APEX1 apurinic/apyrimidinic endodeoxyribonuclease 1 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: APEX1provided by VGNC
Official Full Name: apurinic/apyrimidinic endodeoxyribonuclease 1provided by VGNC
Primary source: VGNC:VGNC:54195
Gene type: protein coding
RefSeq status: INFERRED
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 15

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	15	NC_051819.1 (18043890..18046511)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	15	NC_006597.4 (18269795..18272409)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	15	NC_049236.1 (17910565..17913179)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	15	NC_049275.1 (17726748..17729354)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	15	NC_049756.1 (17781386..17784004)

Chromosome 15 - NC_051819.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables DNA-(apurinic or apyrimidinic site) endonuclease activity	IEA Inferred from Electronic Annotation more info	PubMed
enables double-stranded DNA 3'-5' DNA exonuclease activity	IEA Inferred from Electronic Annotation more info	PubMed
enables endonuclease activity	IEA Inferred from Electronic Annotation more info	PubMed
enables phosphoric diester hydrolase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in base-excision repair	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: DNA-(apurinic or apyrimidinic site) endonuclease

NP_001138591.1

EC 4.2.99.18

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001145119.2 → NP_001138591.1 DNA-(apurinic or apyrimidinic site) endonuclease

Status: INFERRED

Source sequence(s)

JAAUVH010000372

UniProtKB/TrEMBL

A0A8C0KMC3, A0A8C0YV60

Conserved Domains (1) summary

cd09087
Location:62 → 316

Ape1-like_AP-endo; Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases