NUMA1 nuclear mitotic apparatus protein 1 [Homo sapiens (human)] - Gene

Summary

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Official Symbol: NUMA1provided by HGNC
Official Full Name: nuclear mitotic apparatus protein 1provided by HGNC
Primary source: HGNC:8059
See related: Ensembl:ENSG00000137497; HPRD:01236; MIM:164009; Vega:OTTHUMG00000167697
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NUMA

Genomic context

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Location :: 11q13

Sequence :: Chromosome: 11; NC_000011.9 (71713911..71791573, complement)

See NUMA1 in Epigenomics, MapViewer

Chromosome 11 - NC_000011.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Bibliography

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GeneRIFs: Gene References Into Functions What's a GeneRIF?

Numa regulates spindle assemby in conjunction with Eg5.
Title: Interaction of NuMA protein with the kinesin Eg5: its possible role in bipolar spindle assembly and chromosome alignment.
NuMA expression was upregulated in tumours, with a significant association with disease stage in mucinous EOC subtypes, lymph node involvement and patient age
Title: NuMA overexpression in epithelial ovarian cancer.
Low NUMA1 is associtated with glioblastoma.
Title: GAS41 amplification results in overexpression of a new spindle pole protein.
Without functional NuMA, microtubules lose connection to meiosis I spindle poles, resulting in highly disorganized early spindle assembly.
Title: Error-prone mammalian female meiosis from silencing the spindle assembly checkpoint without normal interkinetochore tension.
During apoptotic rearrangement of interchromatin granule clusters, the nuclear matrix (NuMa rearrangement) and chromatin are closely associated. This process occurs in defined stages and depends on the activity of protein phosphatases, caspases and CAD.
Title: Early apoptotic reorganization of spliceosomal proteins involves caspases, CAD and rearrangement of NuMA.
The levels of urinary NMP22 and CK18 in the patients with transitional cell carcinoma of the bladder were significantly higher than those in the non-transitional cell carcinoma of the bladder.
Title: [Expression and clinical significance of nuclear matrix protein 22 and cytokeratin 18 in transitional cell carcinoma of the bladder].
Accurate distribution of NuMA is important for oocyte maturation, zygote and embryo development in humans. Proper assembly of NuMA is likely necessary for bipolar spindle organization and human oocyte developmental competence.
Title: The nuclear mitotic apparatus (NuMA) protein: localization and dynamics in human oocytes, fertilization and early embryos.
NuMA is expressed in interphase nuclei of fibroblasts and oocytes.
Title: Dynamic distribution of NuMA and microtubules in human fetal fibroblasts, developing oocytes and somatic cell nuclear transferred embryos.
Phenotype onset is correlated with NuMA-RARalpha copy number; mice with higher copy number developing disease later than those with lower copy number.
Title: Correlation among nuclear localization of NuMA-RARα, deregulation of gene expression and leukemic phenotype of hCG-NuMA-RARα transgenic mice.
These results suggest that NuMA may provide structural support in the interphase nucleus by contributing to the organization of chromatin.
Title: Silencing of Nuclear Mitotic Apparatus protein (NuMA) accelerates the apoptotic disintegration of the nucleus.

Submit: New GeneRIF Correction See all (29)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

HIV-1 protein interactions

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Protein	Gene	Interaction	Pubs
Tat, p14	tat	Interaction of HIV-1 Tat with NUMA1 in T-cells is identified by a proteomic strategy based on affinity chromatography	PubMed
pol	gag-pol	Positional proteomics analysis identifies the cleavage of human nuclear mitotic apparatus protein 1 (NUMA1) at amino acid residues 2054-2055 by the HIV-1 protease	PubMed

Go to the HIV-1, Human Protein Interaction Database

Interactions

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Products	Interactant	Other Gene	Source	Pubs	Description
NP_006176.1	NP_002060.4	GNAI1	BIND	PubMed	NuMA interacts with Galphai1.
NP_006176.1	NP_037428.2	GPSM2	BIND	PubMed	LGN interacts with NuMA.
Q14980	P61163	ACTR1A	HPRD	PubMed
Q14980	P11171	EPB41	HPRD	PubMed
Q14980	Q9H4G0	EPB41L1	HPRD	PubMed
Q14980	O43491	EPB41L2	HPRD	PubMed
Q14980	P63096	GNAI1	HPRD	PubMed
Q14980	P81274	GPSM2	HPRD	PubMed
Q14980	Q14686	NCOA6	HPRD	PubMed
Q14980	P11309	PIM1	HPRD	PubMed
Q14980	O60216	RAD21	HPRD	PubMed
Q14980	Q14683	SMC1A	HPRD	PubMed
Q14980	O95271	TNKS	HPRD	PubMed
Q14980	O95619	YEATS4	HPRD	PubMed
BioGRID:110980	BioGRID:115425	ACTR1A	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110980	BioGRID:114342	BANF1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110980	BioGRID:117028	CBX6	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110980	BioGRID:107452	CDK2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110980	BioGRID:107456	CDK6	BioGRID	PubMed	Biochemical Activity
BioGRID:110980	BioGRID:108009	DDB1	BioGRID	PubMed	Co-fractionation
BioGRID:110980	BioGRID:114206	DYNLL1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110980	BioGRID:108223	ECT2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110980	BioGRID:116292	EMILIN1	BioGRID	PubMed	Affinity Capture-Western; Co-fractionation; Co-localization; Reconstituted Complex
BioGRID:110980	BioGRID:108349	EPB41	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:110980	BioGRID:108350	EPB41L1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:110980	BioGRID:108351	EPB41L2	BioGRID	PubMed	Reconstituted Complex
BioGRID:110980	BioGRID:108403	ESR1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110980	BioGRID:118949	GPSM2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:110980	BioGRID:115331	HDAC5	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110980	BioGRID:115330	HDAC6	BioGRID	PubMed	Positive Genetic
BioGRID:110980	BioGRID:120968	HDAC8	BioGRID	PubMed	Negative Genetic
BioGRID:110980	BioGRID:109552	HSP90AA1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110980	BioGRID:109558	HSP90AB1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110980	BioGRID:115114	KIAA0101	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110980	BioGRID:115014	MDC1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110980	BioGRID:116691	NCOA6	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110980	BioGRID:116961	NCSTN	BioGRID	PubMed	Co-fractionation
BioGRID:110980	BioGRID:110929	NPM1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110980	BioGRID:110982	NUP98	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110980	BioGRID:111310	PIM1	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:110980	BioGRID:114054	RAE1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:110980	BioGRID:117487	RPAP1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110980	BioGRID:202582	Ranbp2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110980	BioGRID:119602	SIRT7	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110980	BioGRID:121244	SMARCAD1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110980	BioGRID:113871	SMC1A	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110980	BioGRID:114574	SMC3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110980	BioGRID:121411	SMURF1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110980	BioGRID:113188	SUMO1	BioGRID	PubMed	Reconstituted Complex
BioGRID:110980	BioGRID:112497	SUMO2	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110980	BioGRID:112872	TERF1	BioGRID	PubMed	Two-hybrid
BioGRID:110980	BioGRID:112873	TERF2	BioGRID	PubMed	Two-hybrid
BioGRID:110980	BioGRID:119942	TERF2IP	BioGRID	PubMed	Two-hybrid
BioGRID:110980	BioGRID:114207	TNKS	BioGRID	PubMed	Reconstituted Complex
BioGRID:110980	BioGRID:113011	TP53BP1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110980	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110980	BioGRID:113258	VCP	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110980	BioGRID:113306	WHSC1	BioGRID	PubMed	Affinity Capture-RNA
BioGRID:110980	BioGRID:113761	YEATS4	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:110980	BioGRID:116168	YWHAQ	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110980	BioGRID:1205541	tat	BioGRID	PubMed	Reconstituted Complex

Pathways from BioSystems

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Caspase cascade in apoptosis, organism-specific biosystem (from Pathway Interaction Database)
Caspase cascade in apoptosis, organism-specific biosystem
Caspase cascade in apoptosis
Cell Cycle, organism-specific biosystem (from REACTOME)
Cell Cycle, organism-specific biosystem
Cell Cycle
Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
Centrosome maturation, organism-specific biosystem (from REACTOME)
Centrosome maturation, organism-specific biosystemThe centrosome is the primary microtubule organizing center (MTOC) in vertebrate cells and plays an important role in orchestrating the formation of the mitotic spindle. Centrosome maturation is an ...
G2/M Transition, organism-specific biosystem (from REACTOME)
G2/M Transition, organism-specific biosystemCyclin A can also form complexes with Cdc2 (Cdk1). Together with three B-type cyclins, Cdc2 (Cdk1) regulates the transition from G2 into mitosis. These complexes are activated by dephosphorylation of...
Mitotic G2-G2/M phases, organism-specific biosystem (from REACTOME)
Mitotic G2-G2/M phases, organism-specific biosystem
Mitotic G2-G2/M phases
Recruitment of NuMA to mitotic centrosomes, organism-specific biosystem (from REACTOME)
Recruitment of NuMA to mitotic centrosomes, organism-specific biosystemThe NuMA protein, which functions as a nuclear matrix protein in interphase (Merdes and Cleveland 1998), redistributes to the cytoplasm following nuclear envelope breakdown where it plays an essen...
Recruitment of mitotic centrosome proteins and complexes, organism-specific biosystem (from REACTOME)
Recruitment of mitotic centrosome proteins and complexes, organism-specific biosystemThe mitotic spindle becomes established once centrosomes have migrated to opposite poles and the nuclear envelope has broken down. During this stage, interphase centrosomes mature into mitotic centro...

General gene information

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Markers

D11S2921 (e-PCR)
- UniSTS:152074

D11S2560 (e-PCR)
- UniSTS:37928

PMC156606P1 (e-PCR)
- UniSTS:271408

D8S2279 (e-PCR)
- UniSTS:473907

RH46401 (e-PCR)
- UniSTS:66645

WI-16987 (e-PCR)
- UniSTS:76634

NUMA (e-PCR)
- UniSTS:36957

D15S1477 (e-PCR)
- UniSTS:474482

D11S4713 (e-PCR)
- UniSTS:31111

G65532 (e-PCR)
- UniSTS:166573

D12S2124 (e-PCR)
- UniSTS:64446

RH102881 (e-PCR)
- UniSTS:97215

Homology

Homologs of the NUMA1 gene: The NUMA1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and zebrafish.
Map Viewer (Mouse, Rat)
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
protein binding	IPI Inferred from Physical Interaction more info	PubMed
structural molecule activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
G2/M transition of mitotic cell cycle	TAS Traceable Author Statement more info
cell division	IEA Inferred from Electronic Annotation more info
establishment of mitotic spindle orientation	IEA Inferred from Electronic Annotation more info
lung epithelial cell differentiation	IEA Inferred from Electronic Annotation more info
mitotic anaphase	TAS Traceable Author Statement more info	PubMed
mitotic cell cycle	TAS Traceable Author Statement more info
nucleus organization	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
apical part of cell	IEA Inferred from Electronic Annotation more info
chromosome	IEA Inferred from Electronic Annotation more info
cytoplasm	IDA Inferred from Direct Assay more info
cytosol	TAS Traceable Author Statement more info
nuclear matrix	IEA Inferred from Electronic Annotation more info
NOT nucleolus	IDA Inferred from Direct Assay more info
nucleoplasm	TAS Traceable Author Statement more info
nucleus	IDA Inferred from Direct Assay more info
spindle	TAS Traceable Author Statement more info	PubMed
spindle microtubule	TAS Traceable Author Statement more info	PubMed
spindle pole	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: nuclear mitotic apparatus protein 1

Names: nuclear mitotic apparatus protein 1; SP-H antigen; structural nuclear protein; centrophilin stabilizes mitotic spindle in mitotic cells

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_006185.2 → NP_006176.2 nuclear mitotic apparatus protein 1

Status: VALIDATED

Source sequence(s)

AB210007, AP002490, BC027493, BG771637

Consensus CDS

CCDS31633.1

UniProtKB/Swiss-Prot

Q14980

UniProtKB/TrEMBL

Q3SYK8

UniProtKB/TrEMBL

Q4LE64

Related

ENSP00000377298, OTTHUMP00000236571, ENST00000393695, OTTHUMT00000395769

Conserved Domains (2) summary

TIGR02168
Location:684 – 937
Blast Score: 154

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

PHA03307
Location:1746 – 1899
Blast Score: 99

PHA03307; transcriptional regulator ICP4; Provisional

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p10 Primary Assembly

Genomic

NC_000011.9 Reference GRCh37.p10 Primary Assembly

Range

71713911..71791573, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000143.1 Alternate HuRef

Range

68007666..68085181, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.0

Genomic

NC_018922.1 Alternate CHM1_1.0

Range

71577861..71655521, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	ABBA01017542.1 (56974..65213)	None
genomic	ABBA01017543.1	None
genomic	ABBA01017544.1	None
genomic	AF012302.1	AAC33408.1
genomic	AF110460.1	AAD16994.1
genomic	AMYH01003790.1 (171243..224912)	None
genomic	AMYH01003791.1	None
genomic	AP002490.4 (92088..169750)	None
genomic	CH471076.1	EAW74821.1
		EAW74822.1
		EAW74823.1
		EAW74824.1
		EAW74825.1
		EAW74826.1
		EAW74827.1
		EAW74828.1
		EAW74829.1
		EAW74830.1
		EAW74831.1
mRNA	AB208841.1	BAD92078.1
mRNA	AB210007.1	BAE06089.1
mRNA	AB621824.1	BAK64159.1
mRNA	AK290509.1	BAF83198.1
mRNA	AK307577.1	None
mRNA	AK309041.1	None
mRNA	BC004165.2	AAH04165.1
mRNA	BC008345.1	AAH08345.1
mRNA	BC013023.2	AAH13023.1
mRNA	BC027493.1	AAH27493.1
mRNA	BC032228.1	None
mRNA	BC036808.1	None
mRNA	BC043499.1	AAH43499.1
mRNA	BC068539.1	None
mRNA	BC103765.1	AAI03766.1
mRNA	BG771637.1	None
mRNA	Z11583.1	CAA77669.1
mRNA	Z11584.1	CAA77670.1
mRNA	Z14227.1	None
mRNA	Z14228.1	None
mRNA	Z14229.1	None