CkIIalpha Casein kinase II alpha subunit [Drosophila melanogaster] - Gene

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Summary

Official Symbol: CkIIalphaprovided by Flybase
Official Full Name: Casein kinase II alpha subunitprovided by Flybase
Primary source: FLYBASE:FBgn0000258
Locus tag: Dmel_CG17520
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: alphaCK2; anon-WO02059370.53; Cask-II-a; CG17520; CK II; CK-2; CK-II; CK-II alpha; CK2; CK2 alpha; CK2-alpha; CK2a; Ck2alpha; CK2alpha; CkII; CKII; CKII alpha; CKII-alpha; CKIIa; CKIIalfa; ckIIalpha; CKIIalpha; dCK2alpha; dCKII; dCKII alpha; DmCK2alpha; DmCKIIalpha; Dmel\CG17520; Tik

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Genomic context

Location :: 80D1-80D1

Sequence :: Chromosome: 3L; NT_037436.3 (23092680..23096562)

See CkIIalpha in Epigenomics, MapViewer

Chromosome 3L - NT_037436.3 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Coexpressing CK2alpha and CK2beta increases Smo accumulation and induces ectopic Hh target gene expression.
Title: Casein kinase 2 promotes Hedgehog signaling by regulating both smoothened and Cubitus interruptus.
overexpression of Tik elicits ectopic bristles in N(+) flies and suppresses the retinal defects of the gain-of-function allele N(spl).
Title: Functional dissection of Timekeeper (Tik) implicates opposite roles for CK2 and PP2A during Drosophila neurogenesis.
Results describe the isolation of temperature-sensitive alleles of Drosophila CK2alpha.
Title: Drosophila protein kinase CK2 is rendered temperature-sensitive by mutations of highly conserved residues flanking the activation segment.
Coimmunoprecipitation experiments revealed that the alpha-subunit of the protein kinase CK2 (CK2alpha) was associated with soluble Stellate.
Title: Genetically Derepressed Nucleoplasmic Stellate Protein in Spermatocytes of D. melanogaster interacts with the catalytic subunit of protein kinase 2 and carries histone-like lysine-methylated mark.
Dominant-negative CK2alpha induces potent effects on circadian rhythmicity.
Title: Dominant-negative CK2alpha induces potent effects on circadian rhythmicity.
casein kinase II has a role in regulating cAMP-response element-binding protein DNA binding by phosphorylation at specific CK sites
Title: Phosphorylation of conserved casein kinase sites regulates cAMP-response element-binding protein DNA binding in Drosophila.
CK2 alpha binds and phosphorylates ribosomal protein L22
Title: Interaction of casein kinase II with ribosomal protein L22 of Drosophila melanogaster.
Sequencing of full-length cDNA encoding subunits in platelets and megakaryocytic cells
Title: Sequencing of full-length cDNA encoding the alpha and beta subunits of human casein kinase II from human platelets and megakaryocytic cells. Expression of the casein kinase IIalpha intronless gene in a megakaryocytic cell line.
CK2alpha mutant flies show lengthened circadian period, decreased CK2 activity, and delayed nuclear entry of Per; these effects are probably direct, as CK2alpha specifically phosphorylates Per in vitro
Title: A role for casein kinase 2alpha in the Drosophila circadian clock.

Submit: New GeneRIF Correction

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Interactions

Products	Interactant	Other Gene	Source	Pubs	Description
NP_730774.1	NP_542940.1	CkIIbeta	BIND	PubMed	CKII-alpha interacts with CKII-beta.
NP_730774.1		CkIIbeta	BIND	PubMed	CKII-alpha interacts with an unspecified isoform of CKII-beta.
NP_730774.1	NP_524513.1	E(spl)	BIND	PubMed	CKII-alpha interacts with and phosphorylates m8.
NP_730774.1	NP_524511.1	HLHm5	BIND	PubMed	CKII-alpha interacts with and phosphorylates m5.
NP_730774.1	NP_536753.1	HLHm7	BIND	PubMed	CKII-alpha interacts with and phosphorylates m7.
NP_730774.1	NP_477134.1	RpL22	BIND	PubMed	CKII-alpha interacts with rpL22.
BioGRID:71396	BioGRID:67826	BRWD3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:71396	BioGRID:65590	CG10510	BioGRID	PubMed	Two-hybrid
BioGRID:71396	BioGRID:59102	CG12672	BioGRID	PubMed	Two-hybrid
BioGRID:71396	BioGRID:533580	CG14425	BioGRID	PubMed	Two-hybrid
BioGRID:71396	BioGRID:67973	CG31098	BioGRID	PubMed	Two-hybrid
BioGRID:71396	BioGRID:76940	CG31204	BioGRID	PubMed	Two-hybrid
BioGRID:71396	BioGRID:63414	CG3907	BioGRID	PubMed	Affinity Capture-MS
BioGRID:71396	BioGRID:67639	CG4813	BioGRID	PubMed	Affinity Capture-MS
BioGRID:71396	BioGRID:59555	CG4887	BioGRID	PubMed	Two-hybrid
BioGRID:71396	BioGRID:67382	CG4973	BioGRID	PubMed	Affinity Capture-MS
BioGRID:71396	BioGRID:58538	CkIIbeta	BioGRID	PubMed	Affinity Capture-MS; Two-hybrid
BioGRID:71396	BioGRID:62955	CkIIbeta2	BioGRID	PubMed	Affinity Capture-MS; Two-hybrid
BioGRID:71396	BioGRID:58247	Cp38	BioGRID	PubMed	Two-hybrid
BioGRID:71396	BioGRID:71050	Dek	BioGRID	PubMed	Affinity Capture-MS
BioGRID:71396	BioGRID:199342	Dvl1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:71396	BioGRID:199343	Dvl2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:71396	BioGRID:63783	Mfap1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:71396	BioGRID:63381	PHDP	BioGRID	PubMed	Two-hybrid
BioGRID:71396	BioGRID:68299	Pkc98E	BioGRID	PubMed	Two-hybrid
BioGRID:71396	BioGRID:61772	Prp38	BioGRID	PubMed	Affinity Capture-MS
BioGRID:71396	BioGRID:78288	Rab21	BioGRID	PubMed	Two-hybrid
BioGRID:71396	BioGRID:65211	Rbp6	BioGRID	PubMed	Two-hybrid
BioGRID:71396	BioGRID:61304	cad	BioGRID	PubMed	Two-hybrid
BioGRID:71396	BioGRID:58490	dsh	BioGRID	PubMed	Affinity Capture-Western
BioGRID:71396	BioGRID:60868	elB	BioGRID	PubMed	Two-hybrid
BioGRID:71396	BioGRID:68607	pan	BioGRID	PubMed	Biochemical Activity
BioGRID:71396	BioGRID:77702	par-1	BioGRID	PubMed	Two-hybrid

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General gene information

Markers

Dm1528 (e-PCR)
- UniSTS:8329

D1S3696 (e-PCR)
- UniSTS:474274

Dm1529 (e-PCR)
- UniSTS:23004

Pathways from BioSystems

Axon guidance, organism-specific biosystem (from REACTOME)
Axon guidance, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Developmental Biology, organism-specific biosystem (from REACTOME)
Developmental Biology, organism-specific biosystemcomputationally inferred pathway (not manually curated)
L1CAM interactions, organism-specific biosystem (from REACTOME)
L1CAM interactions, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Ribosome biogenesis in eukaryotes, organism-specific biosystem (from KEGG)
Ribosome biogenesis in eukaryotes, organism-specific biosystemRibosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It...
Ribosome biogenesis in eukaryotes, conserved biosystem (from KEGG)
Ribosome biogenesis in eukaryotes, conserved biosystemRibosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It...
Signal transduction by L1, organism-specific biosystem (from REACTOME)
Signal transduction by L1, organism-specific biosystemcomputationally inferred pathway (not manually curated)
Wnt signaling pathway, organism-specific biosystem (from KEGG)
Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
Wnt signaling pathway, conserved biosystem (from KEGG)
Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...

Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein kinase activity	NAS Non-traceable Author Statement more info	PubMed
protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
protein serine/threonine kinase activity	NAS Non-traceable Author Statement more info

Process	Evidence Code	Pubs
Wnt receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
chaeta development	IMP Inferred from Mutant Phenotype more info	PubMed
circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
compound eye development	IMP Inferred from Mutant Phenotype more info	PubMed
lateral inhibition	IMP Inferred from Mutant Phenotype more info	PubMed
locomotor rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
mitosis	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of protein ubiquitination	IMP Inferred from Mutant Phenotype more info
positive regulation of hh target transcription factor activity	IMP Inferred from Mutant Phenotype more info
positive regulation of smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info
protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
protein phosphorylation	NAS Non-traceable Author Statement more info
regulation of protein stability	IMP Inferred from Mutant Phenotype more info

Component	Evidence Code	Pubs
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytosol	IDA Inferred from Direct Assay more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed
protein kinase CK2 complex	IDA Inferred from Direct Assay more info	PubMed
protein kinase CK2 complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
protein kinase CK2 complex	NAS Non-traceable Author Statement more info

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General protein information

Preferred Names: CG17520 gene product from transcript CG17520-RA

Names: CG17520-PA; CG17520-PB; CG17520-PC; CkIIalpha-PA; CkIIalpha-PB; CkIIalpha-PC; NAP1-kinase; alpha subunit of drosophila casein kinase II; casein kinase 2; casein kinase II; casein kinase II alpha subunit; casein kinase II-alpha subunit; protein kinase CK2; timekeeper

NP_524918.1

EC 2.7.11.-

NP_730774.1

EC 2.7.11.-

NP_730775.1

EC 2.7.11.-

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NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.3

Range

23092680..23096562

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_168985.1 → NP_730774.1 casein kinase II alpha subunit, isoform A [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A4V2B8

UniProtKB/Swiss-Prot

P08181

Related

FBpp0070041, FBtr0070042

Conserved Domains (2) summary

pfam00069
Location:37 – 322
Blast Score: 510

Pkinase; Protein kinase domain

cl09925
Location:37 – 322
Blast Score: 499

PKc_like; Protein Kinases, catalytic domain
NM_168986.1 → NP_730775.1 casein kinase II alpha subunit, isoform C [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A4V2B8

UniProtKB/Swiss-Prot

P08181

Related

FBpp0070043, FBtr0070044

Conserved Domains (2) summary

pfam00069
Location:37 – 322
Blast Score: 510

Pkinase; Protein kinase domain

cl09925
Location:37 – 322
Blast Score: 499

PKc_like; Protein Kinases, catalytic domain
NM_080179.4 → NP_524918.1 casein kinase II alpha subunit, isoform B [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A4V2B8

UniProtKB/Swiss-Prot

P08181

Related

FBpp0070042, FBtr0070043

Conserved Domains (2) summary

pfam00069
Location:37 – 322
Blast Score: 510

Pkinase; Protein kinase domain

cl09925
Location:37 – 322
Blast Score: 499

PKc_like; Protein Kinases, catalytic domain

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AE014296.4	AAN11415.1
genomic	AE014296.4	AAN11416.1
mRNA	AY069553.1	AAL39698.1
genomic	AE014296.4	AAF45439.1
mRNA	M16534.1	AAA28429.1