NTRK1 neurotrophic tyrosine kinase, receptor, type 1 [Homo sapiens] - Gene

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Summary

Official Symbol: NTRK1provided by HGNC
Official Full Name: neurotrophic tyrosine kinase, receptor, type 1provided by HGNC
Primary source: HGNC:8031
See related: Ensembl:ENSG00000198400; HPRD:01869; MIM:191315; Vega:OTTHUMG00000041304
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MTC; TRK; TRK1; TRKA; Trk-A; p140-TrkA; DKFZp781I14186
Summary: This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 1q21-q22

Sequence :: Chromosome: 1; NC_000001.10 (156785542..156851642)

See NTRK1 in Epigenomics, MapViewer

Chromosome 1 - NC_000001.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Dermal fibroblasts and myofibroblasts synthesize and secrete all neurotrophins (NTs)and express high-affinity NT receptors TrkA, TrkB, and TrkC.
Title: Role of neurotrophins on dermal fibroblast survival and differentiation.
NGF receptors are localized in the mitochondrial compartment of undifferentiated human podocytes and in all tissues analyzed including rat central nervous system.
Title: Localization of nerve growth factor (NGF) receptors in the mitochondrial compartment: characterization and putative role.
The expressions of both NGF and TrkA in bronchiolar epithelial cells were significantly increased in chronic obstructive pulmonary disease patients.
Title: [A study on expressions of nerve growth factor and its receptor tyrosine kinase receptor A in lung bronchiolar epithelial cells of chronic obstructive pulmonary disease patients].
the existence of an autocrine loop stimulated by proNGF and mediated by TrkA and sortilin, with the activation of Akt and Src, for the stimulation of breast cancer cell invasion.
Title: Pro-nerve growth factor induces autocrine stimulation of breast cancer cell invasion through tropomyosin-related kinase A (TrkA) and sortilin protein.
TrkA moderately down-regulates expression of the beta-secretase beta-site amyloid beta precursor protein cleaving enzyme-1 and upregulates the expression of two enzymes with alpha-secretase activity.
Title: Matrix metalloproteinase-9 participates in NGF-induced α-secretase cleavage of amyloid-β protein precursor in PC12 cells.
The nerve growth factor/TrkA signaling pathway is involved in Alzheimer's disease pathogenesis and can be used as a therapeutic target.
Title: APP is phosphorylated by TrkA and regulates NGF/TrkA signaling.
Reduced neurotrophin receptor tropomyosin-related kinase A expression in human granulosa cells is associated with diminishing ovarian reserve.
Title: Reduced neurotrophin receptor tropomyosin-related kinase A expression in human granulosa cells: a novel marker of diminishing ovarian reserve.
Remarkably, although in five of the groups a higher frequency of the TRKA schizophrenia risk allele was indeed found in the patients compared with the controls, in the three other groups the SNP acted as a protective factor
Title: Dual association of a TRKA polymorphism with schizophrenia.
levonorgestrel-releasing intrauterine system significantly reduced the expression of the NGF receptor, TrkA, in the endometrium and myometrium of patients with adenomyosis.
Title: Effects of LNG-IUS on nerve growth factor and its receptors expression in patients with adenomyosis.
Data suggest that the effects of necdin deletion on the developing nervous system may depend on the relative expression of p75NTR and TrkA in the cells of particular regions of the nervous system.
Title: Necdin and neurotrophin receptors: interactors of relevance for neuronal resistance to oxidant stress.

Submit: New GeneRIF Correction See all (111)

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Phenotypes

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Insensitivity to pain, congenital, with anhidrosis

MIM: 256800

Hereditary sensory and autonomic neuropathy type IV (HSAN IV) is characterized by congenital profound sensory loss affecting perception of pain and temperature, and absence of sweating. Secondary consequences of reduced pain perception include: oral self-mutilation (biting of tongue, lips, and buccal mucosa); fingertip biting; repeated bone fractures and joint trauma. Anhidrosis results in poor thermoregulation in hot environmental conditions and can cause recurrent febrile episodes. Although developmental milestones are usually normal to only mildly delayed, learning problems can be severe. Hyperactivity and emotional lability are common.

Diagnosis Testing

Axon flare after intradermal histamine phosphate injection is absent, a finding in all HSAN types that is not specific to HSAN IV. Mutations in NTRK1 (TRKA), the only gene known to be associated with HSAN IV, are identified by sequence analysis in almost all individuals meeting HSAN IV diagnostic criteria.

Genetic Counseling

HSAN IV is inherited in an autosomal recessive manner. Uniparental disomy (UPD) has been reported. Each child of known carriers has a 25% chance of being affected, a 50% chance of being an asymptomatic carrier, and a 25% chance of being unaffected and not a carrier. Carrier testing for at-risk family members and prenatal testing for pregnancies at increased risk are possible once the disease-causing mutations have been identified in a family.

References

PMID: 20301726

Medullary thyroid carcinoma, familial

MIM: 155240

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Interactions

Products	Interactant	Other Gene	Source	Pubs	Description
AAA36770.1	NP_003020.2	SHC1	BIND	PubMed	Shc interacts with NGFR.
AAA36770.1	NP_892113.3	SHC1	BIND	PubMed	Shc interacts with Trk. This interaction was modelled on a demonstrated interaction between SHC from rat or mouse and Trk from human.
NP_002520.2	NP_006645.2	FRS2	BIND	PubMed	TrkA interacts with FRS2-alpha. This interaction was modelled on a demonstrated interaction between human TrkA and mouse FRS2-alpha.
NP_002520.2	NP_006644.1	FRS3	BIND	PubMed	TrkA interacts with FRS2-beta.
NP_002520.2	NP_005707.1	GIPC1	BIND	PubMed	GIPC interacts with TRKA. This interaction was modelled on a demonstrated interaction between mouse GIPC and rat TrkA.
NP_002520.2	NP_002497.1	NGF	BIND	PubMed	NGF interacts with TrkA. This interaction was modeled on a demonstrated interaction between NGF from human and TrkA from an unspecified species.
NP_002520.2	NP_002497.1	NGF	BIND	PubMed	Interaction between TrkA (PDB ID: 1WWW_X) and NGF (PDB ID: 1WWW_W).
NP_002520.2	NP_002497.1	NGF	BIND	PubMed	Interaction between TrkA (PDB ID: 1WWW_X) and NGF (PDB ID: 1WWW_V).
NP_002520.2	NP_002497.1	NGF	BIND	PubMed	Interaction between TrkA (PDB ID: 1WWW_Y) and NGF (PDB ID: 1WWW_W).
NP_002520.2	NP_002497.1	NGF	BIND	PubMed	Interaction between TrkA (PDB ID: 1WWW_Y) and NGF (PDB ID: 1WWW_V).
NP_002520.2	NP_003020.2	SHC1	BIND	PubMed	ShcA interacts with TrkA.
P04629	P00519	ABL1	HPRD	PubMed
P04629	RICS	ARHGAP32	HPRD	PubMed
P04629	Q03135	CAV1	HPRD	PubMed
P04629	P46108	CRK	HPRD	PubMed
P04629	Q96EY1	DNAJA3	HPRD	PubMed
P04629	P63167	DYNLL1	HPRD	PubMed
P04629	Q8WU20	FRS2	HPRD	PubMed
P04629	O43559	FRS3	HPRD	PubMed
P04629	O14908	GIPC1	HPRD	PubMed
P04629	P62993	GRB2	HPRD	PubMed
P04629	P35568	IRS1	HPRD	PubMed
P04629	Q9Y4H2	IRS2	HPRD	PubMed
P04629	KIDINS220	KIDINS220	HPRD	PubMed
P04629	P27361	MAPK3	HPRD	PubMed
P04629	P42679	MATK	HPRD	PubMed
P04629	Q96PU5	NEDD4L	HPRD	PubMed
P04629	P01138	NGF	HPRD	PubMed
P04629	P08138	NGFR	HPRD	PubMed
P04629	P04629	NTRK1	HPRD	PubMed
P04629	P27986	PIK3R1	HPRD	PubMed
P04629	P19174	PLCG1	HPRD	PubMed
P04629	P18031	PTPN1	HPRD	PubMed
P04629	Q06124	PTPN11	HPRD	PubMed
P04629	P62834	RAP1A	HPRD	PubMed
P04629	P20936	RASA1	HPRD	PubMed
P04629	Q13972	RASGRF1	HPRD	PubMed
P04629	Q9BVN2	RUSC1	HPRD	PubMed
P04629	SH2 B homolog	SH2B1	HPRD	PubMed
P04629	O14492	SH2B2	HPRD	PubMed
P04629	P29353	SHC1	HPRD	PubMed
P04629	SHC (Src homology 2 domain containing) transforming protein 2	SHC2	HPRD	PubMed
P04629	Q92529	SHC3	HPRD	PubMed
P04629	Q13501	SQSTM1	HPRD	PubMed
P04629	Ubiquitin B	UBB	HPRD	PubMed
BioGRID:110969	BioGRID:106543	ABL1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:110969	BioGRID:115091	ARHGAP32	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:110969	BioGRID:107305	CAV1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110969	BioGRID:107315	CBL	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110969	BioGRID:116312	CDC37	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110969	BioGRID:116031	FRS2	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:110969	BioGRID:115978	GIPC1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110969	BioGRID:109142	GRB2	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex
BioGRID:110969	BioGRID:109552	HSP90AA1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110969	BioGRID:109540	HSPA4	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110969	BioGRID:110315	MATK	BioGRID	PubMed	Affinity Capture-Western; Far Western
BioGRID:110969	BioGRID:110698	MYCN	BioGRID	PubMed	Affinity Capture-RNA
BioGRID:110969	BioGRID:110811	NEDD4	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity; Reconstituted Complex
BioGRID:110969	BioGRID:116915	NEDD4L	BioGRID	PubMed	Biochemical Activity
BioGRID:110969	BioGRID:110869	NGF	BioGRID	PubMed	Co-crystal Structure; Reconstituted Complex
BioGRID:110969	BioGRID:110963	NTF3	BioGRID	PubMed	Reconstituted Complex
BioGRID:110969	BioGRID:110969	NTRK1	BioGRID	PubMed	Co-crystal Structure
BioGRID:110969	BioGRID:114523	PIAS2	BioGRID	PubMed	Affinity Capture-RNA
BioGRID:110969	BioGRID:111351	PLCG1	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:110969	BioGRID:111736	PTPN1	BioGRID	PubMed	Protein-peptide
BioGRID:110969	BioGRID:111841	RAP1A	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110969	BioGRID:115576	RGS19	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110969	BioGRID:117455	SH2B1	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:110969	BioGRID:115850	SH2B2	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:110969	BioGRID:112361	SHC1	BioGRID	PubMed	Affinity Capture-Western; Reconstituted Complex; Two-hybrid
BioGRID:110969	BioGRID:119752	SHC3	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110969	BioGRID:112550	SP1	BioGRID	PubMed	Affinity Capture-RNA
BioGRID:110969	BioGRID:114397	SQSTM1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110969	BioGRID:113041	TRAF6	BioGRID	PubMed	Affinity Capture-Western; Biochemical Activity
BioGRID:110969	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-Western

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General gene information

Markers

GDB:593920 (e-PCR)
- UniSTS:157979

RH70890 (e-PCR)
- UniSTS:85791

D1S506 (e-PCR)
- UniSTS:54122

PMC86471P1 (e-PCR)
- UniSTS:273529

D1S506 (e-PCR)
- UniSTS:88479

Genotypes

See NTRK1 SNP Geneview Report
See NTRK1 SNP Genotype Report
See NTRK1 SNP Variation Viewer Report

Homology

Homologs of the NTRK1 gene: The NTRK1 gene is conserved in chimpanzee, , dog, cow, mouse, rat, chicken, and zebrafish.
Map Viewer (Mouse, Rat)

Pathways from BioSystems

ARMS-mediated activation, organism-specific biosystem (from REACTOME)
ARMS-mediated activation, organism-specific biosystemARMS (Ankyrin-Rich Membrane Spanning/Kidins 220) is a 220kD tetraspanning adaptor protein which becomes rapidly tyrosine phosphorylated by active Trk receptors. ARMS is another adaptor protein which ...
Activation of TRKA receptors, organism-specific biosystem (from REACTOME)
Activation of TRKA receptors, organism-specific biosystemTrk receptors can either be activated by neurotrophins or by two G-protein-coupled receptors (GPCRs) although the biological relevance of GPCRs remains to be shown.
Apoptosis, organism-specific biosystem (from KEGG)
Apoptosis, organism-specific biosystemApoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily me...
Apoptosis, conserved biosystem (from KEGG)
Apoptosis, conserved biosystemApoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily me...
Endocytosis, organism-specific biosystem (from KEGG)
Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
Endocytosis, conserved biosystem (from KEGG)
Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
Frs2-mediated activation, organism-specific biosystem (from REACTOME)
Frs2-mediated activation, organism-specific biosystemThe adaptor protein Frs2 (Fibroblast growth factor receptor substrate 2) can mediate the prolonged activation of the MAPK (ERK) cascade.
MAPK signaling pathway, organism-specific biosystem (from WikiPathways)
MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
MAPK signaling pathway, organism-specific biosystem (from KEGG)
MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
MAPK signaling pathway, conserved biosystem (from KEGG)
MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
NGF signalling via TRKA from the plasma membrane, organism-specific biosystem (from REACTOME)
NGF signalling via TRKA from the plasma membrane, organism-specific biosystemTrk receptors signal from the plasma membrane and from intracellular membranes, particularly from early endosomes. Signalling from the plasma membrane is fast but transient; signalling from endosomes...
NGF-independant TRKA activation, organism-specific biosystem (from REACTOME)
NGF-independant TRKA activation, organism-specific biosystemTRK receptors can also be activated by at least two G-protein-coupled receptors (GPCR), the adenosine A2a receptor and the PACAP type I receptor, without involvement of neurotrophins. Activity of bo...
Neurotrophic factor-mediated Trk receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
Neurotrophic factor-mediated Trk receptor signaling, organism-specific biosystem
Neurotrophic factor-mediated Trk receptor signaling
Neurotrophin signaling pathway, organism-specific biosystem (from KEGG)
Neurotrophin signaling pathway, organism-specific biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
Neurotrophin signaling pathway, conserved biosystem (from KEGG)
Neurotrophin signaling pathway, conserved biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
PI3K/AKT activation, organism-specific biosystem (from REACTOME)
PI3K/AKT activation, organism-specific biosystemPI3K/AKT signalling is a major regulator of neuron survival. It blocks cell death by both impinging on the cytoplasmic cell death machinery and by regulating the expression of genes involved in cell...
PLC-gamma1 signalling, organism-specific biosystem (from REACTOME)
PLC-gamma1 signalling, organism-specific biosystemThe activation of phosphlipase C-gamma (PLC-gamma) and subsequent mobilization of calcium from intracellular stores are essential for neurotrophin secretion. PLC-gamma is activated through the phosph...
Pathways in cancer, organism-specific biosystem (from KEGG)
Pathways in cancer, organism-specific biosystem
Pathways in cancer
Prolonged ERK activation events, organism-specific biosystem (from REACTOME)
Prolonged ERK activation events, organism-specific biosystemAfter NGF binding, activated Trk receptors provide multiple docking sites for adaptor proteins and enzymes. Two docking proteins, the Ankyrin-Rich Membrane Spanning protein (ARMS/Kidins220) and Fibro...
Retrograde neurotrophin signalling, organism-specific biosystem (from REACTOME)
Retrograde neurotrophin signalling, organism-specific biosystemNeurotrophin-TRK complexes can be internalized and enter signalling vesicles, which travel retrogradely over long distances from distal nerve terminals to neuronal cell bodies. Such retrograde signal...
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
Signalling by NGF, organism-specific biosystem (from REACTOME)
Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
Signalling to ERKs, organism-specific biosystem (from REACTOME)
Signalling to ERKs, organism-specific biosystemNeurotrophins utilize multiple pathways to activate ERKs (ERK1 and ERK2), a subgroup of the large MAP kinase (MAPK) family, from the plasma membrane. The major signalling pathways to ERKs are via RAS...
Signalling to RAS, organism-specific biosystem (from REACTOME)
Signalling to RAS, organism-specific biosystemSignalling through Shc adaptor proteins appears to be identical for both NGF and EGF. It leads to a fast, but transient, MAPK/ERK activation, which is insufficient to explain the prolonged activation...
Signalling to STAT3, organism-specific biosystem (from REACTOME)
Signalling to STAT3, organism-specific biosystemNeurotrophin-induced increase in Signal transducer and activator of transcription 3 (STAT3; acute-phase response factor) activation appears to underly several downstream functions of neurotrophin sig...
Signalling to p38 via RIT and RIN, organism-specific biosystem (from REACTOME)
Signalling to p38 via RIT and RIN, organism-specific biosystemRIT and RIN are two small guanine nucleotide binding proteins that share more than 50% sequence identity with RAS, including highly conserved core effector domains. Unlike RAS, the C termini of RIT a...
TRKA activation by NGF, organism-specific biosystem (from REACTOME)
TRKA activation by NGF, organism-specific biosystemNeurotrophin functions are mediated by binding of the secreted neurotrophin homodimers to their common neurotrophin receptor p75NTR, and to their cognate tropomyosin related kinase (TRK) receptor. N...
Thyroid cancer, organism-specific biosystem (from KEGG)
Thyroid cancer, organism-specific biosystemThyroid cancer is the most common endocrine malignancy and accounts for the majority of endocrine cancer- related deaths each year. More than 95% of thyroid carcinomas are derived from follicular cel...
Thyroid cancer, conserved biosystem (from KEGG)
Thyroid cancer, conserved biosystemThyroid cancer is the most common endocrine malignancy and accounts for the majority of endocrine cancer- related deaths each year. More than 95% of thyroid carcinomas are derived from follicular cel...
Transcriptional misregulation in cancer, organism-specific biosystem (from KEGG)
Transcriptional misregulation in cancer, organism-specific biosystem
Transcriptional misregulation in cancer
Transcriptional misregulation in cancer, conserved biosystem (from KEGG)
Transcriptional misregulation in cancer, conserved biosystem
Transcriptional misregulation in cancer

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
nerve growth factor binding	IDA Inferred from Direct Assay more info	PubMed
NOT nerve growth factor binding	IDA Inferred from Direct Assay more info	PubMed
nerve growth factor receptor activity	IDA Inferred from Direct Assay more info	PubMed
neurotrophin binding	TAS Traceable Author Statement more info	PubMed
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
receptor activity	IEA Inferred from Electronic Annotation more info
transmembrane receptor protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
Ras protein signal transduction	TAS Traceable Author Statement more info
activation of MAPKK activity	TAS Traceable Author Statement more info
activation of adenylate cyclase activity	TAS Traceable Author Statement more info
activation of phospholipase C activity	TAS Traceable Author Statement more info
axonogenesis involved in innervation	ISS Inferred from Sequence or Structural Similarity more info
cell differentiation	IEA Inferred from Electronic Annotation more info
developmental programmed cell death	ISS Inferred from Sequence or Structural Similarity more info
multicellular organismal development	IEA Inferred from Electronic Annotation more info
negative regulation of cell proliferation	IDA Inferred from Direct Assay more info	PubMed
NOT negative regulation of cell proliferation	IDA Inferred from Direct Assay more info	PubMed
negative regulation of neuron apoptosis	ISS Inferred from Sequence or Structural Similarity more info
nerve growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
nerve growth factor receptor signaling pathway	TAS Traceable Author Statement more info
nervous system development	IEA Inferred from Electronic Annotation more info
phosphatidylinositol-mediated signaling	TAS Traceable Author Statement more info
positive regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
NOT positive regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
positive regulation of NF-kappaB transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
positive regulation of Ras GTPase activity	IDA Inferred from Direct Assay more info	PubMed
NOT positive regulation of Ras GTPase activity	IDA Inferred from Direct Assay more info	PubMed
positive regulation of Ras protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
NOT positive regulation of Ras protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
positive regulation of angiogenesis	IDA Inferred from Direct Assay more info	PubMed
positive regulation of neuron projection development	IDA Inferred from Direct Assay more info	PubMed
NOT positive regulation of neuron projection development	IDA Inferred from Direct Assay more info	PubMed
positive regulation of programmed cell death	ISS Inferred from Sequence or Structural Similarity more info
protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
small GTPase mediated signal transduction	TAS Traceable Author Statement more info
sympathetic nervous system development	ISS Inferred from Sequence or Structural Similarity more info
transmembrane receptor protein tyrosine kinase signaling pathway	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
early endosome membrane	IEA Inferred from Electronic Annotation more info
endosome	TAS Traceable Author Statement more info
integral to plasma membrane	IDA Inferred from Direct Assay more info	PubMed
plasma membrane	TAS Traceable Author Statement more info

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General protein information

Preferred Names: high affinity nerve growth factor receptor

Names: high affinity nerve growth factor receptor; gp140trk; Oncogene TRK; tyrosine kinase receptor A; tropomyosin-related kinase A; TRK1-transforming tyrosine kinase protein

NP_001007793.1

EC 2.7.10.1

NP_001012331.1

EC 2.7.10.1

NP_002520.2

EC 2.7.10.1

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_007493.1 RefSeqGene

Range

5001..71101

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001007792.1 → NP_001007793.1 high affinity nerve growth factor receptor isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) utilizes alternate 5' exons and lacks an internal in-frame exon, compared to variant 2. Translation initiation occurs at an upstream AUG, resulting in a shorter isoform (3) with a unique N-terminus compared to isoform 2.

Source sequence(s)

AL158169, BC062580

Consensus CDS

CCDS30890.1

UniProtKB/TrEMBL

A6NF12

UniProtKB/Swiss-Prot

P04629

Related

ENSP00000376120, OTTHUMP00000234666, ENST00000392302, OTTHUMT00000392277

Conserved Domains (7) summary

cd04971
Location:269 – 349
Blast Score: 374

Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

cd04972
Location:165 – 252
Blast Score: 261

Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

cd05092
Location:468 – 747
Blast Score: 1484

PTKc_TrkA; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase A

pfam07679
Location:168 – 252
Blast Score: 100

I-set; Immunoglobulin I-set domain

smart00082
Location:118 – 160
Blast Score: 102

LRRCT; Leucine rich repeat C-terminal domain

pfam07714
Location:474 – 745
Blast Score: 960

Pkinase_Tyr; Protein tyrosine kinase

pfam13855
Location:68 – 120
Blast Score: 126

LRR_8; Leucine rich repeat
NM_001012331.1 → NP_001012331.1 high affinity nerve growth factor receptor isoform 1 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (1) lacks an internal, in-frame exon, compared to variant 2, resulting in a shorter isoform (1) lacking an internal segment compared to isoform 2.

Source sequence(s)

BC062580, BM685020, M23102

Consensus CDS

CCDS30891.1

UniProtKB/Swiss-Prot

P04629

Related

ENSP00000357179, OTTHUMP00000038736, ENST00000368196, OTTHUMT00000098979

Conserved Domains (7) summary

cd04971
Location:299 – 379
Blast Score: 372

Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

cd04972
Location:195 – 282
Blast Score: 263

Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

cd05092
Location:498 – 777
Blast Score: 1479

PTKc_TrkA; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase A

pfam07679
Location:198 – 282
Blast Score: 101

I-set; Immunoglobulin I-set domain

smart00082
Location:148 – 190
Blast Score: 103

LRRCT; Leucine rich repeat C-terminal domain

pfam07714
Location:504 – 775
Blast Score: 959

Pkinase_Tyr; Protein tyrosine kinase

pfam13855
Location:98 – 150
Blast Score: 124

LRR_8; Leucine rich repeat
NM_002529.3 → NP_002520.2 high affinity nerve growth factor receptor isoform 2 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (2).

Source sequence(s)

BC062580, M23102, X06704

Consensus CDS

CCDS1161.1

UniProtKB/Swiss-Prot

P04629

Related

ENSP00000431418, OTTHUMP00000234668, ENST00000524377, OTTHUMT00000392279

Conserved Domains (7) summary

cd04971
Location:299 – 379
Blast Score: 372

Ig_TrKABC_d5; Fifth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

cd04972
Location:195 – 282
Blast Score: 263

Ig_TrkABC_d4; Fourth domain (immunoglobulin-like) of Trk receptors TrkA, TrkB and TrkC

cd05092
Location:504 – 783
Blast Score: 1480

PTKc_TrkA; Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase A

pfam07679
Location:198 – 282
Blast Score: 101

I-set; Immunoglobulin I-set domain

smart00082
Location:148 – 190
Blast Score: 103

LRRCT; Leucine rich repeat C-terminal domain

pfam07714
Location:510 – 781
Blast Score: 960

Pkinase_Tyr; Protein tyrosine kinase

pfam13855
Location:98 – 150
Blast Score: 125

LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000001.10 Reference GRCh37.p5 Primary Assembly

Range

156785542..156851642

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000133.1 Alternate HuRef

Range

128143945..128209968

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AB019488.2	BAA34355.1
genomic	AL158169.17	CAH70010.1
genomic	AY321513.1	AAP88292.1
genomic	CH471121.2	EAW52900.1
		EAW52901.1
		EAW52902.1
genomic	Y09028.1	None
genomic	Y09029.1	None
genomic	Y09030.1	None
genomic	Y09031.1	None
genomic	Y09032.1	None
genomic	Y09033.1	None
genomic	Y09034.1	None
genomic	Y09035.1	None
genomic	Y09036.1	None
mRNA	AK126428.1	None
mRNA	AK290759.1	BAF83448.1
mRNA	AK312704.1	BAG35582.1
mRNA	BC062580.1	AAH62580.1
mRNA	BC136554.1	AAI36555.1
mRNA	BC144239.1	AAI44240.1
mRNA	BM685020.1	None
mRNA	CR936794.1	None
mRNA	M23102.1	AAA36770.1

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
P04629.4	GenPept	UniProtKB/Swiss-Prot:P04629
Q00182	GenPept	UniProtKB/TrEMBL:Q00182
Q04227	GenPept	UniProtKB/TrEMBL:Q04227