My NCBISign In

Display Settings:

Format

Send to:

Choose Destination

    NUMA1 nuclear mitotic apparatus protein 1 [ Homo sapiens ]

    Gene ID: 4926, updated on 11-May-2012
    Help top of page

    Summary

    Official Symbol
    NUMA1provided by HGNC
    Official Full Name
    nuclear mitotic apparatus protein 1provided by HGNC
    Primary source
    HGNC:8059
    See related
    Ensembl:ENSG00000137497; HPRD:01236; MIM:164009; Vega:OTTHUMG00000167697
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NUMA
    Help top of page

    Genomic context

    Location :
    11q13
    Sequence :
    Chromosome: 11; NC_000011.9 (71713911..71791573, complement)
    See NUMA1 in Epigenomics, MapViewer

    Chromosome 11 - NC_000011.9Genomic Context describing neighboring genes Neighboring gene transient receptor potential cation channel, subfamily C, member 2-like Neighboring gene olfactory receptor, family 7, subfamily E, member 126 pseudogene Neighboring gene ring finger protein 121 Neighboring gene interleukin 18 binding protein Neighboring gene microRNA 3165 Neighboring gene leucine rich transmembrane and 0-methyltransferase domain containing Neighboring gene late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 Neighboring gene chromosome 11 open reading frame 51

    Help top of page

    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
    Helptop of page

    Bibliography

    Related articles in PubMed

    1. Integrative analysis of the ubiquitin proteome isolated using Tandem Ubiquitin Binding Entities (TUBEs). Lopitz-Otsoa F, et al. J Proteomics, 2012 Jun 6. PMID 22178446.
    2. Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, et al. Mol Cell, 2011 Oct 21. PMID 21906983.
    3. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. Wagner SA, et al. Mol Cell Proteomics, 2011 Oct. PMID 21890473.
    4. Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. Oshikawa M, et al. Invest Ophthalmol Vis Sci, 2011 Aug. PMID 21697133.
    5. Comparative proteomic analysis identifies a role for SUMO in protein quality control. Tatham MH, et al. Sci Signal, 2011 Jun 21. PMID 21693764.

    See all (77) citations in PubMed

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. The levels of urinary NMP22 and CK18 in the patients with transitional cell carcinoma of the bladder were significantly higher than those in the non-transitional cell carcinoma of the bladder.
      Title: [Expression and clinical significance of nuclear matrix protein 22 and cytokeratin 18 in transitional cell carcinoma of the bladder].
    2. Accurate distribution of NuMA is important for oocyte maturation, zygote and embryo development in humans. Proper assembly of NuMA is likely necessary for bipolar spindle organization and human oocyte developmental competence.
      Title: The nuclear mitotic apparatus (NuMA) protein: localization and dynamics in human oocytes, fertilization and early embryos.
    3. NuMA is expressed in interphase nuclei of fibroblasts and oocytes.
      Title: Dynamic distribution of NuMA and microtubules in human fetal fibroblasts, developing oocytes and somatic cell nuclear transferred embryos.
    4. Phenotype onset is correlated with NuMA-RARalpha copy number; mice with higher copy number developing disease later than those with lower copy number.
      Title: Correlation among nuclear localization of NuMA-RARα, deregulation of gene expression and leukemic phenotype of hCG-NuMA-RARα transgenic mice.
    5. These results suggest that NuMA may provide structural support in the interphase nucleus by contributing to the organization of chromatin.
      Title: Silencing of Nuclear Mitotic Apparatus protein (NuMA) accelerates the apoptotic disintegration of the nucleus.
    6. Ric-8A and Gi alpha recruit LGN, NuMA, and dynein to the cell cortex to help orient the mitotic spindle.
      Title: Ric-8A and Gi alpha recruit LGN, NuMA, and dynein to the cell cortex to help orient the mitotic spindle.
    7. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    8. Data suggest that pADPr provides a dynamic cross-linking function at spindle poles by extending from covalent modification sites on PARP-5a and NuMA and binding noncovalently to NuMA and that this function helps promote assembly of exactly two poles.
      Title: Interaction between Poly(ADP-ribose) and NuMA contributes to mitotic spindle pole assembly.
    9. Inhibiting Crm1 in early metaphase causes the formation of excess acentriolar spindle poles containing NuMA and B23, but does not affect centrosome numbers.
      Title: Inhibiting Crm1 causes the formation of excess acentriolar spindle poles containing NuMA and B23, but does not affect centrosome numbers.
    10. Kaposi's sarcoma-associated herpesvirus-encoded LANA can interact with the nuclear mitotic apparatus protein to regulate genome maintenance and segregation.
      Title: Kaposi's sarcoma-associated herpesvirus-encoded LANA can interact with the nuclear mitotic apparatus protein to regulate genome maintenance and segregation.
    Submit: New GeneRIF Correction See all (24)
    Help top of page

    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Leukemia, acute promyelocytic, NUMA/RARA type

    Help top of page

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    NP_006176.1 NP_002060.4 GNAI1    BIND  PubMed NuMA interacts with Galphai1. 
    NP_006176.1 NP_037428.2 GPSM2    BIND  PubMed LGN interacts with NuMA. 
    Q14980 P61163 ACTR1A    HPRD  PubMed  
    Q14980 P11171 EPB41    HPRD  PubMed  
    Q14980 Q9H4G0 EPB41L1    HPRD  PubMed  
    Q14980 O43491 EPB41L2    HPRD  PubMed  
    Q14980 P63096 GNAI1    HPRD  PubMed  
    Q14980 P81274 GPSM2    HPRD  PubMed  
    Q14980 Q14686 NCOA6    HPRD  PubMed  
    Q14980 P11309 PIM1    HPRD  PubMed  
    Q14980 O60216 RAD21    HPRD  PubMed  
    Q14980 Q14683 SMC1A    HPRD  PubMed  
    Q14980 O95271 TNKS    HPRD  PubMed  
    Q14980 O95619 YEATS4    HPRD  PubMed  
    BioGRID:110980 BioGRID:115425 ACTR1A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110980 BioGRID:114342 BANF1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110980 BioGRID:108349 EPB41    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:110980 BioGRID:108350 EPB41L1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:110980 BioGRID:108351 EPB41L2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110980 BioGRID:118949 GPSM2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:110980 BioGRID:115331 HDAC5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110980 BioGRID:116691 NCOA6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110980 BioGRID:110929 NPM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110980 BioGRID:111310 PIM1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:110980 BioGRID:117487 RPAP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110980 BioGRID:202582 Ranbp2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110980 BioGRID:121244 SMARCAD1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110980 BioGRID:113871 SMC1A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110980 BioGRID:114574 SMC3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:110980 BioGRID:113188 SUMO1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110980 BioGRID:112497 SUMO2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110980 BioGRID:114207 TNKS    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110980 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110980 BioGRID:113761 YEATS4    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:110980 BioGRID:116168 YWHAQ    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:110980 BioGRID:1205541 tat    BioGRID  PubMed Reconstituted Complex 
    Help top of page

    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    structural molecule activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    G2/M transition of mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    establishment of mitotic spindle orientation IEA
    Inferred from Electronic Annotation
    more info
    		  
    lung epithelial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    mitotic anaphase TAS
    Traceable Author Statement
    more info
    		 PubMed 
    mitotic cell cycle TAS
    Traceable Author Statement
    more info
    		  
    nucleus organization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    apical part of cell IEA
    Inferred from Electronic Annotation
    more info
    		  
    chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    cytosol TAS
    Traceable Author Statement
    more info
    		  
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    spindle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    spindle microtubule TAS
    Traceable Author Statement
    more info
    		 PubMed 
    spindle pole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Help top of page

    General protein information

    Preferred Names
    nuclear mitotic apparatus protein 1
    Names
    nuclear mitotic apparatus protein 1
    SP-H antigen
    structural nuclear protein
    centrophilin stabilizes mitotic spindle in mitotic cells
    Help top of page

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006185.2 → NP_006176.2  nuclear mitotic apparatus protein 1

      Status: VALIDATED

      Source sequence(s)
      AB210007, AP002490, BC027493, BG771637
      Consensus CDS
      CCDS31633.1
      UniProtKB/Swiss-Prot
      Q14980
      UniProtKB/TrEMBL
      Q3SYK8
      UniProtKB/TrEMBL
      Q4LE64
      Related
      ENSP00000377298, OTTHUMP00000236571, ENST00000393695, OTTHUMT00000395769
      Conserved Domains (2) summary
      TIGR02168
      Location:684 – 937
      Blast Score: 154
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      PHA03307
      Location:1746 – 1899
      Blast Score: 99
      PHA03307; transcriptional regulator ICP4; Provisional

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000011.9 Reference GRCh37.p5 Primary Assembly

      Range
      71713911..71791573, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000143.1 Alternate HuRef

      Range
      68007666..68085181, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Help top of page

    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AF012302.1 AAC33408.1
    genomic AF110460.1 AAD16994.1
    genomic AP002490.4 (92087..169749) None
    genomic CH471076.1 EAW74821.1
      EAW74822.1
      EAW74823.1
      EAW74824.1
      EAW74825.1
      EAW74826.1
      EAW74827.1
      EAW74828.1
      EAW74829.1
      EAW74830.1
      EAW74831.1
    mRNA AB208841.1 BAD92078.1
    mRNA AB210007.1 BAE06089.1
    mRNA AB621824.1 BAK64159.1
    mRNA AK290509.1 BAF83198.1
    mRNA AK307577.1 None
    mRNA AK309041.1 None
    mRNA BC004165.2 AAH04165.1
    mRNA BC008345.1 AAH08345.1
    mRNA BC013023.2 AAH13023.1
    mRNA BC027493.1 AAH27493.1
    mRNA BC032228.1 None
    mRNA BC036808.1 None
    mRNA BC043499.1 AAH43499.1
    mRNA BC068539.1 None
    mRNA BC103765.1 AAI03766.1
    mRNA BG771637.1 None
    mRNA Z11583.1 CAA77669.1
    mRNA Z11584.1 CAA77670.1
    mRNA Z14227.1 None
    mRNA Z14228.1 None
    mRNA Z14229.1 None
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q14980.2 GenPept UniProtKB/Swiss-Prot:Q14980
    Q3SYK8 GenPept UniProtKB/TrEMBL:Q3SYK8
    Q4LE64 GenPept UniProtKB/TrEMBL:Q4LE64
    Q59HB8 GenPept UniProtKB/TrEMBL:Q59HB8
    Q7Z757 GenPept UniProtKB/TrEMBL:Q7Z757
    Q86XH4 GenPept UniProtKB/TrEMBL:Q86XH4
    Q96HN5 GenPept UniProtKB/TrEMBL:Q96HN5
    Q9BTE9 GenPept UniProtKB/TrEMBL:Q9BTE9
    Q9UNL7 GenPept UniProtKB/TrEMBL:Q9UNL7
    Q9UPG3 GenPept UniProtKB/TrEMBL:Q9UPG3
    Help top of page

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Links

      Links to other resources

      General information

      Related sites

      Feedback

      Subscription

      Recent activity

      Clear Turn Off Turn On

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...