SIRT7 sirtuin 7 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: SIRT7provided by VGNC
Official Full Name: sirtuin 7provided by VGNC
Primary source: VGNC:VGNC:46188
See related: Ensembl:ENSCAFG00845008831
Gene type: protein coding
RefSeq status: MODEL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 9

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	9	NC_051813.1 (970474..976673)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	9	NC_006591.4 (979255..985455)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	9	NC_049230.1 (1200924..1207098)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	9	NC_049269.1 (995625..1001822)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	9	NC_049750.1 (1122234..1128418)

Chromosome 9 - NC_051813.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables NAD+ binding	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: NAD-dependent protein deacetylase sirtuin-7

XP_022278328.1

EC 2.3.1.286

XP_038340577.1

EC 2.3.1.286

XP_038340578.1

EC 2.3.1.286

XP_038340579.1

EC 2.3.1.286

XP_038340580.1

EC 2.3.1.286

XP_038402220.1

EC 2.3.1.286

XP_038402221.1

EC 2.3.1.286

XP_038402222.1

EC 2.3.1.286

XP_038402223.1

EC 2.3.1.286

XP_038466226.1

EC 2.3.1.286

XP_038466227.1

EC 2.3.1.286

XP_038466228.1

EC 2.3.1.286

XP_038466229.1

EC 2.3.1.286

XP_038479072.1

EC 2.3.1.286

XP_038479078.1

EC 2.3.1.286

XP_038531340.1

EC 2.3.1.286

XP_038531341.1

EC 2.3.1.286

XP_038531343.1

EC 2.3.1.286

XP_038531344.1

EC 2.3.1.286

XP_540490.2

EC 2.3.1.286

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051813.1 Reference ROS_Cfam_1.0

Range

970474..976673

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038675416.1 → XP_038531344.1 NAD-dependent protein deacetylase sirtuin-7 isoform X4

Conserved Domains (2) summary

COG1196
Location:7 → 94

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cl00195
Location:100 → 235

SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
XM_038675415.1 → XP_038531343.1 NAD-dependent protein deacetylase sirtuin-7 isoform X3

Conserved Domains (2) summary

COG1196
Location:7 → 94

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd01410
Location:100 → 314

SIRT7; Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein ...
XM_038675412.1 → XP_038531340.1 NAD-dependent protein deacetylase sirtuin-7 isoform X1

UniProtKB/TrEMBL

A0A8C0KAD5, A0A8C0PJK7, A0A8I3N4Z4, A0A8P0N8H4

Related

ENSCAFP00845012108.1, ENSCAFT00845015582.1

Conserved Domains (2) summary

COG1196
Location:7 → 94

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd01410
Location:100 → 314

SIRT7; Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein ...
XM_038675413.1 → XP_038531341.1 NAD-dependent protein deacetylase sirtuin-7 isoform X2

Conserved Domains (1) summary

cd01410
Location:54 → 268

SIRT7; Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein ...

RNA

XR_005431830.1 RNA Sequence

Alternate UMICH_Zoey_3.1

Genomic

NC_049269.1 Alternate UMICH_Zoey_3.1

Range

995625..1001822

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038484652.1 → XP_038340580.1 NAD-dependent protein deacetylase sirtuin-7 isoform X4

Conserved Domains (2) summary

COG1196
Location:7 → 94

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cl00195
Location:100 → 235

SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
XM_038484651.1 → XP_038340579.1 NAD-dependent protein deacetylase sirtuin-7 isoform X3

Conserved Domains (2) summary

COG1196
Location:7 → 94

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd01410
Location:100 → 314

SIRT7; Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein ...
XM_038484649.1 → XP_038340577.1 NAD-dependent protein deacetylase sirtuin-7 isoform X1

Conserved Domains (2) summary

COG1196
Location:7 → 94

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd01410
Location:100 → 314

SIRT7; Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein ...
XM_038484650.1 → XP_038340578.1 NAD-dependent protein deacetylase sirtuin-7 isoform X2

Conserved Domains (1) summary

cd01410
Location:54 → 268

SIRT7; Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein ...

RNA

XR_005330354.1 RNA Sequence

Alternate UNSW_CanFamBas_1.0

Genomic

NC_049750.1 Alternate UNSW_CanFamBas_1.0

Range

1122234..1128418

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038610301.1 → XP_038466229.1 NAD-dependent protein deacetylase sirtuin-7 isoform X4

Conserved Domains (2) summary

COG1196
Location:7 → 94

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cl00195
Location:100 → 235

SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
XM_038610300.1 → XP_038466228.1 NAD-dependent protein deacetylase sirtuin-7 isoform X3

Conserved Domains (2) summary

COG1196
Location:7 → 94

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd01410
Location:100 → 314

SIRT7; Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein ...
XM_038610298.1 → XP_038466226.1 NAD-dependent protein deacetylase sirtuin-7 isoform X1

Conserved Domains (2) summary

COG1196
Location:7 → 94

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd01410
Location:100 → 314

SIRT7; Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein ...
XM_038610299.1 → XP_038466227.1 NAD-dependent protein deacetylase sirtuin-7 isoform X2

Conserved Domains (1) summary

cd01410
Location:54 → 268

SIRT7; Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein ...

RNA

XR_005398543.1 RNA Sequence

Alternate UU_Cfam_GSD_1.0

Genomic

NC_049230.1 Alternate UU_Cfam_GSD_1.0

Range

1200924..1207098

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038546292.1 → XP_038402220.1 NAD-dependent protein deacetylase sirtuin-7 isoform X1

UniProtKB/TrEMBL

A0A8C0KAD5, A0A8C0PJK7, A0A8I3N4Z4, A0A8P0N8H4

Conserved Domains (2) summary

COG1196
Location:7 → 94

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd01410
Location:100 → 314

SIRT7; Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein ...
XM_038546295.1 → XP_038402223.1 NAD-dependent protein deacetylase sirtuin-7 isoform X4

Conserved Domains (2) summary

COG1196
Location:7 → 94

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cl00195
Location:100 → 235

SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
XM_038546294.1 → XP_038402222.1 NAD-dependent protein deacetylase sirtuin-7 isoform X3

Conserved Domains (2) summary

COG1196
Location:7 → 94

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd01410
Location:100 → 314

SIRT7; Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein ...
XM_038546293.1 → XP_038402221.1 NAD-dependent protein deacetylase sirtuin-7 isoform X2

Conserved Domains (1) summary

cd01410
Location:54 → 268

SIRT7; Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein ...

RNA

XR_005364114.1 RNA Sequence

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

NC_006591.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

Range

979255..985455

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_022422620.2 → XP_022278328.1 NAD-dependent protein deacetylase sirtuin-7 isoform X4

Conserved Domains (2) summary

COG1196
Location:7 → 94

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cl00195
Location:100 → 235

SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
XM_038623150.1 → XP_038479078.1 NAD-dependent protein deacetylase sirtuin-7 isoform X3

Conserved Domains (2) summary

COG1196
Location:7 → 94

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd01410
Location:100 → 314

SIRT7; Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein ...
XM_540490.6 → XP_540490.2 NAD-dependent protein deacetylase sirtuin-7 isoform X1

UniProtKB/TrEMBL

A0A8C0KAD5, A0A8C0PJK7, A0A8I3N4Z4, A0A8P0N8H4

Conserved Domains (2) summary

COG1196
Location:7 → 94

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

cd01410
Location:100 → 314

SIRT7; Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein ...
XM_038623144.1 → XP_038479072.1 NAD-dependent protein deacetylase sirtuin-7 isoform X2

Conserved Domains (1) summary

cd01410
Location:54 → 268

SIRT7; Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein ...