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    Pp1-87B Protein phosphatase 1 at 87B [ Drosophila melanogaster ]

    Gene ID: 49260, updated on 10-May-2012
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    Summary

    Official Symbol
    Pp1-87Bprovided by Flybase
    Official Full Name
    Protein phosphatase 1 at 87Bprovided by Flybase
    Primary source
    FLYBASE:FBgn0004103
    Locus tag
    Dmel_CG5650
    Gene type
    protein coding
    RNA name
    protein phosphatase 1 at 87B
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    87B; CG5650; ck19; Dmel\CG5650; DmPp1-87B; l(3)87Bg; l(3)ck19; l(3)j6E7; Pp-1alpha; PP-1alpha; Pp1; PP1; PP1 87B; PP1 beta87b; PP1-87B; Pp1-87Bb; PP187B; PP1A87B; Pp1alpha-87B; PP1alpha-87B; PP1alpha87B; PP1alpha[[2]]; PP1c; PP1c 87B; Ppl-87B; Su(var)(3)6; Su(var)3-6; Su(Var)3-6; su-var(3)6; Su-var(3)6; Suvar(3)6
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    Genomic context

    Location :
    87B9-87B10
    Sequence :
    Chromosome: 3R; NT_033777.2 (8249343..8251639, complement)
    See Pp1-87B in Epigenomics, MapViewer

    Chromosome 3R - NT_033777.2Genomic Context describing neighboring genes Neighboring gene protein partner of snf Neighboring gene Sarcoglycan beta Neighboring gene CG17202 gene product from transcript CG17202-RA Neighboring gene Sialic acid phosphate synthase Neighboring gene CG5641 gene product from transcript CG5641-RA Neighboring gene CG5245 gene product from transcript CG5245-RA

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A protein complex network of Drosophila melanogaster. Guruharsha KG, et al. Cell, 2011 Oct 28. PMID 22036573.
    2. Sds22/PP1 links epithelial integrity and tumor suppression via regulation of myosin II and JNK signaling. Jiang Y, et al. Oncogene, 2011 Jul 21. PMID 21399659.
    3. Genetic and proteomic evidence for roles of Drosophila SUMO in cell cycle control, Ras signaling, and early pattern formation. Nie M, et al. PLoS One, 2009 Jun 16. PMID 19529778.
    4. Sds22, a PP1 phosphatase regulatory subunit, regulates epithelial cell polarity and shape [Sds22 in epithelial morphology]. Grusche FA, et al. BMC Dev Biol, 2009 Feb 19. PMID 19228425.
    5. Phosphorylation networks regulating JNK activity in diverse genetic backgrounds. Bakal C, et al. Science, 2008 Oct 17. PMID 18927396.

    See all (98) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. PP1 is not a major regulator of the Rbf1/E2F1 pathway in Drosophila
      Title: Normal regulation of Rbf1/E2f1 target genes in Drosophila type 1 protein phosphatase mutants.
    2. Bif regulates PP1 activity, and both proteins influence cytoskeleton dynamics in the growth cone of R cells to allow proper axon targeting.
      Title: Bifocal and PP1 interaction regulates targeting of the R-cell growth cone in Drosophila.
    3. PP1c not only binds TRX, but is a physiologically relevant regulator of TRX function in vivo.
      Title: Trithorax interacts with type 1 serine/threonine protein phosphatase in Drosophila.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:72126 BioGRID:60738 A16    BioGRID  PubMed Two-hybrid 
    BioGRID:72126 BioGRID:61033 CG12620    BioGRID  PubMed Affinity Capture-MS; Two-hybrid 
    BioGRID:72126 BioGRID:60017 CG13994    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:72126 BioGRID:61597 CG1553    BioGRID  PubMed Two-hybrid 
    BioGRID:72126 BioGRID:62533 CG15705    BioGRID  PubMed Two-hybrid 
    BioGRID:72126 BioGRID:58873 CG17209    BioGRID  PubMed Two-hybrid 
    BioGRID:72126 BioGRID:66547 CG17360    BioGRID  PubMed Two-hybrid 
    BioGRID:72126 BioGRID:57860 CG2930    BioGRID  PubMed Two-hybrid 
    BioGRID:72126 BioGRID:66987 CG31291    BioGRID  PubMed Two-hybrid 
    BioGRID:72126 BioGRID:68613 CG31999    BioGRID  PubMed Two-hybrid 
    BioGRID:72126 BioGRID:58377 CG32685    BioGRID  PubMed Two-hybrid 
    BioGRID:72126 BioGRID:59065 CG8316    BioGRID  PubMed Two-hybrid 
    BioGRID:72126 BioGRID:58907 CG9170    BioGRID  PubMed Two-hybrid 
    BioGRID:72126 BioGRID:64921 CG9238    BioGRID  PubMed Two-hybrid 
    BioGRID:72126 BioGRID:62567 Cdk4    BioGRID  PubMed Two-hybrid 
    BioGRID:72126 BioGRID:68286 Doa    BioGRID  PubMed Two-hybrid 
    BioGRID:72126 BioGRID:64582 E(z)    BioGRID  PubMed Phenotypic Enhancement; Phenotypic Suppression 
    BioGRID:72126 BioGRID:58501 HP5    BioGRID  PubMed Two-hybrid 
    BioGRID:72126 BioGRID:64543 I-2    BioGRID  PubMed Affinity Capture-MS; Phenotypic Suppression; Two-hybrid 
    BioGRID:72126 BioGRID:66540 I-t    BioGRID  PubMed Two-hybrid 
    BioGRID:72126 BioGRID:69245 NiPp1    BioGRID  PubMed Phenotypic Suppression; Two-hybrid 
    BioGRID:72126 BioGRID:62684 RhoGAP54D    BioGRID  PubMed Two-hybrid 
    BioGRID:72126 BioGRID:67396 Sirt2    BioGRID  PubMed Two-hybrid 
    BioGRID:72126 BioGRID:59788 Spindly    BioGRID  PubMed Two-hybrid 
    BioGRID:72126 BioGRID:66087 alpha-Est9    BioGRID  PubMed Two-hybrid 
    BioGRID:72126 BioGRID:67428 cdc2c    BioGRID  PubMed Two-hybrid 
    BioGRID:72126 BioGRID:68952 flw    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:72126 BioGRID:61259 lok    BioGRID  PubMed Two-hybrid 
    BioGRID:72126 BioGRID:63592 mri    BioGRID  PubMed Two-hybrid 
    BioGRID:72126 BioGRID:61263 neb    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:72126 BioGRID:68673 nej    BioGRID  PubMed Two-hybrid 
    BioGRID:72126 BioGRID:57644 png    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:72126 BioGRID:66846 put    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:72126 BioGRID:69066 scrib    BioGRID  PubMed Two-hybrid 
    BioGRID:72126 BioGRID:67127 sds22    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:72126 BioGRID:65303 star1    BioGRID  PubMed Two-hybrid 
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    General gene information

    Homology

    • Homologs of the Pp1-87B gene: The Pp1-87B gene is conserved in human, chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, S.pombe, A.thaliana, rice, and P.falciparum.

    Pathways from BioSystems

    • mRNA surveillance pathway, organism-specific biosystem (from KEGG)
      mRNA surveillance pathway, organism-specific biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...
    • mRNA surveillance pathway, conserved biosystem (from KEGG)
      mRNA surveillance pathway, conserved biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    myosin phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein serine/threonine phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    protein serine/threonine phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    protein serine/threonine phosphatase activity NAS
    Non-traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    adult locomotory behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    chromosome condensation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    chromosome condensation NAS
    Non-traceable Author Statement
    more info
    		  
    chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    learning or memory NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    locomotion NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    mitosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    mitotic metaphase plate congression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    mitotic sister chromatid segregation NAS
    Non-traceable Author Statement
    more info
    		  
    mitotic spindle elongation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    olfactory learning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    phagocytosis, engulfment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    protein dephosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    protein dephosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    protein dephosphorylation NAS
    Non-traceable Author Statement
    more info
    		  
    spindle assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    visual learning IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    cytoplasm NAS
    Non-traceable Author Statement
    more info
    		  
    polytene chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    protein phosphatase type 1 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    CG5650 gene product from transcript CG5650-RA
    Names
    CG5650-PA
    Pp1-87B-PA
    protein phosphatase 1
    protein phosphatase 1 at 87B
    suppressor of variegation
    NP_524937.1
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.2

      Range
      8249343..8251639, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080198.3 → NP_524937.1  protein phosphatase 1 at 87B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P12982
      Related
      FBpp0082067
      Conserved Domains (2) summary
      cd07414
      Location:6 – 298
      Blast Score: 1732
      MPP_PP1_PPKL; PP1, PPKL (PP1 and kelch-like) enzymes, and related proteins, metallophosphatase domain
      PTZ00480
      Location:5 – 299
      Blast Score: 1414
      PTZ00480; serine/threonine-protein phosphatase; Provisional
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    mRNA X15583.1 CAA33609.1
    genomic S47852.1 AAB23957.1
    genomic AE014297.2 AAF54810.1
    mRNA AY061063.1 AAL28611.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    PAFF1A.1 GenPept
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    Additional Links

    Gene LinkOut

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