NME1 NME/NM23 nucleoside diphosphate kinase 1 [Homo sapiens] - Gene

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Summary

Official Symbol: NME1provided by HGNC
Official Full Name: NME/NM23 nucleoside diphosphate kinase 1provided by HGNC
Primary source: HGNC:7849
See related: Ensembl:ENSG00000239672; HPRD:01131; MIM:156490; Vega:OTTHUMG00000137474
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NB; AWD; NBS; GAAD; NDKA; NM23; NDPKA; NDPK-A; NM23-H1
Summary: This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Jul 2008]

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Genomic context

Location :: 17q21.3

Sequence :: Chromosome: 17; NC_000017.10 (49230920..49239450)

See NME1 in Epigenomics, MapViewer

Chromosome 17 - NC_000017.10 Genomic Context describing neighboring genes

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Genomic regions, transcripts, and products

Genomic Sequence

Go to nucleotideGraphics FASTA GenBank

Go to reference sequence details

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Bibliography

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest that TSLP might downregulate NME1 expression via STAT3 signaling pathway, affecting TIMP1 expression in influencing trophoblast invasion.
Title: Thymic stromal lymphopoietin downregulates NME1 expression and promotes invasion in human trophoblasts via the activation of STAT3 signaling pathway.
Nm23-H1 protects cells against oxidative stress through the engagement of DNA BER enzyme APE1
Title: Nm23-H1 protein binds to APE1 at AP sites and stimulates AP endonuclease activity following ionizing radiation of the human lung cancer A549 cells.
results indicated that expression patterns of ER, NM23-H1, and HER2 in primary breast cancer lesions warn that cells might have metastatic potential
Title: Expression patterns of ER, HER2, and NM23-H1 in breast cancer patients with different menopausal status: correlations with metastasis.
NM23-H1 gene may be the upstream regulator of metastasis-associated genes in lung cancer.
Title: [Study on invasion and metastasis-associated genes of lung cancer related with NM23-H1 gene].
Functional modulation of the metastatic suppressor Nm23-H1 by oncogenic viruses.
Title: Functional modulation of the metastatic suppressor Nm23-H1 by oncogenic viruses.
Cervical cancer patients with positive nm23-H1 and negative lipocalin 2 expression had the worst recurrence probability and overall survival.
Title: Implication of human nonmetastatic clone 23 Type 1 and its downstream gene lipocalin 2 in metastasis and patient's survival of cancer of uterine cervix.
There is a significant relationship between polymorphism of Nme1-1465 T>C and the prognosis of carcinoma of stomach.
Title: [Correlation of polymorphism of Nme1-1465 T>C and TGFβ1-509 T>C with genetic susceptibility of gastric carcinoma].
Expression of nm23-H1 is associated with poor prognosis in peripheral T-cell lymphoma, not otherwise specified.
Title: Expression of nm23-H1 is associated with poor prognosis in peripheral T-cell lymphoma, not otherwise specified.
nm23-H1 gene could inhibit proliferation and invasion of cervical cancer cells.
Title: [Effects of tumor metastasis suppressor gene nm23-H1 on invasion and proliferation of cervical cancer cell lines].
Using pH titration of LC buffers and MS/MS i.d., recombinant NM23-H1 subjected to autophosphorylation was shown to contain phosphorylated histidine at residue 118 at pH 5 and 6, with each level giving over 75% peptide coverage for identification.
Title: Mass spectrometry detection of histidine phosphorylation on NM23-H1.

Submit: New GeneRIF Correction See all (149)

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Phenotypes

Review eQTL and phenotype association data in this region using PheGenI

Products	Interactant	Other Gene	Source	Pubs	Description
NP_000260.1	NP_039869.1	HHV4gp086	BIND	PubMed	EBNA-3C interacts with Nm23-H1.
P15531	P27695	APEX1	HPRD	PubMed
P15531	O14965	AURKA	HPRD	PubMed
P15531	Q9H8Y8	GORASP2	HPRD	PubMed
P15531	P05556	ITGB1	HPRD	PubMed
P15531	Q8IVT5	KSR1	HPRD	PubMed
P15531	P14174	MIF	HPRD	PubMed
P15531	P15531	NME1	HPRD	PubMed
P15531	Q13232	NME3	HPRD	PubMed
P15531	O00746	NME4	HPRD	PubMed
P15531	O15160	POLR1C	HPRD	PubMed
P15531	Prune	PRUNE	HPRD	PubMed
P15531	P35398	RORA	HPRD	PubMed
P15531	Q92753	RORB	HPRD	PubMed
P15531	P55042	RRAD	HPRD	PubMed
P15531	Q01105	SET	HPRD	PubMed
P15531	P54274	TERF1	HPRD	PubMed
P15531	Q13009	TIAM1	HPRD	PubMed
P15531	Q96HA8	WDYHV1	HPRD	PubMed
BioGRID:110894	BioGRID:112666	AURKA	BioGRID	PubMed	Affinity Capture-Western; Co-fractionation; Two-hybrid
BioGRID:110894	BioGRID:971788	EBNA-LP	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110894	BioGRID:108893	GATA1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110894	BioGRID:117479	GORASP2	BioGRID	PubMed	Two-hybrid
BioGRID:110894	BioGRID:115331	HDAC5	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110894	BioGRID:109894	ITGB1	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:110894	BioGRID:110894	NME1	BioGRID	PubMed	Affinity Capture-Western; Co-crystal Structure; Two-hybrid
BioGRID:110894	BioGRID:110895	NME2	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110894	BioGRID:110896	NME3	BioGRID	PubMed	Affinity Capture-Western; Two-hybrid
BioGRID:110894	BioGRID:110897	NME4	BioGRID	PubMed	Two-hybrid
BioGRID:110894	BioGRID:114909	POLR1C	BioGRID	PubMed	Two-hybrid
BioGRID:110894	BioGRID:121827	PRUNE	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:110894	BioGRID:111817	RAC1	BioGRID	PubMed	Biochemical Activity
BioGRID:110894	BioGRID:112022	RORA	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:110894	BioGRID:112023	RORB	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:110894	BioGRID:112150	RRAD	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110894	BioGRID:112316	SET	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110894	BioGRID:116342	STRAP	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110894	BioGRID:112872	TERF1	BioGRID	PubMed	Reconstituted Complex; Two-hybrid
BioGRID:110894	BioGRID:112930	TIAM1	BioGRID	PubMed	Affinity Capture-Western
BioGRID:110894	BioGRID:113164	UBC	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110894	BioGRID:116430	USP18	BioGRID	PubMed	Affinity Capture-MS
BioGRID:110894	BioGRID:120405	WDYHV1	BioGRID	PubMed	Two-hybrid

Function	Evidence Code	Pubs
ATP binding	IDA Inferred from Direct Assay more info	PubMed
GTP binding	IDA Inferred from Direct Assay more info	PubMed
deoxyribonuclease activity	IDA Inferred from Direct Assay more info	PubMed
gamma-tubulin binding	IEA Inferred from Electronic Annotation more info
identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
kinase activity	IEA Inferred from Electronic Annotation more info
magnesium ion binding	IDA Inferred from Direct Assay more info	PubMed
nucleoside diphosphate kinase activity	IDA Inferred from Direct Assay more info	PubMed
nucleotide binding	IEA Inferred from Electronic Annotation more info
protein binding	IPI Inferred from Physical Interaction more info	PubMed
transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
CTP biosynthetic process	IEA Inferred from Electronic Annotation more info
GTP biosynthetic process	IEA Inferred from Electronic Annotation more info
UTP biosynthetic process	IEA Inferred from Electronic Annotation more info
cell differentiation	IEA Inferred from Electronic Annotation more info
endocytosis	IEA Inferred from Electronic Annotation more info
lactation	IEA Inferred from Electronic Annotation more info
negative regulation of cell proliferation	TAS Traceable Author Statement more info	PubMed
negative regulation of myeloid leukocyte differentiation	IEA Inferred from Electronic Annotation more info
nervous system development	IEA Inferred from Electronic Annotation more info
nucleobase-containing small molecule interconversion	TAS Traceable Author Statement more info
nucleobase-containing small molecule metabolic process	TAS Traceable Author Statement more info
nucleoside diphosphate phosphorylation	IDA Inferred from Direct Assay more info	PubMed
nucleotide metabolic process	IEA Inferred from Electronic Annotation more info
positive regulation of DNA binding	IDA Inferred from Direct Assay more info	PubMed
positive regulation of epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of apoptotic process	TAS Traceable Author Statement more info	PubMed
response to cAMP	IEA Inferred from Electronic Annotation more info
response to drug	IEA Inferred from Electronic Annotation more info
small molecule metabolic process	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
centrosome	IEA Inferred from Electronic Annotation more info
cytoplasm	IDA Inferred from Direct Assay more info	PubMed
cytoplasm	TAS Traceable Author Statement more info	PubMed
cytosol	TAS Traceable Author Statement more info
intermediate filament	IEA Inferred from Electronic Annotation more info
microsome	IEA Inferred from Electronic Annotation more info
mitochondrion	IEA Inferred from Electronic Annotation more info
nucleus	TAS Traceable Author Statement more info	PubMed
perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
soluble fraction	IEA Inferred from Electronic Annotation more info

General protein information

Preferred Names: nucleoside diphosphate kinase A

Names: nucleoside diphosphate kinase A; NDP kinase A; granzyme A-activated DNase; metastasis inhibition factor nm23; tumor metastatic process-associated protein; non-metastatic cells 1, protein (NM23A) expressed in

NP_000260.1

EC 2.7.4.6

NP_937818.1

EC 2.7.4.6

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NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_021169.1 RefSeqGene

Range

5001..13531

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_000269.2 → NP_000260.1 nucleoside diphosphate kinase A isoform b

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate exon compared to variant 1. The resulting isoform (b) has a shorter N-terminus compared to isoform a.

Source sequence(s)

AF487339, BE727815, BF965472, BG715560, BI666785, BM479520, BU600979

Consensus CDS

CCDS11579.1

UniProtKB/Swiss-Prot

P15531

Related

ENSP00000376892, OTTHUMP00000174723, ENST00000393196, OTTHUMT00000268662

Conserved Domains (1) summary

cd04413
Location:5 – 134
Blast Score: 621

NDPk_I; Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside ...
NM_198175.1 → NP_937818.1 nucleoside diphosphate kinase A isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).

Source sequence(s)

AF487339, AL360191, BE727815, BF965472, BG531372, BG715560, BG757842, BI666785, BM479520

Consensus CDS

CCDS11578.1

UniProtKB/Swiss-Prot

P15531

Related

ENSP00000337060, OTTHUMP00000174724, ENST00000336097, OTTHUMT00000268663

Conserved Domains (1) summary

cd04413
Location:30 – 159
Blast Score: 625

NDPk_I; Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside ...

RefSeqs of Annotated Genomes: Build 37.3

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh37.p5 Primary Assembly

Genomic

NC_000017.10 Reference GRCh37.p5 Primary Assembly

Range

49230920..49239450

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate HuRef

Genomic

AC_000149.1 Alternate HuRef

Range

44600187..44608715

Download

GenBank, FASTA, Sequence Viewer (Graphics)

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Related Sequences

Nucleotide		Protein
Heading	Accession and Version	Protein
genomic	AC005839.1 (80040..88570)	None
genomic	CH471109.2	EAW94568.1
genomic	X75598.1	CAA53270.1
mRNA	AF487339.1	AAO85436.1
mRNA	AK291105.1	BAF83794.1
mRNA	AK309160.1	None
mRNA	AL360166.1	None
mRNA	AL360191.1	None
mRNA	BC000293.2	AAH00293.1
mRNA	BC018994.2	AAH18994.1
mRNA	BE727815.1	None
mRNA	BF965472.1	None
mRNA	BG531372.1	None
mRNA	BG715560.1	None
mRNA	BG757842.1	None
mRNA	BI666785.1	None
mRNA	BM479520.1	None
mRNA	BU600979.1	None
mRNA	CR542104.1	CAG46901.1
mRNA	CR542115.1	CAG46912.1
mRNA	X17620.1	CAA35621.1
mRNA	X73066.1	CAA51527.1