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NPY2R neuropeptide Y receptor Y2 [ Homo sapiens (human) ]

Gene ID: 4887, updated on 7-May-2016
Official Symbol
NPY2Rprovided by HGNC
Official Full Name
neuropeptide Y receptor Y2provided by HGNC
Primary source
HGNC:HGNC:7957
See related
Ensembl:ENSG00000185149 HPRD:01216; MIM:162642; Vega:OTTHUMG00000161485
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NPY2-R
Orthologs
Location:
4q31
Exon count:
3
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 4 NC_000004.12 (155173754..155217096)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (156094924..156138248)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377500 Neighboring gene RNA binding motif protein 46 Neighboring gene uncharacterized LOC105377501 Neighboring gene uncharacterized LOC105377502 Neighboring gene uncharacterized LOC102724776 Neighboring gene microtubule associated protein 9

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
    Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
  • G alpha (i) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (i) signalling events, organism-specific biosystemThe classical signalling mechanism for G alpha (i) is inhibition of the cAMP dependent pathway through inhibition of adenylate cyclase. Decreased production of cAMP from ATP results in decreased act...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
    GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.cmbi.kun.nl/7tm/. The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used ...
  • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, organism-specific biosystem
    Neuroactive ligand-receptor interaction
  • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, conserved biosystem
    Neuroactive ligand-receptor interaction
  • Peptide GPCRs, organism-specific biosystem (from WikiPathways)
    Peptide GPCRs, organism-specific biosystem
    Peptide GPCRs
  • Peptide ligand-binding receptors, organism-specific biosystem (from REACTOME)
    Peptide ligand-binding receptors, organism-specific biosystemThese receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins.
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium channel regulator activity TAS
Traceable Author Statement
more info
PubMed 
neuropeptide Y receptor activity TAS
Traceable Author Statement
more info
PubMed 
peptide YY receptor activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
behavioral fear response IEA
Inferred from Electronic Annotation
more info
 
cardiac left ventricle morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
feeding behavior IBA
Inferred from Biological aspect of Ancestor
more info
 
locomotory behavior TAS
Traceable Author Statement
more info
PubMed 
negative regulation of cAMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of excitatory postsynaptic potential IEA
Inferred from Electronic Annotation
more info
 
negative regulation of feeding behavior IEA
Inferred from Electronic Annotation
more info
 
negative regulation of neurological system process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of secretion IEA
Inferred from Electronic Annotation
more info
 
negative regulation of synaptic transmission, glutamatergic IEA
Inferred from Electronic Annotation
more info
 
neuropeptide signaling pathway IEA
Inferred from Electronic Annotation
more info
 
nitric oxide mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
outflow tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell-substrate adhesion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of circadian sleep/wake cycle, non-REM sleep IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 
positive regulation of dopamine secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of peptide secretion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of smooth muscle contraction IEA
Inferred from Electronic Annotation
more info
 
regulation of sensory perception of pain IEA
Inferred from Electronic Annotation
more info
 
secretion IEA
Inferred from Electronic Annotation
more info
 
synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
cytosol IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
nonmotile primary cilium IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
neuropeptide Y receptor type 2
Names
NPY-Y2 receptor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000910.3NP_000901.1  neuropeptide Y receptor type 2

    See identical proteins and their annotated locations for NP_000901.1

    Status: VALIDATED

    Source sequence(s)
    AC104407, U32500, U36269, U42766
    Consensus CDS
    CCDS3791.1
    UniProtKB/Swiss-Prot
    P49146
    Related
    ENSP00000332591, OTTHUMP00000220313, ENST00000329476, OTTHUMT00000365128
    Conserved Domains (2) summary
    pfam00001
    Location:74325
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:61340
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p2 Primary Assembly

    Range
    155173754..155217096
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005263033.3XP_005263090.1  

    See identical proteins and their annotated locations for XP_005263090.1

    UniProtKB/Swiss-Prot
    P49146
    Conserved Domains (2) summary
    pfam00001
    Location:74325
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:61340
    7tm_4; Olfactory receptor
  2. XM_005263034.3XP_005263091.1  

    See identical proteins and their annotated locations for XP_005263091.1

    UniProtKB/Swiss-Prot
    P49146
    Related
    ENSP00000426366, OTTHUMP00000220314, ENST00000506608, OTTHUMT00000365129
    Conserved Domains (2) summary
    pfam00001
    Location:74325
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:61340
    7tm_4; Olfactory receptor

Alternate CHM1_1.1

Genomic

  1. NC_018915.2 Alternate CHM1_1.1

    Range
    156107896..156116345
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)