BCL6 BCL6 transcription repressor [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: BCL6provided by VGNC
Official Full Name: BCL6 transcription repressorprovided by VGNC
Primary source: VGNC:VGNC:96539
See related: Ensembl:ENSCAFG00845022776
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 34

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	34	NC_051838.1 (20032420..20123667, complement)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	34	NC_006616.4 (24206192..24217557, complement)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	34	NC_049255.1 (20295606..20306970, complement)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	34	NC_049294.1 (20061949..20073314, complement)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	34	NC_049775.1 (20055728..20067098, complement)

Chromosome 34 - NC_051838.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Most canine high-grade B-cell lymphomas correspond to human diffuse large C-cell lymphoma with no immunohistochemical expression of BCL6.
Title: Evaluation of the prognostic significance of BCL6 gene expression in canine high-grade B-cell lymphoma.
Canine BCL6 amino acid sequence showed close homology to that of human BCL6 (96.3%) and the analogous expression pattern of BCL6 in the canine lymph node strongly indicates that it has the same role as its human counterpart.
Title: Characterization of canine BCL6 cDNA and detection systems for its protein expression.

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General gene information

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Markers

RH47862 (e-PCR)
- UniSTS:18348

PMC137537P1 (e-PCR)
- UniSTS:270834

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of cytokine production	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of immune system process	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: B-cell lymphoma 6 protein

Names: B cell CLL/lymphoma 6; zinc finger protein 51

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001195404.1 → NP_001182333.1 B-cell lymphoma 6 protein

See identical proteins and their annotated locations for NP_001182333.1

Status: PROVISIONAL

Source sequence(s)

HM008708

UniProtKB/TrEMBL

A0A8C0L701, A0A8C0NSW4, A0A8P0NWE6, E0YDP3, E2RTF3

Conserved Domains (4) summary

PTZ00449
Location:260 → 474

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

sd00017
Location:576 → 596

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18331
Location:8 → 125

BTB_POZ_ZBTB27_BCL6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6)

pfam13465
Location:588 → 613

zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051838.1 Reference ROS_Cfam_1.0

Range

20032420..20123667 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038445394.1 → XP_038301322.1 B-cell lymphoma 6 protein isoform X1

UniProtKB/TrEMBL

A0A8C0L701, A0A8C0NSW4, A0A8P0NWE6, E0YDP3, E2RTF3

Conserved Domains (4) summary

PTZ00449
Location:260 → 474

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

sd00017
Location:576 → 596

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18331
Location:8 → 125

BTB_POZ_ZBTB27_BCL6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6)

pfam13465
Location:588 → 613

zf-H2C2_2; Zinc-finger double domain
XM_038445391.1 → XP_038301319.1 B-cell lymphoma 6 protein isoform X1

UniProtKB/TrEMBL

A0A8C0L701, A0A8C0NSW4, A0A8P0NWE6, E0YDP3, E2RTF3

Conserved Domains (4) summary

PTZ00449
Location:260 → 474

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

sd00017
Location:576 → 596

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18331
Location:8 → 125

BTB_POZ_ZBTB27_BCL6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6)

pfam13465
Location:588 → 613

zf-H2C2_2; Zinc-finger double domain
XM_038445396.1 → XP_038301324.1 B-cell lymphoma 6 protein isoform X1

UniProtKB/TrEMBL

A0A8C0L701, A0A8C0NSW4, A0A8P0NWE6, E0YDP3, E2RTF3

Conserved Domains (4) summary

PTZ00449
Location:260 → 474

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

sd00017
Location:576 → 596

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18331
Location:8 → 125

BTB_POZ_ZBTB27_BCL6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6)

pfam13465
Location:588 → 613

zf-H2C2_2; Zinc-finger double domain
XM_038445395.1 → XP_038301323.1 B-cell lymphoma 6 protein isoform X1

UniProtKB/TrEMBL

A0A8C0L701, A0A8C0NSW4, A0A8P0NWE6, E0YDP3, E2RTF3

Conserved Domains (4) summary

PTZ00449
Location:260 → 474

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

sd00017
Location:576 → 596

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18331
Location:8 → 125

BTB_POZ_ZBTB27_BCL6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6)

pfam13465
Location:588 → 613

zf-H2C2_2; Zinc-finger double domain
XM_038445393.1 → XP_038301321.1 B-cell lymphoma 6 protein isoform X1

UniProtKB/TrEMBL

A0A8C0L701, A0A8C0NSW4, A0A8P0NWE6, E0YDP3, E2RTF3

Conserved Domains (4) summary

PTZ00449
Location:260 → 474

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

sd00017
Location:576 → 596

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18331
Location:8 → 125

BTB_POZ_ZBTB27_BCL6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6)

pfam13465
Location:588 → 613

zf-H2C2_2; Zinc-finger double domain
XM_038445392.1 → XP_038301320.1 B-cell lymphoma 6 protein isoform X1

UniProtKB/TrEMBL

A0A8C0L701, A0A8C0NSW4, A0A8P0NWE6, E0YDP3, E2RTF3

Related

ENSCAFP00845031635.1, ENSCAFT00845040400.1

Conserved Domains (4) summary

PTZ00449
Location:260 → 474

PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional

sd00017
Location:576 → 596

ZF_C2H2; C2H2 Zn finger [structural motif]

cd18331
Location:8 → 125

BTB_POZ_ZBTB27_BCL6; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6)

pfam13465
Location:588 → 613

zf-H2C2_2; Zinc-finger double domain