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EPHA2 EPH receptor A2 [ Canis lupus familiaris (dog) ]

Gene ID: 487421, updated on 11-Apr-2024

Summary

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Official Symbol
EPHA2provided by VGNC
Official Full Name
EPH receptor A2provided by VGNC
Primary source
VGNC:VGNC:40405
See related
Ensembl:ENSCAFG00845004794
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 2
Exon count:
18
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 2 NC_051806.1 (82179960..82207481)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 2 NC_006584.4 (78070108..78097636)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 2 NC_049223.1 (81018093..81045632)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 2 NC_049262.1 (78933025..78960551)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 2 NC_049743.1 (79950185..79977704)

Chromosome 2 - NC_051806.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111093883 Neighboring gene Rho guanine nucleotide exchange factor 19 Neighboring gene uncharacterized LOC119870064 Neighboring gene family with sequence similarity 131 member C Neighboring gene uncharacterized LOC119876084 Neighboring gene chloride voltage-gated channel K

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Effect of dasatinib in a xenograft mouse model of canine histiocytic sarcoma and in vitro expression status of its potential target EPHA2. Ito K, et al. J Vet Pharmacol Ther, 2018 Feb. PMID 28833247
  2. EphrinA1-EphA2 signal induces compaction and polarization of Madin-Darby canine kidney cells by inactivating Ezrin through negative regulation of RhoA. Wakayama Y, et al. J Biol Chem, 2011 Dec 23. PMID 21979959, Free PMC Article
  3. EphA2 engages Git1 to suppress Arf6 activity modulating epithelial cell-cell contacts. Miura K, et al. Mol Biol Cell, 2009 Apr. PMID 19193766, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ephrinA1/EphA2 signal negatively regulates Ezrin and promotes the alteration of cell shape, from flat to columnar shape
    Title: EphrinA1-EphA2 signal induces compaction and polarization of Madin-Darby canine kidney cells by inactivating Ezrin through negative regulation of RhoA.
  2. E-cadherin-based cell-cell contacts enhance EphA-ephrinA signaling, which in turn down-regulates Arf6 activity to enhance E-cadherin-based cell-cell contacts as well as the apical-basal polarization of epithelial cells.
    Title: EphA2 engages Git1 to suppress Arf6 activity modulating epithelial cell-cell contacts.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transmembrane-ephrin receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in axon guidance IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
ephrin type-A receptor 2
XP_022269989.1
XP_038326936.1
XP_038326937.1
XP_038387808.1
XP_038387809.1
XP_038452072.1
XP_038452073.1
XP_038516156.1
XP_038516157.1
XP_544546.2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051806.1 Reference ROS_Cfam_1.0

    Range
    82179960..82207481
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038660228.1 → XP_038516156.1  ephrin type-A receptor 2 isoform X1

    UniProtKB/TrEMBL
    A0A286R219, A0A8C0JWT6, A0A8C0NCL7
    Related
    ENSCAFP00845006780.1, ENSCAFT00845008595.1
    Conserved Domains (5) summary
    cd05063
    Location:607 → 874
    PTKc_EphR_A2; Catalytic domain of the Protein Tyrosine Kinase, Ephrin Receptor A2
    cd09543
    Location:901 → 970
    SAM_EPH-A2; SAM domain of EPH-A2 family of tyrosine kinase receptors
    cd10480
    Location:28 → 201
    EphR_LBD_A2; Ligand Binding Domain of Ephrin type-A Receptor 2
    pfam00041
    Location:438 → 519
    fn3; Fibronectin type III domain
    pfam14575
    Location:537 → 610
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

  2. XM_038660229.1 → XP_038516157.1  ephrin type-A receptor 2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0NCL7
    Conserved Domains (5) summary
    cd05063
    Location:553 → 820
    PTKc_EphR_A2; Catalytic domain of the Protein Tyrosine Kinase, Ephrin Receptor A2
    cd09543
    Location:847 → 916
    SAM_EPH-A2; SAM domain of EPH-A2 family of tyrosine kinase receptors
    pfam00041
    Location:384 → 465
    fn3; Fibronectin type III domain
    pfam14575
    Location:483 → 556
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cl02704
    Location:1 → 147
    EphR_LBD; Ligand Binding Domain of Ephrin Receptors

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049262.1 Alternate UMICH_Zoey_3.1

    Range
    78933025..78960551
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038471008.1 → XP_038326936.1  ephrin type-A receptor 2 isoform X1

    Conserved Domains (5) summary
    cd05063
    Location:607 → 874
    PTKc_EphR_A2; Catalytic domain of the Protein Tyrosine Kinase, Ephrin Receptor A2
    cd09543
    Location:901 → 970
    SAM_EPH-A2; SAM domain of EPH-A2 family of tyrosine kinase receptors
    cd10480
    Location:28 → 201
    EphR_LBD_A2; Ligand Binding Domain of Ephrin type-A Receptor 2
    pfam00041
    Location:438 → 519
    fn3; Fibronectin type III domain
    pfam14575
    Location:537 → 610
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

  2. XM_038471009.1 → XP_038326937.1  ephrin type-A receptor 2 isoform X2

    Conserved Domains (5) summary
    cd05063
    Location:553 → 820
    PTKc_EphR_A2; Catalytic domain of the Protein Tyrosine Kinase, Ephrin Receptor A2
    cd09543
    Location:847 → 916
    SAM_EPH-A2; SAM domain of EPH-A2 family of tyrosine kinase receptors
    pfam00041
    Location:384 → 465
    fn3; Fibronectin type III domain
    pfam14575
    Location:483 → 556
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cl02704
    Location:1 → 147
    EphR_LBD; Ligand Binding Domain of Ephrin Receptors

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049743.1 Alternate UNSW_CanFamBas_1.0

    Range
    79950185..79977704
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038596144.1 → XP_038452072.1  ephrin type-A receptor 2 isoform X1

    Conserved Domains (5) summary
    cd05063
    Location:607 → 874
    PTKc_EphR_A2; Catalytic domain of the Protein Tyrosine Kinase, Ephrin Receptor A2
    cd09543
    Location:901 → 970
    SAM_EPH-A2; SAM domain of EPH-A2 family of tyrosine kinase receptors
    cd10480
    Location:28 → 201
    EphR_LBD_A2; Ligand Binding Domain of Ephrin type-A Receptor 2
    pfam00041
    Location:438 → 519
    fn3; Fibronectin type III domain
    pfam14575
    Location:537 → 610
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

  2. XM_038596145.1 → XP_038452073.1  ephrin type-A receptor 2 isoform X2

    Conserved Domains (5) summary
    cd05063
    Location:553 → 820
    PTKc_EphR_A2; Catalytic domain of the Protein Tyrosine Kinase, Ephrin Receptor A2
    cd09543
    Location:847 → 916
    SAM_EPH-A2; SAM domain of EPH-A2 family of tyrosine kinase receptors
    pfam00041
    Location:384 → 465
    fn3; Fibronectin type III domain
    pfam14575
    Location:483 → 556
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cl02704
    Location:1 → 147
    EphR_LBD; Ligand Binding Domain of Ephrin Receptors

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049223.1 Alternate UU_Cfam_GSD_1.0

    Range
    81018093..81045632
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038531880.1 → XP_038387808.1  ephrin type-A receptor 2 isoform X1

    UniProtKB/TrEMBL
    A0A286R219, A0A8C0JWT6, A0A8C0NCL7
    Conserved Domains (5) summary
    cd05063
    Location:607 → 874
    PTKc_EphR_A2; Catalytic domain of the Protein Tyrosine Kinase, Ephrin Receptor A2
    cd09543
    Location:901 → 970
    SAM_EPH-A2; SAM domain of EPH-A2 family of tyrosine kinase receptors
    cd10480
    Location:28 → 201
    EphR_LBD_A2; Ligand Binding Domain of Ephrin type-A Receptor 2
    pfam00041
    Location:438 → 519
    fn3; Fibronectin type III domain
    pfam14575
    Location:537 → 610
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

  2. XM_038531881.1 → XP_038387809.1  ephrin type-A receptor 2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0NCL7
    Conserved Domains (5) summary
    cd05063
    Location:553 → 820
    PTKc_EphR_A2; Catalytic domain of the Protein Tyrosine Kinase, Ephrin Receptor A2
    cd09543
    Location:847 → 916
    SAM_EPH-A2; SAM domain of EPH-A2 family of tyrosine kinase receptors
    pfam00041
    Location:384 → 465
    fn3; Fibronectin type III domain
    pfam14575
    Location:483 → 556
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cl02704
    Location:1 → 147
    EphR_LBD; Ligand Binding Domain of Ephrin Receptors

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006584.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    78070108..78097636
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_544546.8 → XP_544546.2  ephrin type-A receptor 2 isoform X1

    UniProtKB/TrEMBL
    A0A286R219, A0A8C0JWT6, A0A8C0NCL7
    Conserved Domains (5) summary
    cd05063
    Location:607 → 874
    PTKc_EphR_A2; Catalytic domain of the Protein Tyrosine Kinase, Ephrin Receptor A2
    cd09543
    Location:901 → 970
    SAM_EPH-A2; SAM domain of EPH-A2 family of tyrosine kinase receptors
    cd10480
    Location:28 → 201
    EphR_LBD_A2; Ligand Binding Domain of Ephrin type-A Receptor 2
    pfam00041
    Location:438 → 519
    fn3; Fibronectin type III domain
    pfam14575
    Location:537 → 610
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain

  2. XM_022414281.2 → XP_022269989.1  ephrin type-A receptor 2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0NCL7
    Conserved Domains (5) summary
    cd05063
    Location:553 → 820
    PTKc_EphR_A2; Catalytic domain of the Protein Tyrosine Kinase, Ephrin Receptor A2
    cd09543
    Location:847 → 916
    SAM_EPH-A2; SAM domain of EPH-A2 family of tyrosine kinase receptors
    pfam00041
    Location:384 → 465
    fn3; Fibronectin type III domain
    pfam14575
    Location:483 → 556
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cl02704
    Location:1 → 147
    EphR_LBD; Ligand Binding Domain of Ephrin Receptors
Nucleotide Protein
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