U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

CD274 CD274 molecule [ Canis lupus familiaris (dog) ]

Gene ID: 484186, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
CD274provided by VGNC
Official Full Name
CD274 moleculeprovided by VGNC
Primary source
VGNC:VGNC:38942
See related
Ensembl:ENSCAFG00845016107
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
PDL1; PD-L1
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 1
Exon count:
13
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 1 NC_051805.1 (94015405..94159596)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 1 NC_006583.4 (93993732..94011736)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 1 NC_049222.1 (94260510..94278519)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 1 NC_049261.1 (93771527..93789533)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 1 NC_049742.1 (93496313..93514317)

Chromosome 1 - NC_051805.1Genomic Context describing neighboring genes Neighboring gene Janus kinase 2 Neighboring gene 26S proteasome regulatory subunit 10B-like Neighboring gene insulin like 6 Neighboring gene relaxin 2 Neighboring gene plasminogen receptor with a C-terminal lysine Neighboring gene uncharacterized LOC111096980 Neighboring gene programmed cell death 1 ligand 2 Neighboring gene uncharacterized LOC111096981 Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Immune regulation of canine tumour and macrophage PD-L1 expression. Hartley G, et al. Vet Comp Oncol, 2017 Jun. PMID 26842912
  2. Increased programmed death ligand (PD-L1) and cytotoxic T-lymphocyte antigen-4 (CTLA-4) expression is associated with metastasis and poor prognosis in malignant canine mammary gland tumours. Ariyarathna H, et al. Vet Immunol Immunopathol, 2020 Dec. PMID 33129194
  3. Programmed Cell Death Ligand 1 Expression in Canine Cancer. Shosu K, et al. In Vivo, 2016 May-Jun. PMID 27107075

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Increased programmed death ligand (PD-L1) and cytotoxic T-lymphocyte antigen-4 (CTLA-4) expression is associated with metastasis and poor prognosis in malignant canine mammary gland tumours.
    Title: Increased programmed death ligand (PD-L1) and cytotoxic T-lymphocyte antigen-4 (CTLA-4) expression is associated with metastasis and poor prognosis in malignant canine mammary gland tumours.
  2. immune upregulation in tumor cells and macrophages
    Title: Immune regulation of canine tumour and macrophage PD-L1 expression.
  3. Data indicate that programmed cell death-ligand 1 (PD-L1) was found in the cells of most tumor cell lines, but programmed cell death-1 (PD-1) was not detected in all of the cell lines, only in two mast cell tumor and two lymphoma cell lines.
    Title: Programmed Cell Death Ligand 1 Expression in Canine Cancer.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RefSeq

Process Evidence Code Pubs
involved_in T cell costimulation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cellular response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of T cell proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of T cell proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
programmed cell death 1 ligand 1
Names
programmed death ligand 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001291972.1 → NP_001278901.1  programmed cell death 1 ligand 1 precursor

    See identical proteins and their annotated locations for NP_001278901.1

    Status: PROVISIONAL

    Source sequence(s)
    AB898678
    UniProtKB/TrEMBL
    A0A8C0JVJ1, A0A8C0MRV9, E2RKZ5
    Related
    ENSCAFP00845022568.1, ENSCAFT00845028674.1
    Conserved Domains (2) summary
    cd00096
    Location:21 → 24
    Ig; Ig strand A [structural motif]
    cl11960
    Location:21 → 130
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051805.1 Reference ROS_Cfam_1.0

    Range
    94015405..94159596
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038653529.1 → XP_038509457.1  programmed cell death 1 ligand 1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0JVJ1, A0A8C0MRV9, E2RKZ5
    Conserved Domains (2) summary
    cd00096
    Location:21 → 24
    Ig; Ig strand A [structural motif]
    cl11960
    Location:21 → 130
    Ig; Immunoglobulin domain

  2. XM_038653531.1 → XP_038509459.1  programmed cell death 1 ligand 1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0JVJ1, A0A8C0MRV9, E2RKZ5
    Conserved Domains (2) summary
    cd00096
    Location:21 → 24
    Ig; Ig strand A [structural motif]
    cl11960
    Location:21 → 130
    Ig; Immunoglobulin domain

  3. XM_038653530.1 → XP_038509458.1  programmed cell death 1 ligand 1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0JVJ1, A0A8C0MRV9, E2RKZ5
    Conserved Domains (2) summary
    cd00096
    Location:21 → 24
    Ig; Ig strand A [structural motif]
    cl11960
    Location:21 → 130
    Ig; Immunoglobulin domain

  4. XM_038653525.1 → XP_038509453.1  programmed cell death 1 ligand 1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0JVJ1, A0A8C0MRV9, E2RKZ5
    Conserved Domains (2) summary
    cd00096
    Location:21 → 24
    Ig; Ig strand A [structural motif]
    cl11960
    Location:21 → 130
    Ig; Immunoglobulin domain

  5. XM_038653526.1 → XP_038509454.1  programmed cell death 1 ligand 1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0JVJ1, A0A8C0MRV9, E2RKZ5
    Conserved Domains (2) summary
    cd00096
    Location:21 → 24
    Ig; Ig strand A [structural motif]
    cl11960
    Location:21 → 130
    Ig; Immunoglobulin domain

  6. XM_038653527.1 → XP_038509455.1  programmed cell death 1 ligand 1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0JVJ1, A0A8C0MRV9, E2RKZ5
    Conserved Domains (2) summary
    cd00096
    Location:21 → 24
    Ig; Ig strand A [structural motif]
    cl11960
    Location:21 → 130
    Ig; Immunoglobulin domain

  7. XM_038653528.1 → XP_038509456.1  programmed cell death 1 ligand 1 isoform X1

    UniProtKB/TrEMBL
    A0A8C0JVJ1, A0A8C0MRV9, E2RKZ5
    Conserved Domains (2) summary
    cd00096
    Location:21 → 24
    Ig; Ig strand A [structural motif]
    cl11960
    Location:21 → 130
    Ig; Immunoglobulin domain

  8. XM_038653532.1 → XP_038509460.1  programmed cell death 1 ligand 1 isoform X2

    UniProtKB/TrEMBL
    A0A7D5GBM1, A0A8I3NYT7, A0A8P0S893
    Related
    ENSCAFP00845022593.1, ENSCAFT00845028704.1
    Conserved Domains (2) summary
    cd00096
    Location:21 → 24
    Ig; Ig strand A [structural motif]
    cl11960
    Location:21 → 130
    Ig; Immunoglobulin domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049261.1 Alternate UMICH_Zoey_3.1

    Range
    93771527..93789533
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049742.1 Alternate UNSW_CanFamBas_1.0

    Range
    93496313..93514317
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049222.1 Alternate UU_Cfam_GSD_1.0

    Range
    94260510..94278519
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006583.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    93993732..94011736
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.