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    ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide [ Homo sapiens ]

    Gene ID: 481, updated on 19-May-2012
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    Summary

    Official Symbol
    ATP1B1provided by HGNC
    Official Full Name
    ATPase, Na+/K+ transporting, beta 1 polypeptideprovided by HGNC
    Primary source
    HGNC:804
    See related
    Ensembl:ENSG00000143153; HPRD:01663; MIM:182330; Vega:OTTHUMG00000034590
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ATP1B; MGC1798
    Summary
    The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been described, but their biological validity is not known. [provided by RefSeq, Mar 2010]
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    Genomic context

    Location :
    1q24
    Sequence :
    Chromosome: 1; NC_000001.10 (169075947..169101960)
    See ATP1B1 in Epigenomics, MapViewer

    Chromosome 1 - NC_000001.10Genomic Context describing neighboring genes Neighboring gene SUMO1 pseudogene 2 Neighboring gene ribosomal protein L29 pseudogene 7 Neighboring gene NME/NM23 family member 7 Neighboring gene basic leucine zipper nuclear factor 1 Neighboring gene chromosome 1 open reading frame 114 Neighboring gene solute carrier family 19 (thiamine transporter), member 2

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    Genomic regions, transcripts, and products

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details
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    Bibliography

    Related articles in PubMed

    1. A directed protein interaction network for investigating intracellular signal transduction. Vinayagam A, et al. Sci Signal, 2011 Sep 6. PMID 21900206.
    2. Association of ATP1B1, RGS5 and SELE polymorphisms with hypertension and blood pressure in African-Americans. Faruque MU, et al. J Hypertens, 2011 Oct. PMID 21881522.
    3. N-myc downstream-regulated gene 2, a novel estrogen-targeted gene, is involved in the regulation of Na+/K+-ATPase. Li Y, et al. J Biol Chem, 2011 Sep 16. PMID 21771789.
    4. Epithelial junctions depend on intercellular trans-interactions between the Na,K-ATPase β₁ subunits. Tokhtaeva E, et al. J Biol Chem, 2011 Jul 22. PMID 21642423.
    5. Phospholemman (FXYD1) raises the affinity of the human α1β1 isoform of Na,K-ATPase for Na ions. Cirri E, et al. Biochemistry, 2011 May 10. PMID 21449573.

    See all (57) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. examined polymorphisms in three genes (ATP1B1, RGS5 and SELE) in relation to hypertension and blood pressure in a cohort of African-Americans
      Title: Association of ATP1B1, RGS5 and SELE polymorphisms with hypertension and blood pressure in African-Americans.
    2. interactions between the beta subunits of neighboring cells maintain integrity of intercellular junctions
      Title: Epithelial junctions depend on intercellular trans-interactions between the Na,K-ATPase β₁ subunits.
    3. Na(+)-K(+) ATPase B1 can synergize with adriamycin and reverse drug resistance in MCF7 cells.
      Title: [Synergic effect of Na(+)-K(+) ATPaseB1 and adriamycin on inhibition of cell proliferation and reversal of drug resistance in breast cancer MCF-7 cells].
    4. FXYD1 raises the affinity of the human alpha1beta1 isoform of Na,K-ATPase for Na ions
      Title: Phospholemman (FXYD1) raises the affinity of the human α1β1 isoform of Na,K-ATPase for Na ions.
    5. Silencing of ATP1B1 gene can enhance the proliferation and migration capability of SGC-7901 adenocarcinoma cells.
      Title: [Interference of human Na/K-ATPase B1 subunit on proliferation and migration of gastric adenocarcinoma cell line SGC-7901].
    6. through its interaction with ATP1B1, MLC1 is involved in the control of intracellular osmotic conditions and volume regulation in astrocytes, opening new perspectives for understanding the pathological mechanisms of MLC disease.
      Title: The beta1 subunit of the Na,K-ATPase pump interacts with megalencephalic leucoencephalopathy with subcortical cysts protein 1 (MLC1) in brain astrocytes: new insights into MLC pathogenesis.
    7. Data indicate that CypB through its interaction with Na/K-beta1 might regulate maturation and trafficking of the pump through the secretory pathway.
      Title: Cyclophilin B interacts with sodium-potassium ATPase and is required for pump activity in proximal tubule cells of the kidney.
    8. Results identified that the beta1 subunit of the host Na(+)/K(+)-ATPase beta1 subunit (ATP1B1) interacts with the cytoplasmic domain of both the influenza A and B virus M2 and BM2 proteins.
      Title: Na(+)/K (+)-ATPase β1 subunit interacts with M2 proteins of influenza A and B viruses and affects the virus replication.
    9. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    10. ATP1B1 may confer susceptibility to BP regulation and hypertension in this Chinese population.
      Title: Association of ATP1B1 single-nucleotide polymorphisms with blood pressure and hypertension in a Chinese population.
    Submit: New GeneRIF Correction See all (21)
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    Phenotypes

    Review eQTL and phenotype association data in this region using PheGenI

    Blood pressure regulation QTL

    Common variants at ten loci modulate the QT interval duration in the QTSCD Study.

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    Interactions

    Products Interactant Other Gene Complex Source Pubs Description
    AAH00006.1 NP_036236.1 BACE1    BIND  PubMed BACE1 interacts with ATP1B1 (Na/K-ATPase, beta-subunit). This interaction was modelled on a demonstrated interaction between mouse BACE1 and human Na/K-ATPase, beta-subunit. 
    P05026 P56817 BACE1    HPRD  PubMed  
    P05026 P00533 EGFR    HPRD  PubMed  
    P05026 O00168 FXYD1    HPRD  PubMed  
    P05026 P58549 FXYD7    HPRD  PubMed  
    P05026 P30793 GCH1    HPRD  PubMed  
    P05026 Q5T3J3 LRIF1    HPRD  PubMed  
    BioGRID:106971 BioGRID:107787 CRIP2    BioGRID  PubMed Two-hybrid 
    BioGRID:106971 BioGRID:117107 DDAH2    BioGRID  PubMed Two-hybrid 
    BioGRID:106971 BioGRID:108446 EZH2    BioGRID  PubMed Two-hybrid 
    BioGRID:106971 BioGRID:111363 FXYD1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:106971 BioGRID:109367 HLA-DRA    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106971 BioGRID:109368 HLA-DRB1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106971 BioGRID:109370 HLA-DRB3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106971 BioGRID:109371 HLA-DRB4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106971 BioGRID:109372 HLA-DRB5    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:106971 BioGRID:120905 LRIF1    BioGRID  PubMed Two-hybrid 
    BioGRID:106971 BioGRID:115104 MLL4    BioGRID  PubMed Two-hybrid 
    BioGRID:106971 BioGRID:121520 NDRG2    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:106971 BioGRID:111692 PSME1    BioGRID  PubMed Two-hybrid 
    BioGRID:106971 BioGRID:117968 TRMT2A    BioGRID  PubMed Two-hybrid 
    BioGRID:106971 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
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    General gene information

    Markers

    Genotypes

    Homology

    Pathways from BioSystems

    • Aldosterone-regulated sodium reabsorption, organism-specific biosystem (from KEGG)
      Aldosterone-regulated sodium reabsorption, organism-specific biosystemSodium transport across the tight epithelia of Na+ reabsorbing tissues such as the distal part of the kidney nephron and colon is the major factor determining total-body Na+ levels, and thus, long-te...
    • Aldosterone-regulated sodium reabsorption, conserved biosystem (from KEGG)
      Aldosterone-regulated sodium reabsorption, conserved biosystemSodium transport across the tight epithelia of Na+ reabsorbing tissues such as the distal part of the kidney nephron and colon is the major factor determining total-body Na+ levels, and thus, long-te...
    • Basigin interactions, organism-specific biosystem (from REACTOME)
      Basigin interactions, organism-specific biosystemBasigin is a widely expressed transmembrane glycoprotein that belongs to the Ig superfamily and is highly enriched on the surface of epithelial cells. Basigin is involved in intercellular interaction...
    • Bile secretion, organism-specific biosystem (from KEGG)
      Bile secretion, organism-specific biosystemBile is a vital secretion, essential for digestion and absorption of fats and fat-soluble vitamins in the small intestine. Moreover, bile is an important route of elimination for excess cholesterol a...
    • Bile secretion, conserved biosystem (from KEGG)
      Bile secretion, conserved biosystemBile is a vital secretion, essential for digestion and absorption of fats and fat-soluble vitamins in the small intestine. Moreover, bile is an important route of elimination for excess cholesterol a...
    • Calcium Regulation in the Cardiac Cell, organism-specific biosystem (from WikiPathways)
      Calcium Regulation in the Cardiac Cell, organism-specific biosystemCalcium is a common signaling mechanism, as once it enters the cytoplasm it exerts allosteric regulatory affects on many enzymes and proteins. Calcium can act in signal transduction after influx resu...
    • Carbohydrate digestion and absorption, organism-specific biosystem (from KEGG)
      Carbohydrate digestion and absorption, organism-specific biosystemDietary carbohydrate in humans and omnivorous animals is a major nutrient. The carbohydrates that we ingest vary from the lactose in milk to complex carbohydrates. These carbohydrates are digested t...
    • Carbohydrate digestion and absorption, conserved biosystem (from KEGG)
      Carbohydrate digestion and absorption, conserved biosystemDietary carbohydrate in humans and omnivorous animals is a major nutrient. The carbohydrates that we ingest vary from the lactose in milk to complex carbohydrates. These carbohydrates are digested t...
    • Cardiac muscle contraction, organism-specific biosystem (from KEGG)
      Cardiac muscle contraction, organism-specific biosystemContraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation...
    • Cardiac muscle contraction, conserved biosystem (from KEGG)
      Cardiac muscle contraction, conserved biosystemContraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation...
    • Cell surface interactions at the vascular wall, organism-specific biosystem (from REACTOME)
      Cell surface interactions at the vascular wall, organism-specific biosystemLeukocyte extravasation is a rigorously controlled process that guides white cell movement from the vascular lumen to sites of tissue inflammation. The powerful adhesive interactions that are require...
    • Endocrine and other factor-regulated calcium reabsorption, organism-specific biosystem (from KEGG)
      Endocrine and other factor-regulated calcium reabsorption, organism-specific biosystemCalcium (Ca2+) is essential for numerous physiological functions including intracellular signalling processes, neuronal excitability, muscle contraction and bone formation. Therefore, its homeostasis...
    • Endocrine and other factor-regulated calcium reabsorption, conserved biosystem (from KEGG)
      Endocrine and other factor-regulated calcium reabsorption, conserved biosystemCalcium (Ca2+) is essential for numerous physiological functions including intracellular signalling processes, neuronal excitability, muscle contraction and bone formation. Therefore, its homeostasis...
    • Gastric acid secretion, organism-specific biosystem (from KEGG)
      Gastric acid secretion, organism-specific biosystemGastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections...
    • Gastric acid secretion, conserved biosystem (from KEGG)
      Gastric acid secretion, conserved biosystemGastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections...
    • Hemostasis, organism-specific biosystem (from REACTOME)
      Hemostasis, organism-specific biosystemHemostasis is a physiological response that culminates in the arrest of bleeding from an injured vessel. Under normal conditions the vascular endothelium supports vasodilation, inhibits platelet adhe...
    • Ion channel transport, organism-specific biosystem (from REACTOME)
      Ion channel transport, organism-specific biosystemIon channels mediate the flow of ions across the plasma membrane of cells. They are integral membrane proteins, typically a multimer of proteins, which, when arranged in the membrane, create a pore f...
    • Ion transport by P-type ATPases, organism-specific biosystem (from REACTOME)
      Ion transport by P-type ATPases, organism-specific biosystemThe P-type ATPases (E1-E2 ATPases) are a large group of evolutionarily related ion pumps that are found in bacteria, archaea and eukaryotes. They are referred to as P-type ATPases because they catal...
    • Mineral absorption, organism-specific biosystem (from KEGG)
      Mineral absorption, organism-specific biosystemMinerals are one of the five fundamental groups of nutrients needed to sustain life. Of the minerals, calcium plays innumerable roles in our bodies, serving as a main component of bone as well as an ...
    • Mineral absorption, conserved biosystem (from KEGG)
      Mineral absorption, conserved biosystemMinerals are one of the five fundamental groups of nutrients needed to sustain life. Of the minerals, calcium plays innumerable roles in our bodies, serving as a main component of bone as well as an ...
    • Pancreatic secretion, organism-specific biosystem (from KEGG)
      Pancreatic secretion, organism-specific biosystemThe pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesiz...
    • Pancreatic secretion, conserved biosystem (from KEGG)
      Pancreatic secretion, conserved biosystemThe pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesiz...
    • Protein digestion and absorption, organism-specific biosystem (from KEGG)
      Protein digestion and absorption, organism-specific biosystemProtein is a dietary component essential for nutritional homeostasis in humans. Normally, ingested protein undergoes a complex series of degradative processes following the action of gastric, pancrea...
    • Protein digestion and absorption, conserved biosystem (from KEGG)
      Protein digestion and absorption, conserved biosystemProtein is a dietary component essential for nutritional homeostasis in humans. Normally, ingested protein undergoes a complex series of degradative processes following the action of gastric, pancrea...
    • Proximal tubule bicarbonate reclamation, organism-specific biosystem (from KEGG)
      Proximal tubule bicarbonate reclamation, organism-specific biosystemOne of the major tasks of the renal proximal tubule (PT) is to secrete acid into the tubule lumen, thereby reabsorbing approximately 80% of the filtered bicarbonate (HCO3(-)), as well as generating "...
    • Proximal tubule bicarbonate reclamation, conserved biosystem (from KEGG)
      Proximal tubule bicarbonate reclamation, conserved biosystemOne of the major tasks of the renal proximal tubule (PT) is to secrete acid into the tubule lumen, thereby reabsorbing approximately 80% of the filtered bicarbonate (HCO3(-)), as well as generating "...
    • Salivary secretion, organism-specific biosystem (from KEGG)
      Salivary secretion, organism-specific biosystemSaliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for e...
    • Salivary secretion, conserved biosystem (from KEGG)
      Salivary secretion, conserved biosystemSaliva has manifold functions in maintaining the integrity of the oral tissues, in protecting teeth from caries, in the tasting and ingestion of food, in speech and in the tolerance of tenures, for e...
    • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
      Transmembrane transport of small molecules, organism-specific biosystem
      Transmembrane transport of small molecules

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    sodium:potassium-exchanging ATPase activity TAS
    Traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    ATP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    blood coagulation TAS
    Traceable Author Statement
    more info
    		  
    ion transmembrane transport TAS
    Traceable Author Statement
    more info
    		  
    leukocyte migration TAS
    Traceable Author Statement
    more info
    		  
    potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    response to hypoxia IEA
    Inferred from Electronic Annotation
    more info
    		  
    sodium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    transmembrane transport TAS
    Traceable Author Statement
    more info
    		  
    transport TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    basolateral plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    caveola IEA
    Inferred from Electronic Annotation
    more info
    		  
    integral to membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    sodium:potassium-exchanging ATPase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
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    General protein information

    Preferred Names
    sodium/potassium-transporting ATPase subunit beta-1
    Names
    sodium/potassium-transporting ATPase subunit beta-1
    adenosinetriphosphatase
    Na, K-ATPase beta-1 polypeptide
    Beta 1-subunit of Na(+),K(+)-ATPase
    sodium/potassium-dependent ATPase beta-1 subunit
    sodium/potassium-transporting ATPase beta-1 chain
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    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_023230.1 RefSeqGene

      Range
      5001..31014
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001677.3 → NP_001668.1  sodium/potassium-transporting ATPase subunit beta-1

      Status: REVIEWED

      Source sequence(s)
      AA514770, BC000006, BE223067, BM762099, BQ934151, CD722755, U16799
      Consensus CDS
      CCDS1276.1
      UniProtKB/TrEMBL
      A3KLL5
      UniProtKB/Swiss-Prot
      P05026
      Related
      ENSP00000356789, OTTHUMP00000032537, ENST00000367815, OTTHUMT00000083695
      Conserved Domains (1) summary
      cl08255
      Location:1 – 303
      Blast Score: 1185
      Na_K-ATPase; Sodium / potassium ATPase beta chain

    RefSeqs of Annotated Genomes: Build 37.3

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p5 Primary Assembly

    Genomic

    1. NC_000001.10 Reference GRCh37.p5 Primary Assembly

      Range
      169075947..169101960
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000133.1 Alternate HuRef

      Range
      140321997..140348078
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001001787.1: Suppressed sequence

      Description
      NM_001001787.1: This RefSeq was permanently suppressed because it represents a poorly supported variant with non-consensus splice sites.
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    Related Sequences

    Nucleotide Protein
    Heading Accession and Version
    genomic AL031726.23 CAI18888.1
    genomic CH471067.1 EAW90832.1
      EAW90833.1
    genomic HI573972.1 CBX47475.1
    genomic M25160.1 AAA36352.1
    genomic X17161.1 CAA35040.1
    mRNA AA507932.1 None
    mRNA AA514770.1 None
    mRNA AK290181.1 BAF82870.1
    mRNA AK296059.1 BAG58822.1
    mRNA AK316043.1 BAH14414.1
    mRNA AY545986.1 AAT11781.1
    mRNA AY946016.1 AAX55911.1
    mRNA BC000006.2 AAH00006.1
    mRNA BE223067.1 None
    mRNA BG702024.1 None
    mRNA BM762099.1 None
    mRNA BQ934151.1 None
    mRNA BT009787.1 AAP88789.1
    mRNA CD106723.1 None
    mRNA CD722755.1 None
    mRNA CR407616.1 CAG28544.1
    mRNA U16799.1 AAC50132.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P05026.1 GenPept UniProtKB/Swiss-Prot:P05026
    Q58I20 GenPept UniProtKB/TrEMBL:Q58I20
    Q6LEU2 GenPept UniProtKB/TrEMBL:Q6LEU2
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    Additional Links

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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