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NUMA1 nuclear mitotic apparatus protein 1 [ Homo sapiens (human) ]

Gene ID: 4926, updated on 22-Nov-2014
Official Symbol
NUMA1provided by HGNC
Official Full Name
nuclear mitotic apparatus protein 1provided by HGNC
Primary source
HGNC:HGNC:8059
See related
Ensembl:ENSG00000137497; HPRD:01236; MIM:164009; Vega:OTTHUMG00000167697
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NUMA; NMP-22
Summary
This gene encodes a large protein that forms a structural component of the nuclear matrix. The encoded protein interacts with microtubules and plays a role in the formation and organization of the mitotic spindle during cell division. Chromosomal translocation of this gene with the RARA (retinoic acid receptor, alpha) gene on chromosome 17 have been detected in patients with acute promyelocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2013]
See NUMA1 in Epigenomics, MapViewer
Location:
11q13
Exon count:
36
Annotation release Status Assembly Chr Location
106 current GRCh38 (GCF_000001405.26) 11 NC_000011.10 (72002864..72080693, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (71713910..71791732, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene transient receptor potential cation channel, subfamily C, member 2-like Neighboring gene olfactory receptor, family 7, subfamily E, member 126 pseudogene Neighboring gene ring finger protein 121 Neighboring gene uncharacterized LOC100128494 Neighboring gene interleukin 18 binding protein Neighboring gene microRNA 3165 Neighboring gene leucine rich transmembrane and O-methyltransferase domain containing Neighboring gene late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 Neighboring gene anaphase promoting complex subunit 15

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Tat tat Interaction of HIV-1 Tat with NUMA1 in T-cells is identified by a proteomic strategy based on affinity chromatography PubMed
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human nuclear mitotic apparatus protein 1 (NUMA1) at amino acid residues 2054-2055 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
microtubule binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural molecule activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
establishment of mitotic spindle orientation IEA
Inferred from Electronic Annotation
more info
 
lung epithelial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
mitotic cell cycle TAS
Traceable Author Statement
more info
 
mitotic nuclear division IEA
Inferred from Electronic Annotation
more info
 
nucleus organization TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
apical part of cell IEA
Inferred from Electronic Annotation
more info
 
chromosome IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
dendrite IEA
Inferred from Electronic Annotation
more info
 
extracellular vesicular exosome IDA
Inferred from Direct Assay
more info
PubMed 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
nuclear matrix IEA
Inferred from Electronic Annotation
more info
 
NOT nucleolus IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
spindle TAS
Traceable Author Statement
more info
PubMed 
spindle microtubule IDA
Inferred from Direct Assay
more info
PubMed 
spindle pole IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
nuclear mitotic apparatus protein 1
Names
nuclear mitotic apparatus protein 1
SP-H antigen
nuclear matrix protein-22
structural nuclear protein
centrophilin stabilizes mitotic spindle in mitotic cells

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286561.1NP_001273490.1  nuclear mitotic apparatus protein 1 isoform 2

    See proteins identical to NP_001273490.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AB210007, BC004165, BG754891, BG771637, Z11583, Z11584
    Consensus CDS
    CCDS66156.1
    UniProtKB/TrEMBL
    A0A024R5M9
    UniProtKB/Swiss-Prot
    Q14980
    UniProtKB/TrEMBL
    Q4LE64
    Related
    ENSP00000351851, OTTHUMP00000236522, ENST00000358965, OTTHUMT00000395695
    Conserved Domains (2) summary
    pfam01576
    Location:145986
    Myosin_tail_1; Myosin tail
    cl19113
    Location:564709
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
  2. NM_006185.3NP_006176.2  nuclear mitotic apparatus protein 1 isoform 1

    See proteins identical to NP_006176.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB210007, BC004165, BC027493, BG754891, BG771637
    Consensus CDS
    CCDS31633.1
    UniProtKB/Swiss-Prot
    Q14980
    UniProtKB/TrEMBL
    Q3SYK8
    UniProtKB/TrEMBL
    Q4LE64
    Related
    ENSP00000377298, OTTHUMP00000236571, ENST00000393695, OTTHUMT00000395769
    Conserved Domains (2) summary
    pfam01576
    Location:145986
    Myosin_tail_1; Myosin tail
    cl19113
    Location:564709
    ApoLp-III_like; Apolipophorin-III and similar insect proteins

RNA

  1. NR_104476.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' terminal exon and lacks two alternate internal exons, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the reading frame found in variant 1.
    Source sequence(s)
    BC004165, BC103765, BG754891

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Alternate HuRef

Genomic

  1. AC_000143.1 

    Range
    68007665..68085347
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000011.10 

    Range
    72002864..72080693
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006718570.1XP_006718633.1  

    See proteins identical to XP_006718633.1

    UniProtKB/TrEMBL
    A0A024R5M9
    Related
    ENSP00000478624, ENST00000620566
    Conserved Domains (2) summary
    pfam01576
    Location:145986
    Myosin_tail_1; Myosin tail
    cl19113
    Location:564709
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
  2. XM_006718563.1XP_006718626.1  

    See proteins identical to XP_006718626.1

    UniProtKB/Swiss-Prot
    Q14980
    Conserved Domains (2) summary
    pfam01576
    Location:145986
    Myosin_tail_1; Myosin tail
    cl19113
    Location:564709
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
  3. XM_006718566.1XP_006718629.1  

    See proteins identical to XP_006718629.1

    UniProtKB/Swiss-Prot
    Q14980
    Conserved Domains (2) summary
    pfam01576
    Location:145986
    Myosin_tail_1; Myosin tail
    cl19113
    Location:564709
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
  4. XM_006718562.1XP_006718625.1  

    See proteins identical to XP_006718625.1

    UniProtKB/Swiss-Prot
    Q14980
    Conserved Domains (2) summary
    pfam01576
    Location:145986
    Myosin_tail_1; Myosin tail
    cl19113
    Location:564709
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
  5. XM_006718567.1XP_006718630.1  

    See proteins identical to XP_006718630.1

    UniProtKB/Swiss-Prot
    Q14980
    Conserved Domains (2) summary
    pfam01576
    Location:145986
    Myosin_tail_1; Myosin tail
    cl19113
    Location:564709
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
  6. XM_006718564.1XP_006718627.1  

    See proteins identical to XP_006718627.1

    UniProtKB/Swiss-Prot
    Q14980
    Conserved Domains (2) summary
    pfam01576
    Location:145986
    Myosin_tail_1; Myosin tail
    cl19113
    Location:564709
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
  7. XM_006718569.1XP_006718632.1  

    See proteins identical to XP_006718632.1

    UniProtKB/Swiss-Prot
    Q14980
    Conserved Domains (2) summary
    pfam01576
    Location:145986
    Myosin_tail_1; Myosin tail
    cl19113
    Location:564709
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
  8. XM_006718565.1XP_006718628.1  

    See proteins identical to XP_006718628.1

    UniProtKB/Swiss-Prot
    Q14980
    Conserved Domains (2) summary
    pfam01576
    Location:145986
    Myosin_tail_1; Myosin tail
    cl19113
    Location:564709
    ApoLp-III_like; Apolipophorin-III and similar insect proteins
  9. XM_006718568.1XP_006718631.1  

    See proteins identical to XP_006718631.1

    UniProtKB/Swiss-Prot
    Q14980
    Conserved Domains (2) summary
    pfam01576
    Location:145986
    Myosin_tail_1; Myosin tail
    cl19113
    Location:564709
    ApoLp-III_like; Apolipophorin-III and similar insect proteins

Alternate CHM1_1.1

Genomic

  1. NC_018922.2 

    Range
    71597789..71675562
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)