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    NRCAM neuronal cell adhesion molecule [ Homo sapiens ]

    Gene ID: 4897, updated on 11-May-2012

    Summary

    Official Symbol
    NRCAMprovided by HGNC
    Official Full Name
    neuronal cell adhesion moleculeprovided by HGNC
    Primary source
    HGNC:7994
    See related
    Ensembl:ENSG00000091129; HPRD:07207; MIM:601581; Vega:OTTHUMG00000154973
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KIAA0343; MGC138845; MGC138846
    Summary
    Cell adhesion molecules (CAMs) are members of the immunoglobulin superfamily. This gene encodes a neuronal cell adhesion molecule with multiple immunoglobulin-like C2-type domains and fibronectin type-III domains. This ankyrin-binding protein is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. This gene is also expressed in non-neural tissues and may play a general role in cell-cell communication via signaling from its intracellular domain to the actin cytoskeleton during directional cell migration. Allelic variants of this gene have been associated with autism and addiction vulnerability. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

    Genomic context

    Location :
    7q31
    Sequence :
    Chromosome: 7; NC_000007.13 (107788071..108096841, complement)
    See NRCAM in Epigenomics, MapViewer

    Chromosome 7 - NC_000007.13Genomic Context describing neighboring genes Neighboring gene laminin, beta 1 Neighboring gene laminin, beta 4 Neighboring gene patatin-like phospholipase domain containing 8 Neighboring gene ribosomal protein L7 pseudogene 32 Neighboring gene THAP domain containing 5

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    Q92823 Q01484 ANK2    HPRD  PubMed  
    Q92823 Q02246 CNTN2    HPRD  PubMed  
    Q92823 Q96PK2 MACF1    HPRD  PubMed  
    Q92823 MAGI-3 MAGI3    HPRD  PubMed  
    Q92823 O94856 NFASC    HPRD  PubMed  
    Q92823 Q92823 NRCAM    HPRD  PubMed  
    Q92823 P23467 PTPRB    HPRD  PubMed  
    BioGRID:110953 BioGRID:112763 CNTN2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110953 BioGRID:129226 HSPA12A    BioGRID  PubMed Two-hybrid 
    BioGRID:110953 BioGRID:117048 MACF1    BioGRID  PubMed Two-hybrid 
    BioGRID:110953 BioGRID:129277 MAGI3    BioGRID  PubMed Two-hybrid 
    BioGRID:110953 BioGRID:111751 PTPRB    BioGRID  PubMed Reconstituted Complex 
    BioGRID:110953 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS 

    General gene information

    Markers

    Homology

    Pathways from BioSystems

    • Axon guidance, organism-specific biosystem (from REACTOME)
      Axon guidance, organism-specific biosystemAxon guidance / axon pathfinding is the process by which neurons send out axons to reach the correct targets. Growing axons have a highly motile structure at the growing tip called the growth cone, w...
    • Cell adhesion molecules (CAMs), organism-specific biosystem (from KEGG)
      Cell adhesion molecules (CAMs), organism-specific biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Cell adhesion molecules (CAMs), conserved biosystem (from KEGG)
      Cell adhesion molecules (CAMs), conserved biosystemCell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, em...
    • Developmental Biology, organism-specific biosystem (from REACTOME)
      Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
    • Interaction between L1 and Ankyrins, organism-specific biosystem (from REACTOME)
      Interaction between L1 and Ankyrins, organism-specific biosystemAnkyrins are a family of adaptor proteins that couple membrane proteins such as voltage gated Na+ channels and the Na+/K+ anion exchanger to the spectrin actin cytoskeleton. Ankyrins are encoded by t...
    • L1CAM interactions, organism-specific biosystem (from REACTOME)
      L1CAM interactions, organism-specific biosystemThe L1 family of cell adhesion molecules (L1CAMs) are a subfamily of the immunoglobulin superfamily of transmembrane receptors, comprised of four structurally related proteins: L1, Close Homolog of L...
    • Neurofascin interactions, organism-specific biosystem (from REACTOME)
      Neurofascin interactions, organism-specific biosystemNeurofascin is an L1 family immunoglobulin cell adhesion molecule involved in axon subcellular targeting and synapse formation during neural development. There are a range of different isoforms ident...
    • NrCAM interactions, organism-specific biosystem (from REACTOME)
      NrCAM interactions, organism-specific biosystemThe NgCAM-related cell adhesion molecule (NrCAM) is member of the L1 family involved in the eye development and node of Ranvier. Like all the other members of L1 family NrCAM also has the ability to...

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    ankyrin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    angiogenesis IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    axon guidance TAS
    Traceable Author Statement
    more info
     
    axonal fasciculation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    axonogenesis NAS
    Non-traceable Author Statement
    more info
    PubMed 
    cell-cell adhesion NAS
    Non-traceable Author Statement
    more info
    PubMed 
    central nervous system development NAS
    Non-traceable Author Statement
    more info
    PubMed 
    clustering of voltage-gated sodium channels IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron migration NAS
    Non-traceable Author Statement
    more info
    PubMed 
    positive regulation of neuron differentiation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    regulation of axon extension NAS
    Non-traceable Author Statement
    more info
    PubMed 
    synapse assembly TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    external side of plasma membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    integral to plasma membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    neuron projection NAS
    Non-traceable Author Statement
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    neuronal cell adhesion molecule
    Names
    neuronal cell adhesion molecule
    neuronal surface protein Bravo
    NgCAM-related cell adhesion molecule

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029898.1 RefSeqGene

      Range
      5001..313771
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001037132.2NP_001032209.1  neuronal cell adhesion molecule isoform A precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (A).
      Source sequence(s)
      AB002341, AJ001057, AK127035, BC114570, BU735065, BX538010, DA398450
      Consensus CDS
      CCDS47686.1
      UniProtKB/TrEMBL
      Q14CA1
      UniProtKB/Swiss-Prot
      Q92823
      Related
      ENSP00000401244, OTTHUMP00000207071, ENST00000425651, OTTHUMT00000337942
      Conserved Domains (9) summary
      cd00063
      Location:648737
      Blast Score: 168
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:472539
      Blast Score: 135
      Ig; Immunoglobulin domain
      cd05731
      Location:288358
      Blast Score: 299
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
      cd05868
      Location:375450
      Blast Score: 411
      Ig4_NrCAM; Fourth immunoglobulin (Ig)-like domain of NrCAM (NgCAM-related cell adhesion molecule)
      cd05874
      Location:64140
      Blast Score: 419
      Ig6_NrCAM; Sixth immunoglobulin (Ig)-like domain of NrCAM (Ng (neuronglia) CAM-related cell adhesion molecule)
      pfam07679
      Location:361449
      Blast Score: 172
      I-set; Immunoglobulin I-set domain
      pfam13882
      Location:11631282
      Blast Score: 496
      Bravo_FIGEY; C-terminal domain of Fibronectin type III
      cl00065
      Location:750832
      Blast Score: 114
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:145237
      Blast Score: 245
      Ig; Immunoglobulin domain
    2. NM_001193582.1NP_001180511.1  neuronal cell adhesion molecule isoform D precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and lacks two in-frame exons in the coding region, compared to variant 1. The encoded protein (isoform D) is shorter than isoform A.
      Source sequence(s)
      AK127035, AK299870, BU735065, BX538010, DA292156
      UniProtKB/TrEMBL
      B7Z670
      UniProtKB/Swiss-Prot
      Q92823
      Related
      ENSP00000446469, ENST00000537765
      Conserved Domains (9) summary
      cd00063
      Location:648737
      Blast Score: 169
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:472539
      Blast Score: 135
      Ig; Immunoglobulin domain
      cd05731
      Location:288358
      Blast Score: 299
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
      cd05868
      Location:375450
      Blast Score: 411
      Ig4_NrCAM; Fourth immunoglobulin (Ig)-like domain of NrCAM (NgCAM-related cell adhesion molecule)
      cd05874
      Location:64140
      Blast Score: 419
      Ig6_NrCAM; Sixth immunoglobulin (Ig)-like domain of NrCAM (Ng (neuronglia) CAM-related cell adhesion molecule)
      pfam07679
      Location:361449
      Blast Score: 172
      I-set; Immunoglobulin I-set domain
      pfam13882
      Location:10701189
      Blast Score: 496
      Bravo_FIGEY; C-terminal domain of Fibronectin type III
      cl00065
      Location:750832
      Blast Score: 114
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:145237
      Blast Score: 244
      Ig; Immunoglobulin domain
    3. NM_001193583.1NP_001180512.1  neuronal cell adhesion molecule isoform E precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and lacks three in-frame exons in the coding region, compared to variant 1. The encoded protein (isoform E) is shorter than isoform A.
      Source sequence(s)
      AK127035, BC115736, BU735065, BX538010, DA292156
      Consensus CDS
      CCDS55153.1
      UniProtKB/TrEMBL
      E9PDA4
      UniProtKB/TrEMBL
      Q14BM2
      UniProtKB/Swiss-Prot
      Q92823
      Related
      ENSP00000368310, OTTHUMP00000207042, ENST00000379024, OTTHUMT00000337863
      Conserved Domains (9) summary
      cd00063
      Location:629718
      Blast Score: 168
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:453520
      Blast Score: 135
      Ig; Immunoglobulin domain
      cd05731
      Location:269339
      Blast Score: 299
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
      cd05868
      Location:356431
      Blast Score: 412
      Ig4_NrCAM; Fourth immunoglobulin (Ig)-like domain of NrCAM (NgCAM-related cell adhesion molecule)
      cd05874
      Location:64140
      Blast Score: 419
      Ig6_NrCAM; Sixth immunoglobulin (Ig)-like domain of NrCAM (Ng (neuronglia) CAM-related cell adhesion molecule)
      pfam07679
      Location:342430
      Blast Score: 172
      I-set; Immunoglobulin I-set domain
      pfam13882
      Location:10511170
      Blast Score: 496
      Bravo_FIGEY; C-terminal domain of Fibronectin type III
      cl00065
      Location:731813
      Blast Score: 114
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:145237
      Blast Score: 243
      Ig; Immunoglobulin domain
    4. NM_001193584.1NP_001180513.1  neuronal cell adhesion molecule isoform F precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and lacks four in-frame exons in the coding region, compared to variant 1. The encoded protein (isoform F) is shorter than isoform A.
      Source sequence(s)
      AB002341, AK127035, BU735065, BX538010, DA292156
      UniProtKB/Swiss-Prot
      Q92823
      Related
      ENSP00000407858, ENST00000413765
      Conserved Domains (9) summary
      cd00063
      Location:629718
      Blast Score: 168
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:453520
      Blast Score: 134
      Ig; Immunoglobulin domain
      cd05731
      Location:269339
      Blast Score: 299
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
      cd05868
      Location:356431
      Blast Score: 412
      Ig4_NrCAM; Fourth immunoglobulin (Ig)-like domain of NrCAM (NgCAM-related cell adhesion molecule)
      cd05874
      Location:64140
      Blast Score: 419
      Ig6_NrCAM; Sixth immunoglobulin (Ig)-like domain of NrCAM (Ng (neuronglia) CAM-related cell adhesion molecule)
      pfam07679
      Location:342430
      Blast Score: 172
      I-set; Immunoglobulin I-set domain
      pfam13882
      Location:10391158
      Blast Score: 497
      Bravo_FIGEY; C-terminal domain of Fibronectin type III
      cl00065
      Location:731813
      Blast Score: 114
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:145237
      Blast Score: 243
      Ig; Immunoglobulin domain
    5. NM_005010.4NP_005001.3  neuronal cell adhesion molecule isoform B precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and lacks five in-frame exons in the coding region, compared to variant 1. The encoded protein (isoform B) is shorter than isoform A.
      Source sequence(s)
      AK127035, BC115736, BU735065, BX538010, DA292156
      Consensus CDS
      CCDS5751.1
      UniProtKB/TrEMBL
      Q14BM2
      UniProtKB/Swiss-Prot
      Q92823
      Related
      ENSP00000325269, OTTHUMP00000207068, ENST00000351718, OTTHUMT00000337939
      Conserved Domains (9) summary
      cd00063
      Location:631721
      Blast Score: 175
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:466533
      Blast Score: 134
      Ig; Immunoglobulin domain
      cd05731
      Location:282352
      Blast Score: 299
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
      cd05868
      Location:369444
      Blast Score: 411
      Ig4_NrCAM; Fourth immunoglobulin (Ig)-like domain of NrCAM (NgCAM-related cell adhesion molecule)
      cd05874
      Location:58134
      Blast Score: 418
      Ig6_NrCAM; Sixth immunoglobulin (Ig)-like domain of NrCAM (Ng (neuronglia) CAM-related cell adhesion molecule)
      pfam07679
      Location:355443
      Blast Score: 172
      I-set; Immunoglobulin I-set domain
      pfam13882
      Location:10421161
      Blast Score: 497
      Bravo_FIGEY; C-terminal domain of Fibronectin type III
      cl00065
      Location:734816
      Blast Score: 114
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cl11960
      Location:139231
      Blast Score: 244
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000007.13 Reference GRCh37.p5 Primary Assembly

      Range
      107788071..108096841, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000139.1 Alternate HuRef

      Range
      102150368..102465060, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CRA_TCAGchr7v2

    Genomic

    1. AC_000068.1 Alternate CRA_TCAGchr7v2

      Range
      107149256..107464062, complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001037133.1: Suppressed sequence

      Description
      NM_001037133.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.

      Supplemental Content

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