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    Src64B Src oncogene at 64B [ Drosophila melanogaster ]

    Gene ID: 48973, updated on 10-May-2012
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    Summary

    Official Symbol
    Src64Bprovided by Flybase
    Official Full Name
    Src oncogene at 64Bprovided by Flybase
    Primary source
    FLYBASE:FBgn0262733
    Locus tag
    Dmel_CG7524
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    c-src; C-src1; CG7524; D-src; Dm SRC1; Dmel\CG7524; DmHD-358; dsrc; dSrc; Dsrc; DSrc; Dsrc64; DSrc64; DSRC64; Dsrc64B; DSrc64B; HD-358; MRE5; src; Src; SRC 64B; src1; Src1; src64; Src64; src64b; src64B
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    Genomic context

    Location :
    64B11-64B12
    Sequence :
    Chromosome: 3L; NT_037436.3 (4592671..4626196, complement)
    See Src64B in Epigenomics, MapViewer

    Chromosome 3L - NT_037436.3Genomic Context describing neighboring genes Neighboring gene CG33777 gene product from transcript CG33777-RA Neighboring gene CG42540 gene product from transcript CG42540-RF Neighboring gene CG32246 gene product from transcript CG32246-RB Neighboring gene CG7471 gene product from transcript CG7471-RA Neighboring gene CG13716 gene product from transcript CG13716-RA Neighboring gene axotactin

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Mutations in the catalytic loop HRD motif alter the activity and function of Drosophila Src64. Strong TC, et al. PLoS One, 2011. PMID 22132220.
    2. Maternal and zygotic requirements for src64 during Drosophila cellularization. Strong TC, et al. Genesis, 2011 Dec. PMID 21735539.
    3. Mapping of signaling networks through synthetic genetic interaction analysis by RNAi. Horn T, et al. Nat Methods, 2011 Apr. PMID 21378980.
    4. Robust target gene discovery through transcriptome perturbations and genome-wide enhancer predictions in Drosophila uncovers a regulatory basis for sensory specification. Aerts S, et al. PLoS Biol, 2010 Jul 27. PMID 20668662.
    5. Activation of autophagy during cell death requires the engulfment receptor Draper. McPhee CK, et al. Nature, 2010 Jun 24. PMID 20577216.

    See all (109) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Mutations in a Drosophila src gene, src64, that alter the three HRD amino acids, were identified.
      Title: Mutations in the catalytic loop HRD motif alter the activity and function of Drosophila Src64.
    2. Maternal src64 regulates microfilament contraction throughout cellularization, but that zygotic src64 makes a small, but normally nonessential, contribution during late cellularization.
      Title: Maternal and zygotic requirements for src64 during Drosophila cellularization.
    3. Src64B overexpression induced the formation of specialized haemocytes (lamellocytes), but had no effect on circulating plasmatocyte concentration. Src64B overexpression induced F-actin formation and Jun kinase activation in plasmatocytes.
      Title: The c-src homologue Src64B is sufficient to activate the Drosophila cellular immune response.
    4. Src64B is required for tracheal development and to increase the rate of adherens junction turnover.
      Title: Dual function of Src in the maintenance of adherens junctions during tracheal epithelial morphogenesis.
    5. Study shows that in Drosophila epithelia in situ, levels of Src signaling determine the cellular outcome of Src activation; apoptotic cell death was triggered at high Src levels; lower levels directed antiapoptotic signals while promoting proliferation.
      Title: Differing Src signaling levels have distinct outcomes in Drosophila.
    6. Src, Jun N-terminal kinase, and STAT pathways are inhibited by Drosophila C-terminal Src kinase, which negatively regulates organ growth and cell proliferation
      Title: Drosophila C-terminal Src kinase negatively regulates organ growth and cell proliferation through inhibition of the Src, Jun N-terminal kinase, and STAT pathways.
    7. In the absence of its PH domain, Tec29 constitutively localizes to ring canals, but still requires Src64 for full activation
      Title: Localization of Tec29 to ring canals is mediated by Src64 and PtdIns(3,4,5)P3-dependent mechanisms.
    8. Results demonstrate that regulation of Src64 by Drosophila C-terminal-Src Kinase (Csk) contributes to the packaging of germline cysts by overlying somatic follicle cells during egg chamber formation.
      Title: Csk differentially regulates Src64 during distinct morphological events in Drosophila germ cells.
    9. Src64 acts in a cell-autonomous fashion and is likely to interact with the previously-identified linotte/derailed receptor tyrosine kinase in mushroom body development
      Title: Gain-of-function screen identifies a role of the Src64 oncogene in Drosophila mushroom body development.
    10. Src64 is involved in fusome development and karyosome formation during Drosophila oogenesis.
      Title: Src64 is involved in fusome development and karyosome formation during Drosophila oogenesis.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:71867 BioGRID:64531 ATPsyn-b    BioGRID  PubMed Two-hybrid 
    BioGRID:71867 BioGRID:60292 Akap200    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:71867 BioGRID:58653 Bap60    BioGRID  PubMed Two-hybrid 
    BioGRID:71867 BioGRID:60259 Btk29A    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:71867 BioGRID:64858 CG10133    BioGRID  PubMed Two-hybrid 
    BioGRID:71867 BioGRID:62372 CG10139    BioGRID  PubMed Two-hybrid 
    BioGRID:71867 BioGRID:57762 CG12496    BioGRID  PubMed Two-hybrid 
    BioGRID:71867 BioGRID:65108 CG13041    BioGRID  PubMed Two-hybrid 
    BioGRID:71867 BioGRID:61837 CG1698    BioGRID  PubMed Two-hybrid 
    BioGRID:71867 BioGRID:61638 CG18316    BioGRID  PubMed Two-hybrid 
    BioGRID:71867 BioGRID:68465 CG2218    BioGRID  PubMed Two-hybrid 
    BioGRID:71867 BioGRID:68397 CG31036    BioGRID  PubMed Two-hybrid 
    BioGRID:71867 BioGRID:64135 CG32406    BioGRID  PubMed Two-hybrid 
    BioGRID:71867 BioGRID:566861 CG33993    BioGRID  PubMed Two-hybrid 
    BioGRID:71867 BioGRID:61382 CG3651    BioGRID  PubMed Two-hybrid 
    BioGRID:71867 BioGRID:62199 CG3884    BioGRID  PubMed Two-hybrid 
    BioGRID:71867 BioGRID:62128 Cpr49Ae    BioGRID  PubMed Two-hybrid 
    BioGRID:71867 BioGRID:58143 Dok    BioGRID  PubMed Two-hybrid 
    BioGRID:71867 BioGRID:67692 EloA    BioGRID  PubMed Two-hybrid 
    BioGRID:71867 BioGRID:58668 IP3K2    BioGRID  PubMed Two-hybrid 
    BioGRID:71867 BioGRID:61725 Pgi    BioGRID  PubMed Two-hybrid 
    BioGRID:71867 BioGRID:59459 Pi3K21B    BioGRID  PubMed Two-hybrid 
    BioGRID:71867 BioGRID:66301 Ras85D    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:71867 BioGRID:59069 RhoGAPp190    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:71867 BioGRID:66481 RpL3    BioGRID  PubMed Two-hybrid 
    BioGRID:71867 BioGRID:61093 RpS26    BioGRID  PubMed Two-hybrid 
    BioGRID:71867 BioGRID:63945 Sc2    BioGRID  PubMed Two-hybrid 
    BioGRID:71867 BioGRID:62559 Sema-2a    BioGRID  PubMed Two-hybrid 
    BioGRID:71867 BioGRID:62156 Sin3A    BioGRID  PubMed Two-hybrid 
    BioGRID:71867 BioGRID:61081 Socs36E    BioGRID  PubMed Two-hybrid 
    BioGRID:71867 BioGRID:67815 Spase22-23    BioGRID  PubMed Two-hybrid 
    BioGRID:71867 BioGRID:71867 Src64B    BioGRID  PubMed Two-hybrid 
    BioGRID:71867 BioGRID:57879 Tip60    BioGRID  PubMed Two-hybrid 
    BioGRID:71867 BioGRID:66917 Tm2    BioGRID  PubMed Two-hybrid 
    BioGRID:71867 BioGRID:62900 betaTub56D    BioGRID  PubMed Two-hybrid 
    BioGRID:71867 BioGRID:69557 csw    BioGRID  PubMed Phenotypic Enhancement; Phenotypic Suppression 
    BioGRID:71867 BioGRID:62256 drk    BioGRID  PubMed Phenotypic Suppression; Two-hybrid 
    BioGRID:71867 BioGRID:58076 dx    BioGRID  PubMed Two-hybrid 
    BioGRID:71867 BioGRID:59233 kek5    BioGRID  PubMed Two-hybrid 
    BioGRID:71867 BioGRID:59888 mRpL24    BioGRID  PubMed Two-hybrid 
    BioGRID:71867 BioGRID:58878 mRpS30    BioGRID  PubMed Two-hybrid 
    BioGRID:71867 BioGRID:72097 mod(mdg4)    BioGRID  PubMed Two-hybrid 
    BioGRID:71867 BioGRID:61516 pgant3    BioGRID  PubMed Two-hybrid 
    BioGRID:71867 BioGRID:63177 qkr58E-1    BioGRID  PubMed Two-hybrid 
    BioGRID:71867 BioGRID:65183 sina    BioGRID  PubMed Phenotypic Suppression 
    BioGRID:71867 BioGRID:65738 slif    BioGRID  PubMed Two-hybrid 
    BioGRID:71867 BioGRID:68007 tankyrase    BioGRID  PubMed Two-hybrid 
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    General gene information

    Markers

    Homology

    • Homologs of the Src64B gene: The Src64B gene is conserved in human, chimpanzee, , dog, cow, mouse, rat, chicken, zebrafish, and mosquito.
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    General protein information

    Preferred Names
    CG7524 gene product from transcript CG7524-RJ
    Names
    CG7524-PB
    CG7524-PC
    CG7524-PD
    CG7524-PE
    CG7524-PF
    CG7524-PG
    CG7524-PH
    CG7524-PI
    CG7524-PJ
    Src oncogene at 64B
    Src proto oncogene sequence
    Src64B-PB
    Src64B-PC
    Src64B-PD
    Src64B-PE
    Src64B-PF
    Src64B-PG
    Src64B-PH
    Src64B-PI
    Src64B-PJ
    mRNA-like ncRNA in embryogenesis 5
    NP_001014561.1
    NP_001014562.1
    NP_001014563.1
    NP_001014564.1
    NP_001189050.1
    NP_001189051.1
    NP_001246628.1
    NP_001246629.1
    NP_524934.2
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.3

      Range
      4592671..4626196, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259699.1 → NP_001246628.1  Src oncogene at 64B, isoform J [Drosophila melanogaster]

      Status: REVIEWED

    2. NM_001259700.1 → NP_001246629.1  Src oncogene at 64B, isoform I [Drosophila melanogaster]

      Status: REVIEWED

    3. NM_001014562.2 → NP_001014562.1  Src oncogene at 64B, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P00528
      Related
      FBpp0099944
      Conserved Domains (4) summary
      cd00174
      Location:102 – 153
      Blast Score: 162
      SH3; Src homology 3 domains; SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization of ...
      cd05034
      Location:277 – 539
      Blast Score: 1316
      PTKc_Src_like; Catalytic domain of Src kinase-like Protein Tyrosine Kinases
      cd09933
      Location:158 – 258
      Blast Score: 479
      SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases
      pfam07714
      Location:284 – 536
      Blast Score: 1005
      Pkinase_Tyr; Protein tyrosine kinase

    4. NM_001202121.1 → NP_001189050.1  Src oncogene at 64B, isoform G [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P00528
      Conserved Domains (4) summary
      cd00174
      Location:102 – 153
      Blast Score: 162
      SH3; Src homology 3 domains; SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization of ...
      cd05034
      Location:277 – 539
      Blast Score: 1316
      PTKc_Src_like; Catalytic domain of Src kinase-like Protein Tyrosine Kinases
      cd09933
      Location:158 – 258
      Blast Score: 479
      SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases
      pfam07714
      Location:284 – 536
      Blast Score: 1005
      Pkinase_Tyr; Protein tyrosine kinase

    5. NM_001014564.2 → NP_001014564.1  Src oncogene at 64B, isoform E [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P00528
      Related
      FBpp0099947
      Conserved Domains (4) summary
      cd00174
      Location:102 – 153
      Blast Score: 162
      SH3; Src homology 3 domains; SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization of ...
      cd05034
      Location:277 – 539
      Blast Score: 1316
      PTKc_Src_like; Catalytic domain of Src kinase-like Protein Tyrosine Kinases
      cd09933
      Location:158 – 258
      Blast Score: 479
      SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases
      pfam07714
      Location:284 – 536
      Blast Score: 1005
      Pkinase_Tyr; Protein tyrosine kinase

    6. NM_001014561.2 → NP_001014561.1  Src oncogene at 64B, isoform D [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P00528
      Related
      FBpp0099946
      Conserved Domains (4) summary
      cd00174
      Location:102 – 153
      Blast Score: 162
      SH3; Src homology 3 domains; SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization of ...
      cd05034
      Location:277 – 539
      Blast Score: 1316
      PTKc_Src_like; Catalytic domain of Src kinase-like Protein Tyrosine Kinases
      cd09933
      Location:158 – 258
      Blast Score: 479
      SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases
      pfam07714
      Location:284 – 536
      Blast Score: 1005
      Pkinase_Tyr; Protein tyrosine kinase

    7. NM_080195.3 → NP_524934.2  Src oncogene at 64B, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P00528
      Related
      FBpp0073177
      Conserved Domains (4) summary
      cd00174
      Location:102 – 153
      Blast Score: 162
      SH3; Src homology 3 domains; SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization of ...
      cd05034
      Location:277 – 539
      Blast Score: 1316
      PTKc_Src_like; Catalytic domain of Src kinase-like Protein Tyrosine Kinases
      cd09933
      Location:158 – 258
      Blast Score: 479
      SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases
      pfam07714
      Location:284 – 536
      Blast Score: 1005
      Pkinase_Tyr; Protein tyrosine kinase

    8. NM_001014563.2 → NP_001014563.1  Src oncogene at 64B, isoform F [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P00528
      Related
      FBpp0099948
      Conserved Domains (4) summary
      cd00174
      Location:102 – 153
      Blast Score: 162
      SH3; Src homology 3 domains; SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization of ...
      cd05034
      Location:277 – 539
      Blast Score: 1316
      PTKc_Src_like; Catalytic domain of Src kinase-like Protein Tyrosine Kinases
      cd09933
      Location:158 – 258
      Blast Score: 479
      SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases
      pfam07714
      Location:284 – 536
      Blast Score: 1005
      Pkinase_Tyr; Protein tyrosine kinase

    9. NM_001202122.1 → NP_001189051.1  Src oncogene at 64B, isoform H [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P00528
      Conserved Domains (4) summary
      cd00174
      Location:102 – 153
      Blast Score: 162
      SH3; Src homology 3 domains; SH3 domains bind to proline-rich ligands with moderate affinity and selectivity, preferentially to PxxP motifs; they play a role in the regulation of enzymes by intramolecular interactions, changing the subcellular localization of ...
      cd05034
      Location:277 – 539
      Blast Score: 1316
      PTKc_Src_like; Catalytic domain of Src kinase-like Protein Tyrosine Kinases
      cd09933
      Location:158 – 258
      Blast Score: 479
      SH2_Src_family; Src homology 2 (SH2) domain found in the Src family of non-receptor tyrosine kinases
      pfam07714
      Location:284 – 536
      Blast Score: 1005
      Pkinase_Tyr; Protein tyrosine kinase
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AE014296.4 AFH04299.1
    genomic AE014296.4 AFH04300.1
    genomic AE014296.4 AAF47922.1
    genomic AE014296.4 AAX52735.1
    genomic AE014296.4 AAX52734.1
    genomic AE014296.4 AAX52736.1
    genomic AE014296.4 ADV37487.1
    genomic AE014296.4 AAX52737.1
    mRNA AY051781.1 AAK93205.1
    genomic AE014296.4 ADV37488.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P00528.3 GenPept
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    Additional Links

    Gene LinkOut

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