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    Hsp70Bc Heat-shock-protein-70Bc [ Drosophila melanogaster ]

    Gene ID: 48583, updated on 19-May-2012
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    Summary

    Official Symbol
    Hsp70Bcprovided by Flybase
    Official Full Name
    Heat-shock-protein-70Bcprovided by Flybase
    Primary source
    FLYBASE:FBgn0013279
    Locus tag
    Dmel_CG6489
    Gene type
    protein coding
    RNA name
    Heat-shock-protein-70Bc
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6489; dhsp70; dHsp70; Dm-hsp70; Dmel\CG6489; Hsp 70; hsp-70; hsp70; Hsp70; HSP70; hsp70 87C; Hsp70(87C); Hsp70-BC; Hsp70A7d; hsp70B; Hsp70B; Hsp70Bbc; hsp70Bc; HSP70Bc; Hsp70Bd
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    Genomic context

    Location :
    87B14-87B15
    Sequence :
    Chromosome: 3R; NT_033777.2 (8334798..8337183)
    See Hsp70Bc in Epigenomics, MapViewer

    Chromosome 3R - NT_033777.2Genomic Context describing neighboring genes Neighboring gene CG5834 gene product from transcript CG5834-RA Neighboring gene Heat-shock-protein-70Bb Neighboring gene CG42244 gene product from transcript CG42244-RJ Neighboring gene hugin Neighboring gene mir-284 stem loop

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. Glial Hsp70 protects K+ homeostasis in the Drosophila brain during repetitive anoxic depolarization. Armstrong GA, et al. PLoS One, 2011. PMID 22174942.
    2. The RNA helicase Rm62 cooperates with SU(VAR)3-9 to re-silence active transcription in Drosophila melanogaster. Boeke J, et al. PLoS One, 2011. PMID 21674064.
    3. Physical assessment of toxicology at nanoscale: nano dose-metrics and toxicity factor. Pompa PP, et al. Nanoscale, 2011 Jul. PMID 21547322.
    4. Environmental stress-dependent effects of deletions encompassing Hsp70Ba on canalization and quantitative trait asymmetry in Drosophila melanogaster. Takahashi KH, et al. PLoS One, 2011 Apr 25. PMID 21541022.
    5. Expanded polyglutamine domain possesses nuclear export activity which modulates subcellular localization and toxicity of polyQ disease protein via exportin-1. Chan WM, et al. Hum Mol Genet, 2011 May 1. PMID 21300695.

    See all (333) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. Targeted expression of the chaperone protein Hsp70 in glial cells delays a permanent loss of ion homeostasis associated with repetitive anoxic stress.
      Title: Glial Hsp70 protects K+ homeostasis in the Drosophila brain during repetitive anoxic depolarization.
    2. B52 delivers Topo I to RNA polymerase II-active chromatin loci and DNA topology and mRNA release can be coordinated to control gene expression.
      Title: The SR protein B52/SRp55 is required for DNA topoisomerase I recruitment to chromatin, mRNA release and transcription shutdown.
    3. Variation in most stressed locomotion traits exceeds that caused by Hsp70 mutation, reveals uncoupling between thermoprotection of behavior and performance, and suggests significant genetic variation for trait-specific modifiers of thermotolerance.
      Title: Natural variation in Drosophila stressed locomotion meets or exceeds variation caused by hsp70 mutation: analysis of behavior and performance.
    Submit: New GeneRIF Correction
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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    BioGRID:71513 BioGRID:60138 CG11266    BioGRID  PubMed Two-hybrid 
    BioGRID:71513 BioGRID:57628 CG11380    BioGRID  PubMed Two-hybrid 
    BioGRID:71513 BioGRID:63288 CG12782    BioGRID  PubMed Two-hybrid 
    BioGRID:71513 BioGRID:62860 CG15109    BioGRID  PubMed Two-hybrid 
    BioGRID:71513 BioGRID:63098 CG15676    BioGRID  PubMed Two-hybrid 
    BioGRID:71513 BioGRID:60841 CG16884    BioGRID  PubMed Two-hybrid 
    BioGRID:71513 BioGRID:64715 CG17826    BioGRID  PubMed Two-hybrid 
    BioGRID:71513 BioGRID:61210 CG18094    BioGRID  PubMed Two-hybrid 
    BioGRID:71513 BioGRID:61789 CG1968    BioGRID  PubMed Two-hybrid 
    BioGRID:71513 BioGRID:67235 CG31122    BioGRID  PubMed Two-hybrid 
    BioGRID:71513 BioGRID:65803 CG31534    BioGRID  PubMed Two-hybrid 
    BioGRID:71513 BioGRID:57935 CG32772    BioGRID  PubMed Two-hybrid 
    BioGRID:71513 BioGRID:62107 CG42700    BioGRID  PubMed Two-hybrid 
    BioGRID:71513 BioGRID:68010 CG4730    BioGRID  PubMed Two-hybrid 
    BioGRID:71513 BioGRID:64085 CG4835    BioGRID  PubMed Two-hybrid 
    BioGRID:71513 BioGRID:62666 CG4853    BioGRID  PubMed Two-hybrid 
    BioGRID:71513 BioGRID:65502 CG5618    BioGRID  PubMed Two-hybrid 
    BioGRID:71513 BioGRID:64737 CG5645    BioGRID  PubMed Two-hybrid 
    BioGRID:71513 BioGRID:67212 CG7146    BioGRID  PubMed Two-hybrid 
    BioGRID:71513 BioGRID:64999 CG7945    BioGRID  PubMed Two-hybrid 
    BioGRID:71513 BioGRID:61309 CG9331    BioGRID  PubMed Two-hybrid 
    BioGRID:71513 BioGRID:68262 CG9986    BioGRID  PubMed Two-hybrid 
    BioGRID:71513 BioGRID:60514 CHIP    BioGRID  PubMed Two-hybrid 
    BioGRID:71513 BioGRID:63989 Cpr64Ad    BioGRID  PubMed Two-hybrid 
    BioGRID:71513 BioGRID:66620 Cyp9f2    BioGRID  PubMed Two-hybrid 
    BioGRID:71513 BioGRID:66274 HP1e    BioGRID  PubMed Two-hybrid 
    BioGRID:71513 BioGRID:61671 Lcp2    BioGRID  PubMed Two-hybrid 
    BioGRID:71513 BioGRID:66320 P58IPK    BioGRID  PubMed Two-hybrid 
    BioGRID:71513 BioGRID:67562 SKIP    BioGRID  PubMed Two-hybrid 
    BioGRID:71513 BioGRID:68427 Sry-alpha    BioGRID  PubMed Two-hybrid 
    BioGRID:71513 BioGRID:66459 Tpc1    BioGRID  PubMed Two-hybrid 
    BioGRID:71513 BioGRID:69288 bsk    BioGRID  PubMed Two-hybrid 
    BioGRID:71513 BioGRID:65450 hale    BioGRID  PubMed Two-hybrid 
    BioGRID:71513 BioGRID:607093 lobo    BioGRID  PubMed Two-hybrid 
    BioGRID:71513 BioGRID:72097 mod(mdg4)    BioGRID  PubMed Two-hybrid 
    BioGRID:71513 BioGRID:65379 pip    BioGRID  PubMed Two-hybrid 
    BioGRID:71513 BioGRID:65184 sinah    BioGRID  PubMed Two-hybrid 
    BioGRID:71513 BioGRID:64862 stv    BioGRID  PubMed Two-hybrid 
    BioGRID:71513 BioGRID:61927 trsn    BioGRID  PubMed Two-hybrid 
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    General gene information

    Homology

    • Homologs of the Hsp70Bc gene: The Hsp70Bc gene is conserved in human, chimpanzee, , dog, cow, mouse, rat, zebrafish, A.thaliana, and P.falciparum.

    Pathways from BioSystems

    • Endocytosis, organism-specific biosystem (from KEGG)
      Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Endocytosis, conserved biosystem (from KEGG)
      Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
    • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    • Spliceosome, organism-specific biosystem (from KEGG)
      Spliceosome, organism-specific biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
    • Spliceosome, conserved biosystem (from KEGG)
      Spliceosome, conserved biosystemAfter transcription, eukaryotic mRNA precursors contain protein-coding exons and noncoding introns. In the following splicing, introns are excised and exons are joined by a macromolecular complex, th...
    • Spliceosome, 35S U5-snRNP, organism-specific biosystem (from KEGG)
      Spliceosome, 35S U5-snRNP, organism-specific biosystemStructural complex; Genetic information processing; Spliceosome
    • Spliceosome, Prp19/CDC5L complex, organism-specific biosystem (from KEGG)
      Spliceosome, Prp19/CDC5L complex, organism-specific biosystemStructural complex; Genetic information processing; Spliceosome

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    heat shock-mediated polytene chromosome puffing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    response to heat NAS
    Non-traceable Author Statement
    more info
    		  
    response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    response to hypoxia IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    response to methotrexate IEP
    Inferred from Expression Pattern
    more info
    		  
    Component Evidence Code Pubs
    microtubule associated complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
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    General protein information

    Preferred Names
    CG6489 gene product from transcript CG6489-RA
    Names
    87C locus
    CG6489-PA
    Heat-shock-protein-70Bc
    Hsp70Bc-PA
    heat shock 70
    heat-shock protein 70
    heat-shock-protein 70bc
    protein 70
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    NCBI Reference Sequences (RefSeq)

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.2

      Range
      8334798..8337183
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141952.2 → NP_650209.1  Heat-shock-protein-70Bc [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8INI8
      UniProtKB/Swiss-Prot
      Q9BIR7
      UniProtKB/Swiss-Prot
      Q9BIS2
      Related
      FBpp0082107
      Conserved Domains (1) summary
      PTZ00009
      Location:2 – 608
      Blast Score: 2562
      PTZ00009; heat shock 70 kDa protein; Provisional
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    mRNA BT031349.1 ABY76186.1
    genomic AF295954.1 AAG26908.1
    genomic AF350473.1 AAK30230.1
    genomic AF385408.1 AAK67157.1
    mRNA BT011058.1 AAR31129.1
    genomic AE014297.2 AAN13546.1
    genomic AF350475.1 AAK30232.1
    genomic AF295948.1 AAG26902.1
    genomic AF350487.1 AAK30244.1
    genomic AF295952.1 AAG26906.1
    genomic AF350474.1 AAK30231.1
    genomic AF350483.1 AAK30240.1
    genomic AF350484.1 AAK30241.1
    genomic AF350478.1 AAK30235.1
    genomic AF350481.1 AAK30238.1
    genomic AF350486.1 AAK30243.1
    genomic AF350470.1 AAK30227.1
    genomic AF350488.1 AAK30245.1
    genomic AE014297.2 AAG22149.2
    genomic AF350479.1 AAK30236.1
    mRNA BT011379.1 AAR96171.1
    genomic AF350476.1 AAK30233.1
    genomic AF295961.1 AAG26915.1
    genomic AF350482.1 AAK30239.1
    mRNA BT011541.1 AAS15677.1
    genomic AF295960.1 AAG26914.1
    genomic AF350468.1 AAK30225.1
    genomic AF350471.1 AAK30228.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P02824.1 GenPept
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    Additional Links

    Gene LinkOut

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