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NEFM neurofilament medium chain [ Canis lupus familiaris (dog) ]

Gene ID: 486111, updated on 5-Mar-2024

Summary

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Official Symbol
NEFMprovided by VGNC
Official Full Name
neurofilament medium chainprovided by VGNC
Primary source
VGNC:VGNC:43725
See related
Ensembl:ENSCAFG00845014497
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 25
Exon count:
4
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 25 NC_051829.1 (32692550..32697657, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 25 NC_006607.4 (33076970..33082075, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 25 NC_049246.1 (32663548..32668651, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 25 NC_049285.1 (32647982..32653102, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 25 NC_049766.1 (32497397..32502517, complement)

Chromosome 25 - NC_051829.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111092438 Neighboring gene neurofilament light chain Neighboring gene proteasome subunit alpha type-1-like Neighboring gene uncharacterized LOC111092462

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables structural constituent of cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in neurofilament bundle assembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in intermediate filament IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in postsynaptic intermediate filament cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
neurofilament medium polypeptide
Names
neurofilament, medium polypeptide 150kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051829.1 Reference ROS_Cfam_1.0

    Range
    32692550..32697657 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038435392.1 → XP_038291320.1  neurofilament medium polypeptide isoform X1

    UniProtKB/TrEMBL
    A0A8C0KJ46, A0A8C0P2J8, A0A8I3NWE3, A0A8I3NWH4, A0A8P0PJP7
    Related
    ENSCAFP00845020453.1, ENSCAFT00845025947.1
    Conserved Domains (2) summary
    pfam00038
    Location:100 → 411
    Filament; Intermediate filament protein
    pfam04732
    Location:10 → 74
    Filament_head; Intermediate filament head (DNA binding) region

  2. XM_038435393.1 → XP_038291321.1  neurofilament medium polypeptide isoform X2

    Conserved Domains (1) summary
    pfam00038
    Location:1 → 35
    Filament; Intermediate filament protein

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049285.1 Alternate UMICH_Zoey_3.1

    Range
    32647982..32653102 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038510331.1 → XP_038366259.1  neurofilament medium polypeptide isoform X1

    Conserved Domains (2) summary
    pfam00038
    Location:100 → 411
    Filament; Intermediate filament protein
    pfam04732
    Location:10 → 74
    Filament_head; Intermediate filament head (DNA binding) region

  2. XM_038510332.1 → XP_038366260.1  neurofilament medium polypeptide isoform X2

    Conserved Domains (1) summary
    pfam00038
    Location:1 → 35
    Filament; Intermediate filament protein

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049766.1 Alternate UNSW_CanFamBas_1.0

    Range
    32497397..32502517 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038638098.1 → XP_038494026.1  neurofilament medium polypeptide isoform X1

    Conserved Domains (2) summary
    pfam00038
    Location:100 → 411
    Filament; Intermediate filament protein
    pfam04732
    Location:10 → 74
    Filament_head; Intermediate filament head (DNA binding) region

  2. XM_038638099.1 → XP_038494027.1  neurofilament medium polypeptide isoform X2

    Conserved Domains (1) summary
    pfam00038
    Location:1 → 35
    Filament; Intermediate filament protein

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049246.1 Alternate UU_Cfam_GSD_1.0

    Range
    32663548..32668651 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038573782.1 → XP_038429710.1  neurofilament medium polypeptide isoform X1

    UniProtKB/TrEMBL
    A0A8C0KJ46, A0A8C0P2J8, A0A8I3NWE3, A0A8I3NWH4, A0A8P0PJP7
    Conserved Domains (2) summary
    pfam00038
    Location:100 → 411
    Filament; Intermediate filament protein
    pfam04732
    Location:10 → 74
    Filament_head; Intermediate filament head (DNA binding) region

  2. XM_038573783.1 → XP_038429711.1  neurofilament medium polypeptide isoform X2

    Conserved Domains (1) summary
    pfam00038
    Location:1 → 35
    Filament; Intermediate filament protein

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006607.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    33076970..33082075 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_543237.7 → XP_543237.3  neurofilament medium polypeptide isoform X1

    UniProtKB/TrEMBL
    A0A8C0KJ46, A0A8C0P2J8, A0A8I3NWE3, A0A8I3NWH4, A0A8P0PJP7
    Conserved Domains (2) summary
    pfam00038
    Location:100 → 411
    Filament; Intermediate filament protein
    pfam04732
    Location:10 → 74
    Filament_head; Intermediate filament head (DNA binding) region

  2. XM_038458678.1 → XP_038314606.1  neurofilament medium polypeptide isoform X2

    Conserved Domains (1) summary
    pfam00038
    Location:1 → 35
    Filament; Intermediate filament protein
Nucleotide Protein
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