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NID1 nidogen 1 [ Homo sapiens (human) ]

Gene ID: 4811, updated on 30-Aug-2015
Official Symbol
NID1provided by HGNC
Official Full Name
nidogen 1provided by HGNC
Primary source
HGNC:HGNC:7821
See related
Ensembl:ENSG00000116962; HPRD:00574; MIM:131390; Vega:OTTHUMG00000040071
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NID
Summary
This gene encodes a member of the nidogen family of basement membrane glycoproteins. The protein interacts with several other components of basement membranes, and may play a role in cell interactions with the extracellular matrix. [provided by RefSeq, Jul 2008]
Orthologs
See NID1 in Epigenomics, MapViewer
Location:
1q43
Exon count:
20
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 1 NC_000001.11 (235975830..236065181, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (236139130..236228481, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene lysosomal trafficking regulator Neighboring gene uncharacterized LOC105373215 Neighboring gene RNA, U5E small nuclear 2, pseudogene Neighboring gene uncharacterized LOC105373212 Neighboring gene aconitase 2, mitochondrial pseudogene Neighboring gene G protein-coupled receptor 137B

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Genome-wide association study identifies nidogen 1 (NID1) as a susceptibility locus to cutaneous nevi and melanoma risk.
NHGRI GWA Catalog
  • Degradation of the extracellular matrix, organism-specific biosystem (from REACTOME)
    Degradation of the extracellular matrix, organism-specific biosystemMatrix metalloproteinases (MMPs), previously referred to as matrixins because of their role in degradation of the extracellular matrix (ECM), are zinc and calcium dependent proteases belonging to the...
  • Extracellular matrix organization, organism-specific biosystem (from REACTOME)
    Extracellular matrix organization, organism-specific biosystemThe extracellular matrix is a component of all mammalian tissues, a network consisting largely of the fibrous proteins collagen, elastin and associated-microfibrils, fibronectin and laminins embedded...
  • Laminin interactions, organism-specific biosystem (from REACTOME)
    Laminin interactions, organism-specific biosystemLaminins are a large family of conserved, multidomain trimeric basement membrane proteins. There are many theoretical trimer combinations but only 18 have been described (Domogatskaya et al. 2012, Mi...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
collagen binding IDA
Inferred from Direct Assay
more info
PubMed 
laminin binding IDA
Inferred from Direct Assay
more info
PubMed 
laminin-1 binding IEA
Inferred from Electronic Annotation
more info
 
proteoglycan binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
basement membrane organization TAS
Traceable Author Statement
more info
PubMed 
cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
 
extracellular matrix disassembly TAS
Traceable Author Statement
more info
 
extracellular matrix organization TAS
Traceable Author Statement
more info
 
glomerular basement membrane development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell-substrate adhesion IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
basal lamina IEA
Inferred from Electronic Annotation
more info
 
basement membrane IDA
Inferred from Direct Assay
more info
PubMed 
cell periphery IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome IDA
Inferred from Direct Assay
more info
PubMed 
extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with extracellular matrix ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
Preferred Names
nidogen-1
Names
NID-1
enactin
entactin

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033228.1 RefSeqGene

    Range
    5001..94352
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002508.2NP_002499.2  nidogen-1 precursor

    See identical proteins and their annotated locations for NP_002499.2

    Status: REVIEWED

    Source sequence(s)
    AL122018, AL139161, BQ549657, CN267119, DA269707, DN999415, M30269
    Consensus CDS
    CCDS1608.1
    UniProtKB/Swiss-Prot
    P14543
    Related
    ENSP00000264187, OTTHUMP00000037970, ENST00000264187, OTTHUMT00000096647
    Conserved Domains (8) summary
    smart00135
    Location:10141055
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00539
    Location:106269
    NIDO; Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins
    cd00054
    Location:802840
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00191
    Location:849919
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    cd00255
    Location:429660
    nidG2; Nidogen, G2 domain; Nidogen is an important component of the basement membrane, an extracellular sheet-like matrix. Nidogen is a multifunctional protein that interacts with many other basement membrane proteins, like collagen, perlecan, lamin, and has a ...
    pfam00058
    Location:9921029
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam12947
    Location:762800
    EGF_3; EGF domain
    pfam14670
    Location:12121242
    FXa_inhibition; Coagulation Factor Xa inhibitory site

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p2 Primary Assembly

    Range
    235975830..236065181
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544195.1XP_011542497.1  

    Related
    ENSP00000355554, OTTHUMP00000038291, ENST00000366595, OTTHUMT00000097390
    Conserved Domains (8) summary
    smart00135
    Location:9721013
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00539
    Location:106269
    NIDO; Extracellular domain of unknown function in nidogen (entactin) and hypothetical proteins
    cd00054
    Location:760798
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00191
    Location:807877
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    cd00255
    Location:429660
    nidG2; Nidogen, G2 domain; Nidogen is an important component of the basement membrane, an extracellular sheet-like matrix. Nidogen is a multifunctional protein that interacts with many other basement membrane proteins, like collagen, perlecan, lamin, and has a ...
    pfam00058
    Location:950987
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam12947
    Location:720758
    EGF_3; EGF domain
    pfam14670
    Location:11701200
    FXa_inhibition; Coagulation Factor Xa inhibitory site

Alternate CHM1_1.1

Genomic

  1. NC_018912.2 Alternate CHM1_1.1

    Range
    237411406..237500740
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)