U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

HPN hepsin [ Canis lupus familiaris (dog) ]

Gene ID: 484583, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
HPNprovided by VGNC
Official Full Name
hepsinprovided by VGNC
Primary source
VGNC:VGNC:41772
See related
Ensembl:ENSCAFG00845003738
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See HPN in Genome Data Viewer
Location:
chromosome: 1
Exon count:
14
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 1 NC_051805.1 (118083712..118100079, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 1 NC_006583.4 (116886860..116903191, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 1 NC_049222.1 (118328288..118344658, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 1 NC_049261.1 (117646333..117662660, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 1 NC_049742.1 (117271725..117288073, complement)

Chromosome 1 - NC_051805.1Genomic Context describing neighboring genes Neighboring gene leucine rich repeat LGI family member 4 Neighboring gene FXYD domain containing ion transport regulator 3 Neighboring gene uncharacterized LOC119869745 Neighboring gene sodium voltage-gated channel beta subunit 1 Neighboring gene GRAM domain containing 1A

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables serine-type exopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of epithelial to mesenchymal transition IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cell shape IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
serine protease hepsin
Names
hepsin (transmembrane protease, serine 1)
XP_038309232.1
XP_038324516.1
XP_038324517.1
XP_038324518.1
XP_038324519.1
XP_038385297.1
XP_038385298.1
XP_038449554.1
XP_038449555.1
XP_038449556.1
XP_038449557.1
XP_038513410.1
XP_038513411.1
XP_541697.2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051805.1 Reference ROS_Cfam_1.0

    Range
    118083712..118100079 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038657482.1 → XP_038513410.1  serine protease hepsin isoform X1

    UniProtKB/TrEMBL
    A0A8C0R429, A0A8C0RWA3, A0A8I3RRL2
    Related
    ENSCAFP00845005311.1, ENSCAFT00845006679.1
    Conserved Domains (2) summary
    cd00190
    Location:163 → 400
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam09272
    Location:51 → 159
    Hepsin-SRCR; Hepsin, SRCR

  2. XM_038657483.1 → XP_038513411.1  serine protease hepsin isoform X2

    UniProtKB/TrEMBL
    A0A8C0RWA9, A0A8I3MJ27
    Related
    ENSCAFP00845005349.1, ENSCAFT00845006727.1
    Conserved Domains (2) summary
    cd00190
    Location:100 → 337
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam09272
    Location:1 → 96
    Hepsin-SRCR; Hepsin, SRCR

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049261.1 Alternate UMICH_Zoey_3.1

    Range
    117646333..117662660 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038468588.1 → XP_038324516.1  serine protease hepsin isoform X1

    Conserved Domains (2) summary
    cd00190
    Location:163 → 400
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam09272
    Location:51 → 159
    Hepsin-SRCR; Hepsin, SRCR

  2. XM_038468589.1 → XP_038324517.1  serine protease hepsin isoform X2

    Conserved Domains (2) summary
    cd00190
    Location:100 → 337
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam09272
    Location:1 → 96
    Hepsin-SRCR; Hepsin, SRCR

  3. XM_038468590.1 → XP_038324518.1  serine protease hepsin isoform X3

  4. XM_038468591.1 → XP_038324519.1  serine protease hepsin isoform X3

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049742.1 Alternate UNSW_CanFamBas_1.0

    Range
    117271725..117288073 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038593626.1 → XP_038449554.1  serine protease hepsin isoform X1

    Conserved Domains (2) summary
    cd00190
    Location:163 → 400
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam09272
    Location:51 → 159
    Hepsin-SRCR; Hepsin, SRCR

  2. XM_038593627.1 → XP_038449555.1  serine protease hepsin isoform X2

    Conserved Domains (2) summary
    cd00190
    Location:100 → 337
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam09272
    Location:1 → 96
    Hepsin-SRCR; Hepsin, SRCR

  3. XM_038593628.1 → XP_038449556.1  serine protease hepsin isoform X4

  4. XM_038593629.1 → XP_038449557.1  serine protease hepsin isoform X4

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049222.1 Alternate UU_Cfam_GSD_1.0

    Range
    118328288..118344658 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038529369.1 → XP_038385297.1  serine protease hepsin isoform X1

    UniProtKB/TrEMBL
    A0A8C0R429, A0A8C0RWA3, A0A8I3RRL2
    Conserved Domains (2) summary
    cd00190
    Location:163 → 400
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam09272
    Location:51 → 159
    Hepsin-SRCR; Hepsin, SRCR

  2. XM_038529370.1 → XP_038385298.1  serine protease hepsin isoform X2

    UniProtKB/TrEMBL
    A0A8C0RWA9, A0A8I3MJ27
    Conserved Domains (2) summary
    cd00190
    Location:100 → 337
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam09272
    Location:1 → 96
    Hepsin-SRCR; Hepsin, SRCR

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006583.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    116886860..116903191 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_541697.6 → XP_541697.2  serine protease hepsin isoform X1

    See identical proteins and their annotated locations for XP_541697.2

    UniProtKB/TrEMBL
    A0A8C0R429, A0A8C0RWA3, A0A8I3RRL2
    Conserved Domains (2) summary
    cd00190
    Location:163 → 400
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam09272
    Location:51 → 159
    Hepsin-SRCR; Hepsin, SRCR

  2. XM_038453304.1 → XP_038309232.1  serine protease hepsin isoform X2

    UniProtKB/TrEMBL
    A0A8C0RWA9, A0A8I3MJ27
    Conserved Domains (2) summary
    cd00190
    Location:100 → 337
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam09272
    Location:1 → 96
    Hepsin-SRCR; Hepsin, SRCR
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Miscellaneous