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    leuS leucyl-tRNA synthetase [ Streptococcus sanguinis SK36 ]

    Gene ID: 4806757, updated on 18-May-2013
    Gene symbol
    leuS
    Gene description
    leucyl-tRNA synthetase
    Locus tag
    SSA_0289
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Streptococcus sanguinis SK36 (strain: SK36)
    Lineage
    Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae; Streptococcus
    Sequence :
    NC_009009.1 (281546..284059)

    NC_009009.1Genomic Context describing neighboring genes Neighboring gene glycerol dehydrogenase Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene short chain dehydrogenase

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Genome of the opportunistic pathogen Streptococcus sanguinis. Xu P, et al. J Bacteriol, 2007 Apr. PMID 17277061.

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    Submit: New GeneRIF Correction
    Names
    leucyl-tRNA synthetase
    YP_001034296.1
    • leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_009009.1

      Range
      281546..284059
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_001034296.1 leucyl-tRNA synthetase [Streptococcus sanguinis SK36]

      Status: VALIDATED

      UniProtKB/Swiss-Prot
      A3CKP1
      Conserved Domains (5) summary
      cd07958
      Location:653 – 751
      Blast Score: 351
      Anticodon_Ia_Leu_BEm; Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases
      cd00812
      Location:38 – 229
      Blast Score: 675
      LeuRS_core; catalytic core domain of leucyl-tRNA synthetases
      pfam13603
      Location:253 – 405
      Blast Score: 576
      tRNA-synt_1_2; Leucyl-tRNA synthetase, Domain 2
      PRK00390
      Location:4 – 837
      Blast Score: 3661
      leuS; leucyl-tRNA synthetase; Validated
      cl00015
      Location:471 – 653
      Blast Score: 464
      nt_trans; nucleotidyl transferase superfamily
    Nucleotide Protein
    Heading Accession and Version
    genomic CP000387.1 ABN43746.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases

      Supplemental Content

      Table of contents

      Related information

      • BioProjects
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      • BioSystems
        BioSystems
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • Nucleotide
        Link to related Nucleotide entry
      • Protein
        Link to related protein entry
      • Protein Clusters
        Related Protein Clusters
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • Taxonomy
        Link to related taxonomy entry

      Links to other resources

      General information

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