NPPB natriuretic peptide B [Homo sapiens] - Gene

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Summary

Official Symbol: NPPBprovided by HGNC
Official Full Name: natriuretic peptide Bprovided by HGNC
Primary source: HGNC:7940
See related: Ensembl:ENSG00000120937; HPRD:08974; MIM:600295; Vega:OTTHUMG00000002389
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: BNP
Summary: This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 1p36.2

Sequence :: Chromosome: 1; NC_000001.10 (11917521..11918992, complement)

See NPPB in Epigenomics, MapViewer

Chromosome 1 - NC_000001.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Elevations of N-terminal BNP and troponin I are common in patients with atrial fibrillation and independently related to increased risks of stroke and mortality.
Title: Cardiac biomarkers are associated with an increased risk of stroke and death in patients with atrial fibrillation: a Randomized Evaluation of Long-term Anticoagulation Therapy (RE-LY) substudy.
Elevated NT-proBNP is an independent predictor of mortality in tobacco smokers without known cardiovascular disease, conferring a 2.2 fold increased risk of death
Title: Elevated N-terminal pro-brain natriuretic peptide is associated with mortality in tobacco smokers independent of airflow obstruction.
This to date longest-term analysis of N-terminal proBNP and mortality in patients with proven non-ischaemic cardiomyopathy confirms this cardiac-specific biomarker as powerful, independent risk predictor.
Title: N-terminal pro-B-type natriuretic peptide and long-term mortality in non-ischaemic cardiomyopathy.
These findings indicate that endothelin-1 interacts with HANP and BNP in patients with chronic congestive heart failure. Endothelin-1 is suggested to play an important role in chronic congestive heart failure with preserved ejection fraction.
Title: Endothelin-1 levels in chronic congestive heart failure.
Long-term statin therapy in patients with systolic heart failure and normal cholesterol reduced elevated BNP levels.
Title: Long-term statin therapy in patients with systolic heart failure and normal cholesterol: effects on elevated serum markers of collagen turnover, inflammation, and B-type natriuretic peptide.
N-terminal pro-B-type BNP is a strong independent predictor of worsening renal function within 18 months in patients with systolic heart failure with a high negative predictive value.
Title: NT-pro-BNP predicts worsening renal function in patients with chronic systolic heart failure.
BNP may play a role in hyperadiponectinemia of preeclampsia patients
Title: Potential interaction of brain natriuretic peptide with hyperadiponectinemia in preeclampsia.
Preoperative brain natriuretic peptide level is associated with postoperative acute kidney injury in high-risk patients undergoing cardiac surgery.
Title: Preoperative serum brain natriuretic peptide and risk of acute kidney injury after cardiac surgery.
No statistically significant association was found between Leukocyte count and ACS (Acute Coronary Syndrome). Although there is a trend of increased Leukocyte count noted in patients with increase BNP level.
Title: The role of leukocyte counts in patients with unstable angina pectoris or myocardial infarction; prognostic significance and correlation with plasma brain natriuretic peptide (BNP) levels.
Elevated BNP levels on admittance to the Intensive Care Unit and postoperatively increasing BNP levels are associated with adverse postoperative outcome and are predictive of impaired late survival.
Title: Postoperative increase in B-type natriuretic peptide levels predicts adverse outcome after cardiac surgery.

Submit: New GeneRIF Correction See all (459)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Genome-wide association study identifies eight loci associated with blood pressure.

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Products	Interactant	Other Gene	Source	Pubs	Description
P16860	Q01844	EWSR1	HPRD	PubMed
P16860	P16066	NPR1	HPRD	PubMed
P16860	P17342	NPR3	HPRD	PubMed
BioGRID:110939	BioGRID:108431	EWSR1	BioGRID	PubMed	Two-hybrid
BioGRID:110939	BioGRID:115106	HDAC4	BioGRID	PubMed	Reconstituted Complex
BioGRID:110939	BioGRID:110942	NPR2	BioGRID	PubMed	Reconstituted Complex
BioGRID:110939	BioGRID:110943	NPR3	BioGRID	PubMed	Reconstituted Complex

Function	Evidence Code	Pubs
diuretic hormone activity	TAS Traceable Author Statement more info	PubMed
hormone activity	NAS Non-traceable Author Statement more info	PubMed
peptide hormone receptor binding	IEA Inferred from Electronic Annotation more info
receptor binding	IDA Inferred from Direct Assay more info	PubMed
receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
body fluid secretion	TAS Traceable Author Statement more info	PubMed
cGMP biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
cell surface receptor signaling pathway	NAS Non-traceable Author Statement more info	PubMed
heart development	IEA Inferred from Electronic Annotation more info
inflammatory response	IEA Inferred from Electronic Annotation more info
negative regulation of angiogenesis	TAS Traceable Author Statement more info	PubMed
negative regulation of cell growth	NAS Non-traceable Author Statement more info	PubMed
negative regulation of smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info
positive regulation of renal sodium excretion	TAS Traceable Author Statement more info	PubMed
positive regulation of urine volume	TAS Traceable Author Statement more info	PubMed
receptor guanylyl cyclase signaling pathway	IDA Inferred from Direct Assay more info	PubMed
regulation of blood pressure	NAS Non-traceable Author Statement more info	PubMed
regulation of blood vessel size	IEA Inferred from Electronic Annotation more info
regulation of vascular permeability	TAS Traceable Author Statement more info	PubMed
regulation of vasodilation	NAS Non-traceable Author Statement more info	PubMed
response to calcium ion	IEA Inferred from Electronic Annotation more info
response to drug	IEA Inferred from Electronic Annotation more info
response to hypoxia	IEA Inferred from Electronic Annotation more info
response to organic cyclic compound	IEA Inferred from Electronic Annotation more info
response to peptide hormone stimulus	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
cytoplasm	IEA Inferred from Electronic Annotation more info
extracellular region	TAS Traceable Author Statement more info	PubMed
extracellular space	NAS Non-traceable Author Statement more info	PubMed
nucleus	IEA Inferred from Electronic Annotation more info
perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: natriuretic peptides B

Names: natriuretic peptides B; natriuretic protein; brain type natriuretic peptide; gamma-brain natriuretic peptide; natriuretic peptide precursor B

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_002521.2 → NP_002512.1 natriuretic peptides B preproprotein

Status: REVIEWED

Source sequence(s)

AJ708502, BC025785, M25296

Consensus CDS

CCDS140.1

UniProtKB/Swiss-Prot

P16860

Related

ENSP00000365651, OTTHUMP00000002506, ENST00000376468, OTTHUMT00000006854

Conserved Domains (1) summary

cl02499
Location:97 – 128
Blast Score: 141

ANP; Atrial natriuretic peptide

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000001.10 Reference GRCh37.p5 Primary Assembly

Range

11917521..11918992, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000133.1 Alternate HuRef

Range

11073021..11074492, complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AB037521.1	BAA90441.1
genomic	AL021155.1	CAA15956.1
genomic	CH471130.1	EAW71718.1
		EAW71719.1
genomic	EU326309.1	ACA05917.1
genomic	M31776.1	AAA35603.1
mRNA	AJ708502.1	None
mRNA	BC025785.1	AAH25785.1
mRNA	CR541976.1	CAG46774.1
mRNA	CR542003.1	CAG46800.1
mRNA	M25296.1	AAA36355.1