ttk tramtrack [Drosophila melanogaster] - Gene

Help top of page

Summary

Official Symbol: ttkprovided by Flybase
Official Full Name: tramtrackprovided by Flybase
Primary source: FLYBASE:FBgn0003870
Locus tag: Dmel_CG1856
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 0037/17; 0250/25; 0438/31; 0702/07; 1049/07; 1119/04; 1184/16; 1209/05; 1209/10; 1260/10; 1281/04; 1325/15; 1372/08; 1396/14; 1418/06; 3540; 5125; 5311; anon-EST:Liang-2.9; CG11558; CG1856; clone 2.9; Dmel\CG1856; E(yan)100D; ftz-f2; FTZ-F2; ftzf2/ttk; l(3)02667; l(3)j2A1; l(3)j7B8; osn; oss; ovs; tramtrak; Ttk; TTK; ttk/FTZ-F2; ttk69; Ttk69; TTK69; Ttk88; TTK88; TTKA; ttkp69; twk

Help top of page

Genomic context

Location :: 100D1-100D1

Sequence :: Chromosome: 3R; NT_033777.2 (27539591..27561114)

See ttk in Epigenomics, MapViewer

Chromosome 3R - NT_033777.2 Genomic Context describing neighboring genes

Help top of page

Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

Help top of page

Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

TTK69 is able to bind chromatin in the absence of NuRD, but targeting of NuRD is dependent on TTK69.
Title: Drosophila transcription factor Tramtrack69 binds MEP1 to recruit the chromatin remodeler NuRD.
Results lead to conclude that Ttk69 can either directly or indirectly repress lz gene expression to prevent the premature development of R7 precursor cells in the developing eye of Drosophila.
Title: Ttk69-dependent repression of lozenge prevents the ectopic development of R7 cells in the Drosophila larval eye disc.
Tramtrack69 (TTK69) controls the fates and shapes of all columnar follicle cells
Title: Control in time and space: Tramtrack69 cooperates with Notch and Ecdysone to repress ectopic fate and shape changes during Drosophila egg chamber maturation.
Tramtrack (Ttk), a zinc-finger protein, is essential for the endocycle/gene amplification switch, is regulated negatively by Notch and positively by EcR.
Title: Regulation of the endocycle/gene amplification switch by Notch and ecdysone signaling.
Sina protein may direct the degradation of the transcriptional repressor Tramtrack (Ttk) using two different mechanisms.
Title: Two modes of degradation of the tramtrack transcription factors by Siah homologues.
Deubiquitinylating enzyme UBP64 controls cell fate through stabilization of tkk.
Title: Deubiquitylating enzyme UBP64 controls cell fate through stabilization of the transcriptional repressor tramtrack.
Results suggest that the involvement of Tramtrack in different steps of tube morphogenesis identifies it as a key player in tracheal development.
Title: Tramtrack regulates different morphogenetic events during Drosophila tracheal development.
Tramtrack downregulates Cyclin E expression and is probably involved in the exit of cells from the cell cycle.
Title: Cell cycle diversity involves differential regulation of Cyclin E activity in the Drosophila bristle cell lineage.
the binding of TTK69 prevents the interaction of GAGA with the transcription machinery and compromises its activation potential
Title: Repression by TTK69 of GAGA-mediated activation occurs in the absence of TTK69 binding to DNA and solely requires the contribution of the POZ/BTB domain of TTK69.
identification of a novel allele of tramtrack
Title: The Drosophila female sterile mutation twin peaks is a novel allele of tramtrack and reveals a requirement for Ttk69 in epithelial morphogenesis.

Submit: New GeneRIF Correction See all (15)

Help top of page

Interactions

Products	Interactant	Other Gene	Source	Pubs	Description
BioGRID:71315	BioGRID:67597	AP-50	BioGRID	PubMed	Two-hybrid
BioGRID:71315	BioGRID:61074	Arr1	BioGRID	PubMed	Two-hybrid
BioGRID:71315	BioGRID:58604	CG11138	BioGRID	PubMed	Two-hybrid
BioGRID:71315	BioGRID:60093	CG11327	BioGRID	PubMed	Two-hybrid
BioGRID:71315	BioGRID:57941	CG12680	BioGRID	PubMed	Two-hybrid
BioGRID:71315	BioGRID:67185	CG14317	BioGRID	PubMed	Two-hybrid
BioGRID:71315	BioGRID:68044	CG14546	BioGRID	PubMed	Two-hybrid
BioGRID:71315	BioGRID:57687	CG14815	BioGRID	PubMed	Two-hybrid
BioGRID:71315	BioGRID:59851	CG15436	BioGRID	PubMed	Two-hybrid
BioGRID:71315	BioGRID:78121	CG17168	BioGRID	PubMed	Two-hybrid
BioGRID:71315	BioGRID:60276	CG17292	BioGRID	PubMed	Two-hybrid
BioGRID:71315	BioGRID:67681	CG31365	BioGRID	PubMed	Two-hybrid
BioGRID:71315	BioGRID:68039	CG42235	BioGRID	PubMed	Two-hybrid
BioGRID:71315	BioGRID:62692	CG6459	BioGRID	PubMed	Two-hybrid
BioGRID:71315	BioGRID:64401	CG6486	BioGRID	PubMed	Two-hybrid
BioGRID:71315	BioGRID:61085	CG7200	BioGRID	PubMed	Two-hybrid
BioGRID:71315	BioGRID:64172	CG7386	BioGRID	PubMed	Two-hybrid
BioGRID:71315	BioGRID:66690	CtBP	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:71315	BioGRID:65822	Gnf1	BioGRID	PubMed	Affinity Capture-MS
BioGRID:71315	BioGRID:61232	Hakai	BioGRID	PubMed	Two-hybrid
BioGRID:71315	BioGRID:72892	Irbp	BioGRID	PubMed	Affinity Capture-MS
BioGRID:71315	BioGRID:60943	Ku80	BioGRID	PubMed	Affinity Capture-MS
BioGRID:71315	BioGRID:65438	Mi-2	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:71315	BioGRID:69445	Pp4-19C	BioGRID	PubMed	Two-hybrid
BioGRID:71315	BioGRID:60686	Rab6	BioGRID	PubMed	Two-hybrid
BioGRID:71315	BioGRID:66301	Ras85D	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:71315	BioGRID:60505	RfC3	BioGRID	PubMed	Affinity Capture-MS
BioGRID:71315	BioGRID:67407	Stat92E	BioGRID	PubMed	Two-hybrid
BioGRID:71315	BioGRID:60212	TwdlE	BioGRID	PubMed	Two-hybrid
BioGRID:71315	BioGRID:68671	a	BioGRID	PubMed	Two-hybrid
BioGRID:71315	BioGRID:57554	ac	BioGRID	PubMed	Phenotypic Enhancement; Phenotypic Suppression
BioGRID:71315	BioGRID:59621	aop	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:71315	BioGRID:66028	bcd	BioGRID	PubMed	Two-hybrid
BioGRID:71315	BioGRID:533768	bft	BioGRID	PubMed	Phenotypic Enhancement
BioGRID:71315	BioGRID:68626	bip2	BioGRID	PubMed	Two-hybrid
BioGRID:71315	BioGRID:68910	bon	BioGRID	PubMed	Affinity Capture-MS
BioGRID:71315	BioGRID:63637	ebd1	BioGRID	PubMed	Two-hybrid
BioGRID:71315	BioGRID:66859	eff	BioGRID	PubMed	Two-hybrid
BioGRID:71315	BioGRID:65868	ksr	BioGRID	PubMed	Phenotypic Suppression
BioGRID:71315	BioGRID:59717	lilli	BioGRID	PubMed	Phenotypic Suppression
BioGRID:71315	BioGRID:69215	lolal	BioGRID	PubMed	Two-hybrid
BioGRID:71315	BioGRID:59482	lwr	BioGRID	PubMed	Two-hybrid
BioGRID:71315	BioGRID:68000	msi	BioGRID	PubMed	Phenotypic Suppression
BioGRID:71315	BioGRID:60845	nimC1	BioGRID	PubMed	Two-hybrid
BioGRID:71315	BioGRID:62356	phyl	BioGRID	PubMed	Phenotypic Enhancement; Phenotypic Suppression; Two-hybrid
BioGRID:71315	BioGRID:59347	run	BioGRID	PubMed	Phenotypic Suppression
BioGRID:71315	BioGRID:57555	sc	BioGRID	PubMed	Phenotypic Suppression
BioGRID:71315	BioGRID:58454	sev	BioGRID	PubMed	Phenotypic Suppression
BioGRID:71315	BioGRID:65183	sina	BioGRID	PubMed	Phenotypic Suppression; Two-hybrid
BioGRID:71315	BioGRID:65184	sinah	BioGRID	PubMed	Two-hybrid
BioGRID:71315	BioGRID:68333	stg	BioGRID	PubMed	Phenotypic Suppression
BioGRID:71315	BioGRID:68086	tx	BioGRID	PubMed	Two-hybrid

Help top of page

General gene information

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
RNA polymerase II core promoter proximal region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription	IDA Inferred from Direct Assay more info	PubMed
RNA polymerase II distal enhancer sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
chromatin binding	IDA Inferred from Direct Assay more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
sequence-specific DNA binding transcription factor activity	NAS Non-traceable Author Statement more info
zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
R1/R6 development	IMP Inferred from Mutant Phenotype more info
R7 cell development	IMP Inferred from Mutant Phenotype more info
R7 cell development	TAS Traceable Author Statement more info	PubMed
brain morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
branch fusion, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
branching involved in open tracheal system development	IMP Inferred from Mutant Phenotype more info	PubMed
cell fate determination	TAS Traceable Author Statement more info	PubMed
chitin-based cuticle development	IMP Inferred from Mutant Phenotype more info	PubMed
compound eye cone cell differentiation	IMP Inferred from Mutant Phenotype more info
compound eye corneal lens morphogenesis	IMP Inferred from Mutant Phenotype more info
dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
dorsal appendage formation	IMP Inferred from Mutant Phenotype more info	PubMed
dorsal trunk growth, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
inter-male aggressive behavior	IMP Inferred from Mutant Phenotype more info	PubMed
locomotion involved in locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of transcription from RNA polymerase II promoter	NAS Non-traceable Author Statement more info
negative regulation of transcription, DNA-dependent	IDA Inferred from Direct Assay more info	PubMed
neuron development	IMP Inferred from Mutant Phenotype more info	PubMed
ovarian follicle cell development	IMP Inferred from Mutant Phenotype more info	PubMed
peripheral nervous system development	TAS Traceable Author Statement more info	PubMed
positive regulation of transcription from RNA polymerase II promoter	IDA Inferred from Direct Assay more info	PubMed
regulation of cell shape	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of embryonic cell shape	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of transcription from RNA polymerase II promoter	NAS Non-traceable Author Statement more info
regulation of tube size, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
startle response	IMP Inferred from Mutant Phenotype more info	PubMed
tracheal outgrowth, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
nucleus	IDA Inferred from Direct Assay more info	PubMed
nucleus	NAS Non-traceable Author Statement more info
polytene chromosome	IDA Inferred from Direct Assay more info	PubMed
transcriptional repressor complex	IPI Inferred from Physical Interaction more info	PubMed

Help top of page

General protein information

Preferred Names: CG1856 gene product from transcript CG1856-RE

Names: CG1856-PA; CG1856-PB; CG1856-PC; CG1856-PD; CG1856-PE; CG1856-PF; CG1856-PG; CG1856-PH; Tramtrack88; Ttk88 repressor; enhancer of yan at 100D; oversensitive; schmal; tramtrack; tramtrack-69; tramtrack69; tramtrak; ttk-PA; ttk-PB; ttk-PC; ttk-PD; ttk-PE; ttk-PF; ttk-PG; ttk-PH

Help top of page

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.2

Range

27539591..27561114

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_170566.2 → NP_733445.1 tramtrack, isoform E [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

P42282

Related

FBpp0085186

Conserved Domains (3) summary

pfam05109
Location:267 – 411
Blast Score: 89

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

cl02518
Location:23 – 119
Blast Score: 296

BTB; BTB/POZ domain

cl15478
Location:646 – 669
Blast Score: 83

zf-C2H2; Zinc finger, C2H2 type
NM_170568.2 → NP_733447.1 tramtrack, isoform F [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

P17789

Related

FBpp0085187

Conserved Domains (1) summary

cl02518
Location:23 – 119
Blast Score: 297

BTB; BTB/POZ domain
NM_170565.1 → NP_733444.1 tramtrack, isoform B [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

P42282

Related

FBpp0085188, FBtr0085827

Conserved Domains (3) summary

pfam05109
Location:267 – 411
Blast Score: 89

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

cl02518
Location:23 – 119
Blast Score: 296

BTB; BTB/POZ domain

cl15478
Location:646 – 669
Blast Score: 83

zf-C2H2; Zinc finger, C2H2 type
NM_080172.3 → NP_524911.3 tramtrack, isoform C [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

P17789

Related

FBpp0085189

Conserved Domains (1) summary

cl02518
Location:23 – 119
Blast Score: 297

BTB; BTB/POZ domain
NM_170564.2 → NP_733443.1 tramtrack, isoform A [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

P42282

Related

FBpp0085190

Conserved Domains (3) summary

pfam05109
Location:267 – 411
Blast Score: 89

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

cl02518
Location:23 – 119
Blast Score: 296

BTB; BTB/POZ domain

cl15478
Location:646 – 669
Blast Score: 83

zf-C2H2; Zinc finger, C2H2 type
NM_170567.2 → NP_733446.1 tramtrack, isoform D [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

P17789

Related

FBpp0085191

Conserved Domains (1) summary

cl02518
Location:23 – 119
Blast Score: 297

BTB; BTB/POZ domain
NM_001202400.1 → NP_001189329.1 tramtrack, isoform G [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

P42282

Conserved Domains (3) summary

pfam05109
Location:267 – 411
Blast Score: 89

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

cl02518
Location:23 – 119
Blast Score: 296

BTB; BTB/POZ domain

cl15478
Location:646 – 669
Blast Score: 83

zf-C2H2; Zinc finger, C2H2 type
NM_001202401.1 → NP_001189330.1 tramtrack, isoform H [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/Swiss-Prot

P17789

Conserved Domains (1) summary

cl02518
Location:23 – 119
Blast Score: 297

BTB; BTB/POZ domain

Help top of page

Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AE014297.2	ADV37419.1
genomic	AE014297.2	AAN14282.1
genomic	AE014297.2	AAF57180.1
genomic	AE014297.2	AAF57179.1
genomic	AE014297.2	AAN14283.1
genomic	AE014297.2	AAF57181.1
mRNA	BT001723.1	AAN71478.1
genomic	AE014297.2	ADV37420.1
mRNA	AY122169.1	AAM52681.1
mRNA	X71627.1	CAA50634.1
genomic	AE014297.2	AAF57182.3