official Full Name
    nucleoporin 98kDaprovided by HGNC
    Primary source
    HGNC:8068
    See related
    Ensembl:ENSG00000110713; HPRD:03012; MIM:601021; Vega:OTTHUMG00000011846
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ADIR2; NUP96; NUP196
    Summary
    Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The 98 kDa nucleoporin is generated through a biogenesis pathway that involves synthesis and proteolytic cleavage of a 186 kDa precursor protein. This cleavage results in the 98 kDa nucleoporin as well as a 96 kDa nucleoporin, both of which are localized to the nucleoplasmic side of the NPC. Rat studies show that the 98 kDa nucleoporin functions as one of several docking site nucleoporins of transport substrates. The human gene has been shown to fuse to several genes following chromosome translocations in acute myelogenous leukemia (AML) and T-cell acute lymphocytic leukemia (T-ALL). This gene is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, May 2010]
    Help top of page

    Genomic context

    Location :
    11p15.5
    Sequence :
    Chromosome: 11; NC_000011.9 (3696240..3819022, complement)
    See NUP98 in Epigenomics, MapViewer

    Chromosome 11 - NC_000011.9Genomic Context describing neighboring genes Neighboring gene ADP-ribosyltransferase 1 Neighboring gene cholinergic receptor, nicotinic, alpha 10 (neuronal) Neighboring gene post-GPI attachment to proteins 2 Neighboring gene ras homolog family member G Neighboring gene uncharacterized LOC100506066

    Help top of page

    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
    Helptop of page

    Bibliography

    Related articles in PubMed

    1. Expression of the novel NUP98/PSIP1 fusion transcripts in myelodysplastic syndrome with t(9;11)(p22;p15). Yamamoto K, et al. Eur J Haematol, 2012 Mar. PMID 22103895.
    2. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. Lee KA, et al. J Biol Chem, 2011 Dec 2. PMID 21987572.
    3. NUP98 gene fusions and hematopoietic malignancies: common themes and new biologic insights. Gough SM, et al. Blood, 2011 Dec 8. PMID 21948299.
    4. Structural and functional analysis of an essential nucleoporin heterotrimer on the cytoplasmic face of the nuclear pore complex. Yoshida K, et al. Proc Natl Acad Sci U S A, 2011 Oct 4. PMID 21930948.
    5. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.

    See all (110) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. The fusion genes combining NUP98 exon 11/12 with PSIP1 exon 8 may be implicated in the pathogenesis of myelodysplastic syndrome (MDS).
      Title: Expression of the novel NUP98/PSIP1 fusion transcripts in myelodysplastic syndrome with t(9;11)(p22;p15).
    2. RAE1 transgene may be directly involved in NUP98 fusion-mediated leukemogenesis.
      Title: RNA export factor RAE1 contributes to NUP98-HOXA9-mediated leukemogenesis.
    3. Structural chromosomal rearrangements of NUP98, primarily balanced translocations and inversions, are associated with wide array of hematopoietic malignancies; NUP98 is known to be fused to at least 28 different partner genes in patients. [REVIEW]
      Title: NUP98 gene fusions and hematopoietic malignancies: common themes and new biologic insights.
    4. NUP98/NSD1 identifies a previously unrecognized group of young AML patients, with distinct characteristics and dismal prognosis, for whom new treatment strategies are urgently needed.
      Title: NUP98/NSD1 characterizes a novel poor prognostic group in acute myeloid leukemia with a distinct HOX gene expression pattern.
    5. Ectopic expression of NA10 (Nup98-HoxA10) augments erythroid differentiation of human embryonic stem cells.
      Title: Brief report: ectopic expression of NUP98-HOXA10 augments erythroid differentiation of human embryonic stem cells.
    6. Study identified mitotic phosphorylation of Nup98 as a rate-limiting step in mitotic nuclear pore complexes disassembly.
      Title: Phosphorylation of Nup98 by multiple kinases is crucial for NPC disassembly during mitotic entry.
    7. NUP98/RARG gene rearrangement is associated with acute myeloid leukemia.
      Title: A novel NUP98/RARG gene fusion in acute myeloid leukemia resembling acute promyelocytic leukemia.
    8. results suggest high frequency of cell proliferation gene mutations may contribute to leukemogenesis in NUP98-related leukemia; simultaneous occurrence of FLT3-ITD and WT1 aberrations may have an important role in outcome of NUP98-related leukemia
      Title: High frequencies of simultaneous FLT3-ITD, WT1 and KIT mutations in hematological malignancies with NUP98-fusion genes.
    9. characterized a novel recurrent chromosomal aberration, inv(11)(p15q23) in 2 patients with acute myeloid leukemia. This aberration is predicted to result in the expression of a NUP98-MLL fusion protein that is unable to interact with menin.
      Title: NUP98-MLL fusion in human acute myeloblastic leukemia.
    10. Mapping tests further demonstrated that aa 22-53 in the N-terminal region of H5N1 virus NS2 and the glycine-leucine-phenylalanine-glycine (GLFG) repeat domain (aa 1-511) of human Nup98 are crucial for the interaction of these two proteins.
      Title: Human cellular protein nucleoporin hNup98 interacts with influenza A virus NS2/nuclear export protein and overexpression of its GLFG repeat domain can inhibit virus propagation.
    Submit: New GeneRIF Correction See all (53)
    Help top of page

    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Leukemia, lymphocytic, acute T-cell

    Help top of page

    HIV-1 protein interactions

    Protein Gene Interaction Pubs
    Rev rev the FG repeat region of nup98 interacts directly with the nuclear export sequence of HIV-1 Rev, suggesting a physiological role for nup98 in modulating Rev-dependent RNA export during HIV infection PubMed
    rev Rev can recruit nup98 to the nucleolus PubMed
    rev the FG-containing repeat domain of Nup98 can inhibit Rev-mediated expression of viral proteins PubMed
    rev nup98 is involved in Rev-mediated nuclear export of HIV-1 mRNA through an interaction with eukaryotic initiation factor 5A (eIF-5A) which binds to Rev PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Help top of page

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_624357.1 AAA48443.1     BIND  PubMed Matrix interacts with Nup98. 
    P52948 Q92793 CREBBP    HPRD  PubMed  
    P52948 Q09472 EP300    HPRD  PubMed  
    P52948 O00410 IPO5    HPRD  PubMed  
    P52948 Q14974 KPNB1    HPRD  PubMed  
    P52948 Q8WUM0 NUP133    HPRD  PubMed  
    P52948 P37198 NUP62    HPRD  PubMed  
    P52948 Q99567 NUP88    HPRD  PubMed  
    P52948 P52948 NUP98    HPRD  PubMed  
    P52948 Q9UBU9 NXF1    HPRD  PubMed  
    P52948 P78406 RAE1    HPRD  PubMed  
    P52948 P18754 RCC1    HPRD  PubMed  
    P52948 P55735 SEC13    HPRD  PubMed  
    P52948 Q92973 TNPO1    HPRD  PubMed  
    P52948 P12270 TPR    HPRD  PubMed  
    BioGRID:110982 BioGRID:106821 APC    BioGRID  PubMed Two-hybrid 
    BioGRID:110982 BioGRID:107777 CREBBP    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110982 BioGRID:33472 CRM1    BioGRID  PubMed Two-hybrid 
    BioGRID:110982 BioGRID:108347 EP300    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110982 BioGRID:109315 HDAC1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110982 BioGRID:32720 KAP104    BioGRID  PubMed Two-hybrid 
    BioGRID:110982 BioGRID:110035 KPNB1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110982 BioGRID:120527 MOB1A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110982 BioGRID:110865 NFX1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110982 BioGRID:110929 NPM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110982 BioGRID:120864 NUP133    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110982 BioGRID:34876 NUP159    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110982 BioGRID:33693 NUP82    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110982 BioGRID:110981 NUP88    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110982 BioGRID:115745 NXF1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110982 BioGRID:222088 Nup107    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110982 BioGRID:230667 Nup188    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110982 BioGRID:230673 Nup214    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110982 BioGRID:234738 Nup98    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110982 BioGRID:121365 PARP11    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110982 BioGRID:114663 PTTG1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110982 BioGRID:123869 QRICH2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110982 BioGRID:114054 RAE1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110982 BioGRID:211639 Rae1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110982 BioGRID:110040 TNPO1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110982 BioGRID:119024 TNPO2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110982 BioGRID:113028 TPR    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:110982 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110982 BioGRID:113622 USP7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110982 BioGRID:1205541 tat    BioGRID  PubMed Reconstituted Complex 
    Help top of page

    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Antiviral mechanism by IFN-stimulated genes, organism-specific biosystem (from REACTOME)
      Antiviral mechanism by IFN-stimulated genes, organism-specific biosystemThe ISG proteins generated by IFN pathways plays key roles in the induction of innate and adaptive immune responses.
    • Cell Cycle, organism-specific biosystem (from REACTOME)
      Cell Cycle, organism-specific biosystem
      Cell Cycle
    • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
      Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
    • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
      Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
    • DNA Replication, organism-specific biosystem (from REACTOME)
      DNA Replication, organism-specific biosystemStudies in the past decade have suggested that the basic mechanism of DNA replication initiation is conserved in all kingdoms of life. Initiation in unicellular eukaryotes, in particular Saccharomyce...
    • Disease, organism-specific biosystem (from REACTOME)
      Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
    • Export of Viral Ribonucleoproteins from Nucleus, organism-specific biosystem (from REACTOME)
      Export of Viral Ribonucleoproteins from Nucleus, organism-specific biosystemInfluenza genomic RNA (vRNA), synthesized in the nucleus of the infected host cell, is packaged into ribonucleoprotein (RNP) complexes containing viral polymerase proteins and NP (nucleocapsid). NP ...
    • Gene Expression, organism-specific biosystem (from REACTOME)
      Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
    • Glucose transport, organism-specific biosystem (from REACTOME)
      Glucose transport, organism-specific biosystemCells take up glucose by facilitated diffusion, via glucose transporters (GLUTs) associated with the plasma membrane, a reversible reaction (Joost and Thorens 2001). Four tissue-specific GLUT isoform...
    • HIV Infection, organism-specific biosystem (from REACTOME)
      HIV Infection, organism-specific biosystemThe global pandemic of Human Immunodeficiency Virus (HIV) infection has resulted in tens of millions of people infected by the virus and millions more affected. UNAIDS estimates around 40 million ...
    • HIV Life Cycle, organism-specific biosystem (from REACTOME)
      HIV Life Cycle, organism-specific biosystemThe life cycle of HIV-1 is divided into early and late phases, shown schematically in the figure. In the early phase, an HIV-1 virion binds to receptors and co-receptors on the human host cell surfac...
    • Hexose transport, organism-specific biosystem (from REACTOME)
      Hexose transport, organism-specific biosystemHexoses, notably fructose, glucose, and galactose, generated in the lumen of the small intestine by breakdown of dietary carbohydrate are taken up by enterocytes lining the microvilli of the small in...
    • Host Interactions of HIV factors, organism-specific biosystem (from REACTOME)
      Host Interactions of HIV factors, organism-specific biosystemLike all viruses, HIV-1 must co-opt the host cell macromolecular transport and processing machinery. HIV-1 Vpr and Rev proteins play key roles in this co-optation. Efficient HIV-1 replication likewis...
    • ISG15 antiviral mechanism, organism-specific biosystem (from REACTOME)
      ISG15 antiviral mechanism, organism-specific biosystemInterferon-stimulated gene 15 (ISG15) is a member of the ubiquitin-like (Ubl) family. It is strongly induced upon exposure to type I Interferons (IFNs), viruses, bacterial LPS, and other stresses. On...
    • Immune System, organism-specific biosystem (from REACTOME)
      Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
    • Influenza A, organism-specific biosystem (from KEGG)
      Influenza A, organism-specific biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Influenza A, conserved biosystem (from KEGG)
      Influenza A, conserved biosystemInfluenza is a contagious respiratory disease caused by influenza virus infection. Influenza A virus is responsible for both annual seasonal epidemics and periodic worldwide pandemics. Novel strains ...
    • Influenza Infection, organism-specific biosystem (from REACTOME)
      Influenza Infection, organism-specific biosystemFor centuries influenza epidemics have plagued man, and influenza was probably the disease described by Hippocrates in 412 BC. Today it remains a major cause of morbidity and mortality worldwide with...
    • Influenza Life Cycle, organism-specific biosystem (from REACTOME)
      Influenza Life Cycle, organism-specific biosystemThe virus particle initially associates with a human host cell by binding to sialic acid-containing receptors on the host cell surface. The bound virus is endocytosed by one of four distinct mechanis...
    • Interactions of Rev with host cellular proteins, organism-specific biosystem (from REACTOME)
      Interactions of Rev with host cellular proteins, organism-specific biosystemIn order to facilitate the transport of incompletely spliced HIV-1 transcripts, Rev shuttles between the cytoplasm and nucleus using host cell transport mechanisms (reviewed in Li et al. 2005). Nucl...
    • Interactions of Vpr with host cellular proteins, organism-specific biosystem (from REACTOME)
      Interactions of Vpr with host cellular proteins, organism-specific biosystemVpr has been implicated in multiple processes during HIV-1 replication, including nuclear import of the pre-integration complex (PIC)(Heinzinger et al., 1994), apoptosis (Stewart et al., 1997) and in...
    • Interferon Signaling, organism-specific biosystem (from REACTOME)
      Interferon Signaling, organism-specific biosystemInterferons (IFNs) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. There are three types of IFNs:Type I (IFN-alpha, -beta and others...
    • Late Phase of HIV Life Cycle, organism-specific biosystem (from REACTOME)
      Late Phase of HIV Life Cycle, organism-specific biosystemThe late phase of the HIV-1 life cycle includes the regulated expression of the HIV gene products and the assembly of viral particles. The assembly of viral particles will be covered in a later relea...
    • M Phase, organism-specific biosystem (from REACTOME)
      M Phase, organism-specific biosystemMitosis, or the M phase, involves nuclear division and cytokinesis, where two identical daughter cells are produced. Mitosis involves prophase, prometaphase, metaphase, anaphase, and telophase. Fin...
    • Metabolism, organism-specific biosystem (from REACTOME)
      Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
    • Metabolism of carbohydrates, organism-specific biosystem (from REACTOME)
      Metabolism of carbohydrates, organism-specific biosystemThese pathways together are responsible for: 1) the extraction of energy and carbon skeletons for biosyntheses from dietary sugars and related molecules; 2) the short-term storage of glucose in the b...
    • Metabolism of non-coding RNA, organism-specific biosystem (from REACTOME)
      Metabolism of non-coding RNA, organism-specific biosystemThe term non-coding is commonly employed for RNA that does not encode a protein, but this does not mean that such RNAs do not contain information nor have function. There is considerable evidence tha...
    • Mitotic M-M/G1 phases, organism-specific biosystem (from REACTOME)
      Mitotic M-M/G1 phases, organism-specific biosystem
      Mitotic M-M/G1 phases
    • Mitotic Prometaphase, organism-specific biosystem (from REACTOME)
      Mitotic Prometaphase, organism-specific biosystemThe dissolution of the nuclear membrane marks the beginning of the prometaphase. Kinetochores are created when proteins attach to the centromeres. Microtubules then attach at the kinetochores, and ...
    • NEP/NS2 Interacts with the Cellular Export Machinery, organism-specific biosystem (from REACTOME)
      NEP/NS2 Interacts with the Cellular Export Machinery, organism-specific biosystemThe viral RNP complex is exported from the nucleus via the host cell CRM1 export pathway (Fukuda, 1997; Neumann, 2000; reviewed in Buolo, 2006). The vRNP complex does not interact directly with CRM1 ...
    • Nuclear import of Rev protein, organism-specific biosystem (from REACTOME)
      Nuclear import of Rev protein, organism-specific biosystemNuclear import of Rev involves the cellular proteins including importin-beta and B23 and is mediated by an arginine-rich nuclear localization signal (NLS) within the RNA binding domain of the Rev pr...
    • Nuclear pore complex, organism-specific biosystem (from KEGG)
      Nuclear pore complex, organism-specific biosystemStructural complex; Genetic information processing; RNA processing
    • Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystem (from REACTOME)
      Processing of Capped Intron-Containing Pre-mRNA, organism-specific biosystemCo-transcriptional pre-mRNA splicing is not obligatory. Pre-mRNA splicing begins co-transcriptionally and often continues post-transcriptionally. Human genes contain an average of nine introns per ge...
    • RNA transport, organism-specific biosystem (from KEGG)
      RNA transport, organism-specific biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
    • RNA transport, conserved biosystem (from KEGG)
      RNA transport, conserved biosystemRNA transport from the nucleus to the cytoplasm is fundamental for gene expression. The different RNA species that are produced in the nucleus are exported through the nuclear pore complexes (NPCs) ...
    • Regulation of Glucokinase by Glucokinase Regulatory Protein, organism-specific biosystem (from REACTOME)
      Regulation of Glucokinase by Glucokinase Regulatory Protein, organism-specific biosystemGlucokinase (GCK1) is negatively regulated by glucokinase regulatory protein (GKRP), which reversibly binds the enzyme to form an inactive complex. Binding is stimulated by fructose 6-phosphate and s...
    • Rev-mediated nuclear export of HIV-1 RNA, organism-specific biosystem (from REACTOME)
      Rev-mediated nuclear export of HIV-1 RNA, organism-specific biosystemThe HIV-1 genome contains 9 genes encoded by a single transcript. In order for the virus to replicate, unspliced, singly-spliced and fully spliced viral mRNA must be exported from the nucleus. The H...
    • SLC-mediated transmembrane transport, organism-specific biosystem (from REACTOME)
      SLC-mediated transmembrane transport, organism-specific biosystemProteins with transporting functions can be roughly classified into 3 categories: ATP-powered pumps, ion channels, and transporters. Pumps utilize the energy released by ATP hydrolysis to power the m...
    • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
      Transmembrane transport of small molecules, organism-specific biosystem
      Transmembrane transport of small molecules
    • Transport of Mature Transcript to Cytoplasm, organism-specific biosystem (from REACTOME)
      Transport of Mature Transcript to Cytoplasm, organism-specific biosystemTransport of mRNA through the Nuclear Pore Complex (NPC) is a dynamic process involving distinct machinery and receptor subsets. The separation of the two compartments and the regulation of this tran...
    • Transport of Mature mRNA Derived from an Intronless Transcript, organism-specific biosystem (from REACTOME)
      Transport of Mature mRNA Derived from an Intronless Transcript, organism-specific biosystemTransport of mRNA from the nucleus to the cytoplasm, where it is translated into protein, is highly selective and closely coupled to correct RNA processing.
    • Transport of Mature mRNA derived from an Intron-Containing Transcript, organism-specific biosystem (from REACTOME)
      Transport of Mature mRNA derived from an Intron-Containing Transcript, organism-specific biosystemTransport of mRNA from the nucleus to the cytoplasm, where it is translated into protein, is highly selective and closely coupled to correct RNA processing. This coupling is achieved by the nuclear p...
    • Transport of Mature mRNAs Derived from Intronless Transcripts, organism-specific biosystem (from REACTOME)
      Transport of Mature mRNAs Derived from Intronless Transcripts, organism-specific biosystemTransport of mature mRNAs derived from intronless transcripts require some of the same protein complexes as mRNAs derived from intron containing complexes, including TAP and Aly/Ref. However a number...
    • Transport of Ribonucleoproteins into the Host Nucleus, organism-specific biosystem (from REACTOME)
      Transport of Ribonucleoproteins into the Host Nucleus, organism-specific biosystemAn unusual characteristic of the influenza virus life cycle is its dependence on the nucleus. Trafficking of the viral genome into and out of the nucleus is a tightly regulated process with all viral...
    • Transport of the SLBP Dependant Mature mRNA, organism-specific biosystem (from REACTOME)
      Transport of the SLBP Dependant Mature mRNA, organism-specific biosystemTransport of U7 snRNP and stem-loop binding protein (SLBP) processed mRNA.
    • Transport of the SLBP independent Mature mRNA, organism-specific biosystem (from REACTOME)
      Transport of the SLBP independent Mature mRNA, organism-specific biosystemTransport of the SLBP independent Mature mRNA through the nuclear pore.
    • Vpr-mediated nuclear import of PICs, organism-specific biosystem (from REACTOME)
      Vpr-mediated nuclear import of PICs, organism-specific biosystemVpr appears to function in anchoring the PIC to the nuclear envelope. This anchoring likely involves interactions between Vpr and host nucleoporins.
    • snRNP Assembly, organism-specific biosystem (from REACTOME)
      snRNP Assembly, organism-specific biosystemSmall nuclear ribonucleoproteins (snRNPs) are crucial for pre-mRNA processing to mRNAs. Each snRNP contains a small nuclear RNA (snRNA) and an extremely stable core of seven Sm proteins. The U6 snRNA...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    structural constituent of nuclear pore NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    transporter activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    M phase of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    carbohydrate metabolic process TAS
    Traceable Author Statement
    more info
    		  
    cytokine-mediated signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    glucose transport TAS
    Traceable Author Statement
    more info
    		  
    hexose transport TAS
    Traceable Author Statement
    more info
    		  
    interspecies interaction between organisms IEA
    Inferred from Electronic Annotation
    more info
    		  
    mRNA transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    mitotic prometaphase TAS
    Traceable Author Statement
    more info
    		  
    nuclear pore organization NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    nucleocytoplasmic transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    protein import into nucleus, docking NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    regulation of glucose transport TAS
    Traceable Author Statement
    more info
    		  
    small molecule metabolic process TAS
    Traceable Author Statement
    more info
    		  
    transmembrane transport TAS
    Traceable Author Statement
    more info
    		  
    viral reproduction TAS
    Traceable Author Statement
    more info
    		  
    Component Evidence Code Pubs
    Nup107-160 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Nup107-160 complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    colocalizes_with kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nuclear envelope TAS
    Traceable Author Statement
    more info
    		  
    nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    nuclear pore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nuclear pore NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		 PubMed 
    nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Help top of page

    General protein information

    Preferred Names
    nuclear pore complex protein Nup98-Nup96
    Names
    nuclear pore complex protein Nup98-Nup96
    Nup98-Nup96
    GLFG-repeat containing nucleoporin
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005387.5 → NP_005378.4  nuclear pore complex protein Nup98-Nup96 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) has an in-frame additional segment in the 5' coding region and lacks multiple 3' exons but has an alternate 3' sequence including the coding region and UTR, as compared to variant 1. The encoded isoform 3 has an additional internal segment and a distinct and shorter C-terminus, as compared to isoform 1.
      Source sequence(s)
      AB040538, DB084013, U41815
      Consensus CDS
      CCDS41605.1
      UniProtKB/Swiss-Prot
      P52948
      Related
      ENSP00000380202, OTTHUMP00000013953, ENST00000397007, OTTHUMT00000033508
      Conserved Domains (1) summary
      pfam04096
      Location:740 – 880
      Blast Score: 524
      Nucleoporin2; Nucleoporin autopeptidase

    2. NM_016320.4 → NP_057404.2  nuclear pore complex protein Nup98-Nup96 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AF071076, AF231130, BC012906, DB084013
      Consensus CDS
      CCDS7746.1
      UniProtKB/Swiss-Prot
      P52948
      Related
      ENSP00000316032, OTTHUMP00000013622, ENST00000324932, OTTHUMT00000032766
      Conserved Domains (3) summary
      pfam04096
      Location:723 – 863
      Blast Score: 530
      Nucleoporin2; Nucleoporin autopeptidase
      pfam12110
      Location:1312 – 1610
      Blast Score: 875
      Nup96; Nuclear protein 96
      cl15277
      Location:216 – 329
      Blast Score: 139
      Nucleoporin_FG; Nucleoporin FG repeat region

    3. NM_139131.3 → NP_624357.1  nuclear pore complex protein Nup98-Nup96 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks multiple 3' exons but has an alternate 3' sequence including the coding region and UTR, as compared to variant 1. The encoded isoform 2 has a distinct and shorter C-terminus, as compared to isoform 1.
      Source sequence(s)
      BC041136, DB084013, U41815
      Consensus CDS
      CCDS41606.1
      UniProtKB/Swiss-Prot
      P52948
      Related
      ENSP00000380199, OTTHUMP00000013819, ENST00000397004, OTTHUMT00000033280
      Conserved Domains (1) summary
      pfam04096
      Location:723 – 863
      Blast Score: 524
      Nucleoporin2; Nucleoporin autopeptidase

    4. NM_139132.3 → NP_624358.2  nuclear pore complex protein Nup98-Nup96 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an in-frame exon in the 3' coding region, as compared to variant 1. The encoded isoform 4 lacks an internal segment, as compared to isoform 1.
      Source sequence(s)
      AF071077, AF116074, AF231130, DB084013
      Consensus CDS
      CCDS31347.1
      UniProtKB/Swiss-Prot
      P52948
      Related
      ENSP00000347404, OTTHUMP00000234880, ENST00000355260, OTTHUMT00000392645
      Conserved Domains (3) summary
      pfam04096
      Location:723 – 863
      Blast Score: 529
      Nucleoporin2; Nucleoporin autopeptidase
      pfam12110
      Location:1312 – 1485
      Blast Score: 458
      Nup96; Nuclear protein 96
      cl15277
      Location:216 – 329
      Blast Score: 134
      Nucleoporin_FG; Nucleoporin FG repeat region

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000011.9 Reference GRCh37.p5 Primary Assembly

      Range
      3696240..3819022, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000143.1 Alternate HuRef

      Range
      3430150..3552853, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AB038344.1 BAB11850.1
    genomic AC060812.15 (87218..105185) None
    genomic AC090587.10 None
    genomic CH471158.1 EAX02561.1
      EAX02562.1
      EAX02563.1
      EAX02564.1
      EAX02565.1
      EAX02566.1
    mRNA AB040538.1 BAB18537.1
    mRNA AF071076.1 AAD22395.1
    mRNA AF071077.1 AAD22396.1
    mRNA AF116074.1 AAF19342.1
    mRNA AF231130.1 AAL56659.1
    mRNA AK292882.1 BAF85571.1
    mRNA AK301512.1 BAG63020.1
    mRNA AL133601.1 CAB63736.1
    mRNA AL137613.1 CAB70842.1
    mRNA BC012906.1 AAH12906.2
    mRNA BC041136.1 AAH41136.1
    mRNA BG773331.1 None
    mRNA BT007349.1 AAP36013.1
    mRNA DB084013.1 None
    mRNA EF071958.1 ABK59096.1
    mRNA U41815.1 AAC50366.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P52948.4 GenPept UniProtKB/Swiss-Prot:P52948
    Q9HDC8 GenPept UniProtKB/TrEMBL:Q9HDC8
    Help top of page

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Links

      Links to other resources

      General information

      Related sites

      Feedback

      Subscription

      Recent activity

      Clear Turn Off Turn On

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...