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IRAK4 interleukin 1 receptor associated kinase 4 [ Canis lupus familiaris (dog) ]

Gene ID: 486601, updated on 5-Mar-2024

Summary

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Official Symbol
IRAK4provided by VGNC
Official Full Name
interleukin 1 receptor associated kinase 4provided by VGNC
Primary source
VGNC:VGNC:42089
See related
Ensembl:ENSCAFG00845029210
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 27
Exon count:
16
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 27 NC_051831.1 (10502276..10529893, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 27 NC_006609.4 (35967589..35995188)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 27 NC_049248.1 (36209066..36236651)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 27 NC_049287.1 (10313739..10341482, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 27 NC_049768.1 (10348090..10375692, complement)

Chromosome 27 - NC_051831.1Genomic Context describing neighboring genes Neighboring gene dnaJ homolog subfamily A member 1-like Neighboring gene twinfilin actin binding protein 1 Neighboring gene pseudouridine synthase 7 like Neighboring gene uncharacterized LOC102156873

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
interleukin-1 receptor-associated kinase 4
XP_003433604.1
XP_005637012.1
XP_005637013.1
XP_005637014.1
XP_005637015.1
XP_005637017.1
XP_022266882.1
XP_022266883.1
XP_038294360.1
XP_038294361.1
XP_038294362.1
XP_038294363.1
XP_038294364.1
XP_038294365.1
XP_038294366.1
XP_038294367.1
XP_038294368.1
XP_038369054.1
XP_038369055.1
XP_038369056.1
XP_038369057.1
XP_038369058.1
XP_038369059.1
XP_038369060.1
XP_038369061.1
XP_038369062.1
XP_038433319.1
XP_038433320.1
XP_038433322.1
XP_038433323.1
XP_038433324.1
XP_038433325.1
XP_038433326.1
XP_038433327.1
XP_038433328.1
XP_038496823.1
XP_038496824.1
XP_038496825.1
XP_038496826.1
XP_038496827.1
XP_038496828.1
XP_038496829.1
XP_038496830.1
XP_038496831.1
XP_543727.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051831.1 Reference ROS_Cfam_1.0

    Range
    10502276..10529893 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038438432.1 → XP_038294360.1  interleukin-1 receptor-associated kinase 4 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KC23, A0A8C0TIU6, A0A8I3S726, A0A8P0T666
    Related
    ENSCAFP00845040592.1, ENSCAFT00845051737.1
    Conserved Domains (2) summary
    cd08793
    Location:9 → 106
    Death_IRAK4; Death domain of Interleukin-1 Receptor-Associated Kinase 4
    cd14158
    Location:170 → 457
    STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4

  2. XM_038438433.1 → XP_038294361.1  interleukin-1 receptor-associated kinase 4 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KC23, A0A8C0TIU6, A0A8I3S726, A0A8P0T666
    Conserved Domains (2) summary
    cd08793
    Location:9 → 106
    Death_IRAK4; Death domain of Interleukin-1 Receptor-Associated Kinase 4
    cd14158
    Location:170 → 457
    STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4

  3. XM_038438434.1 → XP_038294362.1  interleukin-1 receptor-associated kinase 4 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KC23, A0A8C0TIU6, A0A8I3S726, A0A8P0T666
    Conserved Domains (2) summary
    cd08793
    Location:9 → 106
    Death_IRAK4; Death domain of Interleukin-1 Receptor-Associated Kinase 4
    cd14158
    Location:170 → 457
    STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4

  4. XM_038438437.1 → XP_038294365.1  interleukin-1 receptor-associated kinase 4 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KC23, A0A8C0TIU6, A0A8I3S726, A0A8P0T666
    Conserved Domains (2) summary
    cd08793
    Location:9 → 106
    Death_IRAK4; Death domain of Interleukin-1 Receptor-Associated Kinase 4
    cd14158
    Location:170 → 457
    STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4

  5. XM_038438435.1 → XP_038294363.1  interleukin-1 receptor-associated kinase 4 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KC23, A0A8C0TIU6, A0A8I3S726, A0A8P0T666
    Conserved Domains (2) summary
    cd08793
    Location:9 → 106
    Death_IRAK4; Death domain of Interleukin-1 Receptor-Associated Kinase 4
    cd14158
    Location:170 → 457
    STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4

  6. XM_038438439.1 → XP_038294367.1  interleukin-1 receptor-associated kinase 4 isoform X2

    Conserved Domains (1) summary
    cd14158
    Location:46 → 333
    STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4

  7. XM_038438436.1 → XP_038294364.1  interleukin-1 receptor-associated kinase 4 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KC23, A0A8C0TIU6, A0A8I3S726, A0A8P0T666
    Conserved Domains (2) summary
    cd08793
    Location:9 → 106
    Death_IRAK4; Death domain of Interleukin-1 Receptor-Associated Kinase 4
    cd14158
    Location:170 → 457
    STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4

  8. XM_038438438.1 → XP_038294366.1  interleukin-1 receptor-associated kinase 4 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KC23, A0A8C0TIU6, A0A8I3S726, A0A8P0T666
    Conserved Domains (2) summary
    cd08793
    Location:9 → 106
    Death_IRAK4; Death domain of Interleukin-1 Receptor-Associated Kinase 4
    cd14158
    Location:170 → 457
    STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4

  9. XM_038438440.1 → XP_038294368.1  interleukin-1 receptor-associated kinase 4 isoform X2

    Conserved Domains (1) summary
    cd14158
    Location:46 → 333
    STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049287.1 Alternate UMICH_Zoey_3.1

    Range
    10313739..10341482 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038513126.1 → XP_038369054.1  interleukin-1 receptor-associated kinase 4 isoform X1

  2. XM_038513127.1 → XP_038369055.1  interleukin-1 receptor-associated kinase 4 isoform X1

  3. XM_038513128.1 → XP_038369056.1  interleukin-1 receptor-associated kinase 4 isoform X1

  4. XM_038513131.1 → XP_038369059.1  interleukin-1 receptor-associated kinase 4 isoform X1

  5. XM_038513129.1 → XP_038369057.1  interleukin-1 receptor-associated kinase 4 isoform X1

  6. XM_038513133.1 → XP_038369061.1  interleukin-1 receptor-associated kinase 4 isoform X2

  7. XM_038513130.1 → XP_038369058.1  interleukin-1 receptor-associated kinase 4 isoform X1

  8. XM_038513132.1 → XP_038369060.1  interleukin-1 receptor-associated kinase 4 isoform X1

  9. XM_038513134.1 → XP_038369062.1  interleukin-1 receptor-associated kinase 4 isoform X2

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049768.1 Alternate UNSW_CanFamBas_1.0

    Range
    10348090..10375692 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038640895.1 → XP_038496823.1  interleukin-1 receptor-associated kinase 4 isoform X1

    Conserved Domains (2) summary
    cd08793
    Location:9 → 106
    Death_IRAK4; Death domain of Interleukin-1 Receptor-Associated Kinase 4
    cd14158
    Location:170 → 457
    STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4

  2. XM_038640896.1 → XP_038496824.1  interleukin-1 receptor-associated kinase 4 isoform X1

    Conserved Domains (2) summary
    cd08793
    Location:9 → 106
    Death_IRAK4; Death domain of Interleukin-1 Receptor-Associated Kinase 4
    cd14158
    Location:170 → 457
    STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4

  3. XM_038640897.1 → XP_038496825.1  interleukin-1 receptor-associated kinase 4 isoform X1

    Conserved Domains (2) summary
    cd08793
    Location:9 → 106
    Death_IRAK4; Death domain of Interleukin-1 Receptor-Associated Kinase 4
    cd14158
    Location:170 → 457
    STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4

  4. XM_038640900.1 → XP_038496828.1  interleukin-1 receptor-associated kinase 4 isoform X1

    Conserved Domains (2) summary
    cd08793
    Location:9 → 106
    Death_IRAK4; Death domain of Interleukin-1 Receptor-Associated Kinase 4
    cd14158
    Location:170 → 457
    STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4

  5. XM_038640898.1 → XP_038496826.1  interleukin-1 receptor-associated kinase 4 isoform X1

    Conserved Domains (2) summary
    cd08793
    Location:9 → 106
    Death_IRAK4; Death domain of Interleukin-1 Receptor-Associated Kinase 4
    cd14158
    Location:170 → 457
    STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4

  6. XM_038640902.1 → XP_038496830.1  interleukin-1 receptor-associated kinase 4 isoform X2

    Conserved Domains (1) summary
    cd14158
    Location:46 → 333
    STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4

  7. XM_038640899.1 → XP_038496827.1  interleukin-1 receptor-associated kinase 4 isoform X1

    Conserved Domains (2) summary
    cd08793
    Location:9 → 106
    Death_IRAK4; Death domain of Interleukin-1 Receptor-Associated Kinase 4
    cd14158
    Location:170 → 457
    STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4

  8. XM_038640901.1 → XP_038496829.1  interleukin-1 receptor-associated kinase 4 isoform X1

    Conserved Domains (2) summary
    cd08793
    Location:9 → 106
    Death_IRAK4; Death domain of Interleukin-1 Receptor-Associated Kinase 4
    cd14158
    Location:170 → 457
    STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4

  9. XM_038640903.1 → XP_038496831.1  interleukin-1 receptor-associated kinase 4 isoform X2

    Conserved Domains (1) summary
    cd14158
    Location:46 → 333
    STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049248.1 Alternate UU_Cfam_GSD_1.0

    Range
    36209066..36236651
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038577394.1 → XP_038433322.1  interleukin-1 receptor-associated kinase 4 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KC23, A0A8C0TIU6, A0A8I3S726, A0A8P0T666
    Conserved Domains (2) summary
    cd08793
    Location:9 → 106
    Death_IRAK4; Death domain of Interleukin-1 Receptor-Associated Kinase 4
    cd14158
    Location:170 → 457
    STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4

  2. XM_038577392.1 → XP_038433320.1  interleukin-1 receptor-associated kinase 4 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KC23, A0A8C0TIU6, A0A8I3S726, A0A8P0T666
    Conserved Domains (2) summary
    cd08793
    Location:9 → 106
    Death_IRAK4; Death domain of Interleukin-1 Receptor-Associated Kinase 4
    cd14158
    Location:170 → 457
    STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4

  3. XM_038577391.1 → XP_038433319.1  interleukin-1 receptor-associated kinase 4 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KC23, A0A8C0TIU6, A0A8I3S726, A0A8P0T666
    Conserved Domains (2) summary
    cd08793
    Location:9 → 106
    Death_IRAK4; Death domain of Interleukin-1 Receptor-Associated Kinase 4
    cd14158
    Location:170 → 457
    STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4

  4. XM_038577395.1 → XP_038433323.1  interleukin-1 receptor-associated kinase 4 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KC23, A0A8C0TIU6, A0A8I3S726, A0A8P0T666
    Conserved Domains (2) summary
    cd08793
    Location:9 → 106
    Death_IRAK4; Death domain of Interleukin-1 Receptor-Associated Kinase 4
    cd14158
    Location:170 → 457
    STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4

  5. XM_038577397.1 → XP_038433325.1  interleukin-1 receptor-associated kinase 4 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KC23, A0A8C0TIU6, A0A8I3S726, A0A8P0T666
    Conserved Domains (2) summary
    cd08793
    Location:9 → 106
    Death_IRAK4; Death domain of Interleukin-1 Receptor-Associated Kinase 4
    cd14158
    Location:170 → 457
    STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4

  6. XM_038577399.1 → XP_038433327.1  interleukin-1 receptor-associated kinase 4 isoform X2

    Conserved Domains (1) summary
    cd14158
    Location:46 → 333
    STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4

  7. XM_038577396.1 → XP_038433324.1  interleukin-1 receptor-associated kinase 4 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KC23, A0A8C0TIU6, A0A8I3S726, A0A8P0T666
    Conserved Domains (2) summary
    cd08793
    Location:9 → 106
    Death_IRAK4; Death domain of Interleukin-1 Receptor-Associated Kinase 4
    cd14158
    Location:170 → 457
    STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4

  8. XM_038577398.1 → XP_038433326.1  interleukin-1 receptor-associated kinase 4 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KC23, A0A8C0TIU6, A0A8I3S726, A0A8P0T666
    Conserved Domains (2) summary
    cd08793
    Location:9 → 106
    Death_IRAK4; Death domain of Interleukin-1 Receptor-Associated Kinase 4
    cd14158
    Location:170 → 457
    STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4

  9. XM_038577400.1 → XP_038433328.1  interleukin-1 receptor-associated kinase 4 isoform X2

    Conserved Domains (1) summary
    cd14158
    Location:46 → 333
    STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006609.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    35967589..35995188
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_022411174.2 → XP_022266882.1  interleukin-1 receptor-associated kinase 4 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KC23, A0A8C0TIU6, A0A8I3S726, A0A8P0T666
    Conserved Domains (2) summary
    cd08793
    Location:9 → 106
    Death_IRAK4; Death domain of Interleukin-1 Receptor-Associated Kinase 4
    cd14158
    Location:170 → 457
    STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4

  2. XM_005636955.3 → XP_005637012.1  interleukin-1 receptor-associated kinase 4 isoform X1

    See identical proteins and their annotated locations for XP_005637012.1

    UniProtKB/TrEMBL
    A0A8C0KC23, A0A8C0TIU6, A0A8I3S726, A0A8P0T666
    Conserved Domains (2) summary
    cd08793
    Location:9 → 106
    Death_IRAK4; Death domain of Interleukin-1 Receptor-Associated Kinase 4
    cd14158
    Location:170 → 457
    STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4

  3. XM_543727.5 → XP_543727.1  interleukin-1 receptor-associated kinase 4 isoform X1

    See identical proteins and their annotated locations for XP_543727.1

    UniProtKB/TrEMBL
    A0A8C0KC23, A0A8C0TIU6, A0A8I3S726, A0A8P0T666
    Conserved Domains (2) summary
    cd08793
    Location:9 → 106
    Death_IRAK4; Death domain of Interleukin-1 Receptor-Associated Kinase 4
    cd14158
    Location:170 → 457
    STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4

  4. XM_005636956.3 → XP_005637013.1  interleukin-1 receptor-associated kinase 4 isoform X1

    See identical proteins and their annotated locations for XP_005637013.1

    UniProtKB/TrEMBL
    A0A8C0KC23, A0A8C0TIU6, A0A8I3S726, A0A8P0T666
    Conserved Domains (2) summary
    cd08793
    Location:9 → 106
    Death_IRAK4; Death domain of Interleukin-1 Receptor-Associated Kinase 4
    cd14158
    Location:170 → 457
    STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4

  5. XM_005636957.3 → XP_005637014.1  interleukin-1 receptor-associated kinase 4 isoform X1

    See identical proteins and their annotated locations for XP_005637014.1

    UniProtKB/TrEMBL
    A0A8C0KC23, A0A8C0TIU6, A0A8I3S726, A0A8P0T666
    Conserved Domains (2) summary
    cd08793
    Location:9 → 106
    Death_IRAK4; Death domain of Interleukin-1 Receptor-Associated Kinase 4
    cd14158
    Location:170 → 457
    STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4

  6. XM_005636960.3 → XP_005637017.1  interleukin-1 receptor-associated kinase 4 isoform X2

    See identical proteins and their annotated locations for XP_005637017.1

    Conserved Domains (1) summary
    cd14158
    Location:46 → 333
    STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4

  7. XM_005636958.4 → XP_005637015.1  interleukin-1 receptor-associated kinase 4 isoform X1

    See identical proteins and their annotated locations for XP_005637015.1

    UniProtKB/TrEMBL
    A0A8C0KC23, A0A8C0TIU6, A0A8I3S726, A0A8P0T666
    Conserved Domains (2) summary
    cd08793
    Location:9 → 106
    Death_IRAK4; Death domain of Interleukin-1 Receptor-Associated Kinase 4
    cd14158
    Location:170 → 457
    STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4

  8. XM_022411175.2 → XP_022266883.1  interleukin-1 receptor-associated kinase 4 isoform X1

    UniProtKB/TrEMBL
    A0A8C0KC23, A0A8C0TIU6, A0A8I3S726, A0A8P0T666
    Conserved Domains (2) summary
    cd08793
    Location:9 → 106
    Death_IRAK4; Death domain of Interleukin-1 Receptor-Associated Kinase 4
    cd14158
    Location:170 → 457
    STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4

  9. XM_003433556.4 → XP_003433604.1  interleukin-1 receptor-associated kinase 4 isoform X2

    See identical proteins and their annotated locations for XP_003433604.1

    Conserved Domains (1) summary
    cd14158
    Location:46 → 333
    STKc_IRAK4; Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4
Nucleotide Protein
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